On a Local Version of a Levi-Civita Connection

고영상 한국수학교육학회 1985 수학교육 Vol.23 No.2

개흉술후 발생한 농흉의 유인 및 외과적 치료

고영상,김공수,Go, Yeong-Sang,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.10

Thoracic empyema is defined as purulent pleural effusion or effusion with positive bacteriology. Recently, the empyema has markedly decreased by developement of antibiotics, but empyemas following thoracotomy were occasionaly reported. During the period of January, 1985 to May,1991, 18 patients with postthoracotomy empyema have been treated in the Department of Thoracic and Cardiovascular Surgery of Chonbuk National University Hospital.There were 17 males and 1 female ranged from 18 years to 67 years of age. The underlying diseases of empyema were tuberculosis [50%], lung cancer [33.3%], esophageal cancer [11.1%],and aspergillosis with tuberculosis[5.6%]. In surgical procedures causing the empyema, there were lobectomy[38.9%], pneumonectomy[22.2%], decortication[16.7%], decortication & lobectomy[11.1%], and esophagectomy [11.1%]. Etiologic organisms in the pleural fluid were Pseudomonas [27.7%], S.aureus [16.7%], mixed infection [16.7%], K.pneumonia [5.6%], M.tuberculosis [5.6%], and no isolation [27.7%]. In 6 cases with BPF, completion pneumonectomy was performed in 1 case, and open thoracostomy in 5 cases. In 12 cases without BPF, closed thoracostomy was performed in 1 case, decortication in 2 cases, decortication & open thoracostomy in 2 cases, and open thoracostomy in 7 cases. In 6 cases with BPF, the fistulas were closed in 4 cases at follow up, the other 2 cases died from pulmonary insufficiency after completion pneumonectomy and open thoracostomy,respectively. In 12 cases without BPF, the empyema cavities were filled with expanded lungs and granulation tissues, except 1 case died from sepsis.

종격동경 검사의 임상적 의의

고영상,조중구,김공수,Go, Yeong-Sang,Jo, Jung-Gu,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.9

The mediastinoscopy was a well known useful diagnostic tool for detection of certain mediastinal tumors ,mediastinal lymph nodes invasion by bronchogenic carcinoma and metastatic cancer. A total of 33 cases of mediastinoscopies were reviewed, which were experienced at Chon Buk National University Hospital from August,1980 to October 1991. Mediastinoscopy was performed through anterior or parasternal approach in 18 cases, cervical approach in 14 cases and both in 1 case. In 12 cases which were used for preoperative stagig of lung cancer, 10 cases[83.3%] had the positive biopsy results at mediastinal nodes. In 11 cases for diagnosis of lymph nodes and masses with unknown lung lesion, small cell carcinoma revealed in 3 cases,squamous cell carcinoma in 2 , adenocarcinoma in 1 case and the others were had the negative biopsy results. In 10 cases for diagnosis of mediastinal tumors, lymphoma revealed in 2 cases, malignant thymoma in 2, sarcoidosis in 2, tuberculous granuloma in 1, mesothelioma in 1, metastatic cancer with unknown origin in 1 case. Thoracotomy was performed in 3 cases of lung cancers, 2 patients with negative biopsy results in preoperative staging and 1 patient with subcarinal lymph node involvement only. Bleeding complications during mediastinoscopy were developed in 2 cases, managed by anterior mini-thoracotomy.

폐 Aspergillosis의 외과적 치료

고영상,김민호,김공수,Go, Yeong-Sang,Kim, Min-Ho,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.9

Pulmonary aspergillosis is relatively rare disease, most commonly presenting pre-existing cavitary disease. This investigation is designed to illustrate the clinical features, preoperative diagnosis and surgical role in the management of this disease. In retrospective review of opeative cases since Jan. 1988, total 16 cases were analysis. Peak incidence of age lies in the 3rd & 5th decade[81.3%].The common presenting symptoms were hemoptysis & blood tinged sputum[90.9%] & all cases had a history of treatment with antituberculous drugs, but the tuberculosis was revealed in only 3 cases in the pathologic studies on specimen after resection. The locations of lesion were upper lobes in 13 cases, lower lobe in 2 cases, and left whole lobe in 1 case. The operative procedures for treatment of aspergillosis were performed. The lobectomy was performed in 7 cases, lobectomy & segmentectomy in 2 cases, lobectomy & decortication in 2 cases, segmentectomy in 3 cases, bilobectomy & segmentectomy in 1 case and pneumonectomy in 1 case. There was one death due to respiratory insufficiency 21 days later,postoperatively, and empyemas & residual space problems were developed in 2 & 3 cases,respectively. The empyemas were treated with open thoracostomy and the dead spaces was filled with granulation tissues within 6 months. During follow up, there was no recurrence. In conclusion, surgical resection is the treatment of choice for symptomatic aspergillosis and needed in asymptomatic patient to prevent possible fatal sequelae in the future.

