Combination treatment for onychomycosis using 1,064 Nd:YAG laser and efinaconazole 10% topical solution

( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery was suggested till present. Systemic antifungal drugs for onychomysosis are effective. However, they require a long treatment time and not suitable for people with other systemic disease. Furthermore, they may cause many side effects such as liver disease. Also, many patients prefer topical drugs or physical treatment. Objectives: The objective of this study was to evaluate the efficacy of combination treatment with a 1064 Nd:YAG laser and efinaconazole 10% Topical Solution. Methods: Ten patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. The effectiveness of treatment were evaluated with before and after photographs. Results: Improvement were shown in 90% of patients after the treatment. However, 10% of patients had no response. Conclusion: This clinical study suggests that combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% Topical Solutionis an effective, safe, and convenient treatment method for onychomycosis.

Combination treatment for onychomycosis using 1,064-Nd:YAG laser and efinaconazole 10% topical Solution

( Sang Ju Lee ),( Dong Woo Suh ),( Won Soon Chung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Onychomycosis is one of the most common nail disease around the world. No specific treatment other than drug therapy and surgery has been suggested till present. Systemic treatment with antifungal drugs for onychomysosis is effective. However, a long treatment time is required and it is not suitable for people with other systemic disease. Furthermore, it may cause many side effects such as liver diseases. For that reasons, topical drugs or physical treatments are preferred by many patients. Recently laser treatment for onychomycosis has been proposed. The efficacy of treatment is less than systemic drugs but, laser is more convenient, safe and accessible in treatment. As a result, the combination therapy using 1064 Nd:YAG laser and efinaconazole 10% topical solution was performed. Two patients with onychomycosis were treated with 1064 Nd:YAG laser (PinPointe FootLaser, Cynosure, Westford, MA, USA) once a month with application of 10% eifnaconazole solution(Jublia, Dong-A EST) once a day. All three patients were treated successfully. We considered a combination treatment of a 1064 Nd:YAG laser and efinaconazole 10% topical solutions would be an effective, safe, and convenient treatment method for onychomycosis.

Three Poems by Yun Dong-ju

Yun Dong-ju,Lee In-soo(번역자) The Academy of Korean Studies 1965 Korea Journal Vol.5 No.9

Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

인의 흡착능 평가를 통한 인공습지 하수처리 시스템의 여재 선발

이홍재,서동철,조주식,허종수 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2

인공습지 하수처리장이 축적되어 하수처리장 수명의 제한인자로 작용하는 인의 포화치를 조사하기 위해 여재 입경별 최대 인 흡착능을 조사하여 최적의 여재를 선정하였고, 또한 유기물과 굴패각의 인 흡착제로서 사용가능 여부를 조사하기 위해 최대 인 흡착능을 조사하였다. 그리고 인공습지 하수처리장에서 하수처리장의 수명을 연장하기 위한 방안을 검토하기 위해 여재별로 흡착제인 유기물 양을 달리하여 최대 인 흡착능을 조사하였고, 최적으로 선정된 여재에 Ca, Mg, Al, Fe 및 굴패각 첨가에 따른 최대 인 흡착능을 조사하였다. 여재 입경별 최대 인 흡착능을 조사한 결과 여재 입경이 작아질수록 최대 인 흡착능이 증가하는 경향으로 여재 대(4~10 mm), 중(2~4 mm) 및 소(0.1~2mm)의 최대 인 흡착능은 각각 8, 10 및 22mg/kg로서 여재 입경이 0.1~2 mm인 여재소(C)가 최적의 여재이었고, 유기물과 굴패각의 최대 인 흡착능을 조사한 결과 유기물이 1,000 mg/kg 및 굴패각이 833 mg/kg이었다. 입경별 여재에 유기물을 첨가하였을 경우 모든 여재에서 유기물 첨가량이 증가할수록 최대 인 흡착능이 점점 증가하였다. 따라서 인공습지 하수처리장에서 수초에 의해 쌓여 부식된 유기물은 인의 흡착능을 증가시켜 인 처리능력을 향상시킬 수 있을 것이라 사료되었다. 최적 여재인 여재 소(C)에 Ca, Mg, Al 및 Fe를 첨가하였을 경우 모든 조건에서 첨가량이 증가할수록 최대 인 흡착능도 점점 증가하였으며, 특히 Ca 0.1% 첨가시 인 흡착능이 885 mg/kg으로 급격히 증가하였다. 굴패각을 여재에 첨가하여 흡착능을 조사한 결과 굴패각을 2% 첨가시 인 흡착능이 약 22 mg/kg에서 약 36 mg/kg으로 약 14 mg/kg이 증가하였다. The phosphorus(P) adsorption capacities of various filter media were investigated in relation to the size and types of filter media to screen the optimum condition. The objective of this study was to evaluate the constructed wetland longevity by improving P adsorption capacity. The maximum P adsorption capacities of filter media A(4∼10 ㎜), B(2∼4 ㎜) and C(0.l∼2 ㎜) were 8, 10 and 22 ㎎/㎏, respectively, showing those increased as the filter media size decreased. Among the experimental media, the optimum filter media size was 0.1-2 ㎜. When the filter medium was supplemented with organic materials which were piled up and decayed in the constructed wetland, the P adsorption capacity was significantly enhanced. Under the conditions of optimum filter media size, the respective maximum P adsorption capacities of filter media C when supplemented with Ca, Mg, Al and Fe were higher than that of filter media C. However the addition of Ca, Mg, Al and Fe to constructed wetland were not recommended because of the possibility of their secondary pollution. The maximum P adsorption capacity of filter media C was 22 ㎎/㎏, but this was increased to 36 ㎎/㎏ when filter media C was supplemented with 2% oyster shell.

