양극성 정동장애와 혈청 Inositol-1-phosphatase 활성도 변화

조현주,김영철,우행원,연규월,조기승 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

Objects : Several lines of possibilites have been oroposed about the etiology of bipolar attective disorder in biological, genetic and psychosocial aspect. The purpose of this study is to inspect the etiology of bipolar affective disorder in biological aspect by measuring the changes of serum inositol-1-phosphatase activity and investing a causal relationship between clinical symptoms and serum inositol-1-phosphatase activities in patients with bipolar affective disorder. Methods : The subjects were 18 inpatients who met DSM-IV diagnostic criteria for bipolar I affective disorder, manic episode and 15 normal controls. Inositol-1-phosphatase activities were measured in serum by using spectrophotometer. Clinical symptoms of patients were assessed by YMRS at admission day and after 2 weeks lithium treatment. Results : 1) Inositol-1-phosphatase activities of the patients were increased to about 2 times as compared with those of normal controls. And the activity levels were decreased gradually to the normal at 14 days. 2) Young's Mania Rating Scale(YMRS) scores were decreased significantly by lithium treatment. 3) Statistical significance could not be found between the change of YMRS scores and the levels of inositol-1-phosphatase activity. Conclusion : In this study, statistical significance could not be found between clinical improvement and inositol-1-phosphatase activities, but the fact that lithium treatment improve the clinical manifestation shown by YMRS score changes, and reverse the increased inositol-1-phosphatase activities suggests the strong association between pathophysiology of bipolar affective disorders and inositide metabolism.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

부산지역 치매요양소 5곳의 건축적 특성파악을 위한 기초연구(Ⅰ)

조영행 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

The aim of this study is to find out the architectural characteristics of five dementia units in Pusan area through observation and archives. The analysis reveals that sample units are located in particular areas. This may give users inconvenience. However, all sample units have a double-corridor type which is not suitable to the dementia unit due to long corridor which may give residents disorientation, 5~7 residents use one room, thus, the units look like asylums, and wandering pathways are not available in most sample units. Finally, the need for a korean style dementia unit, considering architectural characteristics and trends of the dementia unit in Korea, is discussed.

축대칭 왕복엔진의 비정상 난류 유동에 대한 수치 해석

조진행,유홍선,최영기 중앙대학교 생산공학연구소 1992 생산공학연구소 논문집 Vol.1 No.2

A numerical simulation of unsteady axisymmetric turbulent flow was performed for a reciprocating engine including port/valve assembly. The governing equations based on a non-orthogonal coordinate formulation with Cartesian velocity components were used and discretised by the finite volume method with non-staggered variable arrangements. The modified k-ε turbulence model which included the effect of compressibility was used. The results of two-dimensional transient calculation for the axisymmetric configuration were compared with the experimental data. Although slightly low rms velocity was predicted compared to the experimental data, predicted velocity distributions at the valve exit and in-cylinder region showed good agreements with the experimental data. The flow at the valve exit was separated at the same valve lift position with experimental data. The mean flow pattern at the valve exit was found to be more sensitive to valve lift than mass flow rate or valve motion. Two vortices in-cylinder region were generated during the initial intake process. The clockwise main vortex became strong and moved upward to the top wall. The counter-clockwise second vortex became weak and stick to the upper left corner of the cylinder. After middle intake process, new vortex adjacent to upper cylinder wall appeared by the piston motion and therefore, the in-cylinder flow was formed into three vortices. The cylinder pressure just before bottom dead center of piston was higher than inlet pressure and then the reverse flow occured at the valve exit. The in-cylinder flow characteristics were strongly dependent on piston motion, but insensitive to valve motion.

치매요양시설에 적합한 건축적 환경구축을 위한 기초연구 : 경상도와 전라도지역 치매요양소를 중심으로 Focused on Jeolla and Gyeongsang Provinces-

조영행 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

The purpose of this study is to identify the characteristics of the physical setting in dementia units. The data was collected from 6 dementia units in Jeolla and Gyeongsang provinces, from 2003 to 2004 by interview, photo, and documents about the facilities. The findings revealed that firstly, horizontal core system is not appropriate to the long-term care units due to long corridor which give people with dementia disorientation. Secondly, the plan of the sample dementia units showed various peculiar types but most of the dementia units had middle corridors in order to concentrate the spaces around the corridors. This is a trend of the dementia units in South Korea. Thirdly, even though some of the dementia units had wandering pathways in the garden, there are no safe fences in the garden, which protect people with dementia going outside. It is suggested that architectural factors found in the study can be used to the planing of the new dementia unit.

