자궁경부암에서 p53과 human papillomavirus의 분포에 관한 연구

김영식,김대중,김의한,강상균,양승하 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Uterine cervical carcinoma is the most common malignant tumor of woman in Korea. Cervical lesions are associated with various subtypes of human papillomavirus(HPV), and recently there is many reports for interrelationship between p53 gene and HPV in development of cervical carcinoma. HPV is associated with condyloma acuminatum, flat condyloma, cervical intraepithelial neoplasm(CIN), and invasive carcinoma in uterine cervix. Among the subtypes of HPV, type 6b and 11 are reported as low risk group and type 16 and 18 are high risk group. p53 is an one of oncogene which control the cellular proliferation. The loss of p53 function by mutation and complex binding with HPV E6 could act an important role in developmental mechanism of cervical carcinoma. To observe the relationship between expression of p53 and HPV in CIN and invasive carcinoma, we analysed CIN 26 cases and invasive squamous cell carcinoma(SCC) 62 cases processed for immunohistochemical stain using monoclonal mouse anti-p53 and polyclonal anti-bovine papillomavirus. Then positivity of p53 and HPV was compared. The results are as followings: 1) The p53 in CIN showed positive reaction in twelve cases(46.2%) of twenty-six cases. Positive rates of CIN Ⅰ, CIN Ⅱ, and CIN Ⅲ are 33.3%, 42.9%, and 50% respectively. 2) The p53 in invasive squamous cell carcinoma showed positive reaction forty-four cases(71.0%) of sixty-two cases. Positive rates of microinvasive and invasive SCC are 53.8% and 75.5%, respectively. According to cell type, keratinizing type were eighteen cases(81.2%) of twenty-two cases and nonkeratinizing type were ninteen(70.4%) of twenty-seven cases. 3) Papillomavirus revealed low expression rate in CIN(26.9%) and invasive SCC (16.1%). 4) The p53 showed positive reaction in fourteen(82.4%) of papillomavirus-positive seventeen cases. Above results revealed higher positive rate of p53 according to progression of CIN and SCC, and in keratinizing type than in nonkeratinizing type of SCC. Positive rate of papillomavirus was very low, but high positive rate in p53 positive cases which suggest that p53 and HPV corelate in development of cervical carcinoma.

주요 학사 행정업무의 전산화 구현에 관한 연구

全純美,姜興植,金興植,曺大鉉 인제대학교 1988 仁濟論叢 Vol.4 No.2

In these days of information-oriented society, the universities and the colleges in this country have promoted the computerizing their administration affairs for the purpose of the over-all efficiency and rationalization of their's. We report here upon the result of the computerizing about the below items, important area of the administration affairs, i) administration of the entrance examination. ii) administration of the school register. iii) administration of the properties. iv) administration of the student's grades. In the near future, we hope promoting the TIS construction of the INJE university, systematically and continuously.

전자근관장측정기 Root ZX의 정확도에 관한 실험적 연구

강대훈,정관희,윤수한,배광식 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

The purpose of this study was to evaluate the in vitro accuracy of Root ZX(Torita Co., Japan) which is the ratio type electronic apex locator. The 86 extracted human palatal roots of maxillary molar with fully formed apices were used. File lengths with the file tip just visible at the foramen were compared to those measured with Root ZX. For length measuring with Root ZX, saline test model with which the apical 1/3 of each root was submerged into normal saline were designed. The root canal lengths were determined with Root ZX and the radiographs were taken with a file in the canal. The distances from file tips of Root ZX lengths to apecies in radiographs also were measured with Profile projector PJ311(Mitutoyo Co., Japan). The results were as follows : 1. The root canal length determined with electronic apex locator was 0.78±0.53 mm shorter than the length with visual measurement. 2. The file tip of Root ZX lengths was located at 0.85±0.49 mm away from the apex in radiograph. 3. The accuracy of the Root ZX was 79.1% within 0.5mm of visual working length and 96.5% within 1.0mm.

노인 환자에서 경피적 관동맥 중재술 후 조영제 유발 신부전의 발생률, 위험인자와 임상적 의의

김광일,배장환,강현재,채인호,김효수,손대원,김철호,오병희,이명묵,박영배,최윤식 대한노인병학회 2004 대한노인병학회지 Vol.8 No.1

다량의 하부위장관출혈이 병발된 Vibrio vulnificus 패혈증 1예

최주연,유진홍,한석원,이대훈,최민호,박순민,김연식,김선우,신완식,강문원,강성구 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

최근 저자들은 Vibrio vulnificus 감염에 의해 패혈증 및 이차성 피부 병변을 보인 42세의 남자 환자의 치료중 하부 위장관 출혈이 병발된 1예를 경험하였기에 보고하는 바이다. We experienced a case of Vibrop vulnificus septicemia which showed an unusual manifestation such as hematochezia. The patient was a 42-year-old man with chronic liver disease. The blood and wound culture revealed the organism. During intensive care, he suffered from massive hematochezi for several days. Colonoscopy and abdominal CT showed findings suspicious of ischemic colitis. To our knowledge, this is the first unusual case of V.vulnificus infection which showed massive lower gastrointestinal bleeding.

