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박수희,노은하 同德女子大學校 情報科學硏究所 2005 정보과학연구 Vol.9 No.-
산업체 수요지향적인 대학 IT 교과과정 개발 방법론에서는 여러 반복단계를 거치면서 완성도 높은 교과과정을 산출한다. 하나의 반복단계는 준비, 요구분석, 설계, 구현, 실현, 평가 등의 과정으로 나뉘는데, 이 중 요구분석 과정은 새로운 반복단계에서 양질의 산출물을 얻기 위한 주요 과정이다. 본 논문에서는 이전 반복단계의 수행 결과를 바탕으로 이해관계자로부터 요구사항을 수집하고 분석하여 새로운 반복단계를 준비하여 IT 교과과정을 점진적으로 개발하는 과정을 다룬다. 이러한 점진적 개발 프로세스는 지속적으로 발전하는 IT 분야의 특성상 끊임없이 반복되어야 한다. In the methodology of industrial demand-driven college IT curriculum development, the in-depth curriculum development is done throughout many iterations. A single iteration is consisted of several phases: preparation, requirement analysis, design, implementation, realization, and evaluation. Among them, the requirement analysis is an important phase to produce artifacts of good quality. In this paper, based on the artifacts of the previous iteration, stakeholders' requirements are collected and analyzed. A new iteration is started and IT curriculums are incrementally developed. This incremental process needs to be repeated in order to catch up continuous growth of the IT industry.
비정형적 자료 구조의 효율적인 접근을 위한 묶음 읽기 기법
노은하(Eun Ha Rho),김흥환(Heung Hwan Kim),한상영(Sang Yong Han) 한국정보과학회 1995 정보과학회논문지 : 시스템 및 이론 Vol.22 No.12
새로운 계산 모델의 도입과 프로세서 속도의 향상에도 불구하고 기억장치 시스템은 여전히 컴퓨터 시스템의 성능 향상을 제한하는 요인으로 작용해 왔다. 특히 공유되는 전역 자료가 존재하는 경우 기억장치 시스템은 병렬 계산의 성능을 크게 저하시킬 수 있다. 따라서 병렬 컴퓨터 시스템에서 공유 자료 구조에 대한 접근의 지역성 및 효율성은 성능 향상을 위해 매우 중요하다. 본 논문에서는 함수 언어의 제약을 극복하고자 제안된 비정형적 자료 구조인 I-구조에 대한 접근을 효율적으로 하기 위한 자료 모델을 제시한다. 전역 기억장소의 비정형적 자료 구조로부터 한 번에 몇 개의 값을 읽어오는 묶음 읽기 기법을 제안하고, 묶음 읽기를 위한 두 가지 루프 그래프 분할 기법을 고안하였다. 그리고, 묶음 읽기의 효율적인 구현을 위해 비정형적 자료 구조의 새로운 태그 관리 기법을 제시한다. Even with new computational models and improvements in processor speeds, the memory system is still a stumbling block to achieve comparable performance of parallel computer systems. Especially sharing global data in parallel computing may cause a considerable performance degradation. Therefore, efficient handling of shared data structures has been a critical issue in enhancing performance of parallel computer systems. In this paper, we propose a data model for efficient access to I-structures, which are non-strict data structures proposed for alleviating limitations of functional languages. We provide a mechanism to read several elements of an I-structure in a bundle from the global memory into the local memory of each processing unit, and design two different partitioning schemes of loop graphs for data bundling. Also, we devise a new tagging scheme for efficient implementation of this bundling mechanism.
Soh Eun Gyu,Rho Ji Young,Jeong Sooyeon,Kang Se Ri,Choi Keum Ha 대한영상의학회 2022 대한영상의학회지 Vol.83 No.2
Primary pulmonary malignant melanoma is an extremely rare type of melanoma. The radiologic features of primary pulmonary malignant melanoma are nonspecific; however, it almost always presents as a well-demarcated round or lobulated solitary solid nodule or mass. Herein, we report the case of a 78-year-old male with primary pulmonary malignant melanoma that was mistaken for primary pulmonary adenocarcinoma with lepidic growth and was seen as bilateral multiple subsolid nodules on CT.
ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis
Song, Eun Kyung,Jeon, Jimin,Jang, Dong Gil,Kim, Ha Eun,Sim, Hyo Jung,Kwon, Keun Yeong,Medina-Ruiz, Sofia,Jang, Hyun-Jun,Lee, Ah Reum,Rho, Jun Gi,Lee, Hyun-Shik,Kim, Seok Jung,Park, Chan Young,Myung, K American Association for the Advancement of Scienc 2018 Science translational medicine Vol.10 No.462
<P>Developing and mature chondrocytes constantly interact with and remodel the surrounding extracellular matrix (ECM). Recent research indicates that integrin-ECM interaction is differentially regulated during cartilage formation (chondrogenesis). Integrin signaling is also a key source of the catabolic reactions responsible for joint destruction in both rheumatoid arthritis and osteoarthritis. However, we do not understand how chondrocytes dynamically regulate integrin signaling in such an ECM-rich environment. Here, we found that developing chondrocytes express integrin-beta-like 1 (Itgbl1) at specific stages, inhibiting integrin signaling and promoting chondrogenesis. Unlike cytosolic integrin inhibitors, ITGBL1 is secreted and physically interacts with integrins to down-regulate activity. We observed that Itgbl1 expression was strongly reduced in the damaged articular cartilage of patients with osteoarthritis (OA). Ectopic expression of Itgbl1 protected joint cartilage against OA development in the destabilization of the medial meniscus-induced OA mouse model. Our results reveal ITGBL1 signaling as an underlying mechanism of protection against destructive cartilage disorders and suggest the potential therapeutic utility of targeting ITGBL1 to modulate integrin signaling in human disease.</P>
데스메막박리 각막내피층판이식술 후 이식편 실패가 온 환자에서의 데스메막내피각막이식술
오시은(Si Eun Oh),하민지(Min Ji Ha),황웅주(Woong Joo Whang),변용수(Yong-Soo Byun),황형빈(Hyung Bin Hwang),나경선(Kyung Sun Na),노창래(Chang Rae Rho),이현수(Hyun Soo Lee),정소향(So-Hyang Chung),김은철(Eun Chul Kim),조양경(Yang Kyung C 대한안과학회 2020 대한안과학회지 Vol.61 No.12
목적: 데스메막박리 각막내피층판이식술(Descemet stripping endothelial keratoplasty, DSEK) 후 이식편 실패가 온 환자에 2차적 데스메막내피각막이식(Descemet membrane endothelial keratoplasty, DMEK)을 성공적으로 시행하여 이를 보고하고자 한다. 증례요약: 66세 여자 환자가 6년 전 우안에 백내장수술을 받고, 한 차례 인공수정체교환술을 받은 뒤 수포각막병증이 발생하여 데스메막박리 각막내피층판이식술을 시행받았다. 5년간 시력을 잘 유지해오다가, 이식편 실패로 인해 시력이 감소하게 되었다. 해당 환자는 데스메막박리 각막내피층판이식술 후 녹내장이 발병하였던 상태로, 2차 각막이식술은 데스메막내피각막이식술로 시행하였으며 추가적인 공기주입 없이 수술은 성공하였다. 수술 3개월 후 교정시력은 0.2였으며 각막은 투명하였다. 결론: 데스메막박리 자동각막내피층판이식술 후 이식편 실패가 온 환자에서 2차적으로 데스메막내피각막이식술을 성공적으로 시행하였으며 수술 후 5개월까지 각막이식편의 실패 없이 투명한 각막을 유지하였다. Purpose: We report a case of secondary Descemet membrane endothelial keratoplasty (DMEK) to treat graft failure after Descemet stripping endothelial keratoplasty (DSEK). Case summary: A 66-year-old female underwent DSEK of her right eye to treat pseudophakic bullous keratopathy that developed after cataract surgery and intraocular lens exchange. After 5 years, she complained of decreased vision; graft failure was observed. Secondary DMEK was performed; no additional air injection was needed. The corrected visual acuity was 0.2, 3 months after surgery, and the cornea became clear. Conclusions: Visual recovery can be achieved by performing secondary DMEK after primary DSEK graft failure.
광섬유 패치코드를 이용한 Fabry-Perot 간섭계 온도센서
김주하 ( Ju Ha Kim ),정은주 ( Eun Joo Jung ),김명진 ( Myoung Jin Kum ),김계원 ( Gye Won Kim ),노병섭 ( Byung Sup Rho ),최은서 ( Choi Eun Seo ),황성환 ( Hwang Sung Hwan ),이우진 ( Lee Byung Ing Go ),안종배 ( Jong Bae An ) 한국센서학회 2014 센서학회지 Vol.23 No.2
In this paper, we propose and demonstrate a Fabry-Perot interferometer (FPI) optical fiber tip sensor fabricated by a blade-sawing technique using a fiber optic patch cord for high-resolution temperature measurement. The sensor head consists of a short air FP cavity near the tip of a single-mode fiber patch cord tip. The temperature which we can measure is determined through a phase variation of the interference fringes in the reflective spectrum of the sensor. The fiber optic FPI sensor in this work can monitor the environmental temperature very accurately from 40 to 120oC. As a result, the temperature sensitivity is obtained as 38.2 pm/oC.
Kim, Dong Ha,Choi, Yun Jung,Sung, Ki Jung,Yoo, Seon‐,A,Sung, Young Hoon,Kim, Jeong Kon,Choi, Chang‐,Min,Yun, Miyong,Lee, Eun Yong,Jin, Yong Suk,Cook, Seungho,Rho, Jin Kyung,Lee, Jae Cheol John Wiley and Sons Inc. 2018 Molecular Oncology Vol.12 No.12
<P>Central nervous system (CNS) metastasis is one of the serious complications of epidermal growth factor receptor (EGFR)‐mutant lung cancer, which arises due to poor penetration of the brain–blood barrier by EGFR‐tyrosine kinase inhibitors (EGFR‐TKIs). Although osimertinib, a third‐generation EGFR‐TKI, has efficacy against CNS metastases, further treatment modalities are still needed as some of these lesions do not respond to osimertinib, or undergo progression after an initial response to this drug if radiotherapy has already been conducted. Here, we investigated the efficacy of water‐soluble erlotinib (NUFS‐sErt) against these metastases. This agent was synthesized using a nano‐particulation platform technology utilizing fat and supercritical fluid (NUFS™) to resolve the low solubility problem that typically prevents the creation of injectable forms of EGFR‐TKIs. The average NUFS‐sErt particle size was 236.4 nm, and it showed time‐dependent dissolution in culture media. The effects of NUFS‐sErt were similar to those of conventional erlotinib in terms of inhibiting the proliferation of EGFR‐mutant lung cancer cells and suppressing EGFR signaling. In an intraperitoneal xenograft model of HCC827 cells, intraperitoneal administration of NUFS‐sErt produced a dose‐dependent inhibition of tumor growth and enhanced survival rate. Notably, the injection of NUFS‐sErt into the brain ventricle caused significant tumor growth inhibition in an intracranial xenograft model. Hence, our current findings indicate that NUFS‐sErt is a novel, water‐soluble form of erlotinib that can be administered using intraventricular or intrathecal injections. The target cases would be patients with a progressive CNS metastasis and no other therapeutic options. This drug could also be given intravenously to patients with swallowing difficulties or an inability to ingest due to a medical condition.</P>