울산하수처리장의 화학적인 수질개선

박흥석,조영국 울산대학교 1997 공학연구논문집 Vol.28 No.1

본 연구의 목적은 1차 처리를 하는 울산하수처리장을 화학적 응집제의 첨가로 수질을 개선하는 것이었다. 설계당시의 BOD, COD 및 SS의 제거효율은 40 ∼ 60%이었으나 현재의 제거효율은 30∼40% 이다. 그러나 설계당시 고려되지 않았던 총질소와 총인의 제거율은 각각 30%, 3%이었다. 소량의 응집제 Hi-PAX(Poly Aluminum Chloride Silicate)를 펌프동 유입부에 주입하여 모든 항목에서 오염물의 제거율이 향상되었다. 또한 총질소의 제거효율은 3%에서 30%로 총인의 제거효율은 30%에서 90%로 증가하였다. 종합적인 오염인자인 OCP(Oxygen Consumption Potential)는 기존 1차 침전공정은 전체 오염물의 15%정도만 제거할 수 있으며 생물학적 처리는 39%, 그리고 화학적 처리는 50%내외로 처리되는 것으로 나타났다. OCP 1kg 를 처리하는데 소요되는 단위처리비용은 기존 1차 처리 공정의 33%, 1차처리후 생물학적 처리할 경우의 75% 수준이었다. The objective of this study was to upgrade the efficiencies of Ulsan primary municipal wastewater treatment plant by chemical application. The present removal efficiencies of BOD, COD and SS were in the range of 30 ∼ 40% while the design target were 40∼60%. But the removal of total nitrogen and phosphorous, which components were not considered at the time of design, were 30 % and 3 %, respectively. The simple application of small amount of Hi-PaX(Poly Aluminum Chloride Silicate) to the inlet of screw pump shows enhanced removal efficiencies in all contaminants. The removal of SS increased to 80 ∼ 90% while BOD and COD to 70% and 55%, respectively. In addition, the removal of total nitrogen and phosphorous removal also increased from 3% and 25% to 30% and 90%, respectively. The removal of integrated pollution parameter OCP(Oxygen Consumption Potential) in present primary treatment was 15%, 39% in biological treatment after primary treatment and about 50% in chemical treatment. the unit cost of OCP removal in chemical treatment was 33% of that of present primary process, 75% of that of biological treatment after present process.

Agar-Gel Immunodiffusion Test를 이용한 돼지흉막폐염(Swine Pleuropneumoniae)의 진단에 관한 연구

심항섭,장경수,조용성,전무형 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.2 No.-

To establish an effective diagnostic measure for detection of the antibodies against Actinobacillus pleuropneumoniae, that is the primary agent of swine pleuropneumoniae, the methods for micro-agglutination test(MAT) and agar-gel immunodiffusion test(AGID) were improved and standarized and the comparative studies were carried out. The results obtained through the experiments were summarized as follows. 1. The rabbit hyperimmune sera to reference serotypes 1 to 6 were cross-tested with MAT and AGID. The range of antibody titers on MAT was 80 to 1280, showing the cross-reaction in serotypes 3, 4, 5 and 6. In AGID, the range of antigen titers was 8 to 32, and cross-reaction was observed in serotype 5. The optimal concentration of antigen MAT were 1.25㎎/㎖ 2. In AGID, the most promising antigen and the buffer for agar-gel were EDTA-treated antigen and 0.05M tris buffer(pH 7.2), respectively. 3. By the tests for 200 swine sera, it was found that the accumulative frequency of positive reaction for the 6 serotypes were 240 in MAT and 163 in AGID. 4. when compared the results of AGID with those of MAT for 200 swine sera, all sera with MAT titier under 20 were negative in AGID. Of the sera with MAT titer 40 and 80, 24.7% and 93.9% were positive in AGID, respectively. All sera with MAT titer over 160 showed positive in AGID. 5. In conclusion, the established MAT showed high sensitivity but low specificity, whereas AGID revealed low sensitivity but high specificity. The established AGID test was considered very efficient for detection of antibodies and serotyping of swine sera.

