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Yun, Seok Joong,Jeong, Pildu,Kang, Ho Won,Kim, Ye-Hwan,Kim, Eun-Ah,Yan, Chunri,Choi, Young-Ki,Kim, Dongho,Kim, Jung Min,Kim, Seon-Kyu,Kim, Seon-Young,Kim, Sang Tae,Kim, Won Tae,Lee, Ok-Jun,Koh, Gou-Yo Korean Continence Society 2015 International Neurourology Journal Vol.19 No.2
<P><B>Purpose:</B></P><P>MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The aim of the study was to identify and validate urinary cell-free miRNAs that can segregate patients with PCa from those with BPH. </P><P><B>Methods:</B></P><P>In total, 1,052 urine, 150 serum, and 150 prostate tissue samples from patients with PCa or BPH were used in the study. A urine-based miRNA microarray analysis suggested the presence of differentially expressed urinary miRNAs in patients with PCa, and these were further validated in three independent PCa cohorts, using a quantitative reverse transcriptionpolymerase chain reaction analysis. </P><P><B>Results:</B></P><P>The expression levels of hsa-miR-615-3p, hsv1-miR-H18, hsv2-miR-H9-5p, and hsa-miR-4316 were significantly higher in urine samples of patients with PCa than in those of BPH controls. In particular, herpes simplex virus (hsv)-derived hsv1-miR-H18 and hsv2-miR-H9-5p showed better diagnostic performance than did the serum prostate-specific antigen (PSA) test for patients in the PSA gray zone. Furthermore, a combination of urinary hsv2-miR-H9-5p with serum PSA showed high sensitivity and specificity, providing a potential clinical benefit by reducing unnecessary biopsies. </P><P><B>Conclusions:</B></P><P>Our findings showed that hsv-encoded hsv1-miR-H18 and hsv2-miR-H9-5p are significantly associated with PCa and can facilitate early diagnosis of PCa for patients within the serum PSA gray zone.</P>
Seon-Cheol Park,Miyoung Choi,Jin A Choi,Eunjung Park,Ha Jin Tchoe,Jae Kyung Suh,Young Hoon Kim,Seunghee Won,Young-Chul Chung,Kyung-Yeol Bae,Sang-Kyu Lee,Chan Mi Park,이승환 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4
We aimed to compare the efficacy and safety of long-acting injectable (LAI) and oral second-generation antipsychotics (SGAs) in treating schizophrenia by performing a systematic review and meta-analysis. MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library, as well as five Korean databases, were systemically searched to identify studies published from 2000 to 16 April 2015, which compared the efficacy and safety of LAI and oral SGAs. Using data from randomized controlled trials (RCTs), meta-analyses were conducted. In addition, the GRADE (the Grading of Recommendations, Assessment, Development and Evaluation) approach was applied to explicitly assess the quality of the evidence. A total of 30 studies including 17 RCTs and 13 observational studies were selected. The group treated with LAI SGAs was characterized by significantly lower relapse rates, longer times to relapse and fewer hospital days, but also by a higher occurrence of extrapyramidal syndrome and prolactin-related symptoms than that in the group treated with oral SGAs. Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin-related symptoms. Additionally, the use of LAI SGAs should be combined with appropriate measures to reduce dopamine D2 antagonism-related symptoms.
Kim, Sang-Joon,Choi, Seon-Jin,Jang, Ji-Soo,Cho, Hee-Jin,Koo, Won-Tae,Tuller, Harry L.,Kim, Il-Doo Wiley - VCH Verlag GmbH & Co. KGaA 2017 Advanced Materials Vol.29 No.36
<P>Achieving an improved understanding of catalyst properties, with ability to predict new catalytic materials, is key to overcoming the inherent limitations of metal oxide based gas sensors associated with rather low sensitivity and selectivity, particularly under highly humid conditions. This study introduces newly designed bimetallic nanoparticles (NPs) employing bimetallic Pt-based NPs (PtM, where M = Pd, Rh, and Ni) via a protein encapsulating route supported on mesoporous WO3 nanofibers. These structures demonstrate unprecedented sensing performance for detecting target biomarkers (even at p.p.b. levels) in highly humid exhaled breath. Sensor arrays are further employed to enable pattern recognition capable of discriminating between simulated biomarkers and controlled breath. The results provide a new class of multicomponent catalytic materials, demonstrating potential for achieving reliable breath analysis sensing.</P>
Kim, Ji-Hoon,Song, Chang Eun,Shin, Nara,Kang, Hyunbum,Wood, Sebastian,Kang, In-Nam,Kim, Bumjoon J.,Kim, BongSoo,Kim, Ji-Seon,Shin, Won Suk,Hwang, Do-Hoon American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.24
<P>Two semiconducting conjugated polymers were synthesized via Stille polymerization. The structures combined unsubstituted or (triisopropylsilyl)ethynyl (TIPS)-substituted 2,6-bis(trimethylstannyl)benzo[1,2-<I>b</I>:4.5-<I>b</I>′]dithiophene (BDT) as a donor unit and benzotriazole with a symmetrically branched alkyl side chain (DTBTz) as an acceptor unit. We investigated the effects of the different BDT moieties on the optical, electrochemical, and photovoltaic properties of the polymers and the film crystallinities and carrier mobilities. The optical-band-gap energies were measured to be 1.97 and 1.95 eV for PBDT-DTBTz and PTIPSBDT-DTBTz, respectively. Bulk heterojunction photovoltaic devices were fabricated and power conversion efficiencies of 5.5% and 2.9% were found for the PTIPSBDT-DTBTz- and PBDT-DTBTz-based devices, respectively. This difference was explained by the more optimal morphology and higher carrier mobility in the PTIPSBDT-DTBTz-based devices. This work demonstrates that, under the appropriate processing conditions, TIPS groups can change the molecular ordering and lower the highest occupied molecular orbital level, providing the potential for improved solar cell performance.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-24/am401926h/production/images/medium/am-2013-01926h_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am401926h'>ACS Electronic Supporting Info</A></P>
Non‐Volatile Control of 2DEG Conductivity at Oxide Interfaces
Kim, Shin‐,Ik,Kim, Dai‐,Hong,Kim, Yoonjung,Moon, Seon Young,Kang, Min‐,Gyu,Choi, Jong Kwon,Jang, Ho Won,Kim, Seong Keun,Choi, Ji‐,Won,Yoon, Seok‐,Jin,Chang, Hye Jung,Kang WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.33
<P><B>The functionalization of two‐dimensional electron gas (2DEG) at oxide interfaces</B> can be realized integrating 2DEG with multifunctional oxide overlayers by epitaxial growth. Using a ferroelectric Pb(Zr<SUB>0.2</SUB>Ti<SUB>0.8</SUB>)O<SUB>3</SUB> overlayer on 2DEG (LaAlO<SUB>3</SUB>/SrTiO<SUB>3</SUB>), we demonstrate a model system of the functionalized 2DEG, where electrical conductivity of 2DEG can be reversibly controlled with a large on/off ratio (>1000) in a non‐volatile way by ferroelectric polarization switching.</P>