Nanoplasmonic sensors for detecting circulating cancer biomarkers

Ferhan, Abdul Rahim,Jackman, Joshua A.,Park, Jae Hyeon,Cho, Nam-Joon,Kim, Dong-Hwan Elsevier 2018 Advanced drug delivery reviews Vol.125 No.-

<P><B>Abstract</B></P> <P>The detection of cancer biomarkers represents an important aspect of cancer diagnosis and prognosis. Recently, the concept of liquid biopsy has been introduced whereby diagnosis and prognosis are performed by means of analyzing biological fluids obtained from patients to detect and quantify circulating cancer biomarkers. Unlike conventional biopsy whereby primary tumor cells are analyzed, liquid biopsy enables the detection of a wide variety of circulating cancer biomarkers, including microRNA (miRNA), circulating tumor DNA (ctDNA), proteins, exosomes and circulating tumor cells (CTCs). Among the various techniques that have been developed to detect circulating cancer biomarkers, nanoplasmonic sensors represent a promising measurement approach due to high sensitivity and specificity as well as ease of instrumentation and operation. In this review, we discuss the relevance and applicability of three different categories of nanoplasmonic sensing techniques, namely surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS), for the detection of different classes of circulating cancer biomarkers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Nanoplasmonic Ruler for Measuring Separation Distance between Supported Lipid Bilayers and Oxide Surfaces

Ferhan, Abdul Rahim,Š,pač,ková,, Barbora,Jackman, Joshua A.,Ma, Gamaliel J.,Sut, Tun Naw,Homola, Jiř,í,Cho, Nam-Joon American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.21

<P>Unraveling the details of how supported lipid bilayers (SLBs) are coupled to oxide surfaces is experimentally challenging, and there is an outstanding need to develop highly surface-sensitive measurement strategies to determine SLB separation distances. Indeed, subtle variations in separation distance can be associated with significant differences in bilayer-substrate interaction energy. Herein, we report a nanoplasmonic ruler strategy to measure the absolute separation distance between SLBs and oxide surfaces. A localized surface plasmon resonance (LSPR) sensor was employed to track SLB formation onto titania- and silica-coated gold nanodisk arrays. To interpret measurement data, an analytical model relating the LSPR measurement response to bilayer-substrate separation distance was developed based on finite-difference time-domain (FDTD) simulations and theoretical calculations. The results indicate that there is a larger separation distance between SLBs and titania surfaces than silica surfaces, and the trend was consistent across three tested lipid compositions. We discuss these findings within the context of the interfacial forces underpinning bilayer-substrate interactions, and the nanoplasmonic ruler strategy provides the first direct experimental evidence comparing SLB separation distances on titania and silica surfaces.</P> [FIG OMISSION]</BR>

Surface-floating gold nanorod super-aggregates with macroscopic uniformity

Ferhan, Abdul R.,Huang, Youju,Dandapat, Anirban,Kim, Dong-Hwan Springer-Verlag 2018 Nano research Vol.11 No.5

Some fixed fuzzy point results using Hausdorff metric in fuzzy metric spaces

Ferhan Sola Erduran,Cemil Yi Idiz 원광대학교 기초자연과학연구소 2017 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.13 No.5

In this paper, we obtain coupled fixed fuzzy point theorem for a fuzzy mapping in Hausdorff fuzzy metric space and using it, we obtain a common fixed fuzzy point for a hybrid fuzzy pair. Also we give an auxiliary example to support our main theorem.

Comparative color and surface parameters of current esthetic restorative CAD/CAM materials

Egilmez, Ferhan,Ergun, Gulfem,Cekic-Nagas, Isil,Vallittu, Pekka Kalevi,Lassila, Lippo Veli Juhana The Korean Academy of Prosthodonitics 2018 The Journal of Advanced Prosthodontics Vol.10 No.1

