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JNK activation induced by ribotoxic stress is initiated from 80S monosomes but not polysomes
( Tae-sung Kim ),( Hag Dong Kim ),( Yong Jun Park ),( Eunbin Kong ),( Hee Woong Yang ),( Youjin Jung ),( Yongjoong Kim ),( Joon Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.8
Translation is a costly, but inevitable, cell maintenance process. To reduce unnecessary ATP consumption in cells, a fine-tuning mechanism is needed for both ribosome biogenesis and translation. Previous studies have suggested that the ribosome functions as a hub for many cellular signals such as ribotoxic stress response, mammalian target of rapamycin (mTOR), and ribosomal S6 kinase (RSK) signaling. Therefore, we investigated the relationship between ribosomes and mitogen-activated protein kinase (MAPK) activation under ribotoxic stress conditions and found that the activation of c-Jun N-terminal kinases (JNKs) was suppressed by ribosomal protein knockdown but that of p38 was not. In addition, we found that JNK activation is driven by the association of inactive JNK in the 80S monosomes rather than the polysomes. Overall, these data suggest that the activation of JNKs by ribotoxic stress is attributable to 80S monosomes. These 80S monosomes are active ribosomes that are ready to initiate protein translation, rather than polysomes that are already acting ribosomes involved in translation elongation. [BMB Reports 2019; 52(8): 502-507]
K-city 자율주행 경진대회 참가를 위한 자율주행 플랫폼 개발
김태호(Teaho Kim),김동진(Dongjin Kim),민동규(Dongkyu Min),서현지(Hyeonji Seo),윤호진(Hojin yun),정은빈(Eunbin Jung),이진강(Jingang Lee),권혁재(Hyeokjae Kwon),김진석(Jinseok Kim),김대국(Daekuk Kim),문일주(Iljoo Moon),유정흠(Jeongheum You 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11
In this paper, a ROS-based autonomous driving framework designed by team ACCA from the School of Mechanical Engineering, Soongsil University, for the 2021 international college student creative car challenge held in K-city. The autonomous vehicle’s chassis used in this challenge is equipped with Velodyne 3D lidar, a Sick down-looking 2D lidar, Xsens MTi-30 AHRS, CCD camera, webcam, and PC-based controller. First, before the challenge in K-city, we evaluated the ROS-package-based SLAM such as LIO-SAM in a ring-shaped road environment on the campus of Soongsil University. After the successful SLAN and mapping process, the hdl_localization, which is a 3D lidar-based real-time 3D localization package, is used to estimate the global pose with respect to the global frame using NDT scan matching. For lane detection, traffic sign, and traffic signal recognition, the two well-known DNN models are utilized. Based on experimental results from both simulation and an actual autonomous vehicle platform, the Point Instance Network (PINet) for lane detection shows 88% of test accuracy, and the YOLO V4 for the traffic light and sign recognition offers 95% test accuracy.
식사 전후의 사진 비교를 통한 스마트폰 앱의 영양소섭취량 타당도 평가
이혜진(Hyejin Lee),김은빈(Eunbin Kim),김수현(Su Hyeon Kim),임하은(Haeun Lim),박영미(Yeong Mi Park),강준호(Joon Ho Kang),김희원(Heewon Kim),김진호(Jinho Kim),박웅양(Woong-Yang Park),박성진(Seongjin Park),김진기(Jinki Kim),양윤정(Yoon Jun 한국영양학회 2020 Journal of Nutrition and Health Vol.53 No.3
