뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

무작위 대조 이중맹검 시험을 통한 봉독 약침의 류마티스 관절염 치료 효과 연구

이상훈,홍승재,김수영,양형인,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : This study was performed in order to evaluate the effect of bee venom therapy on rheumatoid arthritis by randomized controlled double blind method. Method : RA patients were recruited and divided into an experiment group and a control group by random selection. As a double blind test, the experiment group was treated with bee venom injection on acupoints, and the control group was treated with normal saline injection on acupoints twice a week for 8 weeks. Tender joint count, swollen joint count, morning stiffness, pain, health assessment questionnaire, ESR. and CRP were estimated and analyzed at baseline, and at 1 month and 2 months after bee venom therapy Results : Compared to the control group, the experiment group showed significant decrease in tender joint count swollen joint count, morning stiffness, and health assessment questionnaire after 2 months. Pain, ESR and CRP showed significant decrease in the experiment group after 1 & 2 months. Conclusions : These results suggests that bee venom therapy could be an effective method in the treatment of patients with rheumatoid arthritis.

봉독약침이 류마티스 관절염 환자의 기능회복 및 삶의 질에 미치는 영향

이상훈,이현종,박상민,김수영,박재경,홍승재,양형인,이재동,최도영,김건식,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective: To evaluate the effects of bee venom acupuncture(BVA) on the rehabilitation and quality of life in rheumatoid arthritis(RA) patients Methods: Patients with RA were treated with the BVA therapy twice a week for 3 months. Tender joint counts, swollen joint counts, morning stiffness, Erythrocyte Sedimentation Rate(ESR), C-reactive protein(CRP), patient global assessment, physician global assessment, Korean health assessment questionnaire(KHAQ) were estimated and analyzed before and after BVA therapy. Results: Tender joint counts, swollen joint counts, morning stiffness showed significant decrease after BVA therapy. But, as acute inflammatory reactants, ESR showed no significant difference and CRP showed significant increase after BVA therapy. Patient global assessment physician global assessment, and KHAQ index showed significant improvement after BVA therapy. Conclusions: BVA therapy can improve rehabilitation and health-related quality of life RA patients as well as clinical symptom and signs. Further study is required in more population with large scale including acute inflammatory reaction of BVA therapy.

봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

침 치료가 오십견(五十肩) 환자의 적외선 체열촬영에 미치는 영향

김건형,이로민,남동우,김종인,임사비나,이두익,최도영,이윤호,이재동 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : To observe the effect of acupuncture treatment on Digital Infrared Thermographic Imaging(DITI) in frozen shoulder patients. Methods : 17 voluntary patients received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwanand Gyun-joong, twice a week for 4 weeks. The patients were instructed to practice self exercise during their daily lives. Evaluations were made before treatment, after 1 week of treatment, after 2 weeks, 3 weeks and after 4 weeks of treatment. Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI), Range of Motion(ROM) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). DITI was measured before treatment and after 4weeks of treatment. The obtained data was analyzed. Results : CSA, SPADI, VAS, adduction and extension showed significant(p<0.05) improvement. Abduction and flexion both improved after 4 weeks of treatment, but the improvement was statistically insignificant(p>0.05). DITI showed improvement but the improvement was insignificant(p>0.05). Conclusion : 4 weeks of acupuncture treatment significantly improved CSA, SPADI, VAS, adduction and extension in frozen shoulder patients(p<0.05). The improvement of abduction and flexion after 4 weeks of acupuncture treatment was insignificant(p>0.05). DITI results improved after 4 weeks of acupuncture treatment. But the change of thermal difference was insignificant(p>0.05).

성장단계에 따른 중소기업의 네트워크 유형과 경영성과간의 관계에 대한 연구

이도형(Lee Do Hyung),김충현(Kim Choong Hyun) 한국경영교육학회 2012 한국경영교육학회 학술발표대회논문집 Vol.2012 No.6