PURPOSE. The purpose of this study was to derive and compare the inherent color (hue angle, chroma), translucency ($TP_{SCI}$), surface gloss (${\Delta}E^*_{SCE-SCI}$), and surface roughness ($R_a$) amongst selected shades and brands of three hybrid CAD/CAM blocks [GC Cerasmart (CS); Lava Ultimate (LU); Vita Enamic (VE)]. MATERIALS AND METHODS. The specimens (N = 225) were prepared into square-shaped ($12{\times}12mm^2$) with different thicknesses and shades. The measurements of color, translucency, and surface gloss were performed by a reflection spectrophotometer. The surface roughness and surface topography were assessed by white light interferometry. RESULTS. Results revealed that hue and chroma values were influenced by the material type, material shade, and material thickness (P < .001). The order of hue angle amongst the materials was LU > CS > VE, whereas the order of chroma was VE > CS > LU. $TP_{SCI}$ results demonstrated a significant difference in terms of material types and material thicknesses ($P{\leq}.001$). $TP_{SCI}$ values of the tested materials were ordered as LU > CS > VE. ${\Delta}E^*_{SCE-SCI}$ and $R_a$ results were significantly varied amongst the materials (P < .001) and amongst the shades (P < .05). The order of ${\Delta}E^*_{SCE-SCI}$ amongst the materials were as follows $LU>VE{\geq}CS$, whereas the order of $R_a$ was $CS{\geq}VE>LU$. CONCLUSION. Nano-ceramic and polymer-infiltrated-feldspathic ceramic-network CAD/CAM materials exhibited different optical, inherent color and surface parameters.

Gold Nanowire Bundles Grown Radially Outward from Silicon Micropillars

Huang, Youju,Ferhan, Abdul Rahim,Cho, Seok-Jin,Lee, Haiwon,Kim, Dong-Hwan American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.32

<P>One-dimensional (1D) micro- and nanostructures have become increasingly popular because of their tremendous prospect in various applications. While the design and fabrication of these structures from a single component in two-dimensional (2D) arrays is common, the attainment of hierarchical three-dimensional (3D) architectures made up of multicomponent one-dimensional structures is rare. Herein we report, for the first time, the lateral growth of gold nanowires from the sidewalls of substrate grown silicon micropillars to form a unique 'wire-on-pillar' architecture. Unlike zero-dimensional (OD) point-like, 1D linear, and 2D planar Au structures, the obtained 3D 'wire-on-pillar' Au architecture provides abundant hotspots between adjacent Au wires, which led to remarkably high surface-enhanced Raman scattering (SERS) signals.</P>

A Strategy for the Formation of Gold–Palladium Supra-Nanoparticles from Gold Nanoparticles of Various Shapes and Their Application to High-Performance H₂O₂ Sensing

Huang, Youju,Ferhan, Abdul Rahim,Dandapat, Anirban,Yoon, Chong Seung,Song, Ji Eun,Cho, Eun Chul,Kim, Dong-Hwan American Chemical Society 2015 The Journal of Physical Chemistry Part C Vol.119 No.46

<P>We present a new approach for the synthesis of gold (Au)–palladium (Pd) bimetallic supra-nanoparticles in which densely packed anisotropic Pd nanostructures surround a central Au nanoparticle (rod, sphere, cubic shape). They were obtained by means of Pd crystal growth on Au nanoparticle surfaces which are modified with a mixture of cetyltrimethylammonium bromide (CTAB) and 5-bromosalicylic acid (5-BrSA). From a comparative study with a Au nanorod (NR) as a seed, the use of the CTAB/5-BrSA mixture plays a pivotal role in obtaining such unique supra-structures; the Au NR capped with only CTAB resulted in Au core–continuous Pd shell nanoparticles instead. The Au–Pd supra-nanoparticles provide active surface area for electrocatalytic activities higher than that of the Au@Pd continuous shell nanoparticles, displaying outstanding performance for mediator-free electrochemical detection of H<SUB>2</SUB>O<SUB>2</SUB>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2015/jpccck.2015.119.issue-46/acs.jpcc.5b08423/production/images/medium/jp-2015-08423b_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp5b08423'>ACS Electronic Supporting Info</A></P>

Physical characteristics of ceramic/glass-polymer based CAD/CAM materials: Effect of finishing and polishing techniques

Mugem Asli Ekici,Ferhan Egilmez,Isil Cekic-Nagas,Gulfem Ergun 대한치과보철학회 2019 The Journal of Advanced Prosthodontics Vol.11 No.2

