벌 자상에 의해 발생한 횡문근융해증과 급성신부전

박상곤,김영대,강지은,신정현,신병철,박차영,정춘해 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. The spectrum of causes is quite broad and included disorders of traumatic, metabolic, infectious and toxic origin. However, rhabdomvolvsis and acute renal failure following bee sting is rare and its pathogenesis is not well known. We experienced a case of 63-year-old man with acute renal failure and rhabdomyolysis caused by bee sting. He was stung by bee on scalp and neck. Oliguria was developed within several hours. He has fully recovered after general supportive care including fluid therapy and diuretics. This case demonstrates that rhabdomvolysis with consequent acute renal failure are able to developed by bee sting.

과전류에 의해 용단된 소선의 특성해석에 관한 연구

최충석,김향곤,김동욱 한국안전학회 2004 한국안전학회지 Vol.19 No.1

The PVC insulated flexible cords are used mainly as power supply cords of electric appliance. This electric wire is a stranded wire consisted of dozens of strands. In case stranded wires are disconnected by mechanical stress, it weakens electrically. Finally, the over current flows through stranded wires, and electrical fire occurs. In this study, we analyzed the melting properties of strands by over current, such as melting process, melting current and melting time. And we analyzed that quantity of heat for melting, a cross sectional structure, and surface structure by optical microscope and SEM. As analysis results, melting time decreased as melting current increased. And quantity of heat for melting was low, too. From the cross sectional structure of melted wire, when a melting current low and melting time long, it was found that the dendrite structure grew. However, the dendrite structure is hard to grow because growing time is not enough when a melting current high and melting time short.

벼 생육중기 및 출수기 태풍 "올가" 건풍에 의한 엽신 피해의 품종간 차이와 수량 및 품질 변화

윤영환,김정곤,정남진,곽강수,강양순 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.4

1999년 8월3일~8월4일간 태풍 올가 도래시 건풍에 의한 생육중기 엽신 피해의 품종간 차이와 출수기 이삭 갈변에 따른 수량 및 품질에 미치는 영향을 조사하여 다음과 같은 결과를 얻었다. 1. 잎의 증산량 및 수분저하속도가 클수록, 잎이 길이가 길고 폭이 넓을수록 엽신의 피해정도가 컸다. 2. 이삭의 피해 정도가 증가될수록 임실 및 등숙비율은 현저히 낮아지는 경향이며, 쌀 수량은 무피해 대비 피해 3~5는 14~16%, 피해 7은 28%, 피해 9는 48% 감수하였다. 3. 이삭의 피해 정도별 백미 완전미 비율은 피해 정도가 클수록 감소를 보였으며 피해 0~3에서 63~65%, 피해 5~9에서 42~58%의 분포를 보였다. 4. 이삭의 피해정도가 증가할수록 백도 및 색도치가 낮아지며, 단백질 함량은 증가하고 식미치는 저하하는 경향을 보였다. This study was carried out to characterize the influence of dry wind by typhoon "Olga" during Aug. 3~Aug. 4, 1999 on the rice plant(Oryza sativa L.). For the purpose, the affection of the dry wind during the mid-growing stage and heading stage on the leaf damage, yield and rice quality were investigated. The extent of the leaf damage increased with the increase of leaf size and transpiration rate, and also with the decrease of moisture content in the leaves. The percentage of fertile grain decreased in proportion to the increase of the extent of the panicle damage. Compared with none-damaged rice plants in the panicle, the milled rice yield decreased by 14~16% in the degree 3~5 of the panicle damage, and 28~48% in the degree 7~9. The percentage of head rice was the same in the both milled and brown rice in the degree 0~3 of the panicle damage. Above the degree 5, however, it decreased with the increase of the panicle damage. The whiteness and lightness decreased in proportion to the increase of the degree in the unhulled, brown and milled rice. And, there was a tendency that the protein content in the milled rice increased but eating quality decreased with the increase of the panicle damage.

