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Manzoor, Zahid,Ali, Irshad,Chae, Doobyeong,Koh, Young-Sang The Korean Society for Microbiology 2016 Journal of Bacteriology and Virology Vol.46 No.4
Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the anti-inflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor $(TNF)-{\alpha}$. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of $I{\kappa}B{\alpha}$. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.
Shrestha, Eileen,Kim, Sohyun,Chae, Doobyeong,Manzoor, Zahid,Yoo, Eun-Sook,Kang, Hee-Kyoung,Hyun, Jin-Won,Ko, Mi-Hee,Koh, Young-Sang The Korean Society for Microbiology 2014 Journal of Bacteriology and Virology Vol.44 No.1
Marine algae are rich sources of various biologically active compounds with potential pharmaceutical properties. In the present study, we investigated the inhibitory effects of Plocamium telfairiae extract (PTE) on proinflammatory cytokine production in bone marrow-derived macrophage (BMDMs) and dendritic cells (BMDCs). PTE pre-treatment in LPS-stimulated BMDMs and BMDCs showed a strong inhibition on interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-${\alpha}$ production as compared to non-treated controls. PTE pre-treatment showed significant inhibition on phosphorylation of mitogen-activated protein kinases and degradation of inhibitor of kappa B ( $I{\kappa}B{\alpha}$). Taken together, these results suggest that PTE may have potential anti-inflammatory property and hence, warrant further studies concerning the potentials of PTE for medicinal purpose.
Hosta longipes inhibits melanogenesis by reducing expression of the melanocortin 1 receptor
Lee Jin Woo,Kim Youngseok,Choi Seon-Jun,Kim Sung Hyeok,Ha Chang Woo,Jang Sohee,Chae Doobyeong,Sung Sikwon,함정엽,손은화,김수남 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.4
Background Hosta longipes is a traditional folk medicine that has been used to treat otitis media, inflammation, skin ulcers, and snake bites for a long time. Several phytochemicals isolated from H. longipes exhibit cytotoxic activity against cancer cells or anti-neuroinflammatory effects against microglial cell lines. However, studies on their physiological activity have been relatively few. Objective The goal of this study was to investigate a new role for H. longipes in the skin, and we characterized its inhibitory effects on melanin biosynthesis. Results In this study, we confirmed that pigmentation in α-melanocyte stimulating hormone-induced B16F10 cells and zebrafish was ameliorated by the addition of H. longipes ethanol extract (HLE) and that the hexane (Hx) fraction had a better whitening effect than any other fraction. The active two compounds isolated from the Hx fraction were identified as linolenic acid and linoleic acid. HLE, the Hx fraction, and two compounds inhibited melanin formation by blocking the melanocortin 1 receptor signaling. Conclusion Taken together, the potential for antimelanogenesis by HLE will provide insight into the development of new skin-whitening products for photodamaged skin. Background Hosta longipes is a traditional folk medicine that has been used to treat otitis media, inflammation, skin ulcers, and snake bites for a long time. Several phytochemicals isolated from H. longipes exhibit cytotoxic activity against cancer cells or anti-neuroinflammatory effects against microglial cell lines. However, studies on their physiological activity have been relatively few. Objective The goal of this study was to investigate a new role for H. longipes in the skin, and we characterized its inhibitory effects on melanin biosynthesis. Results In this study, we confirmed that pigmentation in α-melanocyte stimulating hormone-induced B16F10 cells and zebrafish was ameliorated by the addition of H. longipes ethanol extract (HLE) and that the hexane (Hx) fraction had a better whitening effect than any other fraction. The active two compounds isolated from the Hx fraction were identified as linolenic acid and linoleic acid. HLE, the Hx fraction, and two compounds inhibited melanin formation by blocking the melanocortin 1 receptor signaling. Conclusion Taken together, the potential for antimelanogenesis by HLE will provide insight into the development of new skin-whitening products for photodamaged skin.
TRANHONG QUANG,Nguyen Thi Thanh Ngan,Chau Van Minh,Phan Van Kiem,Nguyen Xuan Nhiem,BUIHUU TAI,Nguyen Phuong Thao,Doobyeong Chae,Vivek Bhakta Mathema,고영상,이제현,양서영,김영호 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
Kalopanax pictus (Araliaceae) is a deciduous treedistributed in Korea, Japan, and China. The stem bark ofK. pictus has been functionally used as a traditional crude drugfor the treatment of various inflammatory diseases. In thepresent study, we describe the inhibitory effects of oleananetypetriterpenes and saponins isolated from the stem bark ofK. pictus on production of pro-inflammatory cytokines inLPS-stimulated bone marrow-derived dendritic cells. Of thecompounds tested, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3b,6b,23-trihydroxyolean-12-en-28-oicacid 28-O-b-D-glucopyranoside (3), nipponogenin E (6),3b,6b,23-trihydroxyolean-12-en-28-oic acid (7), and caulophyllogenin(19) significantly inhibited the production ofIL-12 p40 and IL-6 with IC50 values ranging from 3.3 to 9.1 lM. Compounds 2, 3, 7, and 19 significantly suppressedthe secretion ofTNF-a with IC50 ranging from8.8 to 20.0 lM. These data provide scientific support for the use of K. pictusstem bark and its triterpene and saponin components in theinhibition of pro-inflammatory cytokine secretion, includingIL-12 p40, IL-6, and TNF-a, and for prevention and treatmentof inflammatory diseases.