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송성섭,이경우,김호순 서울市立大學校 1997 論文集 Vol.31 No.-
Major reasons for youth problems include weakened home education, unhealthy and demoralizing school enviornment and uneducational social surroundings. Among the reasons, the weakened home education can be a cause for the unhealthy school enviornment because nuclear families and single-parent families are thought to be less strict on youth home education. And uneducational social surroundings are the results of people's success-oriented mind, youth exposures to adult entertainment, side effects of mass media and the abscence of leisure education and the opportunity to enjoy what youth desire. In order to correct the problematic behavior of juveniles, a distinction should be made between serious and minor problems: that is because seriousness and harmfulness of a problematic behavior depends on the pattern of the behavior. When making the distinction, motivation, circumstances and the value system of the society should be taken into account. There can be many possible solutions and effective approaches to the youth problems, but solving the problems through sports is considered to be the most ideal one. One definition of 'physical education' says that it helps imperfect humans to become perfect-physically, mentally, and socially-through body movements and activities. Accordingly, the values ot physical education are divided into physical, mental and social-cultural values: sports is an area of physical education and it includes competition. Therefore, it is important to use sports to offer youth the opportunties to fulfill their physical, mental and social desires. Sports can also help youth to develop feelings and positive outlook and adapt to society.
김호순 한국병원약사회 1997 병원약사회지 Vol.14 No.2
Malnutrition은 "lean body mass"의 감소로 병원에 입원한 수술 및 암환자에게 흔히 발견된다. 적절한 영양공급이 이루어져야 면역능력, 정상세포의 유지 및 재생이 가능하므로 malnutrition상태는 환자의 회복속도를 저해하며 균감염 등 합병증 발생률과 사망률을 증가시킨다.
수술환자에서 Thiopental 약동학의 동정맥 차이와 이의 약력학적 의의
김호순,신현택,민성원,김광우 한국병원약사회 1992 병원약사회지 Vol.9 No.1
The arterial and venous difference of thiopental pharmacokinetics and its impact on the onset of pharmacologic effect were examined in 6 male surgical patients with normal renal and hepatic functions during short time period of 6hrs post-intravenous bolus injection over 5 second (5㎎/㎏). Arterial and venous blood samples were withdrawn from radial arteries and cephalic or basilica veins, respectively at the time of right before and after injection(0), 5, 10, 20, 30, 45(sec), 1, 2, 5, 10, 30(min), 1, 2, 3, 4, 5, 6(hrs). Serum concentrations of thiopental were determined by reverse phase, high performance liquid chromatography and the clinical endpoints of anesthesia induction were interpreted as the time of loss of consciousness by observing spontaneous closing of eyes and loss of eyelash reflex. As the results, significant differences between arterial and venous concentrations were noted during early phase lasting up to 10minutes. Arterial data was best fitted to tri exponential decay model and venous data to bi-exponential decay model. In analyzing pharmacokinetic parameters with serum data of 6 hrs duration, there were no significant differences in AUCo-∞, AUCo-t, and clearance(p>0.05), but significant differences in peak concentrations(arterial : 103.97±12.15, venous : 17.487±5.206㎍/㎖), and times to peak(arterial : 0.167±0.037, venous : 1.653±0.712min), AUMCo-t, MRT, apparent terminal half-life and apparent steady-state volume of distribution. Spontaneous eye closures were observed within 20 seconds(range : 10~20sec) after the end of injection where arterial concentrations were at peak(n=3) or right after peak(n-3) and otherwise, venous concentrations were at low or even almost at zero(n=3) and otherwise, venous concentrations were at low or even almost at zero(n=3), reflection the fact that arterial concentrations are directly correlated to the clinical efficacy and more important in pharmacokinetic and dynamic aspect of drug.
오호탕(五虎湯)이 백서(白鼠)의 호흡기계(呼吸器系)에 미치는 영향(影響)
김호순,한상환,Kim, Ho-Soon,Han, Sang-Whan 대한한방내과학회 1994 大韓韓方內科學會誌 Vol.15 No.1
These studies were carried out to investigate the effects of Ohotang water extract on the inhibitory contractile action of acetylcholine in control rat. The results of these were as follows; 1. Contractile force of acetylcholine from trachea smooth muscle in control rat was significantly inhibited by Ohotang. 2. Dose-response of acetylcholine pretreated Ohotang in control rat was significantly inhibited. 3. Inhibitory contractile action of acetylcholine pretreated propranolol in control rat was significantly inhibited by Ohotang. 4. Contractile force of acetylcholine pretreated indomethacin from trachea smooth muscle in control rat was not significantly changed. 5. Inhibitory contractile action of acetylcholine pretreated methylene blue in control rat was not significantly changed.