여성 외음부에 발생한 선상 편평상피세포암종

김창옥,양기화,강석진,이안희,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1

濟州道의 未利用 食用植物에 관한 硏究 : 그 榮養成分과 資源 With Emphasis on Resources and untritional Constituents

康順善 제주대학교 1976 논문집 Vol.8 No.-

1) 本調査는 1975年 10月부터 1976年 9月까지 濟州道에 分布되어 있는 野生食用植物에 對하여 生育相, 利用部位, 重要特殊成分, 榮養成分을 調査하여 目錄化하였다. (Table 4) 2) 野生食用植物의 調査種數는 一年生 草本 20種, 多年生草本 98種, 越年生草本 12種, 灌木13종, 그리고 喬木 8種, 其他 3種으로 總 47科에 154種을 調査하였다. 3) 그리고 86種 對하여는 民間藥材로 많이 利用되고 있으나 藥用植物로서의 栽培는 없었다. 4) 生育地別로는 山野에 51種, 野地, 路邊에 71種 砂丘, 海邊에 8種, 水邊에 24種이 분포되어 있었다. 5) 利用部位 별로는 全草 84種, 뿌리 28種, 新초部位 14種, 꽃 12種 그리고 種實 및 果肉이 9種으로 調査되었다. 6) 野生植物의 調査 總數 154種의 粉末試料에 對한 一般成分의 平均値는 水分 12.7%, 蛋白質 18.0%, 脂肪 3.5%, 糖質 41%, 纖維 17.1%, 無機質 7.7%, 粗澱粉 22.5%로 采蔬栽培作物에 비하여 纖維가 높고, 糖分이 적은 傾向이나 他營養成分은 비슷한 水準이 었으며, 7) 蛋白質 含量은 十字花科와 豆科에 屬한 植物이 大體로 높아 20∼30%인 것이 30種이나 되며, 30%이상인 것은 고추냉이, 닭오갈피, 민바퀴나물까치수염꽃, 명아주, 드름, 고추나무, 으름덩굴, 수영等의 9種이다. 8) 食糧價値가 큰 것은 粗澱粉 含量이 높은 植物種을 들수 있으며, 참비름의 種實은 混食用으로 利用할 수 있고, 野生食用植物은 菜蔬代用 補助食糧으로 價値가 있다. 1. This survey was carried out from Oct. 1975 to Oct. 1975 for the growth phases, useful parts, major special and nutritional constituents of the wild (edible) plants grown in Jeju Island. 2. It was dealt with total 154 wild edible plants including 20 annual grasses. 12 overyearing grasses, 98-polyannual grasses, 13. shrubs, 8 tall trees and 3 other. 3. 86 plants among them have been used for the raw materials of medicine among the people, but no cultivation was fonnd. 4. 51 plants were growing on moor and hills. 71 were on the roadsides and flat grounds. 5. 84 plants were able to use for all grasses, 28 for roots. 14 for young leaves and sprouts, 12 for flowers and 19 for for seeds and Fruits. 6. Average value of general constituents for the dry powdered samples of 154 plants were 12.7%of water, 18.0% of protein, 3.5% of fat, 41% of sugars, 17.1% of cellulose, 7.7% of minerals and 22.5% of crude strach, and these results showed higher cellulose contents and lower contents than the culture plants, but other componants were much similar level. 7. Protein contents were appeared higher level in Brassicaceae and papilionaceae among 154 plant, 30were in20-30% and 9 such as Gochhunangi, Darkogalphi, Minbaquinamul, Ggachisuyeomggoch, Meongaju, Deureum, Gochunamul Eurmdeongul and Suyoung were above 30%. 8. Edible wild plants were possible to use the substitutional foods.

