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( Doo Byung Chay ),( Han Byoul Cho ),( Min Young Chang ),( Chung Won Lee ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
To analyzed the expression of GLUT-1 in epithelial ovarian cancer (EOC) and to evaluate its clinical significance. Illumina microarray was used to identify differentially expressed genes in 3 EOC cells. To validate the microarray data, mRNA and protein level of GLUT-1 was examined by real-time PCR and immunohistochemistry (IHC) and compared with clinicopathological parameters including survival data. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. PCR and immunohistochemistry demonstrated that GLUT-1 expression was significantly increased in EOC (p=0.029 and p<0.001, respectively). Particularly, IHC demonstrated that GLUT-1 expression in serous ovarian cancer was significantly higher than non-serous types (p=0.036). On survival analysis, GLUT-1 overexpression (HR = 4.80 [1.02-22.10], p=0.027) and lymph node (LN) metastases (HR = 8.35 [1.05-46.21], p=0.016) conferred a significantly worse overall survival. GLUT-1 expression is remarkably up-regulated in EOC and predicts a poor overall survival.
Factors associated with prediction of residual lesion in conization
( Bo Ram Choi ),( Doo Byung Chay ),( Han Byoul Cho ),( Hyun Sun Lim ),( Young Tae Kim ),( Jae Hoon Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-
We investigated factors affecting margin involvement, follow-up cytology and high risk human papillomavirus (HPV) testing within 6 months after conization, following surgical treatment after conization as predictors of incomplete excision in conization. One thousand four hundred forty six patients who underwent conization due to diagnose and treat cervical intraepithelial neoplasia (CIN) in Gangnam Serverance and Severance Hospital from January 2008 to December 2011 were included in this retrospective study. We analyzed their clinical and pathologic characteristics. Aging (odd ratio [OR], 1.039; 95% confidence interval [CI], 1.022-1.056), high grade group of preconization cytology(OR, 1.800; 95% CI, 1.333-2.431), preconization high risk HPV testing positivity (OR, 5.215; 95% CI, 1.824-5.215) were statistically significant factors that affect conization margin positivity. The width of specimen in conization was predictive factor for follow-up cytology within 6 months after conization (OR, 0.579; 95% CI, 0.370-0.906). Low grade group of preconization cytology (OR, 0.619; 95% CI, 0.426-0.900), preconizaton HPV testing positivity (OR, 4.726; 95% CI, 2.172-10.28) were significantly different in follow-up high risk HPV testing within 6 months after conization. Aging (OR, 1.066; 95% CI, 1.044-1.090), high grade group of preconization cytology (OR, 2.293; 95% CI, 1.575-3.338), preconization high risk HPV testing (OR, 4.560; 95% CI, 2.158-9.639), local anesthesia (OR, 1.885; 95% CI, 1.136-3.128) were relative to the following surgical treatment after conization. It is important to predict residual lesion after conization that affected by age, parity, preconization cytology and high risk HPV testing, anesthesia. These findings could be used to determine appropriate follow-up protocols.
( Ji Hui Choi ),( Geum Seon Sohn ),( Doo Byung Chay ),( Han Byoul Cho ),( Jae-hoon Kim ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3
Objective The main aim of this study was to evaluate cancer antigen 125 (CA125)/carcinoembryonic antigen (CEA) ratio (CCR), as a reliable marker to differentiate ovarian mucinous carcinoma from other epithelial ovarian carcinomas (EOCs), namely serous, clear cell, and endometrioid carcinomas. Methods Female patients suffering from different kinds of EOCs whom were subjected to elective surgery at the Gangnam Severance Hospital between January 2008 and December 2016, were included in this study. The serum levels of CA125 and CEA were assayed using commercially available kits per the manufacturer's instructions. Results The CCR in mucinous carcinoma (mean 32.1) was significantly lower than that of clear cell (mean 235.0) and endometrioid carcinoma (mean 427.0) in stage I (all P<0.05). In stage II-IV, CCR in mucinous carcinoma (mean 37.6) was significantly lower than that of serous carcinoma (mean 148.0) (P<0.01). The sensitivity and specificity of CCR in detecting mucinous carcinoma from other types of EOC was 75.0% and 77.5%, respectively in stage I and 100.0% and 84.4%, respectively in stage II-IV (both cut-off value <90.7). Conclusion The present results suggest that pretreatment CCR might provide higher specificity and clinically relevant information as a criterion for the differentiation between ovarian mucinous carcinoma and other types of EOC.