광양만으로 유입하는 하천하구에서의 이화학적 특성 : 우수기 직후 유입하천에 따른 영향 effect of inputting rivers after rainy season in summer

김은영,정흥호,정호승,조환익,황주찬,최상원 한국환경과학회 2004 한국환경과학회지 Vol.13 No.9

Physicochemical characteristics of Kwangyang Bay, have been investigated on the effects of inputting rivers just after rainy season in summer 2003. The results ranged from 4.96~8.01 mg/L for DO, 1.16~3.09 mg/L for COD, 7.21~67.71 μM for DIN and 0.12~121.84 μM for phosphate. The COD of Yeosu Area was 1.19~3.09 mg/L, Kwangyang Area was 1.23 ~ 2.76 mg/L. The COD of Wallae cheon in Yeosu Area was 3.09 mg/L and Donghoan in Kwangyang Area was 2.76 mg/L. The reason of high COD might be industrial sewage of organic chemical plants and iron foundry. DIN of Yeosu Area and Kwangyang Area were 7.21--63.43 μM and 8.43 67.71 μM respectively. The average phosphate of Yeosu Area was 23.65 μM. The source of phosphate might be industrial sewages of fertilizer plant and phosphate gypsum stocked with high amounts. The metal concentrations were measured in the range of 1.01~175.10 ㎍/L for Cu, 0.13~1.78 ㎍/L for Cd, 1.13~5.21 ㎍/L for Pb, 1.58~13.57 ㎍/L for Cr and 1.07~20.68 ㎍/L for As. The average Cu concentration was 78.99 ㎍/L in Kwangyang Area. The source of Cu might be industrial sewage of iron foundry. The average Cr concentration of Yeosu Area was 9.07 ㎍/L. That is 2 times higher than Kwangyang Bay 5.74 gg/L, because of sewage of chemical plants.

광양만 유역 퇴적토 중의 다환방향족탄화수소류

정흥호,정호승,김은영,조환익,황주찬,최상원 한국환경과학회 2004 한국환경과학회지 Vol.13 No.6

Polycyclic aromatic hydrocarbons(PAHs) in sediments of Kwangyang bay on Korea, have been investigated by gas chromatography-mass spectrometery (GC/MS). The average content of total PAHs in all samples was 2,211ppb, and the range was from 36 to 22,699pph. The higher concentrations were found in sediment sampled near Kwangyang iron processing plant, Taeindo. The resulting distributions of PAHs according to the number of aromatic ring and molecular ratios of specific aromatic compounds (phenanthrene, anthracene, fluoranthene and pyrene) have been discussed in terms of sample location, origin of the organic matter. Four, five and six rings of PAHs were mainly found near to Kwangyang iron processing plant, and three and four rings near to Yeosu chemical kombinat. This result typically indicated the local characteristics, depending on the origin of PAHs.

편마비 환자의 건측에 적용한 고유수용성 신경근 촉진법이 환측 근 긴장도에 미치는 영향

우영근,조규행,유은영 한국전문물리치료학회 2002 한국전문물리치료학회지 Vol.9 No.2

The purpose of this study was to investigate the effect of proprioceptive neuromuscular facilitation (PNF) approach on the spasticity of affected side in patients with hemiplegia, Three subjects with hemiplegia participated in this study. In single-subject research design (a multiple baseline across individuals) was employed in this study. The intervention program including PNF to the unaffected side was introduced for 30 minutes each day during each intervention phase. Muscle tone of affected side was measured with Tone Assessment Scale, and active hip abduction distance of affected side was taken with the subject supine. And then the muscle tone and the hip abduction distance were measured again 30 minutes later following the intervention. The results showed that the PNF application had some beneficial effects on both muscle tone and active hip abduction. This results suggests that PNF application to non-paretic limb can be effective in reducing muscle tone and improving hip abduction range on paretic limb in persons with hemiplegia. However, further research is needed to prove the effect of PNF application on functional improvement.