대장균 frp 프로모터와 SoxS의 상호작용

고영상 제주대학교 생명과학연구소 1998 제주생명과학연구 Vol.1 No.-

fpr 유전자는 대장균에서 NADPH:ferredoxin oxidoreductase를 코딩하는 유전자로서 슈퍼 옥사이드 스트레스 시 유도되는 soxRS 조절군에 속한다. 순수 분리한 SoxS 전사조절단백 질이 fpr 프로모터 상위부위에 결합함을 gel mobility shift와 DNase I protection 분석을 통하여 관찰하였다. SoxS 단백질은 fpr 프로모터 상위부위에 결합하여 -69에서 -49 사이의 염기서열을 DNase I 절단으로부터 보호하였다. 이 부위에서 SoxS 결합부위 (soxbox) 염기 서열이 soxRS조절군에 속하는 다른 유전자의 경우와 그 방향성이 반대로 나타났다. RNA 중합효소에 의한 fpr 프로모터의 전사가 SoxS 첨가에 의하여 활성화됨을 in vitro에서 관찰하였다. 이상의 결과들은 SoxS 단백질이 fpr 프로모터 상위부위의 soxbox에 결합하며 fpr 유전자의 경우 soxbox의 방향성이 반대로 위치함을 시사한다. SoxS RNA 중합효소 간의 상호작용에 대하여 고찰하였다. The fpr gene, encoding NADPH:ferredoxin oxidoreductase in Escherichia coli, is a member of the soxRS regulon, induced by superoxide-generating agents. The binding of the purified SoxS protein to the fpr promoter upstream sequence was demonstrated by gel mobility shift and DNase I protection assays. Purified SoxS protein bound to the fpr promoter and protected nucleotides between -69 and -49 from DNase I cleavage. This region contains a soxSbinding (soxbox) sequence in reverse orientation. The in vitro transcription from the fpr promoter by RNA polymerse was activated by addition of purified SoxS. these results suggest that SoxS binds to the soxbox sequence in reverse orientation in the fpr gene unlike in other known genes of the soxRS regulon. Possible modes of interaction between SoxS and RNA polymerase were presented.

C¹a regularity of the interfaces for solutions of the degenerates parabolic p-laplacian equation

고영상 경기대학교 사회과학연구소 1997 경기대학교 기초과학논문집 Vol.10 No.2

Lehich 증후군;치험1례

고영상,구자홍,김공수,Go, Yeong-Sang,Gu, Ja-Hong,Kim, Gong-Su 대한흉부심장혈관외과학회 1993 Journal of Chest Surgery (J Chest Surg) Vol.26 No.10

Leriche syndrome ia a common entity which causes ischemia of the lower extremities. Since the introduction of aortic resection and homograft replacement by Oudot in 1951, reconstructive procedures to restore distal blood flow by either endarterectomy or, later, with prosthetic graft have become standardized. Recently we experienced a case of Leriche syndrome. A 50 year-old male patient admitted with intermittent claudication, impotence, and symmetrical atrophy at lower extremities. Aortogram revealed complete obstruction at infrarenal abdominal aorta and Doppler sonogram revealed only minimal blood flow at left femoral artery.Successful surgical treatment was accomplished with endarterectomy at proximal left renal artery and a bypass from abdominal aorta at the level of both renal arteries to both external iliac arteries with bifurcated Gore-tex vascular graft. After bypass operation, we did palpate with arterial pulse at both popliteal artery.He was recovered without complication.

On some properties of solutions and interface of the degenerate parabolic p-laplacian equation

고영상 경기대학교기초과학연구소 1997 기초과학논문집 Vol.10 No.2

Homotopy Equivalence의 몇 가지 성질에 대하여

고영상 경기대학교연구교류처 1984 論文集 Vol.15 No.2

Orientia tsutsugamushi에 감염된 인간 피부 미세혈관 내피세포의 산화 활성

고영상,Koh Young-Sang 한국미생물학회 2005 미생물학회지 Vol.41 No.3

Transcripts levels of superoxide dismutases increase slightly following infection of human dermal microvascular endothelial cells(HMEC-1) by the obligae intracellular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus. In addition, fluorescence-activated cell sorter analysis demonstrates significant intracellular peroxide activity in infected cells within 5 hr after exposure to O. tsutsugamushi. Furthermore, infected cells experienced a significant depletion of glutathiones. These results support hypothesis that cells infected by this intracellular bacterium experience oxidant-mediated injury. Scrub typhus의 원인병원체인 Orientia tsutsugamushi에 감염된 인간 피부 미세혈관 내피세포(HMEC-1)에서 superoxide dismutase 유전자의 발현이 증가하였다. O. tsutsugamushi 접촉 후 5 시간 이내에 감염된 세포에서 세포내 peroxide 존재를 유세포 분석을 통하여 관찰할 수 있었다. 또한 감염된 세포는 세포 내 glutathione이 심하게 고갈됨을 관찰하였다. 이 결과들은 이 절대세포내 기생세균에 감염된 숙주세포가 산화-매개 손상 받음을 시사한다.