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郭庚度,朴柄珏,金鎬順,徐萬哲,金鐘大 嶺南大學校附設 基礎科學硏究所 1988 基礎科學硏究 Vol.8 No.-
The electronic states of the antimicrobial phenzine and its derivatives were examined by Extended H?uckel Method. It was found that the sum of nucleophilic reactivity index for trans 1,2, and 4 positions, ?? in a molecule was found to be related antimicrobial activity. The index, ??, should be applied to biological activity as well as antimicrobial activity.
Torilin from Torilis japonica (Houtt.) DC. Blocks hKv1.5 Channel Current
Kwak, Yong-Geun,Kim, Dae-Keun,Ma, Tian-Ze,Park, Sun-Ah,Park, Hoon,Jung, Young-Hoon,Yoo, Dong-Jin,Eun, Jae-Soon The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.10
Torilin was purified from Torilis japonica (Houtt.) DC., and its effects on a rapidly activating delayed rectifier $K^+$ channel (hKv1.5), cloned from human heart and stably expressed in Ltk cells, as well as the corresponding $K^+$ current (the ultrarapid delayed rectifier, $I_{KUR}$) were assessed in human atrial myocytes. Using the whole cell configuration of the patch-clamp technique, torilin was found to inhibit the hKv1.5 current in time and voltage-dependent manners, with an $IC_50$ value of $2.51{\pm}0.34\;{\mu}M$ at +60 mV. Torilin accelerated the inactivation kinetics of the hKv1.5 channel, and slowed the deactivation kinetics of the hKv1.5 current, resulting in a tail crossover phenomenon. Additionally, torilin inhibited the hKv1.5 current in a use dependent manner. These results strongly suggest that torilin is a type of open-channel blocker of the hKv1.5 channel.
Korean Red Ginseng affects ovalbumin-induced asthma by modulating Th1 and Th2 related cytokine
Soon-Young Lee,Min-Hee Kim,Seung-Hyun Kim,Taeho Ahn,Sung-Won Kim,Yi-Seong Kwak,Ik-Hyun Cho,Seung-Yeol Nah,Seung-Sik Cho,Kyung Mok Park,Dae-Hun Park,Chun-Sik Bae 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
BACKGROUND: Asthma is a chronic pulmonary disease caused by various allergens. According to the Global Asthma Network, 339 million people suffered from asthma in 2018. Numerous treatments for asthma are available; however, they are frequently associated with adverse effects such as growth retardation, neurological disorders, and physiological disorders (e.g., immunosuppression, hypertension, hyperglycemia, and osteoporosis). Methods: We evaluated Korean Red Ginseng water extract (KRGWE) as a potential therapeutic or preventive component of anti asthmatic drugs. Eighty-four BALB/c mice were assigned to 6 treatment groups: control, ovalbumin-induced asthma group, dexamethasone treatment group, and 3 groups treated with KRGWE at 5, 25, or 50 mg/kg/day for 5 days. Anti-asthmatic effects of KRGWE were assessed based on biological changes, such as white blood cell counts and differential counts in the bronchoalveolar lavage fluid, serum IgE levels, and histopathological changes in the lungs, and Th1 and Th2 related cytokines by examining anti-asthmatic mechanisms. Results: KRGWE affected ovalbumin-induced changes, such as increased white blood cell counts, increased IgE levels, and morphological changes. (mucous hypersecretion, epithelial cell hyperplasia, inflammatory cell infiltration) by downregulating cytokines such as IL-12, IL-4, and IL-6. Conclusion: KRGWE is a promising drug for asthma treatment.
