클리높타이로라이트에서 1- 부텐의 골격이성화 반응

김명완,김종호,서곤,홍석봉 한국공업화학회 1998 한국공업화학회 연구논문 초록집 Vol.1994 No.1

제올라이트 촉매에서 나프탈렌의 선택적 알킬화반응

김명완,서 곤,김종호 전남대학교 촉매연구소 1998 촉매학술발표회 Vol.- No.15

아로마 흡입요법이 요역동학검사 환자의 불안과 심박변이도에 미치는 효과

김명완,유양숙,조옥희,조성준 기초간호학회 2009 Journal of korean biological nursing science Vol.11 No.1

최근 의학의 발달로 평균수명이 연장되면서 고연령층의 건 강문제에 대한 관심이 증가하고 있는데, 특히 장년층 이상에 서 배뇨장애를 호소하는 환자가 빠른 속도로 늘어나고 있다. 노인의 경우, 특별한 질병이 없어도 하부요로의 변화나 수면 중 항이뇨호르몬의 과다분비 등에 의해 노인성 요실금이 발생 할 수 있으며, 그 외에 뇌졸중이나 파킨슨씨병 등 뇌의 기질적 인 병변으로 방광의 비억제성 수축 또는 절박성 요실금이 악화 될 수 있고, 당뇨, 고혈압, 외상 등으로 요절박, 요실금, 요주 저, 약뇨, 야간빈뇨, 잔뇨감 등의 다양한 배뇨장애 증상이 나 타날 수 있다(Korea Continence Society, 2005).

헤테로폴리산 담지 메조포러스 물질에서 아이소프로필 나프탈렌의 알킬화반응

김명완,김왕기,김종호,서곤 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

The alkylation of 2-isopropyl naphthalene with isopropyl alcohol was studied over heteropoly acid catalyst supported on mesoporous material. The physicochemical state of loaded heteropoly acid was investigated using XRD, nitrogen adsorption and FT-IR techniques. Heteropoly acid was highly dispersed on the wall of mesoporous material, and retained its Br□nsted acidity. The initial conversion of 2-isopropyl naphthalene was high over the heteropoly acid catalyst supported on mesoporous material, while that was negligible over bulk heteropoly acid. The high selectivity for β,β - diisopropyl naphthalene was explained by the uniform mesopore inducing transition-state shape selectivity.

광촉매 적용 살균공기정화장치 개발

김종범,김명완,조동련,서곤,김종호 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1

현대인은 밀폐된 공간에서 생활하면서 여러 유해 화학물질이나 세균 등에 많이 노출되어 있다. 지금까지의 공기 정화는 대부분 필터나 화학물질을 이용하는 방법으로 완전 제거가 곤란할 뿐 아니라 인체에 다른 피해를 주기도 하였다. 이에 비해 산화티탄 광촉매에 자외선을 조사하면 표면에 강한 산화력을 가지는 물질이 생성되어 유해 유기화학물질의 완전분해나 살균이 가능하다. 이 연구에서는 무기물 필터에 광촉매를 고정하여 공기 중의 부유세균을 효율적으로 제거하는 장치를 개발하였다. 사용한 광촉매 코팅 무기물 필터 및 장치의 살균 능력을 Escherchia coli(ATCC11229), 황색포도상구균(ATCC43300), Serratia marcescens (ATCC13880), 인플루엔자 바이러스A(PR8)로 조사한 결과, 모든 세균과 바이러스의 제거율이 99.9% 이상이었다. 아울러 이 장치를 이용한 대표적인 악취 물질의 분해 실험에서도 우수한 분해 능력을 보였으며, 병원에 설치하여 병원내의 부유세균이 효과적으로 제거되는 것을 확인하였다.

