http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Dry–Wet Cycling on the Residual Strength Characteristics of Coal Measure Soil
Gang Huang,Mingxin Zheng 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.11
Coal measure soils are the main component in the slip zones of landslides along the Changli highway in China. Therefore, exploring the residual strength of coal measure soil affected by dry–wet cycling is helpful for evaluating landslides. However, very few researchers have reported on the residual strength behavior of coal measure soil subjected to dry–wet cycling. In this study, we performed three tests (ring shear test, scanning electron microscopy test, and mercury intrusion porosimetry test) to evaluate the residual strength behavior of coal measure soil under different dry–wet cycles. Our results indicated that the peak strength decreased with increasing dry–wet numbers and that dry–wet cycling had no evident effect on the residual strength. Moreover, the residual strength in the slip soil was approximately proportional to the normal stress. Furthermore, the degeneration of peak cohesion exponentially increased, and the porosity and fractal diameter also increased with the dry–wet numbers. The connection between mineral particles changed from a stable layered structure to an unstable chain structure. Consequently, we inferred the failure mechanism of K213-type shallow landslides and formulated appropriate preventive measures. This study is of great significance for understanding the mechanical behavior of the slip zone of coal measure soil and predicting the re-emergence of coal measure soil landslides.
Expression and Underlying Roles of IGFBP-3 in Paclitaxel-Treated Gastric Cancer Sgc-7901 Cells
Huang, Gang,Dang, Zhong-Feng,Dang, Ya-Mei,Cai, Wei,Li, Yuan,Chen, Yi-Rong,Xie, Xiao-Dong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Purpose: To study the expression of insulin-like growth factor binding proteins (IGFBPs) in paclitaxel-treated gastric cancer SGC-7901 cells, and to further investigate underlying mechanisms. Materials and Methods: Real time PCR and Western blot assays were applied to detect the mRNA and protein expression of IGFBP-2, -3 and -5 after paclitaxel (10 nM) treatment of SGC-7901 cells. In addition IGFBP-3 expression was silenced by RNA interference to determine effects. Cell viability was determined by MTT assay. Cell cycling and apoptosis were assessed by flow cytometry. Results: Compared to the control group, only IGFBP-3 expression was elevated significantly after paclitaxel (10 nM) treatment (p<0.05). Paclitaxel treatment caused cell cycle arrest and apoptosis via downregulating Bcl-2 expression. However, the effect could be abrogated by IGFBP-3 silencing. Conclusions: IGFBP-3 exhibits anti-apoptotic effects on paclitaxel-treated SGC-7901 cells via elevating Bcl-2 expression.
Huang, Gang,Zhang, Chunfu,Li, Shunzi,Khemtong, Chalermchai,Yang, Su-Geun,Tian, Ruhai,Minna, John D.,Brown, Kathlynn C.,Gao, Jinming Royal Society of Chemistry 2009 Journal of materials chemistry Vol.19 No.35
<P>Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T<SUB>2</SUB> relaxivity. The nanoprobes are specific in targeting α<SUB>v</SUB>β<SUB>6</SUB>–expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.</P> <P>Graphic Abstract</P><P>Surface functionalization of SPIO nanoparticles with lung cancer peptides enables the specific targeting to α<SUB>v</SUB>β<SUB>6</SUB>–positive H2009 cancer cells, verified by cell uptake and MR imaging. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b902358e'> </P>
SINGULARITIES AND STRICTLY WANDERING DOMAINS OF TRANSCENDENTAL SEMIGROUPS
Huang, Zhi Gang,Cheng, Tao Korean Mathematical Society 2013 대한수학회보 Vol.50 No.1
In this paper, the dynamics on a transcendental entire semigroup G is investigated. We show the possible values of any limit function of G in strictly wandering domains and Fatou components, respectively. Moreover, if G is of class $\mathfrak{B}$, for any $z$ in a Fatou domain, there does not exist a sequence $\{g_k\}$ of G such that $g_k(z){\rightarrow}{\infty}$ as $k{\rightarrow}{\infty}$.