동진강 유역내 하천의 특성별 영향평가

윤순강,김원일,김진호,김선종,고문환,엄기철 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

본 연구는 동진강 유역의 수질 보전을 위한 기초자료를 얻기 위하여 동진강 본류와 이에 유입되는 정읍천을 대상으로 2001년 5월부터 11월까지 수질 모니터링을 실시하였다. 동진강 본류의 수질은 BOD기준으로 상수원 Ⅱ~Ⅳ등급(2.84~6.45 ㎎/L)으로 지점별로는 DJ6(정읍천 합류후)이 4.07㎎/L로 높게 나타나 Ⅲ급수의 수질을 유지하였다. COD는 지점별로 11.20~32.96 ㎎/L의 범위로 정읍천 합류후의 농도가 32.96 ㎎/L로 가장 높게 나타나 정읍천을 통한 본류의 오염물질량의 증가를 알 수 있었다. T-N의 경우 4.16~5.84 ㎎/L의 범위로 유역 전반에 걸쳐 오염이 이루어지고 있는 것으로 나타났고, T-P의 경우 BOD, COD와 마찬가지로 정읍천 합류후가 0.19 ㎎/L로 타 지점에 비하여 놀게 조사되었다. 본류의 COD의 경우 장마후 갈수기에 높은 농도를 나타냈고, T-P의 경우는 하천의 유량이 증가하는 홍수기보다 장마전 갈수기의 오염정도가 높고 이후 장마후 갈수기로 갈수록 수질이 악화되는 것으로 조사되었다. 동진강 수질의 오염은 주로 하류로 갈수록 그 정도가 심하게 나타나는데, 이것은 정읍천을 통해 유입되는 도시 생활하수와 인근 공장단지의 산업폐수가 그 주 요인으로 오염물질(BOD, COD T-N 및 T-P)의 농도가 상승하는 주원인이 되고 있다. 따라서, 동진강 수계의 수질관리를 위해 주 오염원이 되고 있는 정읍천의 도시생활하수와 공장단지에서 방류되는 산업폐수의 제어에 대한 대책이 먼저 이루어져야 할 것으로 판단된다. Irrigation water quality along Donjin river watershed was monitored to find a possible pollutants, for maintaining water quality to achieve food safety through water quality preservation of river. As a pollution indicators, such as Biological Oxygen Demand(BOD), Chemical Oxygen Demand(COD), Total Nitrogen(T-N), and Total Phosphate(T-P) in Dongjin river were examined from May to November in 2001. The results were as follows : The BOD level of Dongji n river ranged from 2.84 to 6.45 mg/L, which would be in a Ⅱ~Ⅳ grade of the potable water criteria by Ministry of Environment. Averaged BOD level of downstream DJ6(After Jeongupcheon confluence) was 4.07 mg/L. The average COD level of Dongjin river ranged from 11.20 to 32.96 mg/L. COD level of DJ6 rapidly increased rapidly after the junction of Dongjin river and Jungupcheon because it showed the latter had relatively high pollution level. T-N content were significantly high in all sites of Dongjin river ranged through 4.16 to 5.84 mg/L. T-P examined high concentration than another thing point by 0.19 mg/L after Jeongupcheon confluence as BOD and COD. COD of main stream was expressed high concentration to dry season after rainy season. In case of T-P, pollution degree of dry season before rainy season appeared and examined that quality of water was worsened go by dry season after rainy season. The water quality of Dongjin river was deteriorated with inflow of Jungupcheon polluted by municipal and industrial sites near Jungup city.

석고판 경량 간막이 벽체의 구성방법에 따른 차음성능에 관한 연구

이태강,정진연,김선우 대한건축학회 2005 대한건축학회논문집 Vol.21 No.2

This paper aims to investigate the characteristics of partition walls which are light weighted, dry walls of gypsum boards, These partition walls are prospected to be new ones to cope with M.C.(Modular Coordination), flexibility, non-bearing system, substitution to masonry works. The number of tested partition walls are 16 which are varied with core materials, depth and construction methods. These partitions of sound insulation characteristics of light weighted partitions were tested in reverberation room. And compared with 0.5B and 1B masonry wall of sound insulation performance, the partitions are evaluated by R_w performance. The sound insulation performance of the gypsum board partitions are as good as the performance of masonry wall.

만경강 유역내 하천의 특성별 영향 평가

윤순강,이종식,정구복,김민경,김선종,고문환,엄기철 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4

