한국노인약물역학코호트에서 폐암 발생률, 사망률 및 생존율, 1994-1998

최남경,윤경은,허대석,김윤이,이승미,박병주 한국역학회 2002 Epidemiology and Health Vol.24 No.2

Purpose : This study was conducted to estimate incidence, mortality and survival rate of lung cancer in the elderly people in Korea. Methods : Study population was Korean Elderly Phamacoepidemiologic Cohort (KEPEC). The lung cancer incidence cases were detected from three different sources, medical utilization database of the Korea Medical Insurance Corporation (KMIC), the database from the National Cancer Registry, and the database from the Regional Cancer Registry. The hospital survey to confirm the final diagnosis of the potential cases was conducted. A specialist on lung cancer reviewed the abstracted data to confirm the final diagnoses. The lung cancer death cases were detected from the mortality database at National Statistical Office. Incidence rate, survival rate and mortality rate of lung cancer and their 95% confidence intervals were estimated with SAS Window ver.8.1. Results : There were 213 confirmed lung cancer cases in KEPEC between Jan. 1994 and Dec. 1998. Age-standardized incidence rate of lung cancer to the Korean population was estimated to be 316.9 per 100,000 person-years in male and 65.2 per 100,000 person-years in female. Age-standardized mortality rate of lung cancer to the Korean population was estimated to be 342.3 per 100,000 person-years in male and 84.8 per 100,000 person-years in female. One years survival rate was 17% in male and 11% in female. Two year survival rate was 2% in male and 4% in female. Conclusion : Age-standardized incidence rate, age-standardized mortality rate and survival rate of lung cancer in the elderly Korean may be useful for further study and making health policy for managing lung cancer in the elderly.

위성 ATM망에 적합한 응용서비스 모형 개발

최명수,박남철,박형준,김경호,이성로 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-

The use of the Internet is much increased and the multimedia data such as voice and image should be processed in the Internet. The required characteristics of the communication networks for the 21-st century Internet are the fusion between communications and broadcasting, high speed, large capacity, high intelligence, and personalization. In realizing the characteristics mentioned above, the ATM is the only technique that can practically guarantee QoS and is the core technique in super high-speed service networks. In this paper, we will investigate the international study of the high-speed the satellite communication and then research plans for developing and providing optimum application services.

4세대 이동 멀티미디어 시스템의 연구동향 분석

최명수,박형준,박남철,김경호,이성로 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-

In this paper, we first define 4th-generation multimedia systems that play an important role in 21C information society. Nest, we investigate and analyze the international trend of the related research and then predict the evolutionary model for 155Mbps wireless mobile multimedia systems.

자궁외 임신의 임상적 고찰

최경남,정두용 건국대학교 1995 學術誌 Vol.39 No.2

This study was undertaken to evaluate the clinical characteristics of the 80 women with ectopic pregnancies who were admitted to and treated at the department of Obstetrics and Gynecology, Konkuk University Hospital from January 1,1992 to October 31,1994. The main results were as follows . The incidence of ectopic pregnancy was one in thirty-nine deliveries(80/3097). The most frequent age group was in 30∼34 years of ages. According to age distribution, the incidence of ectopic pregnancy was highest(45.5%) in 40-44 age group. 33.7% of patients were nulliparas and, 70% of patients experienced artificial abortion. According to the past history, pelvic inflammatory disease was in 23.8%, laparoscopic tubal ligation was in 21.1% and previous operation was in 38.8%. On symptomatological analysis, lower abdominal pain was encountered in 95%, vaginal spotting or bleeding in 70%. The most frequent interval between last menstrual period and the onset of symptom was 7∼8 weeks in 58.8%. Hemoglobin value over 10.0 mg/dl was 77.5%, and below 7.0 gm/dl was 1.3%. Ectopic pregnancy was implanted on ampulla portion of tube in 91.3%, and 88.8% was ruptured. Urine hCG test was positive in 96.3% and culdocentesis was positive In 98.7%. Estimated blood loss into peritoneal cavity was less than 500 ml in 56.3% and 1500 ml or more in 2.5%. 46.3% of all cases were transfused.76.2% of ectopic pregnancies were treated by salpingectomy. Key word : Ectopic pregnancy