전침 자극에 의한 오디 괄약근 운동성 변화에 관한 연구

이성구,김명완,김홍자,서동환,이상수,김동일,유교상,주연호,민병일,김지훈 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Background/Aims: This study was designed to evaluated the effects of electroacupuncture on the sphincter of Oddi (SO) motility in humans and to correlate the manometric findings with plasma cholecystokinin (CCK) levels. Methods: Eleven patients (M: F= 5: 6) who had various kinds of biliary disorders were enrolled. SO motility was monitored with a conventional low-compliant continuously perfused technique using ERCP (n=9) or percutaneous transhepatic cholangioscope (n=2). After baseline monitoring for phasic wave contractions of SO, electroacupuncture was applied at a specific acupoint, GB 34, in these 11 patients. A nonspecific acupoint 5 cm away from GB 34 was selected as a control. Manometric parameters of SO were also checked in 6 subjects during stimulation of the control acupoint. CCK plasma levels were measured during the time course of electroacupuncture stimulation. Result: All the manometric parameters including the basal pressure of SO, amplitude, frequency and duration of phasic wave contraction of SO were significantly decreased (p< 0.05) during electroacupuncture stimulation. The inhibition of SO contractility was accompanied by increased CCK plasma levels. After removal of electroacupuncture stimulation, restoration of amplitude and duration to basal condition were noted. A tendency towards the return of SO contractility was also observed in basal pressure and frequency. Stimulation of the control acupoint, however, did not affect the SO contractility and plasma CCK levels. Conclusions: Electroacupuncture stimulation of acupoint GB 34 showed reversible inhibition of SO contraction in humans. We speculate that the response of SO to electroacupuncture stimulation may be mediated by some neurohormonal mechanisms including CCK release. (Korean Journal of Gastrointestinal Motility 2000;6:44-41)

Comparison of the anesthetic effects of 2,2,2-tribromoethanol on ICR mice derived from three different sources

이미리,서혜린,김명완,조준용,송현근,정영석,황대연,김길수 한국실험동물학회 2018 Laboratory Animal Research Vol.34 No.4

This study was conducted to compare the anesthetic effects of 2,2,2-tribromoethanol (TBE, Avertin®) in ICR mice obtained from three different sources. TBE (2.5%) was intraperitoneally injected at three doses: high-dose group (500 mg/kg), intermediate-dose group (250 mg/kg), and low-dose group (125 mg/kg). Anesthesia time, recovery time, end-tidal peak CO2 (ETCO2), mean arterial blood pressure, heart rate, oxygen saturation (SpO2), body temperature, pH, PCO2, and PO2 of the arterial blood were measured. Stable anesthesia was induced by all doses of TBE and the anesthesia time was maintained exhibited dose dependency. No significant differences in anesthetic duration were found among the three different strains. However, the anesthesia time was longer in female than in male mice, and the duration of anesthesia was significantly longer in female than in male mice in the high-dose group. The recovery time was significantly longer for female than male mice in the intermediate- and high-dose groups. In the ICR strains tested, there were no significant differences in the mean arterial blood pressure, SPO2, arterial blood PCO2, and PO2, which decreased after TBE anesthesia, or in heart rate and ETCO2, which increased after TBE anesthesia. In addition, body temperature, blood biochemical markers, and histopathological changes of the liver, kidney, and lung were not significantly changed by TBE anesthesia. These results suggested that ICR mice from different sources exhibited similar overall responses to a single exposure to TBE anesthesia. In conclusion, TBE is a useful drug that can induce similar anesthetic effects in three different strains of ICR mice.

엔진 배기가스 냉각장치 성능분석

신재익(Jaeik Shin),김명완(Myoungwan Kim),장경우(gyeongwoo Jang) 한국추진공학회 2020 한국추진공학회 학술대회논문집 Vol.2020 No.11

인간의 Jurkat T세포에서 프로스타글란딘 PGE₂) (PGE₂)의 cAMP 경로를 통한 인터페론 감마(INF--γ ) 유전자의 methylation

전병훈,주성민,정재성,김명완,윤용갑,박현,정헌택,한동민,김원신,Jeon, Byung-Hun,Ju, Sung-Min,Jeong, Jae-Sung,Kim, Myung-Wan,Yun, Young-Gab,Park, Hyun,Chung Hun-taeg,Han, Dong-Min,Kim, Won-Sin 한국생명과학회 2004 생명과학회지 Vol.14 No.4