본 연구는 만경강 유역의 수질 보전을 위한 기초자료를 얻기 위하여 만경강 본류와 이에 유입되는 지천을 선정하여 2001년 5월부터 11월까지 매월 수질 모니터링을 실시하였다. 만경강 유역내 본류 및 지천의 유기물과 영양염류 함량을 조사한 결과, 본류의 T-N은 3.78~12.68 ㎎/L였으며, 지천중 축산폐수가 유입되는 익산천의 농도가 가장 높았다. 본류의 T-P의 BOD는 각각 0.043~0.864 ㎎/L와 2.59~13.29 ㎎/L였으며, 지천중 익산천이 가장 높았다. 본류의 COD는 12.9~119.5 mg/L였으며, 지천중 도시생활하수가 유입되는 추천이 가장 높았다. 만경강 유역 수질저하의 주 원인은 축산폐수였으며, 도시생활하수가 그 다음으로 중요한 원인으로 평가되었다. 만경강 본류의 T-N과 T-P는 하천의 유량이 증가하는 홍수기인 7~8월보다 장마선 갈수기인 5~6월에 높았고, COD는 장마전 갈수기보다 홍수기에 높았으며 장마가 완전히 끝난 영농후 갈수기인 9~11월에도 수질저하가 지속되었다. 만경강에 유입되는 지천중 전반적으로 수질오염이 심각한 익산천과 추천은 영농후 갈수기에 수질이 가장 저하되었고 상대적으로 홍수기에는 양호하였다. A survey on four tributaries along with Mankyeong River was carried out to get the information for the water quality improvement and control. Typical paddy farming were major agricultural practices in Kosancheon and Soyangcheon. Iksancheon was livestock raising watershed. Chucheon was urban watershed. Water quality in six sites of main stream and four sites of tributaries in Mankyeong River were investigated from May to August in 2001. The concentration of nutrients in main stream of Mankyeong River were in the range of 3.78~12.68 mg/L for total nitrogen, 0.043~0.864 mg/L for total phosphorus, 2.59~13.29 mg/L for BOD and 12.9~119.5 mg/L for COD, respectively. Water quality of Mankyeong River mostly exceeded the standard water quality criteria of Korea. Major causes of water pollution were evaluated as sewage of swine and urban area. Among the four tributaries, water quality in agricultural practices, Kosancheon and Soyangcheon was relatively less polluted. While, the highest level of water pollution measured in Iksancheon was due to livestock The water quality of Iksancheon and Chucheon was generally more polluted in the dry period than in rainy period.

IgA 신병증의 임상 및 병리학적 고찰

이강욱,최영환,신영태,노흥규,서광선 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Twenty eight cases of primary IgA nephropathy were diagnosed and studied in the Department of Internal Medicine, Chungnam National University Hospital over a period of 49 months from June 1981 to July 1985. The results were summerized as follows: 1. These cases represented 45.2% of patients with primary glomerular diseases undergoing renal biopsy and immunofluorescent studies during the same period. 2. There were 20 males and 8 females. They were 15 to 54 years old and the average age was 29.1. 3. The main symptoms were loin pain, gross hematuria, myalgia, fatigability and generalized edema in 18, 15, 12, 12, and 4 cases, respectively. Upper respiratory tract infection symptoms were presented in 50% of the cases of all patient just before and during the course of disease. 4. Proteinuria was observed in 27 cases and hematuria was seen in 23 cases, Among hematuria, the gross hematuria was observed in 15 cases. Hypoalbuminemia and hypercholesterolemia was presented in 4 cases with generalized edema. Serum BUN and creatinine were elevated in 3 cases with marked decreased Creatinine Clearence in 3 cases (Ccr<50ml/min). 5. The light microscopic findings showed mainly mesangial proliferative glomerulonephritis and focal and segmental glomerular sclerosis in 11 and 7 cases, respectively. Immunofluorescent microscopic findings disclosed diffuse mesangial deposit of IgA in all cases. IgG, igM, C3 and fibrinogen deposits were observed in mesangium in 5, 4, 20, and 7 cases, respectively.

C6 glia 세포에서 유도성 Nitric Oxide Synthase 유전자 발현조절에 관한 연구

배진영,허강민,배소현,박지선,이충재,이재흔,석정호 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

To investigate transcriptional regulation of iNOS gene by LPS and cytokines, the production of NO, expression of iNOS mRNA and protein, binding activity of nuclear factor-kappa B(NF-kB), and promoter activity of iNOS gene were examined in rat C6 glial cells. LPS, interferon-gamma(IFN-γ), and tumor necrosis factor-alpha (TNF-α) stimulated the production of NO, which was increased synergistically by co-treatment. By the treatment of LPS, iNOS mRNA expression was initiated at 1 h, markedly increased by 3 h, and decreased gradually afterward. iNOS mRNA expression was markedly enhanced by mixture of LPS, IFN-γ and TNF-α. iNOS protein synthesis was increased by the treatment of mixture LPS and cytokine mixture. Treatment of LPS stimulated NF-kB activation, and the activation reached to the maximum level at 30 min, and the treatment of mixture of LPS and cytokines increased the activation. To determine the effect of NF-kB binding activity on iNOS promoter activation, CAT assay was performed. iNOS promoter activity was increased by the treatment with LPS for 5.5 h, and further increased by the combined treatment with LPS and cytokines. These results suggest that NF-kB activation by LPS and cytokines may play a significant role in the induction of the iNOS gene.

