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조선정,최돈찬 龍仁大學校 自然科學硏究所 1999 自然科學硏究所論文誌 Vol.4 No.1
Many mammals in temperate zone are affected by the distinctive changes of four seasons. Their reproductive status is active under summer climate and inactive under severe winter weather. The golden hamsters(Mesocricetus auratus) are seasonal breeding animals whose sexual activties are regulated by the photoperiod. Melatonin is a hormone secreted from the pineal gland, which transmits the photoperiodic information into reproductive endocrine system. The synthesis and release of melatonin reflect photoperiod. A proper administration of melatonin suppresses the sexual function. In the present study, the effects of melatonin on the gonadal activity were examined in golden hamsters received melatonin in the evening daily or once in 2, 3, 4, 5, 6, or 7 days. The results showed that testicular regression of golden hamsters was occurred in animals received melatonin injections every day and every other day in the evening. The injections of melatonin once in 3, 4, 5, 6 or 7 days had no effects on gonadal function. The present investigation suggests that the effects of photoperiod on the reproduction of male golden hamsters is mediated by the melatonin.
조명찬,주인종,김대중,이병직,정형배,이명묵,박영배,최윤식,서정돈,이영우 대한내과학회 1990 대한내과학회지 Vol.38 No.3
We reviewed 549 electrocardiograms obtained from 95 patients with Korean hemorrhagic fever to investigate the incidence and electrocardiographic characteristics, observe evolutional changes in those findings during the course of illness, identify the correlations with clinical findings, and then suggest pathophysiologic mechanisms in the development of abnormal electrocardiographic findings. The overall incidence of electrocardiographic abnormalites was 95.7%, and the frequency of each phase was 87.8% in the febrile phase, 91.3% in the hypotensive phase, 86.5% in the oliguric phase, 76.4% in the diuretic phase and 43.0% in the convalescent phase. The cardinal electrocardiographic findings were QT prolongation(82.1%), sinus bradycardia(73.7%), prominent U wave(53.7%), tall and peaked T wave(51.6%), ST-T changes(41.1 %) and sinus tachycardia(35.8%). The most frequently observed electrocardiographic findings of each phase were sinus tachycardia in the febrile and hypotensive phase, QT prolongation in the oliguric phase, sinus bradycardia in the diuretic phase and prominent U wave in the convalescent phase. The occurrence of abnormal electrocardiograms increased in patients with high serum creatinine levels during the oliguric and diuretic phases. The electrocardiographic abnormalities that persisted to the convalescent phase were QT prologation(seven cases), prominent U wave(seven cases), sinus bradycardia(five cases), and tall and peaked T wave(four cases). Even though almost all of the electrocardiographic abnormalities were mild and recovered shortly after the convalescent phase and there were no diagnostic electrocardiograms, we observed noteworthy electrocardiographic characteristics and evolutional changes during the course of illness and suggested the primary electrocardiographic changes in Korean hemorrhagic fever.
The Test for Verifying a Tip-Over Analysis of a Dry Storage Cask
Don g-Hak Kim,Ki-Seog Seo,Ju-Chan Lee,Chun-Hyung Cho,Hyun-Kee Jang,Byung-Il Choi 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.3
사용후연료 건식저장용기의 전복사고조건에 대한 1/3 축소모델의 시험을 실시하여 전복해석에 대한 검증을 하였다. 전복해석은 전복각도에 따른 위치에너지와 동일한 운동에너지를 가지는 초기각속도를 이용하여 결정된 각 점에서의 속도를 충돌직전 모델에 대한 초기경계값으로 입력하여 해석하였다. 전복시험에 따른 캐니스터의 구조적 건전성을 확인하기 위하여 육안검사와 함께 액체침투법과 초음파 탐상법와 같은 비파괴검사를 실시하였다. 전복충격에 의하여 저장용기의 뚜껑 에 변형 이 발생되었지만 캐니스터의 구조적 건전성이 유지되었다. 시험에서 취득한 변형률과 가속도를 해석결과와 비교하여 해석 에 대한 검증을 실시하였다. 해석결과는 시험결과보다 대체로 두 배 정도의 큰 값을 주는 것으로 나타났다. A test of the 1/3 scale model was conducted to verify the tip-over analysis of a dry. concrete storage cask under a hypothetical accident condition. The tip-over analysis was executed using the velocity at each point as the initial conditions of the model just before the impact. The initial velocity was determined from the initial angular velocity, which would make the equivalent kinetic energy to the potential energy. To confirm the structural integrity of the canister, the visual testing and the non-detective testings such as Liquid Penetrant testing and Ultrasonic Testing were conducted. The lid of a storage cask was plastically deformed near the impact point. The structural integrity of storage cask was maintained. To verify the tip-over analysis the strains and the accelerations acquired by the tip-over test were compared with those by the analyses. The results of the analysis were larger than the test results about two times.