알코올 의존 환자의 의사 결정에서의 보속적인 경향

김남욱,구정훈,이은,최유경,정영철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : The relationship between substance dependence and poor decision making has received much attention inrecent years. This study aimed to test the hypothesis that alcohol dependent subjects would demonstrate a more perseverative decision-making pattem, during ambiguous situations. Methods : 15 alcohol dependent patients and 15 healthy normal controls performed a novel computerized decision-making task, which presented figures of coins. The subjects were instructed to guess whether the total number of coins was 'odd' or' even'. Besides these two response, one could select a third altemative - 'pass' - in case the chances were assumed to be low. Results : There was significant difference in performance between the two groups (F=4.339, P=0.008). The control groupgained 15.4±14.4 points, whereas the alcohol dependent group lost 0.6±5.3 points. The normal control group demonstrated a tendency to make more pass responses as the trials were repeated. In contrast, the alcohol dependent group didn't make use of the altemative, but kept challenging between 'odd' and 'even', although they sensed that the chances were low. Conclusion : The alcohol dependent patients demonstrated a more rigid and perseverative response pattem and showed deficits in making use of compromise altematives.

다차원 신호모형 해석을 통한 DOA 추정기법

박남철,최명수,박형준,김경호,이성로 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-

The Location-Informing service is based on the GPS data from the satellite. Until now, the service has been free. However, it may become charged. Therefore, we research the methods that can find the location-information using the antennas in future mobile communication systems and investigate the signal arrival direction estimation methods with considering practical environments.