Acral Lentiginous Melanoma

김영대,강석진,허미경,김병기,김선무 대한병리학회 1986 Journal of Pathology and Translational Medicine Vol.20 No.2

하수오니 시용토양에서 작물의 중금속 흡수이행에 미치는 석회의 영향

정구복,김원일,이종식,윤순강 한국환경농학회 2002 한국환경농학회지 Vol.21 No.1

공단 하수오니의 농경지 유입에 따른 토양의 중금속 함량과 작물체로의 중금속 흡수이행에 미치는 석회시용 효과를 조사하였다. 공단하수오니 및 돈분퇴비를 각각 25, 50 Mg/ha 시용토양에 석회를 3 Mg/ha 처리하여 함량을 분석하였다. 시험후 토양의 중금속 함량은 공단하수오니에서 대조구(NPK 처리구) 및 돈분퇴비보다 높았으며, 특히 공단하수오니 50 Mg/ha 시용구에서는 구리, 아연, 니켈 및 크롬함량이 대조구와 비교하여 12∼48배 높은 농도를 보였다. 공단하수오니 시용으로알타리무로 흡수 이행된 구리, 아연 및 니켈 함량은 증가하여 알타리무 엽중의 농도가 식물독성 피해농도를 초과하는 수준이였다. 공단하수오니 시용토양에서 석회시용으로 알타리무 엽과 뿌리중 구리, 아연 및 니켈 함량은 크게 감량되었으며, 시험후 토양의 pH와 알타리무중 구리, 아연 및 니켈 함량과는 고도의 부의상관을 보였다. 이상의 결과에서 석회시용이 중금속이 다량 함유된 하수오니 유입으로 인한 작물의 독성피해와 중금속 흡수 이행성을 경감시킬 수 있는 일시적인 개량방법으로 이용될 수 있을 것으로 생각되었다. The effect of lime on plant availability of heavy metals in soils amended with industrial sewage sludge (ISS) or pig manure compost (PMC) was investigated. A pot experiment with Altari radish (Raphanus sativus) was conducted. Industrial sewage sludge and pig manure compost were added at 25 and 50 Mg/ha, and lime was added at 3 Mg/ha. Heavy metal contents of ISS treated soils after experiment were higher than those in control (NPK plot) and PMC treatment. Specially, the contents of copper, zinc, nickel and chromium in the 50 Mg/ha of ISS treated soils were higher 12~48 times than those in control. Copper, zinc, and nickel contents in Altari radish leaves cultivated at the ISS treated soil exceeded the critical levels of plant toxicity. Copper, zinc, and nickel contents in Altari radish leaves and roots cultivated at the ISS treated soil were reduced by the addition of lime. Copper, zinc, and nickel contents in Altari radish leaves were negatively correlated with soil pH after experiment. It concluded that liming would reduce the uptake of heavy metals by plants and be a temporary method of reclamation at the highly heavy metal accumulated soils by ISS.

일차배양된 설치류 호흡기 상피세포로부터의 점액소 분비에 대한 수종 약물의 영향

이충재,석정호,이재흔,허강민,박지선,배소현,노삼길,박상철 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

1. PKC activator인 PMA는 일차배양 HTSE세포로부터의 뮤신분비를 0.1μM 농도에서 30%, 1μM 농도에서 80% 가량 증가시켰다. 2. 식물 유래 성분으로, flavonoid의 일종인 TFR은 일치배양 HTSE 세포로부터의 뮤신분비를 10μM 농도에서 50%, 100μM 농도에서 80% 가량 증가시켰다. 3. 양이온성 폴리펩티드인 PLL 및 PLA는 일차 배양 HTSE 세포로부터의 뮤신분비를 0.01 - 10μM 농도에서 용량의존적으로 감소시켰다. 4. 결론적으로, 본 연구에서 얻어진 결과들은 새로운 거담제 및 점액용해제나 단백분해 효소제가 아닌 호흡기 류신의 생성/분비를 조절해 줄 수 있는 신개념의 약물을 개발함에 있어 극히 일부분이나마 단서를 제공하고 있다고 하루 수 있을 것이다. In the present study, we tried to investigate whether phorbol myristate acetate(PMA), trihydroxymethoxy-flavanone rutinoside(TFR) and cationic polypeptides significantly affect mucin release(secretion) from cultured hamster tracheal surface epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of each agent to assess the effect on 3H-mucin release. The results were as follows : (1) Both PMA and TFR significantly increased mucin release from cultured HTSE cells ; (2) Cationic polypeptides including po1y-L-lysine(PLL, mw 7,500) and poly-L-arginine(PLA, mw 10,800) significantly inhibited mucin release from cultured HTSE cells, in a dose-dependent manner. This finding suggests us that PMA and TFR be further studied for the possible use as mild expectorants and cationic polypeptides might function as a regulator for hyper-secretion of mucus, both by direct acting on airway mucin-secreting cells, during the treatment of chronic airway diseases.