신생기업은 태생적으로 자원이 부족하여 신생기업의 한계를 경험하게 된다. 이러한 한계를 극복하기 위하여 자신의 통제하에 있지 않은 자원을 보다 손쉽게 이용하고자 네트워크를 활용하게 된다. 이러한 네트워크는 기업들이 치열한 경쟁환경 속에서 살아남고 지속적인 성장을 가능케하며, 기업의 발전에 있어서 중요한 모델로 주목받아왔다. 하지만, 많은 연구들이 단일 혹은 제한된 네트워크에만 주목함으로써 네트워크의 효용성에 대해 많은 논란이 제기되고 있다. 더구나 기업들은 다양한 네트워크의 형태를 보유하고 있으며, 기업의 상황에 따라 그 중요성은 다르게 나타날 수 있다. 따라서 본 연구에서는 기업의 성장단계에 따라 네트워크 유형이 성과에 미치는 차별적 영향을 분석하기 위하여 국내 247개 기업을 대상으로 설문조사를 실시하였으며 실증분석 결과는 다음과 같다.첫째, 사회적 네트워크는 신생기업의 성과에 유의한 영향을 미치지 않는 것으로 나타난 반면, 성장기업의 성과에는 오히려 유의한 부(-)의 영향을 미치는 것으로 나타났다. 둘째, 평판 네트워크는 신생·성장기업 모두의 성과에 유의한 정(+)의 영향을 미치며, 신생기업의 성과에 더 큰 영향을 미치는 것으로 나타났다. 셋째, 정보 네트워크 역시 신생·성장기업의 성과에 정(+)의 영향을 미치며, 신생기업의 성과에 더 큰 영향을 미치는 것으로 나타났다.본 연구를 통하여 기업들, 특히 신생기업들은 높은 평판을 보유하고 있는 기업들이나 혹은 시장에 대한 정보를 제공해줄 수 있는 기업들과 관계를 맺는 것이 시장에 긍정적인 신호효과와 정당성을 확보하는 데 도움을 주어 결과적으로 기업의 성과를 향상시켜 줄 것이다. 즉 기업가의 개인적 관계보다는 평판이 높은 기업 혹은 정보를 제공해줄 수 있는 기업과의 관계를 맺는 것이 성과에 도움이 될 수 있다는 것을 시사해주고 있다. New start-up firms are more likely to experience liability of newness because of scarce resources. In order to overcome these limitations and to make utilization of resources which are not under their direct control, they try to build networks which are known as contributing to achieving firm performances. Although many studies have been done so far, however, they have been so much focused on one or limited networks that there is still strong debate about their utilities. Furthermore, firms have various networks and their importance can vary according to firms' situations. Thus, this study aims to empirically analyze the effects of network types on firm performances throughout growth stages. For this, questionnaire surveys were administered targeting 247 companies that operate their businesses in Korea. The followings are found:Firstly, it was found that social networks don't have any effects on start-up firms' performances while they have significantly negative effects of growing firms'. Secondly, reputation networks are found to have significantly positive effects on both start-up and growing firms' performances while they have more effects on start-ups. Thirdly, information networks are also found to have the same effects as reputation networks do.Through this study, we found that if firms and especially start-ups establish sound and good networks or partnerships with those with good reputations or those which can provide useful market information, they will have positive signalling effects and obtain legitimacy which in turn improve their performances. In other words, this study implies that establishing networks with those with good reputations or informations will help start-ups to achieve high performances rather than social and personal networks.

소형민수헬기 능동진동제어시스템 개발

김남조(Nam-Jo Kim),곽동일(Dong-Il Kwak),강우람(Woo-Ram Kang),황유상(Yoo-Sang Hwang),김도형(Do-Hyung Kim),김찬동(Chan-Dong Kim),이기진(Ki-Jin Lee),소희섭(Hee-Soup So) 한국항공우주학회 2022 韓國航空宇宙學會誌 Vol.50 No.3

헬기의 능동진동제어시스템(AVCS)은 주로터로부터 발생되는 진동을 제어하며, 수동형 진동저감장치 대비 저중량으로 우수한 진동저감 성능을 발휘한다. 본 논문에서는 FxLMS 알고리즘을 기반으로 타코미터 및 가속도 센서 신호를 통해 연산된 제어명령을 하중발생기(CFG)로 전달하여 소형 민수헬기의 진동을 제어하는 소프트웨어 개발 및 검증 내용을 제시하였다. DO-178C /DO-331 표준에 따라 모델 기반 설계 기법을 통해 진동제어 소프트웨어를 개발하였으며, PILS 및 HILS 환경에서 실시간 작동 성능을 평가하였다. 특히, PILS 환경에서는 LDRA 기반 검증 커버리지를 통해 소프트웨어의 신뢰성을 향상시켰다. AVCS를 소형민수헬기에 적용하기 위해 지상/비행시험을 통해 대상 헬기 동적응답특성 모델을 획득하였다. 이를 기반으로 시스템 최적화 분석 및 비행시험을 통해 최적 성능을 발휘하는 AVCS 형상을 결정하고, STC 인증을 획득하였다. Active vibration control system(AVCS) for helicopter enables to control the vibration generated from the main rotor and has the superb vibration reduction performance with low weight compared passive vibration reduction device. In this paper, FxLMS algorithm-based vibration control software of the light civil helicopter tansmits the control command calculated using the signals of the tachometer and accelerometers to the circular force generator(CFG) is developed and verified. According to the RTCA DO-178C/DO-331, the vibration control software is developed through the model based design technique, and real-time operation performance is evaluated in PILS(processor in-the loop simulation) and HILS(hardware in-the loop simulation) environments. In particular, the reliability of the software is improved through the LDRA-based verification coverage in the PIL environments. In order to AVCS to light civil helicopter(LCH), the dynamic response characteristic model is obtained through the ground/flight tests. AVCS configuration which exhibits the optimal performance is determined using system optimization analysis and flight test and obtain STC certification.

Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과

이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy

작은 地方政府로 가는 길 : 서비스 供給方式의 刷新과 組織,人力의 再整備를 중심으로 Centered on the Innovation of Public Service Provision and the Rightsizing of Local Governments

李都炯 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.1

Our local governments show a tendency to be overgrown bodies because of our authoritarian politico-administrative culture, local administrators' selfish minds and their budget-maximizing behaviors. If we did not solve these problems, our local self-government would not be effectively established owing to the bad factors of overexpanded government. Accordingly, we must innovate the provision systems of local public services through the institutionalization of privatization or user charges. These strategies can eliminate inefficiency in our self-governing bodies, and can help them to become small(and strong) governments. Also, we should cut down the complicated and over-staffed organizational structures of our local governments in order that they may have just sizes. For this, we need restructuring our local public organizations, and rightsizing man power structures of local governments.

殘留應力이 스프링破斷에 미치는 影響

李道衡,金達羽,金明元 淸州大學校 1982 論文集 Vol.15 No.2

The effect of residual stress on the fracture of a coil spring has been examined by measuring residual stress with X-ray stress analyzer. The scanning electron micrographs of the stress rupture specimen have also been examined. The results showed that this failure began at the inclusions where the largest residual stress was measured. Inclusion was acted as a stress concentrator and crack initiator in this fatigue fracture.