Clinical Significance of Classification of Graves` Disease According to the Characteristics of TSH receptor Antibodies

(Won Bae Kim),(Hyun Kyung Chung),(Young Joo Park),(Do Joon Park),(Hong Kyu Lee),(Bo Youn Cho) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.3

N/A Background:It has been widely accepted that the epitope (s) and/or functional characteristics of thyrotropin receptor antibodies (TSHRAb) from Graves` patients are heterogenous among patients. However, the clinical significance of such heterogeneity has not been systematically evaluatedyet. We were to elucidate and find the clinical significance of heterogeneity for TSH receptor antibodies in Graves` disease. Methods:We measured stimulating TSHRAb (TSAb) activities using CHO-hTSHR cells, FRTL-5 cells and chimeric receptor expressing cells (Mc1+2 and Mc2), specific blocking TSHRAb (TSBAb) activities using Mc2 cells and TBII activities using porcine thyroid membrane in 136 patients with untreated hyperthyroid Graves` disease. Results: Based on various TSHRAb activities from each patient, the patients could be categorized into 7 subgroups by cluster analysis; 1) Group 1 (n=41) was characterized by moderate TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, typical TSAb epitope, rare blocking antibodies and high TBII activities. 2) Group 2 (n=16) was characterized by the presence of blocking TSHRAb in most patients, albeit the other characteristics were the same as those in Group 1. 3) Group 3 (n=19) patients had low TSAb activities bothin CHO-hTSHR cells and in FRTL-5 cells, seldom had blocking TSHRAb, but they had high TBII activities. 4) Group 4 (n=30) could be categorized as `mild disease` group, as they had low activities in all kinds of TSHRAb assay and had low antim icrosomal antibody activities. 5) Group 5 (n=14) was characterized by moderate TSAb activities with atypical epitope (s), rare blocking TSHRAb and moderate TBII activities. 6) Group 6 (n=10) patients had veryhigh TSAb activities with typical epitopes, seldom blocking TSHRAb and low TBII activities. 7) Group 7 (n=6) was characterized by very high TSAb activities with atypical epitopes and high TBII activities. Pretreatment serum thyroid hormone level was low only in group 4 patients compared to the other 6 groups (p<0.05). The size of goiter was significantly larger in those in group 1 and group 3 (p<0.05) compared to the other 5 groups. The prevalence of clinically significant ophthalmopathy was higher in group 2 patients than the other 6 groups (50%vs.27.5%,p=0.06). Among 6 kinds of TSHRAb activities, only the blocking TSHRAb activity was significantly associated with the presence of ophthalmopathy in multivariate analysis. Conclusion:These results suggest that the differences inepitopes for TSAb or the presence of blocking TSHRAb is not a major factor in determining the degree of thyrotoxicosis in Graves` disease. Although the pathogenic mechanism is not clearyet, we suggest that patients with ophthalmopathy have different TSHRAb repertoire from those without ophthalmopathy in Graves` disease.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

환율, 금리, 주가사이의 동적연관성 연구

홍정효(Chung-Hyo Hong),조혜원(Hae-Won Cho) 전북대학교 산업경제연구소 2010 아태경상저널 Vol.2 No.1

본 연구는 2000년 1월부터 2008년 말까지 콜금리, 3년물 국채금리, 원달러 외환시장 및 KOSPI자료를 이용하여 원달러 환율 및 장단기 금리 변화량, KOSPI수익률사이의 동적연관성을 실증적으로 분석하였다. 실증분석결과 첫째, 콜금리와 원달러 외환시장사이에는 장기적인 균형관계가 존재하고 있으나, 콜금리와 KOSPI, 원달러와 KOSPI사이에는 장기적인 균형관계가 존재하지 않는 것으로 나타났다. 3년물 국채금리는 콜금리와 공적분관계가 있으나 원달러, KOSPI와는 공적분관계가 존재하지 않는 것으로 나타났다. 둘째, 3년물 국채금리는 KOSPI 및 원달러 환율간에는 피드백적인 관계가 존재하고 있으나, 3년물 국채금리의 KOSPI 및 원달러에 대한 영향력이 그 반대의 경우보다 상대적으로 더 강한 것으로 나타났다. 세째, KOSPI와 원달러 환율사이에도 피드백적인 영향력이 존재하고 있으나 KOSPI의 원달러 환율변화에 대한 영향력이 그 반대의 경우 보다 더 강한 것으로 나타났다. 다섯째, 콜금리는 원달러 외환시장에만 영향력을 미치고 있으며, 장단기 금리사이에는 3년물 국채금리가 콜금리에 대한 영향력을 미치고 있으나 그 반대의 경우는 존재하지 않는 것으로 나타났다. 여섯째, 전반적으로 4가지 금융시계열모두 호재보다는 악재에 더 민감하게 반응하는 정보의 비대칭적인 특성이 존재하는 것으로 나타났다. 이러한 실증분석결과는 투자자들의 투자 및 위험관리전략 수립 뿐 아니라 정책당국자들의 통화 및 금융정책수립에 다소 나마 기여를 할 수 있을 것으로 보여 진다. We try to examine on the short term lead-lag relationship between call, KOSPI and won dollar spot markets with a vector error correction model, Granger causality test and impulse response analysis. This paper uses daily return data covering from January 2000 to December 2008. The major results are as follows; First, according to empirical test based on the Granger causality, the returns of won/dollar spot market Granger causes call market but vice versa. Second, we find a bilateral influence between won/dollar and KOSPI spot markets but the impact of KOSPI is relatively more dominant than of that of won/dollar market. Third, we also find that there is no influence between call and KOSPI markets in a statistically significant level. We hope these kinds of empirical results might be helpful for the investors to set up a asset portfolio and risk management system.