퉁퉁마디로부터 염에 의하여 유도되는 Aldolase 유전자의 분리 및 발현분석

차준영,네티 엘마와티,김순길,이증주,임채오,정우식,이곤호,손대영 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-

Soil salinity is one of the most serious abiotic stresses limiting the productivity of agricultural crops. To cope with salt stress, plants respond with physiological, developmental and biochemical changes, including the synthesis of a number of proteins and the induction of gene expression. Salicornia herbacea is a halophytic plant that grows in salt marches and on muddy seashores. In order to understand the biochemical and molecular mechanisms of salt tolerance in S. herbacea, we isolated several genes that involved in the salt tolerance by mRNA differential display.Here we report the cloning of a cDNA encoding fructose-1, 6-bisphosphate aldolase, named ShADL, which is 1293 bp long and contains an open reading frame consisted of 359 amino acids with calculated molecular mass of 39 kDa. ShADL protein showed 86% identity with Arabidopsis and 78% with aldolase of common ice plant. Northern blot analysis revealed that the transcript of ShADL gene was increased dramatically depending on the NaCI concentrations.

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

간척지 벼 담수직파재배시 토양 염농도별 적정 최아정도

최원영,이규성,김정곤 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.4

간척지에서 벼 담수직파재배시 입모 향상을 위하여 토양 염 농도별 적정 최아 정도를 구명하기 위하여 시험한 결과는 다음과 같다. 가. 입모수는 저염 토양은 건종자 파종에서만 적었고 그 외 처리에서는 비슷하였으며, 중염 토양은 반대로 최아 0㎜와 건종자 파종에서 많았다. 나. 출수기는 저염 토양에서는 최아 4㎜가 8월 18일인데 비하여 2 ㎜와, 0 ㎜에서는 같았으나 소독후 건조종자 파종에서는 1일이 늦었으며. 중염 토양에서는 최아 4㎜에 비해 2㎜는 같았고 건조종자 파송에서는 1일이 늦었으나 0㎜ 파송에서는 오히려 1일이 빨랐다. 다. 저염 토양에서는 ㎡당립수가 최아 4>2>0㎜>건종자 순으로 많아 쌀 수량도 최아2~4 ㎜에서 많았으며, 중염 토양에서는 도복에 강하고 등숙비율이 높은 최아 0㎜와 건 조종자 파송에서 쌀 수량이 많았다. 따라서 저염 토양에서는 최아 2~4㎜가 적당하고, 중염 토양에서는 최아 0㎜ 또는 소독 후 건조종자 파종이 적당할 것으로 판단된다. This study was conducted to examine an appropriate pregermination treatment of rice seeds for wet seeding on the wet surface of a reclaimed saline soil. It was conducted at the Gyehwado Substation of the Honam Agricultural Research Institute in 2002~2003. Two soil saline solutions (0~0.1% NaCl and 0.3~0.4% NaCl) and four pregermination seed treatments (nonsoaking, water absorption only, 2 ㎜ pregerminated, and 4 ㎜ pregerminated) were used. The experiment was carried out in a split plot design with three replications. At low soil salinity (0~0.1% NaCl), the number of spikelets and the percentage of ripened grain increased with a longer sprouting length of rice seed compared with that of nonsoaking (dry seeds) and water absorption only. Pregerminated seed treatments showed significant high rice yield performance in low saline conditions indicating pregerminated treatments are necessary for good seedling establishment and growth of rice. However, rice seeds treated with nonsoaking and water absorption only had higher yield performance in a medium soil salinity level (0.3~0.4%) than the pregerminated ones. This result indicated that pregerminated seeds seeded under a medium soil salinity level could have damaged shoot tips and roots, thus the growth would be retarded and soaking seeds float because of high soil salinity.

