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Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
Kimura, Yasuaki,Yamatsugu, Kenzo,Kanai, Motomu,Echigo, Noriko,Kuzuhara, Takashi,Shibasaki, Masakatsu Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.3
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu.
Design and Synthesis of Resin-Conjugated Tamiflu Analogs for Affinity Chromatography
Yasuaki Kimura,Kenzo Yamatsugu,Motomu Kanai,Noriko Echigo,Takashi Kusuhara,Masakatsu Shibasaki 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.3
Two types of resin-conjugated Tamiflu analogs were synthesized by modifying our original synthetic route of oseltamivir phosphate (Tamiflu). The prepared resins bound to influenza virus neuraminidase, the main target of Tamiflu. The resins will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the rarely observed abnormal behavior exhibited by some influenza patients treated with Tamiflu
Cranioplasty with Custom-made Artificial Bone after Resection of Multilobular Bone Tumor in a Dog
최성진,Muneki Honnami,I-Li Liu,Kenichi Yamamoto,Shinsuke Ohba,Ryosuke Echigo,Shigeki Suzuki,Ryouhei Nishimura,Ung-il Chung,Nobuo Sasaki,Manabu Mochizuki 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.1
A 7-year-old spayed female Welsh corgi presented with a mass of the skull. The mass was diagnosed asmultilobular bone tumor and surgically removed. To treat a large bone defect after the tumor removal, custom-madeartificial bone fabricated by a 3-dimensional ink-jet printer was implanted in the defect. Follow-up computed tomographyevaluation was performed for 4.3 years. The implant was well integrated with the skull and had covered the largebone defect during the follow-up period. Gradual degradation of the implant began 6 weeks after surgery. It providesan additional option for the treatment of large bone defect.