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Long-Term Changes in Post-Stroke Depression, Emotional Incontinence, and Anger
Boseong Kwon,Eun-Jae Lee,박성호,Ji Sung Lee,Min Hwan Lee,Daeun Jeong,Dongwhane Lee,Hyuk Sung Kwon,Dae-Il Chang,Jong-Ho Park,Jae-Kwan Cha,허지회,Sung-Il Sohn,Dong-Eog Kim,Smi Choi-Kwon,Jong S. Kim 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.2
Background and Purpose Long-term changes in post-stroke depression (PSD), post-stroke emotional incontinence (PSEI), and post-stroke anger (PSA) have rarely been studied. Methods This is a sub-study of EMOTION, a randomized, placebo-controlled trial, that examined the efficacy of escitalopram on PSD, PSEI, and PSA in patients with stroke. We interviewed patients at the long-term period (LTP) using predefined questionnaires: Montgomery-Åsberg depression rating scale (MADRS) for PSD, modified Kim’s criteria for PSEI, and Spielberger trait anger scale for PSA. Additionally, the ENRICHD Social Support Instrument (ESSI) for the social support state and the modified Rankin Scale (mRS) were measured. We investigated the changes in and factors behind PSD, PSEI, and PSA at LTP. Results A total of 222 patients were included, and the median follow-up duration was 59.5 months (interquartile range, 50 to 70). Compared to the data at 6 months post-stroke, the prevalence of PSEI (11.7% at 6 months, 6.3% at LTP; P=0.05) and mean anger score (21.62, 16.24; P<0.01) decreased, while the prevalence of PSD (35.6%, 44.6%; P=0.03) and mean MADRS (6.16, 8.67; P<0.01) increased at LTP. ESSI was associated with PSD and PSA, but not with PSEI. The effect of the baseline National Institutes of Health Stroke Scale score on PSD decreased over time. The effect of low social support on PSD was greater than that of mRS at LTP. Conclusions The prevalence and degree of PSD significantly increased, while those of PSEI and PSA decreased at LTP. PSD in this stage appeared to be more closely associated with a lack of social support than patients' physical disabilities.
Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice
Daeun Lee,Ye‑Ram Kim,김재성,Donggyu Kim,Sojin Kim,Sun Young Kim,Kiseok Jang,Jong‑Dae Lee,Chul‑Su Yang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.4
Schizophyllan (SPG), produced by Schizophyllumcommune, is an exopolysaccharide with multiple academicand commercial uses, including in the food industryand for various medical functions. We previously demonstratedthat SPG conjugated with c-Src peptide exerted asignificant therapeutic effect on mouse models of the acuteinflammatory diseases polymicrobial sepsis and ulcerativecolitis. Here we extended these results by investigatingwhether SPG exerted a protective effect against mitochondrialdamage in the liver via sirtuin 3 (SIRT3) induction,focusing on the deacetylation of succinate dehydrogenase A(SDHA) and superoxide dismutase 2 (SOD2). Liver damagemodels induced by alcohol or conjugated linoleic acid (CLA,which simulates lipodystrophy) in SIRT3−/−,SOD2−/−,andSDHA−/−mice were used. Results showed that dietary supplementationwith SPG induced SIRT3 activation; this wasinvolved in mitochondrial metabolic resuscitation that counteredthe adverse effects of alcoholic liver disease and CLAinduceddamage. The mitochondrial SIRT3 mediated thedeacetylation and activation of SOD2 in the liver and SDHA in adipose tissues, suggesting that SPG supplementationreduced ethanol-induced liver damage and CLA-inducedadverse dietary effects via SIRT3–SOD2 and SIRT3–SDHAsignaling, respectively. Together, these results suggest thatdietary SPG has a previously unrecognized role in SIRT3-mediated mitochondrial metabolic resuscitation duringmitochondria-related diseases.
Kim, Sunho,Kim, Royoung,Nam, Hee-Jo,Kim, Ryeo-Gyeong,Ko, Enjin,Kim, Han-Su,Shin, Jihye,Cho, Daeun,Jin, Yurhee,Bae, Soyeon,Jo, Ye Won,Jeong, San Ah,Kim, Yena,Ahn, Seoyeon,Jang, Bomi,Seong, Jiheyon,Lee, Korea Genome Organization 2020 Genomics & informatics Vol.18 No.3
This paper describes a community effort to improve earlier versions of the full-text corpus of Genomics & Informatics by semi-automatically detecting and correcting PDF-to-text conversion errors and optical character recognition errors during the first hackathon of Genomics & Informatics Annotation Hackathon (GIAH) event. Extracting text from multi-column biomedical documents such as Genomics & Informatics is known to be notoriously difficult. The hackathon was piloted as part of a coding competition of the ELTEC College of Engineering at Ewha Womans University in order to enable researchers and students to create or annotate their own versions of the Genomics & Informatics corpus, to gain and create knowledge about corpus linguistics, and simultaneously to acquire tangible and transferable skills. The proposed projects during the hackathon harness an internal database containing different versions of the corpus and annotations.
Staphylectomy using CO₂ laser for the treatment of nasopharyngeal stenosis in a cat
Ingeun Kim,Jong Baek Kim,Taewan Kim,Donghyeok Yoo,Eunchae Yoon,Daeun Kim,Ji Hyun Park,Yoonho Roh,Dongbin Lee 한국예방수의학회 2023 예방수의학회지 Vol.47 No.4
Nasopharyngeal stenosis is defined as a morphological transition of narrowing at the nasopharyngeal region. A 2-yearold, castrated male, Korean short hair cat was referred to the animal medical center, Gyeongsang National University. According to clinical signs, diagnostic imaging, and physical examination, nasopharyngeal stenosis was diagnosed. The staphylectomy was performed using a CO2 laser, and there were not any post-operative complications. The patient was discharged in two days. This report describes the case of nasopharyngeal stenosis in cat and represents that laser ablation could be a good option for surgical management of the nasopharyngeal region with a low complication rate.
