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Current Insights on Cholangiocarcinoma Research: a Brief Review
Mathema, Vivek Bhakta,Na-Bangchang, Kesara Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Colangiocarcinoma (CCA) is a progressively fatal disease which generally occurs due to malignant transformation of hepatic biliary cholangiocytes. The incidence of CCA has been increasing worldwide and there is an urgent requirement for effective diagnosis and treatment strategies against this devastating disease. Different factors including liver-fluke infestation, viral hepatitis, exogenous nitrosamine-mediated DNA damage, and chronic inflammation have been linked to CCA genesis. However, the risk factors and underlying complex mechanisms leading to development of CCA are not sufficiently understood to devise an effective targeted treatment therapy. In this review, we summarize currently known epidemiological and pathological aspects of the disease and briefly describe various potential biomarkers and experimental anticancer phytochemicals related to CCA research. In addition, we also sum up recent findings that link chronic inflammation of hepatic biliary cholangiocytes with CCA. The collective information concisely presented in this article would provide useful insights into the current understanding of this cancer.
Zahid Manzoor,Vivek Bhakta Mathema,채두병,유은숙,강희경,현진원,이남호,고미희,고영상 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1
The anti-inflammatory effects of extracts of theseaweed Sargassum macrocarpum (SME) in bone marrowderivedmacrophages (BMDMs) and dendritic cells (BMDCs)were investigated. Primary BMDMs and BMDCs wereused for cytokine production and western blot analysis. SME (0-50 μg/mL) pre-treatment resulted in a stronginhibitory effect against interleukin (IL)-12 p40, IL-6, andtumor necrosis factor (TNF)-α production in CpG-stimulatedBMDMs and BMDCs. SME pre-treatment caused a stronginhibitory effect against NF-κB activation, as evaluatedusing degradation of IκBα and the NF-κB reporter geneassay. SME has significant anti-inflammatory propertiesand warrants further study regarding potential use as amedicinal food.
Kang, Sung-Ha,Koo, Jung-Eun,Hong, Hye-Jin,Mathema, Vivek Bhakta,Koh, Young-Sang The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.1
The present study aims to evaluate the anti-inflammatory effect of methanol extract from leaves of $Carpinus$ $tschonoskii$ (CE) on R848-stimulated primary bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs). Primary BMDMs and BMDCs were used for pro-inflammatory cytokine production. Human embryonic kidney cell line 293T (HEK293T) was used to access NF-${\kappa}B$ activity. In all cases, R848 was used to stimulate the cells. The CE (0~150 ${\mu}g/ml$) was treated to BMDMs, BMDCs, and HEK293T cells. CE pre-treatment in R848-stimulated BMDMs and BMDCs showed a dose-dependent inhibitory effect on pro-inflammatory cytokine (e.g., IL-12 p40, IL-6, and TNF-${\alpha}$) production as compared to non-treated controls. In NF-${\kappa}B$ reporter gene assay, the CE pre-treatment inhibited NF-${\kappa}B$-dependent luciferase activity in a dose-dependent manner. Overall, our findings suggest that CE has significant inhibitory effect on pro-inflammatory cytokine production and deserve further studies concerning potentials of CE for medicinal uses.
Kiem, Phan Van,Anh, Hoang Le Tuan,Nhiem, Nguyen Xuan,Minh, Chau Van,Thuy, Nguyen Thi Kim,Yen, Pham Hai,Hang, Dan Thuy,Tai, Bui Huu,Mathema, Vivek Bhakta,Koh, Young-Sang,Kim, Young Ho The Pharmaceutical Society of Japan 2012 Chemical & pharmaceutical bulletin Vol.60 No.2
<P>The rhizomes of <I>Hedychium coronarium</I> have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11<I>E</I>,13-trien-16,15-olide (<B>1</B>) and 16-methoxylabda-8(17),11<I>E</I>,13-trien-15,16-olide (<B>3</B>), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (<B>2</B>), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (<B>4</B>), coronarin A (<B>5</B>), and corronarin E (<B>6</B>) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds <B>1</B>—<B>3</B> were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC<SUB>50</SUB> ranging from 4.1±0.2 to 9.1±0.3 μ<SMALL>M</SMALL>. Compounds <B>1</B> and <B>3</B> showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC<SUB>50</SUB> values of 46.0±1.3 and 12.7±0.3 μ<SMALL>M</SMALL>. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from <I>H. coronarium</I>.</P>
TRANHONG QUANG,Nguyen Thi Thanh Ngan,Chau Van Minh,Phan Van Kiem,Nguyen Xuan Nhiem,BUIHUU TAI,Nguyen Phuong Thao,Doobyeong Chae,Vivek Bhakta Mathema,고영상,이제현,양서영,김영호 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
Kalopanax pictus (Araliaceae) is a deciduous treedistributed in Korea, Japan, and China. The stem bark ofK. pictus has been functionally used as a traditional crude drugfor the treatment of various inflammatory diseases. In thepresent study, we describe the inhibitory effects of oleananetypetriterpenes and saponins isolated from the stem bark ofK. pictus on production of pro-inflammatory cytokines inLPS-stimulated bone marrow-derived dendritic cells. Of thecompounds tested, 16,23,29-trihydroxy-3-oxo-olean-12-en-28-oic acid (1), 4,23,29-trihydroxy-3,4-seco-olean-12-en-3-oate-28-oic acid (2), 3b,6b,23-trihydroxyolean-12-en-28-oicacid 28-O-b-D-glucopyranoside (3), nipponogenin E (6),3b,6b,23-trihydroxyolean-12-en-28-oic acid (7), and caulophyllogenin(19) significantly inhibited the production ofIL-12 p40 and IL-6 with IC50 values ranging from 3.3 to 9.1 lM. Compounds 2, 3, 7, and 19 significantly suppressedthe secretion ofTNF-a with IC50 ranging from8.8 to 20.0 lM. These data provide scientific support for the use of K. pictusstem bark and its triterpene and saponin components in theinhibition of pro-inflammatory cytokine secretion, includingIL-12 p40, IL-6, and TNF-a, and for prevention and treatmentof inflammatory diseases.