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( Jung-min Shin ),( Soo Jung Kim ),( Xue Mei Li ),( Jin Gwi Yoo ),( Dong-kyun Hong ),( Jin-hyup Lee ),( Chong Won Choi ),( Kyung-duck Park ),( Chang Deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ),( 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Alopecia areata (AA) is a chronic, relapsing hair-loss disorder that is considered to be a T-cell-mediated autoimmune disease. Several animal models for AA have been created to investigate the pathophysiology and screen for effective therapeutic targets. Objectives: As C3H/HeJ mice develop AA spontaneously in a low frequency, a novel animal model is needed to establish an AA-like condition faster and more conveniently. In this study, we present a novel non-invasive AA rodent model that avoids skin or lymph-node cell transfer. Methods: We simply injected C3H/HeJ mice subcutaneously with interferon-gamma (IFNγ) along with polyinosinic:polycytidylic acid (poly[I:C]), a synthetic dsRNA, to initiate innate immunity via inflammasome activation. Results: Approximately 80% of the IFNγ and poly(I:C) co-injected mice showed patchy AA lesions after 8 weeks. None of the mice displayed hair loss in the IFNγ or poly(I:C) solely injection group. Immunohistochemical staining of the AA lesions revealed increased infiltration of CD4+ and CD8+ cells infiltration around the hair follicles. IFNγ and poly(I:C) increased the expression of NLRP3, IL-1b, CXCL9, CXCL10, and CXCL11 in mouse skin. Conclusion: Taken together, these findings indicate a shorter and more convenient means of AA animal model induction and demonstrate that inflammasome-activated innate immunity is important in AA pathogenesis.
( Jung Min Bae ),( Ki-heon Jeong ),( Chong Won Choi ),( Ji Hun Park ),( Hee Jung Lee ),( Hee Jung Kim ),( Sang Hoon Lee ),( Sang Ho Oh ),( Jeonghyun Shin ),( Hee Young Kang ),( Weon Ju Lee ),( Hyun Je 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Vitiligo remains a major challenge in dermatology. However, much of the treatment remains unclear, because little evidence is available. Objectives: To answer some critical questions pertaining to management of vitiligo patients. Methods: A modified Delphi process among 31 vitiligo experts was conducted. A total of 12 clinical vitiligo treatment questions without clear answers were collected via a vote. To address each question, two members performed systematic literature reviews and prepared draft statements along with the levels of evidence and strength of recommendation. After reviewing the draft, all expressed their extent of agreement from 1 (strong disagreement) to 9 (strong agreement) for each item. The drafts were revised to reflect suggested comments. Voting continued until the agreement rate did not change. Results: The consensus process was completed after five rounds. We identified the best answers to 12 key questions, including issues on long-term phototherapy, systemic and topical corticosteroids, topical calcineurin inhibitors, immunosuppressants, excimer laser treatment, and surgical interventions. Conclusion: This consensus would complement current guidelines and aid both physician and patient decisionmaking in the treatment of vitiligo.
Four-week Repeated Dose Toxicity Test for Myelophil in SD Rats
Jung, Jong-Mi,Shin, Jang-Woo,Son, Jin-Young,Seong, Nak-Won,Seo, Dong-Seok,Cho, Jung-Hyo,Cho, Chong-Kwan,Son, Chang-Gue The Society of Korean Medicine 2009 대한한의학회지 Vol.30 No.3
Aim : To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats. Methods : Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis. Results : No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil. Conclusion : Myelophil should be very safe when used in a clinical application with a wide therapeutic index.
Case Report : High-Dose Fentanyl Patch for Cancer Pain of a Patient with Cholangiocarcinoma
( Jung Han Kim ),( Mi Kim ),( Chong Won Sung ),( Hyeoung Su Kim ),( Hyun Joo Jang ),( Young Chul Shin ),( Joo Young Jung ) 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.3
We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain. A 52-year-old man was referred to our hospital because of severe cancer pain that was 7/10 on a numeric rating scale (NRS). He had been diagnosed with locally advanced cholangiocarcinoma 3 months previously. We prescribed weak opioids and an antidepressant, but his pain was not relieved. We introduced strong opioids (transdermal fentanyl patches for the background pain and a short-acting opioid for the breakthrough pain) and his pain was tolerable on 250 ㎍/hr of fentanyl patches for 3 months. With time, however, his pain intensity became worse and this reached up to 8/10 to 9/10 on the NRS. Percutaneous transhepatic biliary drainage was performed, which did not relieve his pain. We increased gradually the dose of transdermal fentanyl to 1,050 ㎍/hr (20 patches). At this dose, the patient was mentally alert, with good pain control (NRS 2/10 to 3/10) and no exacerbation of side effects. To the best of our knowledge, we report here on the highest dose of transdermal fentanyl that has been successfully used for treating a patient suffering from visceral cancer pain. (Korean J Intern Med 2010;25:337-340)
A case of generalized granuloma annulare following BCG vaccination
( Jung-woo Ko ),( Dong-kyun Hong ),( Kyung-duck Park ),( Chong Won Choi ),( Young Lee ),( Young-joon Seo ),( Jeung-hoon Lee ),( Jin-hyup Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Generalized granuloma annulare (GGA) is a rare benign granulomatous dermatosis characterized by disseminated dermal papules forming an annular or nonannular configuration. Clinical associations between generalized granuloma annulare and diabetes mellitus, thyroid disease, malignancy, infection, and vaccination have been reported. A 2-month-old girl presented with a month history of multiple erythematous papules on the whole body. She had received a Bacillus Calmette-Guerin (BCG) on the left upper arm 1 month prior. Histopathological examination revealed degenerated collagen bundles surrounded by a wall of palisaded histiocytes in the dermis. All skin lesions were resolved after 2 weeks without any specific treatment. The BCG vaccine contains a live, attenuated strain of bovine tuberculin bacteria Mycobacterium bovis. Skin complications caused by BCG vaccination vary from local reactions to disseminated BCG infections. Our observation expands the spectrum of skin reactions associated with BCG vaccination.
Comparative proteomic analysis of human follicular dermal papilla cells and fibroblasts
Chong Hyun Won,Chae Hwa Kim,Oh Sang Kwon,Yong Jung Kang,Jeon Hae Chan,Hyeon Gyeong Yoo,Jin Ho Chung,Kyu Han Kim,Hee Chul Eun,Kun Cho,Jong Soon Choi,Won Seok Park,Nok Hyun Park 대한피부과학회 2009 대한피부과학회 학술발표대회집 Vol.61 No.2