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( Hua Qi Pan ),( Su Ya Yu ),( Chun Feng Song ),( Nan Wang ),( Hui Ming Hua ),( Jiang Chun Hu ),( Shu Jin Wang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.3
A new actinomycete strain NA4 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antifungal activities against soilborne fungal pathogens. It was identified as Streptomyces cavourensis by morphological, physiological, and phylogenetic analyses based on its 16S rRNA gene sequence. The main antifungal components were isolated and identified from the fermentation culture as bafilomycins B1 and C1. These compounds exhibited significant antifungal activities and a broad antifungal spectrum. The results suggest that the Streptomyces cavourensis NA4 and bafilomycins B1 and C1 could be used as potential biocontrol agents for soilborne fungal diseases of plants.
Hu Ni-juan,Li Chun-hua,Wang Pei,Wu Gui-wen,Ma Liang-xiao,Zhu Jiang 사단법인약침학회 2023 Journal of Acupuncture & Meridian Studies Vol.16 No.1
Background: De qi , the needling sensation, is important in acupuncture treatment. Almost all studies believe that deep needling and manipulation could achieve a significant de qi sensation. However, relatively few studies have examined the effect of psychological factors on de qi, and those that did often reached different conclusions. Objectives: To explore the influence of psychologic factors on de qi in patients with primary dysmenorrhea (PD). Methods: Sixty-eight PD patients with cold and dampness stagnation were randomly allocated to de qi (deep insertion using thick needles, with manipulation, n=17) and non-de qi groups (shallow insertion using thin needles, without manipulation, n=51). Both groups received bilateral needling at Sanyinjiao (SP6) for 30 min. De qi was assessed using the Acupuncture De qi Clinical Assessment Scale (ADCAS). The patients’ acupuncturerelated anxiety and their expectations of the relationship between needle sensation and curative effect were evaluated using a five-point and four-point scale, respectively. Results: Within the de qi group, all patients experienced the de qi sensation, although anxiety levels were unrelated to de qi. Patients’ expectations correlated negatively with de qi timing, and positively with electric sensation. Within the non-de qi group, 59.5% of patients experienced de qi. Between those who experienced it and those who did not, no significant differences were found in anxiety levels, although patients’ expectations differed significantly. Among patients who experienced de qi sensations in the non-de qi group, anxiety and throbbing were positively correlated. Additionally, patients’ expectations correlated positively with de qi intensity, as well as coldness, and numbness. Conclusion: Psychological factors should be considered when studying de qi since PD patients’ expectations could influence the de qi sensation at SP6.
Shu-Hua Yang,Kai-Chiang Yang,Chih-Wei Chen,Ting-Chun Huang,Yuanhui Sun,Ming-Hsiao Hu 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.5
Study Design: In vitro cell culture study. Purpose: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus pulposus (NP)-like phenotype. Overview of Literature: MSCs offer a cell source to the cell-based therapy for intervertebral disc degeneration. TGF-β1 is used to induce MSCs to differentiate into NP-like cells; however, an undesired expression of collagen type I has been reported. Statins reportedly stimulate expression of bone morphogenetic protein-2 (BMP-2) and promote the chondrogenic phenotype to NP cells. However, the effects of statins with or without TGF-β1 on the differentiation of MSCs into NP-like cells remain unclear. Methods: Human MSCs were treated with TGF-β1 alone, lovastatin alone, and simultaneous or sequential treatment with TGF-β1 and lovastatin. After the proposed stimulation, the total RNA was extracted to assess the expression profile of NP cells-specific genes. Hematoxylin–eosin staining was used for examining the microscopic morphology. Furthermore, we detected the syntheses of S-100 protein, aggrecan , and collagen type II in the extracellular matrix using immunohistochemical staining. Results: Simultaneous or sequential treatment of TGF-β1 and lovastatin could further augment the BMP-2 overexpression compared with lovastatin-alone treatment. However, the mRNA expression of aggrecan and collagen type II was not compatible with the expression level of BMP-2 . Immunohistochemical studies revealed compatible production of aggrecan, collagen type II , and S-100 protein in all three groups treated with lovastatin. Cells in groups treated with lovastatin were less populated than that in the group treated with TGF-β1 alone. Conclusions: This study demonstrates a promising role of lovastatin in inducing human MSCs into NP-like cells. However, further optimization of cell density before lovastatin treatment, treatment duration, and combination with TGF-β1 are warranted to attain better stimulatory effects.
An Efficient Multi-PCA Based On-line Monitoring Scheme for Multi-Stages Imperial Smelting Process
Zhi-kun Hu,Zhi-wen Chen,Wei-Hua Gui,Chun-hua Yang,Lin-zi Yin,Xiao-qi Peng 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.2
Imperial Smelting Process (ISP) is one of the main methods for Zinc and Lead smelting. In this paper, we firstly focus on its unique characteristics that ISP consists of many feeding cycles repeated in a similar way, and the normal process changes and multiple operating conditions would be frequently found in the process which would always lead to false alarms. To this end, we classify each feeding cycles of ISP into initial stage, transition stage, and steady stage, and use standard PCA, first order perturbation (FOP) based recursive dynamic PCA and multi-mode approach to deal with them respectively. The monitoring results using real data show that the proposed scheme can be able to eliminate false alarms and detect faults efficiently.
