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- 저자 : Fangfang Hu (검색결과 5 건)
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Fangfang Yu,Xiaobo Chen,Clark A. Cory,Zhixuan Yang,Yingwen Hu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.7
Project schedule management is an important aspect of project management. Earned value management (EVM) and its extension methods are widely adopted in project schedule management in various previous studies, however, most of these studies adopted schedule performance indicators based on definiteness condition and historical data, which ignored the impact of uncertainty and dynamics. So the decision risk in schedule management has been increased dramatically. Therefore, this paper proposed an active construction dynamic schedule management model based on fuzzy earned value management (F-EVM) and BP neural network (BP-NN). Firstly, the fuzzy theory was introduced into EVM to evaluate the schedule performance when the project finish schedule cannot be deterministic expression. Then, the main resource planning was functioned as input variables to predict the schedule in advance through BP-NN. Finally, the future action plans was adjusted based on the results to achieve active control of the project schedule. The case results indicated that the introduction of F-EVM effectively reduced influence of subjective estimation on uncertainty in the data measurement process. And the proposed dynamic schedule management model gave a 32.06% better mean absolute percentage error (MAPE) than the existing methods for estimated project duration. Hence, the proposed model provided a more accurate estimation of the project duration and considered the uncertainty and dynamics of the construction project, thereby achieving more effective management of project schedule.
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Qian Zhang,Changpeng Hu,Jingbin Huang,Wuyi Liu,Wenjing Lai,Faning Leng,Qin Tang,Yali Liu,Qing Wang,Min Zhou,Fangfang Sheng,Guobing Li,Rong Zhang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of themidbrain and the striatum and is an important pathologic basis of Parkinson’s disease (PD). Recent research has shownthat dynamin-related protein 1 (Drp1)-mediated aberrant mitochondrial fission plays a crucial role in dopaminergicnerve cell apoptosis. However, the upstream regulatory mechanism remains unclear. Our study showed that Drp1knockdown inhibited aberrant mitochondrial fission and apoptosis. Importantly, we found that ROCK1 was activated inan MPP+-induced PD cell model and that ROCK1 knockdown and the specific ROCK1 activation inhibitor Y-27632blocked Drp1-mediated aberrant mitochondrial fission and apoptosis of dopaminergic nerve cells by suppressing Drp1dephosphorylation/activation. Our in vivo study confirmed that Y-27632 significantly improved symptoms in a PDmouse model by inhibiting Drp1-mediated aberrant mitochondrial fission and apoptosis. Collectively, our findingssuggest an important molecular mechanism of PD pathogenesis involving ROCK1-regulated dopaminergic nerve cellapoptosis via the activation of Drp1-induced aberrant mitochondrial fission.
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Chao Tang,Jianmei Chen,Yuxin Li,Xinchao Liu,Lili Zhang,Fangfang Wang,Jia Hu,Xudong Cao,Tao Jiang 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.2
Three new pyridine-cored alkyl-substituted carbazole derivatives of 2,6-bis(2,7-dimethyl-9H-carbazol-9-yl)pyridine(2,7-MeCzPy), 2,6-bis(3,6-dimethyl-9H-carbazol-9-yl) pyridine (3,6-MeCzPy) and 2,6-bis(3,6-di-tert-butyl-9H-carbazol-9-yl)pyridine (3,6-tBuCzPy) were synthesized by means of connecting methyl or tert-butyl substituents on the3,6 or 2,7 positions of carbazole with pyridine ring as the core. The influence of different alkyl and linkages modeon the thermal, photophysical, electrochemical properties and devices electrolumiescent (EL) performances of thecompounds were comprehensively studied. In solution-processed blue or green phosphorescent organic light-emittingdiodes (PHOLEDs) with bis[2-(4,6-difluorophenyl)-pyridinato-N,C2] picolinate iridium(III) (FIrpic) or fac-tris(2-phenylpyridine)iridium (Ir(ppy)3) as phosphorescent dopants, EL performances follow the same sequence of 2,7-MeCzPy> 3,6-tBuCzPy > 3,6-MeCzPy, the trend is consistent with the value of triplet energies (ET). Devices hosted by2,7-MeCzPy achieving the best EL performance, exhibited maxima 13.6 cd A−1 and 7.0 lm W−1 for current efficiency(CE) and power efficiency (PE) in blue PHOLEDs, maxima 26.2 cd A−1 and 16.2 lm W−1 for CE and PE in greenPHOLEDs.
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2019 Novel Coronavirus (COVID-19) Pneumonia: Serial Computed Tomography Findings
Jiangping Wei,Huaxiang Xu,Jingliang Xiong,Qinglin Shen,Bing Fan,Chenglong Ye,Wentao Dong,Fangfang Hu 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.4
From December 2019, Coronavirus disease 2019 (COVID-19) pneumonia (formerly known as the 2019 novel Coronavirus [2019nCoV]) broke out in Wuhan, China. In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. She was diagnosed with COVID-19 infection confirmed by real-time reverse-transcriptase-polymerase chain reaction. CT showed rapidly progressing peripheral consolidations and ground-glass opacities in both lungs. After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions.
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Functional mechanisms for diabetic nephropathy-associated genetic variants
Hong Xu,Chengxin Gong,Yonghu Xu,Yongfang Fan,Xingzi Liu,Chaopeng Xiong,Luling He,Changle Liu,Shenqiang Rao,Wen Xiao,Lu Ding,Lan Tang,Fangfang Hu,Mengqi Xiong,Mei Yang,Shangdong Liang 한국유전학회 2016 Genes & Genomics Vol.38 No.7
Diabetic nephropathy (DN) is one of the major complications of diabetes. A tremendous amount of genetic variations have been identified to be associated with DN. However, most of them only generate from statistical associations at the DNA level, generally without direct functional evidence regarding their association mechanisms underlying DN. Based on the publicly available datasets and resources, this study performed integrative analyses (expression quantitative trait loci analysis, differential gene expression analysis and functional prediction analysis) to detect the molecular functional mechanisms underlying the associations for DN. Among 150 selected (P\E-4) genetic associations that were archived in the public databases, two single nucleotide polymorphisms (SNPs) (rs3135377 and rs9469220) have been found to act as cis-effect regulators of the ‘‘identified’’ gene (HLADRA and HLA-DRB1). These eQTL genes have differential expression signals in the DN-associated cell groups. These SNPs were predicted as regulatory sites by utilizing online prediction tools. Our data suggest potential mechanistic links underlying the association between DN and two identified SNPs. These results could help us to have a deeper understanding of the functional relevance of genetic variants with susceptibility to DN, which is useful for pursuit of in-depth validation studies to dissect their involvements and molecular functional mechanisms in DN.
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