국내에서 분리된 Vancomycin 내성 장구균에 대한 분자역학적 연구

김수정,이남용,배직현,이경원,이위교,김의종,최명식,백경란,김성민,송재훈 대한감염학회 1998 감염 Vol.30 No.1

목 적 : 장구균은 병원 감염의 원인균으로서 최근 그 빈도와 중요성이 증가하고 있다. 특히 vancomycin에 내성을 보이는 장구균(VRE)은 효과적인 치료약제가 드물고, 그 내성 유전자가 vancomycin에 감수성을 보이는 다른 장구균이나 그람양성 구균에 전달될 수 있어 임상적인 중요도가 더욱 크다. 본 연구에서는 국내 5개 병원에서 분리된 VRE 균주의 표현형과 유전형을 결정하고, 분자역학적 방법을 이용하여 유전적 연관성 여부를 밝히고자 하였다. 방 법 : 각 병원에서 수집된 균주는 환자의 임상 검체에서 또는 VRE 집락화에 대한 선별검사에서 분리된 균주였다. 이들을 대상으로 vancomycin과 teicoplanin의 MIC를 측정하여 표현형을 결정하였으며, PCR로 vancomycin 내성 유전자를 증폭하여 유전형을 결정하였다. 또한 이들중 vanA와 vanB 유전자를 갖는 균주들을 대상으로 플라스미드 분석과 PFGE를 시행하였다. 결 과 : VRE로 최종 동정된 균주들은 42균주(E. faecium 21주, E. faecalis 6주, E. avium 2주, E. casseliflavus 13주)였으며, 항균제 감수성 양상으로 결정한 표현형은 VanA, VanB, VanC형이 각각 14주(33%), 7주(17%), 21주(50%)였다. PCR로 결정한 유전형은 vanA 12주(E. faecium), vanC 16주 였으며, 이중 VanA의 표현형을 보인 E. faecium 2주가 VanB의 유전형으로 판명된 것을 제외하면 표현형과 유전형은 모두 일치하였다. 플라스미드 분석과 PFGE 결과, 병원내 동일 균주의 전파 가능성이 5개 병원중 3병원에서 증명되었다. 결 론 : 국내 병원에서도 vancomycin 내성 유전자를 갖는 VRE가 다수 분리되고 있음을 확인할 수 있었으며, 연구 결과 일부 병원에서 내성균주의 병원내 전파 가능성을 시사하였다. 아직까지 국내에서 VRE로 인한 감여보고는 적지만 곧 임상적으로 문제가 될 것으로 판단되며, 따러서 내성균의 발생이나 확산을 억제하기 위한 노력과 감시가 필요할 것으로 생각된다. Background : Enterococci have emerged in recent years as a frequent cause of life-threatening nosocomial infections. The emergence of vancomycin-resistant enterococci(VRE) presents as an increasingly important problem particularly in the treatment and the potential dissemination of vancomycin-resistance. The purpose of this study is to determine the phenotypes and genotypes of VRE isolated from five hospitals and to study the genetic relatedness among them. Methods : Antimicrobial susceptibility patterns and amplification of vancomycin resistance genes were used for phenotyping and genotyping of 42 VRE isolates respectively. For 21 isolates with vanA or vanB gene, plasmid profiles and pulsed field gel electrophoresis(PFGE) patterns were analyzed for molecular epidemiologic study. Results : Out of 42 isolates, 21 were identified as E. faecium, 6 as E. faecalis, 2 as E. avium, and 13 as E. casseliflavus. Phenotyping showed 14 isolates as VanA(33%), 7 as VanB(17%) and 21 as VanC(50%). Genotyping resulted in 12 isolates as VanV(5 of E. faecalis and 7 of e. faecium) and 9 as VanB(all E. faecium). Genotyping results were concordant with phenotyping results except for the two E. faecium isolates of VanA which had VanB genotype. Intrahospital spread of the same strains was proven in three hospitals by plasmid profiles and PFGE analysis. Conclusion : The study demonstrated a considerable number of VRE isolates in Korea and intrahospital spread proven by molecular epidemiologic methods. Although VRE infection has been considered very are in Korea, practical guidelines including restriction of vancomycin usage and surveillance, are warranted to prevent infection and dissemination of VRE.

HFC-134a와 대체냉매 HFC-152a에 CF_3I를 혼합한 자동차냉매 특성

권일욱,박찬수,홍경한,문기선,최운수,서의경,윤갑식,이종인,하옥남 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

These days, an attention of environment has been increasing all over the world. to prevent the green house effect and destruction of an ozone layer, an ozone destruction potential(ODP) be zero and a refrigerant for low global warming potential(GWP) is needed. HFC-134a, in which hydrogen is mixed instead of chlorine is a refrigerant used for automobile conditioners and its destruction potential is ecologically zero. However, it is not considered as a perfect substitutive refrigerant as its GWP is high. It is studied refrigerant mixtures in which HFC-134a, HFC-152a and CF_3I with low GWP and zero ODP are mixed by experimentally and concluded as follows; 1. with the variation of speed of compressor outside temperature and flow rate, the heat of evaporator and compressor and coefficient of performance was varied, and influenced the air conditioner. 2. The pressure of evaporator was decreased with increasing the speed of compressor and that of the refrigerant HFC-134a was higher 21% than that of azotrope refrigerant mixed with CF_3I. The overall capacity of condensor and evaporator was increased and HGC-134a was higher than azotrope refrigerant mixed with CF_3I 3. The capacity of evaporator with the refrigerant HFC-134a was higher 6% than azotrope refrigerant mixed with CF31 and the required power with zaotrope refrigerant mixed with CF_3I was higher 11% than that of HFC-134a. 4. The COP of the refrigerant FHC-134a was higher 31% in 1000RPM. when outside temperature was increased, COP was decreased. 5. Performance of HFC-134a is better than azotrope refrigerant mixed with CF_3I but prefered zaotrope refrigerant mixed with CF_3I considering the environment.