개에서 Sevoflurane 마취중에 Diltiazem 투여가 심혈관계 및 산소화에 미치는 영향
곽일용,조대순 대한마취과학회 1993 Korean Journal of Anesthesiology Vol.26 No.5
Diltiazem was administered by two different dosages with 200 μg/kg 1V+10 μg/kg/min infusion, 400 μg/kg 1V+20 μg/kg/min infusion, in order to assess the interaction between sevoflurane and diltiazem on the cardiovascular function and oxygenation in dogs during inhalation of 1.0 MAC of sevoflurane. Significant decrease in heart rates, mean arterial pressure, pulmonary vascular resistance, systemic vascular resistance, coronary perfusion pressure were observed. Subsequently rate pressure product, as a parameter of myocardial oxygen consumption, decreased with no significant changes of oxygen extraction ration in 1.0 MAC of sevoflurane anesthesia with the above dosages of diltiazem in dogs. The author concludes that concomittent use of diltiazem in clinical doses induced tolerable hemodynamic depression and no untoward effects on oxygenation during maintenance of anesthesia with 1 MAC of sevoflurane. These combination would be safe for anesthetic cares in patient with ischemic heart diseases and coronary arte diseases in which adequate oxygen supply in the heart is essentially necessary.
Soon-Young Lee,Min-Hee Kim,Seung-Hyun Kim,Taeho Ahn,Sung-Won Kim,Yi-Seong Kwak,Ik-Hyun Cho,Seung-Yeol Nah,Seung-Sik Cho,Kyung Mok Park,Dae-Hun Park,Chun-Sik Bae 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.4
Background: Asthma is an incurable hyper-responsive disease of the pulmonary system that is caused by various allergens, including indoor and outdoor stimulators. According to the Global Asthma Network, 339 million people suffered from asthma in 2018, with particularly severe forms in children. Numerous treatments for asthma are available; however, they are frequently associated with adverse effects such as growth retardation, neurological disorders (e.g., catatonia, poor concentration, and insomnia), and physiological disorders (e.g., immunosuppression, hypertension, hyperglycemia, and osteoporosis). Methods: Korean Red Ginseng has long been used to treat numerous diseases in many countries, and we investigated the anti-asthmatic effects and mechanisms of action of Korean Red Ginseng. Eighty-four BALB/c mice were assigned to 6 treatment groups: control, ovalbumin-induced asthma group, dexamethasone treatment group, and 3 groups treated with Korean Red Ginseng water extract (KRGWE) at 5, 25, or 50 mg/kg/day for 5 days. Anti-asthmatic effects of KRGWE were assessed based on biological changes, such as white blood cell counts and differential counts in the bronchoalveolar lavage fluid, serum IgE levels, and histopathological changes in the lungs, and by examining anti-asthmatic mechanisms, such as the cytokines associated with Th1, Th2, and Treg cells and inflammation pathways. Results: KRGWE affected ovalbumin-induced changes, such as increased white blood cell counts, increased IgE levels, and morphological changes (mucous hypersecretion, epithelial cell hyperplasia, inflammatory cell infiltration) by downregulating cytokines such as IL-12, IL-4, and IL-6 via GATA-3 inactivation and suppression of inflammation via NF-κB/COX-2 and PGE₂ pathways. Conclusion: KRGWE is a promising drug for asthma treatment.
( Dae Hyun Lim ),( Mimi Kim ),( Dae Won Jun ),( Min Jung Kwak ),( Jai Hoon Yoon ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ),( Bo Kyeong Kang ) 대한소화기학회 2021 Gut and Liver Vol.15 No.1
Background/Aims: To date, studies on various noninvasive techniques have been suggested to evaluate the degree of liver fibrosis. We aimed to investigate the diagnostic performance of serum asialo α1-acid glycoprotein (AsAGP) in the diagnosis of liver cirrhosis compared with chronic hepatitis for clinically useful result. Methods: We conducted a case-control study of 96 patients with chronic liver disease. Chronic hepatitis was defined as the presence of chronic liver disease on ultrasonography, with a liver stiffness of less than 5.0 kPa as shown on magnetic resonance elastography (MRE). Liver cirrhosis was defined as liver stiffness of more than 5.0 kPa on MRE. The serum AsAGP concentration was compared between the two groups. Results: Serum AsAGP levels were significantly higher in patients with cirrhosis than in those with chronic hepatitis (1.83 μg/mL vs 1.42 μg/mL, p<0.001). Additionally, when comparing patients in each cirrhotic group (Child-Pugh grades A, B, and C) to those with chronic hepatitis, AsAGP levels were significantly higher in all the cirrhotic groups (p<0.05, p<0.01, p<0.001, respectively). The sensitivity and specificity of AsAGP for detecting cirrhosis were 79.2% and 64.6%, respectively, and the area under the curve value was 0.733. The best diagnostic cutoff to predict cirrhosis was 1.4 μg/mL. AsAGP and bilirubin were found to be independent risk factors for the prediction of cirrhosis in the logistic regression analysis. Conclusions: Serum AsAGP showed an acceptable diagnostic performance in predicting liver cirrhosis. (Gut Liver 2021;15:109-116)