PURPOSE. The aim of this study was to compare the effect of different finishing and polishing techniques on water absorption, water solubility, and microhardness of ceramic or glass-polymer based computer-aided design and computer-aided manufacturing (CAD/CAM) materials following thermocycling. MATERIALS AND METHODS. 150 disc-shaped specimens were prepared from three different hybrid materials and divided into five subgroups according to the applied surface polishing techniques. All specimens were subjected up to #4000 grit SiC paper grinding. No additional polishing has been done to the control group (Group I). Other polishing procedures were as follows: Group II: two-stage diamond impregnated polishing discs; Group III: yellow colored rubber based silicone discs; Group IV: diamond polishing paste; and Group V: Aluminum oxide polishing discs. Subsequently, 5000-cycles of thermocycling were applied. The analyses were conducted after 24 hours, 7 days, and 30 days of water immersion. Water absorption and water solubility results were analyzed by two-way ANOVA and Tukey post-hoc tests. Besides, microhardness data were compared by Kruskal-Wallis and Mann- Whitney U tests (P<.05). RESULTS. Surface polishing procedures had significant effects on water absorption and solubility and surface microhardness of resin ceramics (P<.05). Group IV exhibited the lowest water absorption and the highest microhardness values (P<.05). Immersion periods had no effect on the microhardness of hybrid ceramic materials (P>.05). CONCLUSION. Surface finishing and polishing procedures might negatively affect physical properties of hybrid ceramic materials. Nevertheless, immersion periods do not affect the microhardness of the materials. Final polishing by using diamond polishing paste can be recommended for all CAD/CAM materials.

Fabrication of Plasmon-Active Polymer-Nanoparticle Composites for Biosensing Applications

Abhinay Mishra,Abdul Rahim Ferhan,Chee Meng Benjamin Ho,Joohyun Lee,Dong-Hwan Kim,Young Jin Kim,Yong-Jin Yoon 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.8 No.3

Polymer-nanoparticle composites find relevance in various fields ranging from optoelectronics to the biomedical sciences. Various efforts have been made to devise fabrication strategies that are simple, robust,and reproducible. Herein, we demonstrate a universal strategy to fabricate plasmon-active polymer-nanoparticle composites, exemplified by the incorporation of gold nanoparticles (AuNPs) into a triethylene glycol dimethacrylate (TEGDMA) polymer scaffold. The TEGDMA scaffold was synthesized on a planar glass support substrate via surface-initiated atomic transfer radical polymerization, followed by the immersion of the TEGDMA-coated glass substrate in a solution of AuNPs prepared via conventional wet-chemical synthesis. This led to the strong attachment of AuNPs to the TEGDMA nanolobes, which was confirmed by the UV absorption peak at 527 nm, due to localized surface plasmon resonance of AuNPs. More importantly, the nanolobe architecture facilitates nanoparticle trapping while allowing molecular access to the nanoparticle surface. This enabled us to further functionalize the incorporated AuNPs with thrombin binding aptamer and utilize the biofunctionalized polymer-nanoparticle composite as a thrombin sensor. The synergistic combination of metallic nanoparticles acting as a sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and to screen biomolecules allowed the detection of thrombin with good sensitivity down to 0.01 ng/mL with a linear range over three orders of magnitude. Our work paves the way for the fabrication of reliable biomolecular sensors based on the polymer brush-nanoparticle architecture.

The effects of high-fat diet on implant osseointegration: an experimental study

Serkan Dü,ndar,Ferhan Yaman,Muhammed Fatih Ozupek,Arif Saybak,Mehmet Gul,Fatih Asutay,Mustafa Kirtay,Ibrahim Hanifi Ozercan 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.4

Objectives: In this study, we investigated whether a high-fat diet (HFD) affected the bone implant connection (BIC) in peri-implant bone. Materials and Methods: Four male rabbits were used in this study. Dental implant surgery was introduced into each tibia, and four implants were integrated into each animal. In both the normal diet (ND) group (n=2) and HFD group (n=2), 8 implants were integrated, for a total of 16 integrated implants. The animals continued with their respective diets for 12 weeks post-surgery. Afterward, the rabbits were sacrificed, and the BIC was assessed histomorphometrically. Results: Histologic and histomorphometric analyses demonstrated that BIC was not impaired in the HFD group compared to the ND group. Conclusion: Within the limitations of this study, we found that HFD did not decrease the BIC in rabbit tibias.