본 연구는 만 19세 이상 60세 미만 성인남녀 98명을 대상으로 스마트폰 앱인 Gene-Health을 이용하여 식사 기록을 통해 분석된 영양소섭취량과 동일한 날의 식사 섭취 전과 후의 사진비교를 통해 섭취량을 추정하여 분석된 영양소섭취량을 비교함으로 Gene-Health의 타당도를 조사하기 위해 수행되었다. 주요 결과는 다음과 같다. 첫째, Gene-Health의 영양소섭취량과 사진을 통해 추정한 영양소섭취량을 비교한 결과 에너지, 탄수화물, 지방, 지방으로부터의 에너지 섭취비율은 통계적으로 유의한 차이가 없었으나 단백질 섭취량과 단백질로부터의 에너지 섭취 비율은 Gene-Health가 높았고, 탄수화물로부터의 에너지 섭취비율은 사진추정군이 높았다. 둘째, Gene-Health와 사진을 통한 영양소섭취량의 상관성은 에너지, 탄수화물, 단백질, 지방섭취량과 탄수화물 비율, 단백질 비율, 지질 비율은 모두 상관계수 0.382–0.708로 유의적인 양의 상관관계를 보였다. 셋째, Gene-Health와 사진을 통한 에너지, 탄수화물, 단백질, 지방섭취량과 탄수화물 비율, 단백질 비율, 지질 비율의 가중 카파 계수는 0.588–0.662로 상당히 일치하는 경향을 보였다. 에너지와 다량영양소, 다량영양소 섭취비율의 same agreement는 41.8%–48.0%이며 adjacent agreement는 75.5%–88.8%였다. 본 연구를 통하여 Gene-Health는 에너지와 다량영양소 섭취량을 추정하기 위한 타당한 도구라고 사료된다. 추후 연구에서는 다양한 연령과 여성 참가자를 확대하여 성별과 연령에 따른 Gene-Health의 타당도를 연구할 필요가 있다. Purpose: This study was conducted to evaluate the validity of the Gene-Health application in terms of estimating energy and macronutrients. Methods: The subjects were 98 health adults participating in a weight-control intervention study. They recorded their diets in the Gene-Health application, took photographs before and after every meal on the same day, and uploaded them to the Gene-Health application. The amounts of foods and drinks consumed were estimated based on the photographs by trained experts, and the nutrient intakes were calculated using the CAN-Pro 5.0 program, which was named ‘Photo Estimation’. The energy and macronutrients estimated from the Gene-Health application were compared with those from a Photo Estimation. The mean differences in energy and macronutrient intakes between the two methods were compared using paired t-test. Results: The mean energy intakes of Gene-Health and Photo Estimation were 1,937.0 kcal and 1,928.3 kcal, respectively. There were no significant differences in intakes of energy, carbohydrate, fat, and energy from fat (%) between two methods. The protein intake and energy from protein (%) of the Gene-Health were higher than those from the Photo Estimation. The energy from carbohydrate (%) for the Photo Estimation was higher than that of the Gene-Health. The Pearson correlation coefficients, weighted Kappa coefficients, and adjacent agreements for energy and macronutrient intakes between the two methods ranged from 0.382 to 0.607, 0.588 to 0.649, and 79.6% to 86.7%, respectively. Conclusion: The Gene-Health application shows acceptable validity as a dietary intake assessment tool for energy and macronutrients. Further studies with female subjects and various age groups will be needed.
HOT GAS HALOS IN EARLY-TYPE GALAXIES AND ENVIRONMENTS
Kim, Eunbin,Choi, Yun-Young,Kim, Sungsoo S. The Korean Astronomical Society 2013 Journal of The Korean Astronomical Society Vol.46 No.1
We investigate the dependence of the extended X-ray emission from the halos of optically luminous early-type galaxies on the small-scale (the nearest neighbor distance) and large-scale (the average density inside the 20 nearest galaxies) environments. We cross-match the 3rd Data Release of the Second XMMNewton Serendipitous Source Catalog (2XMMi-DR3) to a volume-limited sample of the Sloan Digital Sky Survey (SDSS) Data Release 7 with $M_r$ < -19.5 and 0.020 < z < 0.085, and find 20 early-type galaxies that have extended X-ray detections. The X-ray luminosity of the galaxies is found to have a tighter correlation with the optical and near infrared luminosities when the galaxy is situated in the low large-scale density region than in the high large-scale density region. Furthermore, the X-ray to optical (r-band) luminosity ratio, $L_X/L_r$, shows a clear correlation with the distance to the nearest neighbor and with large-scale density environment only where the galaxies in pair interact hydrodynamically with seperations of $r_p$ < $r_{vir}$. These findings indicate that the galaxies in the high local density region have other mechanisms that are responsible for their halo X-ray luminosities than the current presence of a close encounter, or alternatively, in the high local density region the cooling time of the heated gas halo is longer than the typical time between the subsequent encounters.