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Face Stability Analysis of Slurry Shield Tunnels in Rock–Soil Interface Mixed Ground
Ping Lu,Da-Jun Yuan,Jian Chen,Dalong Jin,Jun Wu,Weiping Luo 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.6
When shield tunneling in rock-soil interface (RSI) mixed ground, maintaining the stability of the tunnel face is very challenging. This study aims at the investigation of the face stability of slurry shield tunnels in RSI mixed ground. A new apparatus was developed to simulate pressurized slurry supporting the tunnel face in centrifuge tests. The progressive failure of the tunnel face was triggered with slow decrease of slurry pressure. With two equivalent model tunnels of circular shape and semicircular shape, the variations of soil (water) pressure and the displacement field in front of the tunnel can be obtained simultaneously. The face failure was found to be a local collapse in the upper soil layer. The limit support pressure was picked out at the sudden change of the measured soil or water pressures. Then the classical wedge-prism model was introduced and modified to calculate the limit support pressure for slurry shield tunnels in RSI mixed ground considering the partial collapse. Numerical analysis was applied to verify the theoretical analysis and sensitivity analysis was performed to estimate the influence of different parameters on the theoretical solutions.
Seismic Response of Two Site Models and Their Effects on the Railway Cable-Stayed Bridge
Jin Zhang,Zhen-yu Yang,Da-ping Yuan,Shi-xiong Zheng,Yi-ran Hu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.12
In order to accurately analyze the seismic response of the site and their effects on a railway cable-stayed bridge, the site condition of the railway cable-stayed bridge was surveyed, and geotechnical exploration holes ZK1 and ZK2 were set near the left and right tower of the bridge to gain the detailed geological data, then 32 representative ground motions records were selected corresponding to the site characteristics, and the equivalent linear and nonlinear model were established to analyze the site seismic response of 32 representative ground motions based on the Deepsoil Software. Next, to investigate the influence of site seismic response on the long-span railway cable-stayed bridge, the seismic response of the cable-stayed bridge considering site effect are calculated and evaluated via time history analysis under one-dimensional and multi-point excitation based on the ANSYS platform. At last, several critical and meaningful conclusions are drawn.
Risk Factors for Anxiety in Major Depressive Disorder Patients
Li-Min Xin,Lin Chen,Zhen-Peng Ji,Suo-Yuan Zhang,Jun Wang,Yan-Hong Liu,Da-Fang Chen,Fu-De Yang,Gang Wang,Yi-Ru Fang,Zheng Lu,Hai-Chen Yang,Jian Hu,Zhi-Yu Chen,Yi Huang,Jing Sun,Xiao-Ping Wang,Hui-Chun 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.3
Objective: To analyze the sociodemographic and clinical factors related to anxiety in patients with major depressive disorder (MDD). Methods: This study involved a secondary analysis of data obtained from the Diagnostic Assessment Service for People with Bipolar Disorders in China (DASP), which was initiated by the Chinese Society of Psychiatry (CSP) and conducted from September 1, 2010 to February 28, 2011. Based on the presence or absence of anxiety-related characteristics, 1,178 MDD patients were classified as suffering from anxious depression (n=915) or non-anxious depression (n=263), respectively. Results: Compared with the non-anxious group, the anxious-depression group had an older age at onset (t=−4.39, p<0.001), were older (t=−4.69, p<0.001), reported more lifetime depressive episodes (z=−3.24, p=0.001), were more likely to experience seasonal depressive episodes (χ2=6.896, p=0.009) and depressive episodes following stressful life events (χ2=59.350, p <0.001), and were more likely to have a family history of psychiatric disorders (χ2=6.091, p=0.014). Their positive and total scores on the Mood Disorder Questionnaire (MDQ) and the 32-item Hypomania Checklist (HCL-32) (p<0.05) were also lower. The logistic regression analysis indicated that age (odds ratio [OR]=1.03, p<0.001), a lower total MDQ score (OR=0.94, p=0.011), depressive episodes following stressful life events (OR=3.04, p<0.001), and seasonal depressive episodes (OR=1.75, p=0.039) were significantly associated with anxious depression. Conclusion: These findings indicate that older age, fewer subclinical bipolar features, an increased number of depressive episodes following stressful life events, and seasonal depressive episodes may be risk factors for anxiety-related characteristics in patients with MDD.
Yu Jian,Li Wen,Hou Guo-jun,Sun Da-peng,Yang Yuan,Yuan Sheng-xian,Dai Zhi-hui,Yin Hao-zan,Sun Shu-han,Huang Gang,Zhou Wei-ping,Yang Fu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC. Furthermore, cFAM210A reduced the proliferation, stemness, and tumorigenicity of HCC cells. Mechanistically, HBx increased the N6-methyladenosine (m6A) level of cFAM210A by promoting the expression of RBM15 (an m6A methyltransferase), thus inducing the degradation of cFAM210A via the YTHDF2-HRSP12-RNase P/MRP pathway. cFAM210A bound to YBX1 and inhibited its phosphorylation, suppressing its transactivation function toward MET. These findings suggest the important role of circular RNAs in HBx-induced hepatocarcinogenesis and identify cFAM210A a potential target in the prevention and treatment of HBV-related HCC.