조갑진균증에서 Ciclopirox Nail Lacquer의 치료효과
박경찬,김정애,방형돈,조광현,윤재일,김병수 대한감염학회 1995 감염 Vol.27 No.3
배경 및 목적:조갑진균증의 치료에 있어 국소용 항진균제는 조갑판을 통과하지 못하기 때문에 치료율이 낮은 것으로 알려졌으나 최근 조갑판을 통과하여 조상에서도 높은 치료농도를 유지할 수 있는 국소용 항진균제인 ciclopirox nail lacquer가 개발되었다. 이에 본 저자들은 8% ciclopirox nail lacquer 단독 도포의 조갑진균증에서의 치료 효과와 안전성을 알아 보기 위한 연구를 수행하였다. 방법:표적 조갑판의 감염된 면적의 비율이 50%이하인 경증의 조갑진균증 환자 27명을 평가 대상으로 하였으며 8% ciclopirox nail lacquer 1일 1회 도포요법으로 6개월간 치료하였다. 매 방문시마다 감염면적 비율을 기록하였고 치료 전과 치료 후 진균 검사를 시행하였다. 결과: 1)표적조갑판의 감염 면적이 치료 전 평균 28.9%에서 치료 종료시 4.7%로 통계적으로 유의하게 감소하였다(p<0.001). 2)KOH 직접 도말 검사와 진균 배양 검사에서 모두 음성인 진균학적 완치율은 치료 종료시 77.8%였다. 3)부작용으로는 3명(11.1%)에서 일시적 작열감, 조갑 감입 등을 호소하였다. 결론:경증의 조갑진균증 치료에 있어 8% ciclopirox nail lacquer는 비교적 좋은 치료 효과를 보이며 부작용이 적은 약제로 생각된다. Background: Topical antifungal agents have been ineffective in the treatment of onychomycosis because they could not reach the infected nail bed. 8% ciclopirox nail lacquer is a new topical antimycotic which is characterized by excellent penetration into the nail plate. We performed a study to assess the therapeutic efficacy and safety of 8% ciclopirox nail lacquer in the treatment of onychomycosis. Methods: We assessed 27 onychomycotic patients whose affected area of target nail plate was not more than 50%. The patients were instructed to apply 8% ciclopirox nail lacquer once daily and evaluated monthly for 6 months. Mycological examinations were done before and after the treatment. Overall efficacy, tolerability, cosmetic acceptance and adverse effects were assessed at the end of 6 months' treatment. Results: The mean percentage of affected area decreased from 28.9% to 4.7%. Mycological cure rate was 77.8% at the end of the treatment. Overall efficacy assessed by physician and patients were similar and evaluated as complete cure in 48% and 44%, respectively. Tolerability and cosmetic acceptance were excellent or good in most of the patients. No systemic adverse effects were found, but 3 patients complained of mild prickling sensation or ingrowing toe nail. Conclusions: These data suggest that 8% ciclopirox nail lacquer is safe and effective in the treatment of mild onychomycosis.