Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

브로콜리 추출물의 향장활성 효과

김대용ㆍ조석철ㆍ권혁선ㆍ김미경(Dae Young KimㆍSeok chul ChoㆍHyuk sun KwonㆍMee Kyung Kim) 한국인체미용예술학회 2016 한국인체미용예술학회지 Vol.17 No.1

In this study, we investigated the anti-oxidative effects, antimicrobial, and anti-inflammatory activities of the extracts from broccoli to evaluate its use as a functional ingredient in cosmetics. The extracts are WE (water extract at RT), MWE (mineral water extract at RT), EE (70% ethanol extract at RT), and USEE (heat process for 12 hours at 60℃ after ultrasonification for six hours with 70% ethanol). The measurements of the total polyphenol content from broccoli extracts were highest in EE at 425.24±13.9 mg/g dry. The result of electron donating ability of EE was the highest at 10,000 ㎍/㎖ as 97.81% and increased in a concentration-dependent manner. The ferric reducing antioxidant powder (FRAP) of EE was the highest at 10,000 ㎍/㎖ as 1235.6 μM. In an antimicrobial activity test, the EE showed significant antimicrobial activity against S. epidermidis, S. aureus, E. coli, P. acnes, and P. ovale. Furthermore, broccoli extract exhibited no cytotoxicity in RAW 264.7 cells. Also anti- inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited following treatment with EE of 1,000 ㎍/㎖. Therefore, the broccoli ethanol extract can be used as a resource of natural cosmetic material for functional cosmetics.

All-carbon-based cathode for a true high-energy-density Li-O₂ battery

Lim, Hee-Dae,Yun, Young Soo,Cho, Se Youn,Park, Kyu-Young,Song, Min Yeong,Jin, Hyoung-Joon,Kang, Kisuk Elsevier 2017 Carbon Vol.114 No.-

<P>Li-O-2 batteries have a high theoretical energy density; however, their current cathode system based on a heavy metal framework strikingly diminishes their real energy density. Herein, we report the fabrication of all-carbon-based cathodes composed of conventional active carbon and a carbon mesh (CM) framework produced from waste silk fabric by simple pyrolysis. CM frameworks show a high electrical conductivity of similar to 150 S cm(-1), good tensile strength of 34.1 +/- 5.2 MPa, and a Young's modulus of 4.03 +/- 0.7 GPa, as well as a well-ventilated ordered macroporous structure. These all-carbon-based cathodes exhibit stable cycling and high energy densities of similar to 2600 Wh kg(-1) based on total electrode weight, which are 4-15 times higher than those of conventional air cathodes. (C) 2016 Elsevier Ltd. All rights reserved.</P>

연속 주조의 응고와 벌징에 관한 3차원 해석

조종래,김영대 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.2

본 논문은 연속주조에 있어서 내부결함의 주원인 벌징현상을 탄소성과 크리프를 동시에 고려한 3차원모델을 이용하여 2차원모델을 이용한 해석에서 알 수가 없는 측면의 영향을 평가하는데 목적이 있다. 각 부분의 빠른 해석결과를 알 수 있도록 응고해석과 벌징해석을 잇는 전산프로그램을 개발하였다. 2차원 비정상상태에 열전달방정식을 유한차분법을 이용하여 응고해석을 실시하여 주조속도와 슬래브폭에 따른 응고현상을 확인하였다. 벌정해석에 있어 크리프변형의 영향을 분석하였으며, 특히 주조방향의 변형률에 큰 영향을 미치는 것을 확인하였다. 슬래브폭 변화의 영향을 확인하기 위해 2차원해석과 3차원해석의 벌징량과 변형률의 차이를 비교한 결과, 슬래브 폭이 두께의 3배보다 작을 때에는 반드시 3차원 해석이 필요하다는 것을 확인하였다. In this paper, the bulging behavior of the solidified shell in continuously cast slabs has been numerically analyzed using three-dimensional elasto-plastic and creep finite element method. Three-dimensional model has been applied. in order to investigate the effect of the narrow face shell on restraining the bulging deflection. Solidification analysis has been carried out by two-dimensional finite difference method. In this way. strains occurring at the solidification front near the narrow face of the slab. as well as those occurring in the board face have been computed. The accuracy of the model has been verified by comparing the results of analysis with those of experiment. In addition. the effect of the slab width and casting speed on the bulging has been discussed.