호남지방에 적합한 우량조림 수종의 선발에 관한연구

위흡,朴炳益,高大植,姜聲然,金榮浩 全北大學校 1987 論文集 Vol.29 No.-

In order to select the superior race of red pine, some characteristics of individual trees of the three natural population selected from Byonsan area (lower inland parts of Byonsan, higher inland parts of Byonsan, seaside outland of Byonsan) were analyzed and compared with already reported superior population (Chuwang-san, An-Myeon-do, Odea-san). The study also investigated the variation of the wood quality of red pine in Byonsan area. The results obtained are summerized as follows; 1. The seed weight in the three natural populations selected from Byonsan area renged from 6.00g to 11.10g. The weight of seeds from the lower inland parts of Byonsan were the heaviest with an average value of 8.64g. 2. According to the classification based on the straightness of the stem, over 70% of all the natural red pine in Byonsan area were classified as A grade. The trees in the lower inland part showed the highest value in A-grade gopulation with a value over 80%. 3. There was no significant statistical differences among three natural red pine populations selected from Byonsan area, in the clear-length, seed length, seed width, seed weight and serration density. 4. As the above results, the natural red pine population of the lower inland parts of Byonsan, among three natural populations were defined by the superior individual trees. 5. The variation of the moisture content at D.B.H. was increased with an annual ring from the pith and the moisture content with height was increased as the measured point became higher. 6. The specific gravity with annual ring at D.B.H. ascended rapidly from pith to the 7th annual ring. From the 8th annual ring to the bark there was no variation. The specific gravity with its height decreased at the measured point became heighter and the average specific gravity based green wood in Bonsan area was 0.9±0.018. 7. The average shrindage of red pine in Byonsan area showed that the tangential direction was 5.62±0.794% the radial direction was 2.98±0.611% and the longitudinal direction was 0.30±0.96%. The ratio of the shirinkage compared with the tangential, radial and the longitudinal direction was 18.7:9.9:1. The tangential dirction shirinkage was shown 1.89 times more than the radial direction shirinkage. We knew it is comprehensible that in each section the shirinkage in the sap wood was larger than the shirinkage of the heart wood and variation of shirindage with height showed a decrease from the butt end to the top in the radial, tangential and longitudinal direction respectively. 8. We suppose that the tracheid length of the early wood at D.B.H. has no differences among the east, west, south and north directions and became longer while along with annual ring from the pith to the 20th annual ring, but there was no variation from the 20th annual ring to the bark. The variation of tracheid length with height showed sharp rising from the butt end to the point of 3.2m, but showed a decrease gradually from the point of 4.2m to the top of the tree. The average tracheid length of the early wood as 3.05±0.251mm.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.

관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이

한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.

Shape-controllable Micro-lens Arrays via Direct Transfer of Photo-curable Polymer Droplets for Sub-wavelength Imaging

Dae-Shik Kang,Kahp-Yang Suh 한국생산제조학회 2012 한국생산제조시스템학회 학술발표대회 논문집 Vol.2012 No.10

A Control of Pretilt Angles for Homeotropic Aligned NLC on the SiOx Thin Film Surface by Electron Beam Evaporation

Kang, Hyung-Ku,Han, Jin-Woo,Kang, Soo-Hee,Kim, Jong-Hwan,Kim, Oung-Hwan,Hwang, Jeoung-Yeon,Seo, Dae-Shik The Korean Institute of Electrical and Electronic 2005 Transactions on Electrical and Electronic Material Vol.6 No.6

We studied the control of pretilt angles for homeotropic aligned nematic liquid crystal (NLC) on SiOx thin film surface by $45^{\circ}$ evaporation method with electron beam system. The uniform vertical LC alignment on. the SiOx thin film surfaces with electron beam evaporation was achieved. It is considered that the LC alignment on SiOx thin film by $45^{\circ}$ electron beam evaporation is attributed to elastic interaction between LC molecules and micro-grooves at the SiOx thin film surface created by evaporation. The pretilt angles of about $3.5^{\circ}$ in aligned NLC on SiOx thin film surfaces by electron beam evaporation of $45^{\circ}$ were measured. Consequently, the high pretilt angles of the NLC on the SiOx thin film by $45^{\circ}$ oblique electron beam evaporation method can be achieved.