Primary Research on Theoretical Performance and Powder Supply Characteristics of Powder Rocket
Deng, Zhe,Hu, Chun-bo,Hu, Song-qi,Xu, Yi-hua The Society for Aerospace System Engineering 2015 International Journal of Aerospace System Engineer Vol.2 No.2
The powder propellant rocket which uses micron-sized particles as fuel is storable and costly. Functions like thrust control and multiple-ignition can be realized by changing powder mass flow rate. In this paper, we discuss the theoretical performance of bi-propellant and mono-propellant powder rocket. When used as the fluidization gas, helium can improve specific impulse dramatically. The stability of the powder feeding device is preliminarily quantified through metal/N2O powder rocket hot fire tests.
Zhi-kun Hu,Wei-hua Gui,Chun-hua Yang,Peng-cheng Deng,Steven X. Ding 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.4
A new classification method for fault waveform is proposed based on discrete orthogonal wavelet transform (DOWT) and hybrid support vector machine (hybrid SVM) for fault type of a three-phase voltage inverter. The waveforms of output voltage obtained from the faulty inverter are decomposed by DOWT into wavelet coefficient matrices, through which we can obtain singular value vectors acted as features of time-series periodic waveforms. And then a multi-classes classification method based on a new Huffman Tree structure is presented to realize 1-v-r SVM strategy. The extracted features are applied to hybrid SVM for determining fault type. Compared to employing the structure based on ordinary binary tree, the superiority of the proposed SVM method is shown in the success of fault diagnosis because the average Loo-correctness of the SVM based on Huffman tree structure exceed the general SVM 3.65%, and the correctness reaches 99.6%.
Zhi-kun Hu,Wei-hua Gui,Chun-hua Yang,Fei Xu 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
A feature vectors extracting method for similarity measurement between a referenced sequence and an analyzed sequence is proposed. The referenced sequence and analyzed sequence are compressed into two wavelet matrices by Discrete Orthogonal Wavelet Transform (DOWT), respectively. A singular value vector and the multi-subspaces of the referenced matrix are derived from wavelet matrices by singular value decomposition (SVD). Consequently, a uniform subspace of which all sequences are mutual orthogonal can be constructed by serializing multi-subspaces, and the analyzed feature vectors can also be obtained by inner product transformation between analyzed sequence and all sequences derived from the multi-subspaces. The similarity is measured between the analyzed feature vector and the singular value vector of the referenced sequence. The simulation results show that the proposed method is improved in the dimension, accuracy and anti-noise ability with little sensitivity sacrifice.
Fu-Wei Zhao,Min Luo,Yue-Hu Wang,Ma-Lin Li,Gui-Hua Tang,Chun-Lin Long 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11
A new piperidine alkaloid and three known tetranortriterpenoids were isolated from the methanol extracts of the rhizomes of Arisaema decipiens Schott (Araceae) and their chemical structures were identified as (-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl) piperidine (1), 6-deacetylnimbin (2), 28-deoxonimbolide (3) and nimbin (4). The N-methylated derivative (1a) of 1 was synthesized. Compound 1 exhibited weak inhibitory activity against the MCF-7 cell line, while compound 1a showed potential inhibitory activity against the MCF-7 cell line with an IC50 value of 4.6 μM and weak inhibitory activity against K562 and SK-OV-3 cells. This plant in genus Arisaema is firstly reported as the source of limonoids that are considered a natural antitumor herbal medicine.
Yang, Xiao-Li,Zhang, Cheng-Dong,Wu, Hua-Yu,Wu, Yong-Hu,Zhang, Yue-Ning,Qin, Meng-Bin,Wu, Hua,Liu, Xiao-Chun,Lina, Xing,Lu, Shao-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Trichostatin A (TSA) is a histone deacetylase (HDAC) inhibitor. We here investigated its effects on proliferation and apoptosis of the CNE2 carcinoma cell line, and attempted to establish genome-wide DNA methylation alteration due to differentially histone acetylation status. After cells were treated by TSA, the inhibitory rate of cell proliferation was examined with a CCK8 kit, and cell apoptosis was determined by flow cytometry. Compared to control, TSA inhibited CNE2 cell growth and induced apoptosis. Furthermore, TSA was found to induce genome-wide methylation alteration as assessed by genome-wide methylation array. Overall DNA methylation level of cells treated with TSA was higher than in controls. Function and pathway analysis revealed that many genes with methylation alteration were involved in key biological roles, such as apoptosis and cell proliferation. Three genes (DAP3, HSPB1 and CLDN) were independently confirmed by quantitative real-time PCR. Finally, we conclude that TSA inhibits CNE2 cell growth and induces apoptosis in vitro involving genome-wide DNA methylation alteration, so that it has promising application prospects in treatment of NPC in vivo. Although many unreported hypermethylated/hypomethylated genes should be further analyzed and validated, the pointers to new biomarkers and therapeutic strategies in the treatment of NPC should be stressed.