Ryu, Daeun,Kim, Seok Jin,Hong, Yourae,Jo, Areum,Kim, Nayoung,Kim, Hee-Jin,Lee, Hae-Ock,Kim, Kihyun,Park, Woong-Yang American Association for Cancer Research 2020 Clinical Cancer Research Vol.26 No.4
<P><B>Purpose:</B></P><P>In multiple myeloma, extramedullary progression is associated with treatment resistance and a high mortality rate. To understand the molecular mechanisms controlling the devastating progression of myeloma, we applied single-cell RNA-sequencing (RNA-seq) to myeloma in the bone marrow and myelomatous pleural effusions or ascites.</P><P><B>Experimental Design:</B></P><P>Bone marrow or extramedullary myeloma samples were collected from 15 patients and subjected to single-cell RNA-seq. The single-cell transcriptome data of malignant plasma cells and the surrounding immune microenvironment were analyzed.</P><P><B>Results:</B></P><P>Comparisons of single-cell transcriptomes revealed the systematic activation of proliferation, antigen presentation, proteasomes, glycolysis, and oxidative phosphorylation pathways in extramedullary myeloma cells. The myeloma cells expressed multiple combinations of growth factors and receptors, suggesting autonomous and pleiotropic growth potential at the single-cell level. Comparisons of the tumor microenvironment revealed the presence of cytotoxic T lymphocytes and natural killer (NK) cells in both the bone marrow and extramedullary ascites, demonstrating a gene-expression phenotype indicative of functional compromise. In parallel, isolated myeloma cells persistently expressed class I MHC molecules and upregulated inhibitory molecules for cytotoxic T and NK cells.</P><P><B>Conclusions:</B></P><P>These data suggest that myeloma cells are equipped with specialized immune evasion mechanisms in cytotoxic microenvironments. Taken together, single-cell transcriptome analysis revealed transcriptional programs associated with aggressive myeloma progression that support autonomous cell proliferation and immune evasion.</P>
호혜적 개발협력을 위한 주요 국가의 STI 시스템 분석 및 협력방향 - 브라질, 인도를 중심으로 -
김왕동(Wangdong Kim),임덕순(Deok Soon Yim),선인경(Inkyoung Sun),김은주(Eun Joo Kim),이다은(Daeun Lee),유제현(Jehyun Yu),이정원(Jung-won Lee),김기국(Ki-Kook Kim),최용인(Yongin Choi),김원호(Wonho Kim),조충제(Chungje Jo),박민경(Minkyoung P 과학기술정책연구원 2021 정책연구 Vol.- No.-
Reciprocal development cooperation refers to “all activities in the public and private sectors that benefit the donor country’s national interest as well as poverty eradication and economic and social development in the recipient country”. The Korean governments development cooperation paradigm is expected to gradually shift from a humanitarian level to a reciprocal level. However, in the case of science and technology innovation, it is difficult to acquire information about countries that are subject to reciprocal development cooperation. Therefore, in this study, the conceptual framework for reciprocal development cooperation was established and STI systems of major countries were analyzed to provide basic STI data and to suggest directions for reciprocal development cooperation. In this study, two countries, Brazil and India, were selected for analysis by applying three criteria: “differentiation from existing research,” “relevance to national interests and national tasks,” and “possibility of securing data”. In this study, the STI system components of Brazil and India were classified and analyzed into macro-environment, STI governance, STI investment and achievements, STI human resources, STI innovative actors, and STI support organizations. The reciprocal development cooperation agenda was described focusing on three dimensions: “what”, “how” and “who”. First, in the perspective of “what”, climate change, digital transformation, infectious diseases, and other issues were derived as cooperation contents. Second, policy advice and joint research, human exchange, and so on, were suggested as cooperation methods. Third, universities, GRIs, and companies were suggested as cooperation partners. Brazils STI system is characterized by a weak national R&D budget, excellent research manpower and strong basic research, lack of connection and creation of innovation demand between universities and companies, weak industrial competitiveness, lack of science and technology policy and strategy, policy implementation, and coordination of inefficiency and slow-step administration. The characteristics of the Indian STI system include inefficient governance and lack of interconnection led by the government, insufficient investment in STI between the government and the private sector, abundant STI manpower and global talent, the pursuit of R&D activities centered on universities and public research institutes rather than the private sector, bureaucratic and bureaucratic An inefficient STI support organization was identified. In-depth interviews and consultations were conducted with experts from each country to derive the Korea-Brazil development cooperation agenda and the Korea-India development cooperation agenda. The interview and advisory groups were largely divided into policymakers(public officials) for each country, researchers(researchers and professors), and local experts(embassies and dispatchers). The detailed agenda contents are described in Chapters 6 and 7. This study is expected to contribute to the theoretical construction of the field of development cooperation, and to the derivation of the governments Korea-Brazil and Korea-India STI cooperation agenda. The study also can contribute to the demand for STI system information of Brazil and India. However, this study has limitations in responding to more demand by the government by selecting Brazil and India as two countries for reciprocal development cooperation. Therefore many more countries besides Brazil and India should be explored in the future. In addition, in order to improve the reliability and validity of the STI cooperation agenda between Korea-Brazil and Korea-India, interviews and consultations with more experts are required.