병원내 생리기능 검사실의 적정 업무환경에 관한 연구

배형준,윤기은,김승곤,나동진,문희주,김태전,박정오 서울보건대학 1999 서울보건대학 부설 병원경영연구소 논문집 Vol.4 No.2

The purpose of this study was to suggest guideline for optimal work environment of physiological laboratory in hospital. Therefore this study was carried out to analyze the actual condition of laboratory system, major equipments and persons. The period of survey was from September to November 1997 and the objects were 123 laboratory. The major results of this study were as follows. 1. The optimal areas of general ECG room, exercise ECG room and echocardiology room were all 9-18㎡, that of Holter ECG room was 3-12㎡. The optimal areas of neurosystem laboratory were all 9-12㎡, those of respiratory system laboratory were all 9-18㎡. 2. The optimal number of persons laboratory of hospital 500 beds and less were 2∼3, those of 501∼700 beds were 3∼4.701∼1.000 beds were 4∼5 and over 1.001 beds were 7∼8 persons in circulatory system laboratory. The optimal number of persons laboratory of hospital 500 beds less than were 1∼2, those of 501∼700 beds were 3∼4, 701∼1.000 beds were 6∼7 and over 1.001 beds were over 8 persons in neurosystem laboratory. The optimal number of persons laboratory of hospital 500 beds and less 1. those 501∼1.000 beds were 1∼2 and over 1.001 beds were 2∼3 persons in repiratory system laboratory. 3. The optimal number of equipments of general ECG were 2∼3 in the 500∼1.000 beds hospital. there were 3∼4 units in the 1,001 beds. The optimal number of equipment EEG were both 1∼2 in the hospital 500 beds and less and 501∼700 beds. those were 4∼5 units in hospital over 701 beds. The optimal number of equipments of spirograph were both 1∼2 in the hospital 500 and less and 501∼1.000 beds. those were 2∼3 units in the over 1.001 beds. 4. In view of speciality and legal problem of physiofunctional test. we sugget that non-licensee were so quickly change place licensee in the interests of optimal work environment. 5. We suggest that to upgrade qualitative level of domestic equipment and to the more amplify utilization with respect to domestic equipment for the purpose of reducing loss of foreign money.

尿中 Aminolevulinic Acid와 Porphobilinogen의 비교 조사 연구

나동진,윤기은,김승곤,문희주,김태전,박정오 서울保健大學 1990 論文集 Vol.10 No.1

This studies were examined to measure total ALA and PBG concentration in Urine, and find the relationship of correlation among them in 57 men unexposed and 43 men exposed by mercury. The results were summarized as the following; 1. In 100 populations total urine ALA concentration was 0.85±0.17㎎% in male, in female were 0.40 ± 0.04㎎% (normal value : 0.54㎎%). 2. Urine ALA concentration in male were 1.04∼1.11mg% for the ages between 30 ∼ 49 was the highest and then in female were 0.58㎎% for the ages between 40 - 59 was the highest. 3. In 100 populations total urine PBG concentration was 0.03㎎% in male, in female were 0.02㎎% (normal value : 0.03㎎%). 4. Urine PBG concentration in male were 0.05㎎% for the ages between 30-49 was the highest. 5. In unexposed men group total urine ALA concentration was 0.13±0.03㎎% in male, in female were 0.11±0.0l㎎%. 6. In exposed men group total urine ALA concentration was 1.81±0.55㎎% in male, ill female were 0.78±0.09㎎%, there was differences in attention showing male was higher than the female (P<0.05). 7. In unexposed men group total urine PBG concentration was 0.02㎎% in male, in female were 0.0l㎎%. 8. In exposed men group total urine PBG concentration was 0.06㎎% in male, in female were 0.04㎎%,there was differences in attention showing male was higher than the female (P<0.05).

供血者에서의 HBsAg 發現率과 生化學的 檢査値에 관한 硏究

문희주,윤기은,김승곤,라동진,김태전,박정오,최범열 서울保健大學 1988 論文集 Vol.8 No.1

안동호 상류 운곡천의 이화학적 수질특성과 식물플랑크톤 군집 특성

이중복,이희무,이건주,박정원,박재충,김동걸,권기석 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

This investigation is about the characteristics of phytoplankton community and physciochemical water quality of specific 6-point the Woon-kog stream system in upsteam of the Andong Lake. DO value was showed over 8.1㎎/L at each site and COD_Mn, BOD, T-N, T-P tend to increase as they stream down and that the existence and dominance of phytoplankton was low and it was difficult to conclude the definite correlation of water quality and phytoplankton community. Finally, it seemed to be desirable that alternatives for pollutional reduction should be made and performed on the basis of the continuous monitoring of the inflow to preserve the Andong Lake.