환율, 금리, 주가사이의 동적연관성 연구

조혜원(hye-won cho),홍정효(Chung-Hyo Hong) 한국산업경제학회 2009 한국산업경제학회 정기학술발표대회 논문집 Vol.- No.추계

노화 흰쥐 간에 미치는 비타민 A 급성과다 효과 ㅣ.조직학적 연구와 Alkaline phosphatase 활성

조현국,박원학,정형재 嶺南大學校 基礎科學硏究所 1993 基礎科學硏究 Vol.13 No.-

급성 비타민 A 과다가 노화과정의 진행정도(3, 6, 20개월)에 따라 간장에 미치는 영향을 형태학 및 효소화학적으로 관찰하였다. 대조군에 대한 광학현미경적 변화로 3, 6개월군은 대체로 그 형태가 잘 보존되어 있으나 20개월군에서는 동양혈관의 확장, 불규칙한 간세포삭, 국소적 세포팽창과 염증세포의 침윤이 관찰하였다. 비타민 A 투여 3개월군에서의 광학현미경적 변화로, 간소엽의 주변부변성이 관찰되었으며, 6개월군에서는 중심정맥과 간정맥 내막의 섬유증식, 그리고 섬유모세포와 성상세포의 중식이 국소적으로 형성되었다. 20개월군에서는 소엽 전반에 걸친 동양혈관의 확장, 간정맥 경계부의 섬유중식, 중심정맥과 동양혈관의 심한 섬유증식에 기인된 동양혈관 내막에서의 적혈구 정체 및 세포질의 소실도 관찰되었다. 효소활성의 변화로, 혈액중의 ALT, AST는 변화가 없는 반면, ALP 활성은 비타민 A 투여 20개월군에서 증가하는 경향을 보였다. The effect of acute hypervitaminosis A on liver tissue, obtained from 3,6, 20months of rats, were studied by analyzing morphological changes and serum enzyme activities. In light microscopic results of control groups(3,6 months), the tissue structure is preserved well, whereas from 20 months old group, dilatation of sinosoids, irregular hepatic cell cord, and focal cell swelling and infiltration of inflammatory cell were observed. From the 3 months groups treated with vitamin A, peripheral degeneration in the hepatic lobule was observed. From the 6 months groups, fibrosis of central and portal veins, and formation of focal proferation of fibroblasts and Kupffer cells. The dilatation of sinusoids in the whole liver tissue, fibrosis of continuity of liver tissue in adjacent lobule, and focal stagnated red blood cells(caused from the fibrosis of central vein and sinusoids) with cytoplasmic loss were observed from 20 months group. The activity of serum ALP level in 20 months group treated with vitamin A, compared with 3, 6 months groups, was increased, while the changes of serum ALT and ASt activities were insignificant.

Feedback 을 고려한 연결정보 추출 알고리즘에 관한 연구

趙南景,元忠常 충주대학교 1997 한국교통대학교 논문집 Vol.32 No.2

In this study, we have developed the PLD design tool which realizes the digital circuit as PLD,by using EDIF netlist of the digital circuit designed at OrCAD. We propose the alorithms, JIE(Joined Informantion Extractor) which extacts the connecting information between both cells in order to realize the digital circuit as PLD using EDIF netlist,FND(Feedback Node Detector) which searches for whether feedback exists or not ,BEG(Boolean Equation Generator) which generates boolean equation and so on. Also, algorithm generating JEDEC file of GAL 6001 and GAL 6002, has a form of EPLD which is bigger than PLD.

