정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

전침 자극에 의한 오디 괄약근 운동성 변화에 관한 연구

이성구,김명완,김홍자,서동환,이상수,김동일,유교상,주연호,민병일,김지훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Background/Aims: This study was designed to evaluated the effects of electroacupuncture on the sphincter of Oddi (SO) motility in humans and to correlate the manometric findings with plasma cholecystokinin (CCK) levels. Methods: Eleven patients (M: F= 5: 6) who had various kinds of biliary disorders were enrolled. SO motility was monitored with a conventional low-compliant continuously perfused technique using ERCP (n=9) or percutaneous transhepatic cholangioscope (n=2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint, GB 34, in these 11 patients. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of SO were also checked in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during the time course of electroacupuncture stimulation. Result: All the manometric parameters including the basal pressure of SO, amplitude, frequency and duration of phasic wave contraction of SO were significantly decreased (p< 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After removal of electroacupuncture stimulation, restoration of amplitude and duration to basal condition were noted. A tendency towards the return of SO contractility was also observed in basal pressure and frequency. Stimulation of the control acupoint, however, did not affect the SO contractility and plasma CCK levels. Conclusions: Electroacupuncture stimulation of acupoint GB 34 showed reversible inhibition of SO contraction in humans. We speculate that the response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release. (Korean Journal of Gastrointestinal Motility 2000;6:44-41)

실란 펄스 플라즈마 공정에서의 화학농도 변화

김동주,김교선 江原大學校 産業技術硏究所 2005 産業技術硏究 Vol.25 No.A

We investigated numerically the evolutions of several chemical species which are important for film growth and particle generation in the pulsed SiH₄ plasmas. During the plasma-on, the SiH_(x) concentration increases with time mainly by the generation reaction from SiH₄, but, during the plasma-off, decreases because of the hydrogen adsorption reaction. During the plasma-on, the concentrations of negative ions increase with time by the polymerization reactions of negative ions and those become almost zero in the sheath regions because of the electrostatic repulsion. During the plasma-off, the concentrations of negative ions decrease with time by the neutralization reactions with positive ions and some negative ions can diffuse toward the sheath regions because there is no electric field inside the reactor. The polymerized negative ions of higher mass can be reduced successfully by using the pulsed plasma process.

學生 生活의 質 改善에 關한 硏究 : 大學生活 經驗에 따른 新入生의 意識變化 Changes in Freshmen's Expectations for Higher Education through Collegians' Experiences

김언주,박영철,김교헌,박동철,허윤근,사명규 충남대학교 1992 學生生活硏究 Vol.19 No.-

1. 인적사항 ‘부모님과의 가치관의 차이가 없다’가 48.2%이고 ‘가치관의 차이가 있다’가 51.8%로 나타났다. 한 학기를 지낸 후 부모님과의 가치관의 차이에는 별다른 변화를 보이지 않고 있다. 재학 중 침식형태를 보면, 전체 학생 중 약 39%가 자책이 아닌 하숙, 기숙사, 자취 또는 친척집에서 다니고 있었다. 신입생들은 대체로 원만한 인간관계를 유지하고 있는 것으로 나타났다. 대학별로는 예술대학이 가장 높았으며 약학대학이 평균보다 낮았다. 그런데 입학당시에 비해 한 학기를 지낸 후 원만한 인간관계를 유지하고 있다는 반응율이 낮아졌다. 이런 점은 다른 여러 가지 이유가 있겠으나 주된 이유는 대학사회라는 급격히 변화한 환경에 적응을 잘 하지 못한데서 연유된다고 생각된다. 이상과 같은 인적사항에 대한 분석 결과는 부모님과 자녀 또는 기성세대와 대학생들 간의 긴밀한 대화의 통로를 마련할 것과, 원만한 인간관계 개발을 위한 프로그램의 개발 및 종합적인 주거환경에 대한 대학교육목적 달성의 차원에서의 장기적인 대책 수립이 요망된다.

공정 변수 변화에 따른 실란 플라즈마내 음이온 특성

김교선,김동주 江原大學校 産業技術硏究所 1995 産業技術硏究 Vol.15 No.-

We have studied the generation and behavior of negative ions in silane plasmas. The negative ions were formed by homogeneous reaction in silane plasma and the behavior of negative ions were predicted by solving the model equations. The concentration profiles of negative ions were shown as a function of reactor length and time. The effects of process variables such as reactor pressure, flow rate and electrical field strengths on the behavior of negative ions were analyzed.

약물 유해반응 보고지침 -임상시험의 안전성에 관한 정보 관리지침 -

지동현,김훈교,배진우,손동렬,김인범,전용관,박혜연 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

TiO₂가 코팅된 Polyethylene 입자를 이용한 페놀과 톨루엔의 광분해

김동주,최상근,조준형,김교선 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B

The photodegradation of phenol and toluene with the Ti0₂-coated polyethylene (PE) particles were investigated in the slurry type photocatalytic reactor, changing the Ti0₂ particle sizes, initial phenol and toluene concentrations, and the oxygen flow rate. The nano-sized Ti0₂ photocatalyst particles were prepared by the diffusion flame reactor and they were coated onto PE particles by using the hybridization system for the efficient recollection of Ti0₂- coated particles after photodegradation experiments. The degradation efficiencies of phenol and toluene with the Ti0₂-coated PE particles were more than 90% after photodegradation of 80 minutes for most cases. The efficiencies of photodegradation with the Ti0₂-coated PE particles were found to be lower than those by the pure Ti0₂ particles by 50%, because of the decrease in specific surface area of Ti0₂ particles in PE particles.

DeSOx/DeNOx 효율 개선을 위한 펄스 코로나 방전하에서 기체미립자 전환반응의 적용

김동주,최유리,김교선 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

In this paper, we investigated the post-combustion removal of nitrogen oxide(N0?) and sulfur oxide(S0?) which is based on the gas to particle conversion process by the pulsed corona discharge. Under normal pressure, the pulsed corona discharge produces the energetic free electrons which dissociate gas molecules to form the active radicals. These radicals cause the chemical reactions that convert SO? and NO? into acid mists and these mists react with NH? to form solid particles. Those particles can be removed from the gas stream by conventional devices such as electrostatic precipitator or bag filter. The reactor geometry was coaxial with an inner wire discharge electrode and an outer ground electrode wrapped on a glass tube. The simulated flue gas with SO? and NO? by adding NH? and H?O in the gas stream. We also measured the rmoval efficiency of SO? and NO? in a cylinder type corona discharge reactor and obtained more than 90% of removal efficiency in these experimental conditions. The effects of process variables such as the inlet concentrations of SO?, NH? asnd H?O, residence time, pulse frequencies and applied voltages were investigated.

저온 플라즈마와 광촉매에 의한 NO/SO_(2) 제거

김동주,김교선 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

In this study, we analyzed the effects of several process variables on the removal efficiencies of NO and SO_(2) by the dielectric barrier discharge process combined with photocatalysts. The TiO_(2) photocatalysts were coated onto the spherical-shaped glass beads as dielectric materials by the dip-coating method toe analyze the effects of photodegradation reaction on the NO and SO_(2) removal. As the voltage applied to the plasma reactor increases, or as the pulse frequency of applied voltage increases, the NO and SO_(2) removal efficiencies increase. Also an the residence time increases, or as the initial concentration of NO decreases, the NO and SO_(2) removal efficiencies increase. The higher the amount of TiO_(2) particles coated onto the glass bead is, the larger the surface area of TiO_(2) particles for the photodegradation reaction is and the NO and SO_(2) are removed more quickly by the faster photodegradation reactions.