Kwak, Dong Shin,Jun, Dae Won,Seo, Jae Gu,Chung, Won Seok,Park, Soon-Eung,Lee, Kang Nyeong,Khalid-Saeed, Waqar,Lee, Hang Lak,Lee, Oh Young,Yoon, Byung Chul,Choi, Ho Soon Wolters Kluwer Health | Lippincott Williams Wilkin 2014 European journal of gastroenterology & hepatology Vol.26 No.12
AIM:: Although numerous animal studies suggest that probiotic therapy has beneficial effects in various liver diseases, the evidence for beneficial effects in human liver disease is controversial. This study was carried out to investigate the efficacy of probiotic therapy in alleviating small intestinal bacterial overgrowth (SIBO) and permeability in chronic liver disease. METHODS:: Fifty-three patients with chronic liver disease were randomized to either probiotic therapy or placebo. Six bacterial species were used: Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophilus. After 4 weeks, changes in the composition of fecal bacteria, SIBO, intestinal permeability, and clinical symptoms were examined. RESULTS:: Three of the six probiotic species, B. lactis, L. rhamnosus, and L. acidophilus, increased in the feces of the probiotic therapy group (P<0.001), whereas there was no change in fecal microbiota in the placebo group. SIBO disappeared in many individuals of the probiotic therapy group, but none in the placebo (24 vs. 0%, P<0.05). General gastrointestinal symptoms also improved more in the probiotic group and improvement in intestinal permeability was slightly but not significantly more frequent in the probiotic arm than the placebo arm (50 vs. 31.3%, P=0.248). Numbers of lactobacilli in stool were correlated negatively with intestinal permeability (P for trend<0.05). Liver chemistry did not improve significantly in either group. CONCLUSIONS:: We conclude that short-term probiotic administration in chronic liver disease is effective in alleviating SIBO and clinical symptoms, but ineffective in improving intestinal permeability and liver function.
Dae-Ho Heo,Yun-Gi Kwak,Feel-Soon Kang,Byoung-Hee Lee 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.8
Electric vehicle (EV) on-board chargers (OBC) use high-frequency transformers for isolation between the grid power and the propulsion battery. Additionally, low voltage dc-to-dc converters (LDC) require high-frequency transformers for high step-down and electrical isolation. Although a high-frequency transformer is used for isolation, it is desirable to minimize the use of magnetic materials because the isolation breakdown between the windings of the transformer occurs due to vibration. It also increases the weight and volume, and reduces the mileage of vehicles. Therefore, this paper proposes an OBC–LDCintegrated system without additional windings by dividing the transformer windings used for the OBC. Depending on the connection state of the selective switch in the proposed system, it is divided into a propulsion battery charging mode and an auxiliary battery charging mode. At the same time, the selective switch converts the required transformer turns ratio in the changed operation mode. The proposed OBC–LDC integrated system is verified through prototype experiments. In addition, the volume and weight of a conventional vehicle charger and the proposed integrated charger are compared, and the economic benefits of the proposed charger are derived through cost model analysis (CMA).
Dae Yong Yi,Soon Chul Kim,Ji Hyuk Lee,Eun Hye Lee,Jae Young Kim,Yong Joo Kim,Ki Soo Kang,Jeana Hong,Jung Ok Shim,Yoon Lee,강빈,Yeoun Joo Lee,Mi Jin Kim,Jin Soo Moon,Hong Koh,JeongAe You,Young-Sook Kwak 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1
The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: 1) definition and diagnosis of overweight and obesity in children and adolescents; 2) principles of treatment of pediatric obesity; 3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; 4) pharmacotherapy; and 5) bariatric surgery.