Huang, Hou-Gang,Luo, Xi,Wu, Shuai,Jian, Bin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
MicroRNAs (miRNAs) are emerging as critical regulators in carcinogenesis and tumor progression. Recently, miR-99a has been reported as a tumor suppressor gene in various human cancers, but its functions in the context of anaplastic thyroid cancer (ATC) remain unknown. In this study, we reported that miR-99a was commonly downregulated in ATC tissue specimens and cell lines with important functional consequences. Overexpression of miR-99a not only dramatically reduced ATC cell viability by inducing cell apoptosis and accumulation of cells at G1 phase, but also inhibited tumorigenicity in vivo. We then screened and identified a novel miR-99a target, mammalian target of rapamycin (mTOR), and it was further confirmed by luciferase assay. Up-regulation of miR-99a would markedly reduce the expression of mTOR and its downstream phosphorylated proteins (p-4E-BP1 and p-S6K1). Similar to restoring miR-99a expression, mTOR down-regulation suppressed cell viability and increased cell apoptosis, whereas restoration of mTOR expression significantly reversed the miR-99a antitumor activity and the inhibition of mTOR/p-4E-BP1/p-S6K1 signal pathway profile. In clinical specimens and cell lines, mTOR was commonly overexpressed and its protein levels were statistically inversely correlated with miR-99a expression. Taken together, our results demonstrated for the first time that miR-99a functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting the mTOR/p-4E-BP1/p-S6K1 pathway in ATC cells. Given these, miR-99a may serve as a novel prognostic/diagnostic and therapeutic target for treating ATC.
Singularities and strictly wandering domains of transcendental semigroups
Zhi Gang Huang,Tao Cheng 대한수학회 2013 대한수학회보 Vol.50 No.1
In this paper, the dynamics on a transcendental entire semi- group G is investigated. We show the possible values of any limit function of G in strictly wandering domains and Fatou components, respectively. Moreover, if G is of class B, for any z in a Fatou domain, there does not exist a sequence {gk} of G such that gk(z)→ ∞ as k → ∞.
Yingxin Huang,Xueyong Zhao,Hongxuan Zhang,Wisdom Japhet,Xiaoan Zuo,Yayong Luo,Gang Huang 한국식물학회 2009 Journal of Plant Biology Vol.52 No.3
We monitored the allometric effects for greenhouse- grown Agriophyllum squarrosum plants in response to variations in population density and the availability of soil nutrients and water. Biomass allocations were sizedependent. The plasticity of roots, stems, leaves, and reproductive effort was “true” in response to changes in nutrient content. At a low level of soil minerals, plants allocated more resources to the development of roots and reproductive organs than to leaves, but data for stem allocations were consistent for tradeoffs between the effects of nutrients and plant size. The plasticities of leaf allocation and reproductive effort were “true” whereas those of root and stem allocations were “apparent” in response to fluctuations in soil water, being a function of plant size. Decreasing soil water content was associated with higher leaf allocation and lower reproductive effort. Except for this “apparent” plasticity of leaf allocation, none was detected with population density on biomass allocation. Architectural traits were determinants of the latter. For roots, the determining trait was the ratio of plant height to total biomass; for stems and reproduction, plant height; and for leaves, the ratio of branch numbers to plant height.
( Gang Wang ),( Yan Yang ),( Chunfeng Wang ),( Jianzhong Huang ),( Xiao Wang ),( Ying Liu ),( Hao Wang ) 대한통증학회 2020 The Korean Journal of Pain Vol.33 No.3
Background: Garlic oil is a rich source of organosulfur compounds including diallyl disulfide and diallyl trisulfide. There have been studies showing the neuroprotective actions of these organosulfur compounds. However, the potential of these organosulfur compounds in neuropathic pain has not been explored. The present study was aimed at investigating the pain attenuating potential of diallyl disulfide and diallyl trisulfide in chronic constriction injury (CCI)-induced neuropathic pain in rats. The study also explored their pain-attenuating mechanisms through modulation of H<sub>2</sub>S, brain-derived neurotrophin factor (BDNF) and nuclear factor erythroid 2-related factor 2 (Nrf2). Methods: The rats were subjected to CCI injury by ligating the sciatic nerve in four places. The development of neuropathic pain was measured by assessing mechanical hyperalgesia (Randall-Selittotest), mechanical allodynia (Von Frey test), and cold allodynia (acetone drop test) on 14th day after surgery. Results: Administration of diallyl disulfide (25 and 50 mg/kg) and diallyl trisulfide (20 and 40 mg/kg) for 14 days led to a significant reduction in pain in CCI-subjected rats. Moreover, treatment with these organosulfur compounds led to the restoration of H<sub>2</sub>S, BDNF and Nrf2 levels in the sciatic nerve and dorsal root ganglia. Coadministration of ANA-12 (BDNF blocker) abolished pain attenuating actions as well as BDNF and the Nrf2 restorative actions of diallyl disulfide and diallyl trisulfide, without modulating H<sub>2</sub>S levels. Conclusions: Diallyl disulfide and diallyl trisulfide have the potential to attenuate neuropathic pain in CCI-subjected rats possibly through activation of H<sub>2</sub>S-BDNF-Nrf2 signaling pathway.