롤로기어캠의 모델링에 관한 연구

조승래,이춘만,정원지 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.3

In this paper, we developed an automated program for the modeling and emulation of three-dimensional roller gear cam mechanisms. The three-dimensional modeling of a roller-gear cam employs coordinate transformations based on the con-tact condition. The wire frame modeling followed by the shading technique using triangular meshing elements incorporat-ed the "tangent path technique" to reduce the number of data and computational load. Computer simulations for two kinds of products for roller-gear cam mechanism illustrate the relative motion between the modeled roller-gear cam and a turret and thus show the effectiveness of the proposed modeling.

유한 저크(Finite Jerk)를 이용한 수직 MC(machining center)의 가속도 최적화에 대한 연구

정원지,조영덕,이춘만,윤상환 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

By the reason of increased demand of high productivity and quality, the manufacturer have an effort in many directions of a machine tool industries. Among there, we proposed method of decreasing displacement in MC(machining center). In other words, Quality related with vibration of a tool cutting products. For decreasing it, improved by optimizing a shape of the column-part and acceleration curves of motors In this paper we could find design factors has much influence on decreasing the displacement using the DOE(Design of Experiments) and optimized the level of the factors using ADAMS^(R) and MINITAB^(R). And we suggest optimized a acceleration curve using Matlab^(R).

800m 달리기 後 血壓 및 心博數의 變化와 回復에 관한 硏究 : Concerning Overweight, Normal, and Underweight Students In a Girls' Middle School 女子中學校 肥滿, 正常, 低體重學生을 中心으로

원충희,曺圭勇 公州大學校스포츠科學硏究所 1999 스포츠科學硏究所論文集 Vol.- No.13

The purpose of this study is to observe the recovery of blood pressure and heartbeat rate of overweight, normal, and underweight students after they run 800m race and apply the results to class. To serve this aim, the blood pressure and the heartbeat rate in the normal situation without exercising, immediately, 5, 10, and 15 minutes after 800m race were comparatively analyzed. The subjects were 36 girl students from K-Middle School and they were taken out at random and measured both in the classroom and on the playground. For the athletic load quantity, the blood pressure and heartbeat rate were measured after 800m race without any special training. The data were statistically computerized in the method of SPSS/PC Program and the differences of blood pressure and heartbeat rate in the three groups were verified in the method of a one-way ANOVA. The results obtained from the analysis were as follows. 1. In normal situation, the blood pressure of the overweight students showed 119/71.08㎜Hg, the normal students 118.00/70.08㎜Hg, the underweight students 118.83/74.00㎜Hg, and the heartbeat rate of the overweight students showed 78.17/min., the normal students 79.17/min., the underweight students 77.25/min. As a result, the systolic blood pressure of the overweight students and the normal students were nearly the same, however the underweight students showed a bit lower. The heartbeat rates of three groups were almost the same. 2. Immediately after 800m race, the systolic blood pressure of the overweight students was the highest and that of the normal students was the lowest and there was a little difference between the overweight students and the other two groups, and the diastolic blood pressure was higher than that at resting in all the three groups. And the heartbeat rate showed almost twice the usual. 3. In 5 minutes after 800m race, the systolic blood pressure of the normal students recovered rapidly, the underweight students by 72.62% and the overweight students by 54.14%. The diastolic blood pressure of the underweight students dropped much, and the normality of the other two groups approached that of the resting time. The heartbeat rate of all the groups recovered nearly to that of the resting time. 4. In 10 minutes after 800m race, the systolic blood pressure of the underweight students became completely normal and the overweight students recovered by 67.31%, and the diastolic blood pressure of all the groups recovered normally, The heartbeat rate became normal in order of the underweight, normal, overweight student group. 5. In 15 minutes after 800m race, the systolic blood pressure of overweight students recovered by 81.32%, and the diastolic blood pressure of all the groups showed lower than that at resting. The change of the heartbeat rate became normal in order of the underweight, normal, overweight student group.

증발농축을 이용한 방사선 필름의 폐액처리 특성

조영미,정원문,임봉수,박영성 대전대학교 환경문제연구소 2001 환경문제연구소 논문집 Vol.5 No.-

A concetrated evaporation experimnt was carried out in this study, to find out the removal and concoentration efficiency of havy metals from concentration process as well as analysis and investigation for the characteristics of the condensed water. In the experiment of wastewater treatment from X-ray film by using concentrated evaporation, the results show that COD removal efficency rate was more than about 99%, the major toxic metals, including Pb, CN, F, Zn was almost removed. It could be seen that the early boiling point of each wastewater was 108.5℃ for the wastewater of the fixing solution, 106.7℃ for the wastewater of developing solution and 107℃ for the mixture(1:1) of both wastewater. The increasing rate of boiling point was the greatest in the wastewater of the developing solution and the mixture and the wastewater of fixing solution in descending order. The boiling point under latm in a vacuum was 30℃ for the wastewater of the developing solution, 37℃ for the wastewater of fixing solutions, and 35℃ for the mixture.