釜山地域 施設園藝 現況 및 問題點과 發展方向

이재필,정순재,오주성,진동호 동아대학교 농업생명과학연구소 2001 農業生命資援硏究 Vol.10 No.1

In short is as follows to research the present situation and mooted point, to get ready development direction of horticulture equipment in Busan. 1.Area of culture equipment in Busan is that vegetables was formed 1.7% for 435ha of nationwide 82,465ha, florist crops was formed 6.7% for 220ha of nationwide 3,299.2ha in standard of 1998. 2.In the present situation of equipment of vegetable culture, fruit vegetables are a lot more in culture area and productive quantity. There is mainly cultivated tomato, cucumber and unripe red pepper. 3.In the present position of equipment of florist crops area, cut flower is formed 76.8% as 169ha in nationwide florist crops area. There is mainly cultivated carnation, rose, gladiolus. 4.In the usual present position of frame materials in equipment, vegetables equipment is built at 82.5% with iron frames. But iron frames is far the lower rate as 22.6% than 87.1% of nation rate in florist crops. It should be converted to iron frames for the durability and efficiency management of environment. 5.In the usual present situation of covering material in equipment, it is in use soft film as 97.8% and have the lots use of PE, EVA film. 6.In the present position of environment management of equipment, as 88% used soft film which is habitual means, Heat culture is used warm-air heater around 95%. In overhead non-woven fabric. Heat culture is used warm-air heater around 95%. In overhead flooding of equipment, the overhead flooding used hose is a lot most as 50.1%, it its increased the farmhouse which use sprinkler or dripping flooding materials, also. 7.The system of equipment is movable style is 55%, fixed style is 45%. the type is the single span is many more as 73.5% than 26.5% of multi span. The direction is, in case of single span is east and west, in case of multi span is mainly south and north. 8.The nutriculture area is took vegetables were 4.7ha and florist crops were 3ha. In the case of florist crops, rose was 4.3ha and eggplant was 0.3ha. In the case of florist crops, rose was 3ha by crops. In has to consider a special countermeasure in application and supply of farmhouse used the equipment in Busan because Busan was fell behind than other city in nutriculture area and culture technique. 9.In the export of horticulture equipment crops, vegetables are tomato, cucumber, florist crops are rose, chrysanthemum and europeans orchid but the work has not yet born fruit. It must be solve mooted point of low grade article, lack information. etc. So it is brought up the export horticulture.

다발성 말초신경병증의 조기진단 : 적외선 체열촬영검사와 전류지각역치검사의 조합진단 Combination Diagnosis Using by Digital Infrared Thermogram and Current Perception Threshold

이삼규,김재형,최인성,이소영,한재영,조성렬,김재휴,노성만,정민영,정동진,김현성 全南大醫大 2001 전남의대학술지 Vol.37 No.3

β-naphthol 유도체 합성 및 항종양활성 검토

이주영,류수진,박예진,황순호,이마세,김인종,김동현,김신규 慶熙大學校 1996 論文集 Vol.25 No.-

Sythesis of β-naphthol derivatives and their anti-tumor activity were investigated. Binaphthol 1 obtained from β-naphthol by oxidative C-C bond formation(phenoloxydation) was converted into its derivatives. Treatment of 1 with POCl_3 followed by aziridine introduction gave phosphoryl aziridine 3. Also, diaziridine 5 was obtained from 1 by chlorination and successive aziridine introdution. Typical chemical transformation of 1 to obtain ester-type afforded compound 7 and 8. Compound 5 was the most effective derivative of the tested compounds on their anti-tumor activity.

황산산성 용액에서 기체 발생 속도에 의한 히드라진과 요오드의 반응속도에 관한 연구

이송주,박동화 광주보건대학 1989 論文集 Vol.14 No.-

We have studied the kinetics of the N₂H₄=l₂ reaction in sulfuric acid media by gas evolution Choi?? has explained that the reaction of N₂H₄-Br₂processes through the Competitive Consecutive Second order reaction mechanism, and we have assumed N₂H₄-l₂ reaction processes through the same mechanism. The rate constant(k'₁) was found to be 0.87~0.98X 10^(-1) M^(-1) sec^(-1) with change in [N₂H₄]_(0), [l₂]_(0), 2a(=2[N₂H₄3_(0)-(l₂]) and inversely proportional to hydrogen concentration. we have also found th at, as k₃ is constant, a comparatively stable intermediate is present .