유치원 아동의 Resazurin Disc검사에 의한 우식활성에 영향을 미친 요인에 관한 연구

조선아,김대업,이광희,양영숙 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1

The puopose of this study was to analyze the influence of socioeconomic backgrounds and home dental behavior on the caries activity scores by resazurin disc method, 332 preschool children (boys 179, girls 153) in Iksan area were examined for their caries experience and caries activity. The parents of the children were asked to answer the questionnaire about socioeconomic backgrounds and home dental behavior. The sample was divided into five groups according to RD test score. The relationship between each group and a questionnaire was compared and analyzed. The following results were obtained. 1. No significant differences was found for child's age and sex, baby-sitter, sibling rank and tooth brushing frequency among five groups (p<0.05). 2. A statistical significance was obtained in the relationship between RD test score & dft rate (p<0.05). 3. No significant difference was found for parent's age, number of family and mother's physique among five groups (p<0.05). Siginificant difference was found for parent's education level among five groups (p<0.05). 4. No significant difference was found mother's oral hygiene state among five groups (p>0.05). 5. Children sucking human milk had more high RD test score than those who sucking bovine milk (p<0.05).

免疫組織化學的 方法에 依한 마우스組織에서의 Toxoplasma 抗原 檢出에 關한 硏究

趙裕行,李英河,羅榮彦,辛大煥 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

This study was performed to identify the Toxoplasma antigens from the mice tissue chronically infected with Toxoplasma gondii Beverley strain by peroxidase-antiperoxidase(PAP) method. The 21 mice divided into two groups, control group (3mice) and cortisone-treated group (18mice). In cortisone-treated group, the mice were injected with 0.5mg of cortisone acetate twice a week for 6 week subcutaneously and 3 mice were sacrified at each week. The brain, lung, heart, liver, spleen, kidney, small intestine and skeletal muscle of mice were removed immediately after death. The removed tissues were fixed with 10% buffered neutral formalin, and then PAP method and H-E staining were done. The results were obtained as follows: 1. The cysts were found in the brain entirely, in the heart at 4 weeks, and in the skeletal muscle at 5 weeks. The number and size of cysts in the brain were increased in proportion to total dose of cortisone acetate in mice. Tachyzoites of Toxoplasma gondii showed at 4, 5 and 6 week in brain. 2. The brain, speen and skeletal muscle showed highly positive immunoreactivity. The liver, heart and small intestine were moderately positive, but lung and kidney showed weekly positive immunoreactivity by PAP method. 3. There were a chronic inflammatory responses in the brain, liver and heart but the remaining organs were almost normal appearance. And tachyzoites were found in the brain, associated with severe inflammatory changes. The present study revealed that tachyzoites and immunoreactivity of Toxoplasma were easily detected by PAP immune complex method.

간암과 간세포이형성 부위의 철침착 저항성에 대한 조직학적 연구

조욱행,강대영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Liver cell dysplasia(LCD) is commonly associated with some liver diseases such as liver cirrhosis or hepatocellular carcinoma and has been regarded as a premaligant condition. In order to clarify the question of whether or not LCD is a premalignant liver lesion, iron special staining, Prussian blue, was done. The specimens were collected at the department of pathology, Chungnam National University College of Medicine from January 1983 to September 1992. The results were as follows: 1. Of observed 48 cases, 34 were hepatocellular carcinoma(70.8%), 11 were metastatic carcinoma(22.9%), and 3 were hepatoblastoma(6.3%). 2. LCD was present in 26 of 34 cases(76.5%) of hepatocellular carcinoma, 5 of 11 cases(45.5%) of metastatic carcinoma, and 1 of 3 case(33.3%) of hepatoblastoma. 3. The carcinoma cells were free of iron deposition(iron excluding foci) in contrast to the neighboring dysplastic or nonneoplastic normal hepatocytes. 4. The presence of iron deposition in LCD cases was similar to or more severe than that of normal hepatocytes. In summary, the results obtained from the present study indicate that LCD reflects neither a regenerating condition nor a premalignant lesion but suggests a reactive change or accompaning lession.

風路에 의한 都市氣候環境 改善에 관한 硏究

조용수,도근영,강대석 東亞大學校海洋資源硏究所 2004 硏究論文集 Vol.16 No.-

There are many mountains and isn't much development district in Busan area. so, progressing in the large-scale reclamation with the urbanization. It thinks for the climate change in Busan area to accelerate by the reclamation. The way of making improve to the city environment aggravation which comes in the urbanization and the reclamation. There is the city vegetation and city planning in this way. The following was concluded from this study. 1) The minimum temperature rose remarkably in Seoul and Daegu by urbanization but, in this case, the maximum temperature rose remarkably in Busan by progressing of urbanization. 2) As a result of the study, Indoc-kyo plays a role of the wind road but, The very few influences occur. 3) The high-rise apartment building district and the four-lane road compared favorably with the low-rise building district and two-lane road for influx of sea wind.