Real-world Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Newly Treated Korean Patients With Asthma: A Retrospective Cohort Study

Choi Nam-Kyong,Shantakumar Sumitra,Kim Mi-Sook,Lee Chang-Hoon,Cheng Wendy Y,Bobbili Priyanka,Yang Bo Ram,Lee Joongyub,Hinds David,Duh Mei Sheng,Korves Caroline,Park Heung-Woo 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.2

Purpose: Although asthma treatment guidelines recommend regular inhaled medication, real-world treatment patterns and outcomes in South Korea have not been examined. We examined real-world treatment patterns and outcomes among patients treated for asthma in South Korea. Methods: This retrospective cohort study utilized data from the South Korean National Health Insurance database (2013–2016). Newly treated patients with asthma aged ≥18 years without history of chronic obstructive pulmonary disease were included. Initial and maintenance medication prescriptions were examined. Treatment discontinuation and switch were described. Asthma exacerbation rates, poor asthma control, and healthcare resource utilization (HRU) were compared between maintenance treatment groups (inhaled versus oral) using adjusted incidence rate ratios (aIRR) and hazard ratios (aHR). Results: Overall, 1,054,707 patients initiated any asthma medication; 37,868 patients initiated inhaled (n = 9,983, 26.4%) or oral (n = 27,885, 73.6%) maintenance medication. More patients initiating inhaled versus oral asthma medication discontinued treatment within 12 months (94.4% vs. 86.3%; P < 0.0001). Patients treated with inhaled and oral medication switched treatment (2.5% and 2.3%; P = 0.4160, respectively). Patients initiating inhaled medication had significantly lower rates of asthma exacerbation (aIRR, 0.52; 95% CI, 0.39–0.69), lack of asthma control (aHR, 0.55; 95% CI, 0.48–0.62; P < 0.0001), all-cause and asthma-related HRU versus oral medication. Conclusions: Despite current asthma guidelines, more patients in South Korea were prescribed oral than inhaled medications, resulting in suboptimal asthma management and increased HRU. This study highlights the need to reduce oral corticosteroid prescriptions for optimized treatment in asthma management.

Increase in Mortality Rate Following Coprescription of Cisapride and Contraindicated Drugs

Choi, Nam-Kyong,Hahn, Seokyung,Park, Byung-Joo Harvey Whitney Books Company 2007 The Annals of Pharmacotherapy Vol.41 No.4

<P>BACKGROUND: No epidemiologic study, as of this writing, has been published on the use of cisapride with contraindicated drugs and its relation to mortality rates in a population-based setting. OBJECTIVE: To estimate the prevalence of concomitant use of cisapride with contraindicated drugs and evaluate the association between this and the risk of mortality. METHODS: Claims data were obtained from the Health Insurance Review Agency of Korea. The study population consisted of patients younger than 85 years who visited clinics or hospitals in the city of Busan as new users of cisapride between November 1, 2000, and April 30, 2002. The coprescription of cisapride was defined as prescribing cisapride with one or more contraindicated drugs with the same prescription. Nationwide mortality data were also used. The prevalence of coprescribing cisapride was estimated and the association between this and the risk of mortality was assessed by rate ratios (RRs). The RRs were estimated using Cox's regression model with time-dependent covariate, adjusted for age, sex, and comorbidities. RESULTS: A total of 36,865 patients out of 56,012 claims were newly prescribed cisapride; of these, 1175 patients (3.2%) were concomitantly prescribed at least one contraindicated drug, which suggested adjusted mortality RRs of 14.08 (95% CI 7.41 to 26.76) for recent users and 1.33 (95% CI 0.92 to 1.93) for past users of cisapride. CONCLUSIONS: Despite the discontinuation of the drug's commercial marketing, cisapride was still in use in clinics and hospitals in Busan. In many cases, cisapride was co-prescribed with contraindicated drugs, which is associated with increased mortality rates.</P>