We have examined the effects of S-nitroso-N-acetylpenicillamine (SNAP), prostaglandin $E_2$ (PG $E_2$) and dibutric cyclic AMP (dbcAMP) on the methylation of interferon- ${\gamma}$ (IFN- ${\gamma}$ ) gene in human Jurkat T cells. The CpG dinucleotide which is critical for promoter function of IFN- ${\gamma}$ gene was methylated by treatment with SNAP, PG $E_2$ and dbcAMP, respectively. The DNA methylation induced by PG $E_2$ was suppressed by the addition of 2',5'-dideoxyadenosine (DDA), an inhibitor of adenylyl cyclase, but the suppression was not observed in SNAP treated cells. The NO production was not enhanced in PG $E_2$ or dbcAMP treated cells. The methylation induced by PG $E_2$ and dbcAMP was not suppressed by the addition of $N^{G}$-methyl-L-arginine (L-NMMA), NO synthase inhibitor. In conclusion, the inhibition of INF- ${\gamma}$ gene expression by PG $E_2$ was associated with the methylation of INF- ${\gamma}$ gene by elevation of intracellular cAMP in human Jurkat T cells. However, the methylation induced by PG $E_2$ might not be mediated through the NO production.rough the NO production. 본 연구에서 인간의 백혈병세포주인 Jurkat T 세포에서 인터페론 감마(INF-${\gamma}$ 유전자의 methylation에 대한 S-nitroso-N-acetylpenicillamine (SNAP), 프로스타글란딘 $E_2$ (PG $E_2$) 그리고 dibutric cyclic AMP (dbcAMP)의 효과를 조사하였다. 인터페론 감마 유전자의 프로모터기능에 아주 중요한 디뉴클레오티드인 CpG는 SNAP, PG $E_2$, 그리고 dbcAMP를 각각 처리하였을 때 methylation되었다. PG $E_2$에 의해서 유도된 그 methylation은 아데닐산 사이클라제의 저해제의 하나인 2',5'-dideoxyadenosine (DDA)에 의해서 억제되었지만, SNAP에 의해서 유도된 methylation은 DDA에 의해서 억제되지 않았다. PG $E_2$나 dbcAMP를 처리한 세포에서 일산화질소(NO)의 생성의 증가는 나타나지 않았으며, PG $E_2$나 dbcAMP에 의해 유도된 인터페론 감마유전자의 methylation도 일산화질소합 성효소의 저해제인 $N^{G}$ -methyl-L-arginine (L-NMMA)에 의해서 억제되지 않았다. 따라서 인간의 Jurkat T 세포에서 PG $E_2$에 의한 인터페론 감마 유전자의 발현 억제는 세포내의 cAMP생성경로를 통한 인터페론 감마 유전자의 methylation과 연관되어있으나 일산화질소의 생성경로와는 무관한 것으로 보인다.화질소의 생성경로와는 무관한 것으로 보인다.

전립선암 노인 환자의 하부요로증상

조옥희,유양숙,차경숙,김명완,Cho, Ok-Hee,Yoo, Yang-Sook,Cha, Kyeong-Sook,Kim, Myung-Wan 한국가정간호학회 2011 가정간호학회지 Vol.18 No.2

Purpose: The purpose of this study was to investigate the degree of LUTS (Lower Urinary Tract Symptoms) and factors affecting LUTS in patients with prostate cancer. Methods: Fifty-four patients with prostate cancer participated and they completed a structured questionnaire at a hospital in Seoul. The LUTS level was measured by using the International prostate symptom score (1992) and the data were analyzed by Wilcoxon rank sum test and Kurskal-Wallis test. Results: Most subjects obtained a higher than moderate LUTS score. The participants who had a lower perceived health status and did not drink alcohol were more likely to had a lower LUTS score than other patients who had higher perceived health status and drink alcohol. In addition, eye diseases were significantly associated with the LUTS score. In LUTS, all the patients received higher IPSS-QOL (International prostate symptom score quality of life) and frequency, nocturia. Conclusion: For proper nursing care related to LUTS, nurses should focus on the factors identified when performing nursing assessments and should develop nursing intervention programs for symptoms management.