Prevalence and Seroprevalence of High-Risk Human Papillomavirus Infection :
Kim, Min-A,Oh, Jin-Kyoung,Chay, Doo Byung,Park, Dong Choon,Kim, Seok Mo,Kang, Eun-Suk,Kim, Jae-Hoon,Cho, Chi-Heum,Shin, Hai-Rim,Seo, Kyung Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2010 Obstetrics and gynecology Vol.116 No.4
<P>OBJECTIVE:: To estimate the prevalence and seroprevalence of high-risk human papillomavirus (HPV) in Korean girls and women. METHODS:: We estimated the seroprevalence of HPV subtypes 16 and 18 among 1,094 girls and women aged 9-59 years and the prevalence of genital high-risk HPV among 902 women aged 20-59 years who visited our institution for a medical checkup. Genital high-risk HPV DNA was measured using liquid hybridization and polymerase chain reaction assays. Serum antibodies to HPV subtypes 16 and 18 were measured using a multiplexed competitive luminex technique. RESULTS:: The prevalence of genital high-risk HPV was 12.6% among Korean women aged 20-59 years. It reached a peak of 23.2% at 20-29 years of age, decreasing thereafter but increasing again to 12.4% at 50-59 years of age. Human papillomavirus 56 was the most common subtype followed by HPV 18, HPV 52, and HPV 16. The seroprevalence of HPV subtypes 16 and 18 was 8.7% among Korean girls and women aged 9-59 years. It reached its highest peak of 13.4% at 25-29 years of age and decreased thereafter. It then reached a second peak of 10.9% at 40-49 years of age and plateaued thereafter. The seroprevalences of HPV subtypes 16 and 18 were 7.4% and 2.7%, respectively. In multivariable analysis, the prevalence and seroprevalence of high-risk HPV were correlated only with the number of lifetime sexual partners. CONCLUSION:: High-risk HPV infection is common among Korean women. Our epidemiological data on high-risk HPV infection will help to assess vaccine policy and to establish a baseline for estimating vaccine efficacy. LEVEL OF EVIDENCE:: III.</P>
Prevalence and Seroprevalence of Low-risk Human Papillomavirus in Korean Women (초)
홍연 ( Yeon Hong ),( Min A Kim ),( Jin Kyoung Oh ),( Doo Byung Chay ),( Dong Choon Park ),( Seok Mo Kim ),( Eun Suk Kang ),( Jae Hoon Kim ),( Chi Heum Cho ),( Hai Rim Shin ),( Kyung Seo ) 대한산부인과학회 2010 대한산부인과학회 학술대회 Vol.96 No.-
( Jisup Kim ),( Jinkyoung Kong ),( Soohyn Kim ),( Min Ae Cho ),( Doo Byung Chay ),( Soon Won Hong ),( Jae-hoon Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Lynch syndrome (LS) is an autosomal dominant genetic condition which increases the risk of developing colorectal, endometrial, and various other cancers. Inefficiency of selective screening method based on personal/family history has led to general use of universal screening method with 4-antibody panel (MLH1, MSH2, MSH6, PMS2) for detecting Mismatch Repair (MMR) gene deficiency. For cost-effectiveness of universal Lynch screening the use of 2-antibody panel composed of MSH6 and PMS2 have been suggested in patients with colorectal cancer. The purpose of this study is to evaluate the immunohistochemisrty results of missmatch repair gene expression in endometrial cancer. 방법: 120 endometrial carcinoma specimens derived from patients who performed hysterectomy from 2009 to 2016 were stained with 4-antibody panel (MLH1, MSH2, MSH6, PMS2) 결과: Overall, 49 out of 120 cases (40.8%) showed loss expression in at least one MMR genes. 16 case (21.3%) showed loss of MLH1 and PMS2. 11case (9.2%) showed loss of MSH2 and MSH6. 11 case (9.2%) showed loss of MSH6. 1 case showed loss of PMS2 expression. There was no case showing isolated loss of MLH1 or MSH2. 결론: Our finding proves the utility of 2-antibody panel (MSH6, PMS2) in screening of Lynch syndrome in endometrial cancer. Considering the cost-effectiveness, 2-antibody panel should be implemented for universal screening for Lynch syndrome in endometrial cancer patients.