야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

흰쥐 視床下部 神經細胞의 [met]^(G4635)-enkephalin과 Oxytocin 同所存在性에 關한 免疫組織化學的 硏究

李永植,李永基,張家鏞,趙斗英 서울醫大 1990 精神醫學 Vol.15 No.2

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

블리스터 시험법을 이용한 열증착 금박막의 기계적 성질 측정

문호정,함순식,엄윤용,조영호,Moon, Ho-Jeong,Ham, Soon-Sik,Earmme, Yun-Young,Cho, Young-Ho 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.3

Mechanical properties, including Young's modulus, residual stress and rupture strength, of a thermally evaporated gold film have been measured form a blister test. In a theoretical study, the priniple of minimum potential energy and that of virtual work have been applied to the pressurized circular membrane problem, and load-deflection relations have been derived for typical membrane deflection mode of spheroidal shape. In an experimental study, circular gold membranes of 4800 A-thickness and 3.5mm diameter were fabricated by the silicon electropolishing technique. Mecahnical properties of the thin gold films were deduced from the load-deflection curves obtained by the blister test, Young's moduli, obtianed from blister test, have been in the range of 45-70 GPa, while those of bulk gold have been in the range of 78-80 GPa. Residual stresses in the evaporated gold films have been measured as 28-110MPa in tension, The rupture strength of the gold film has turned out to be almost equal to that of dental gold alloy (310-380MPa). It has been demonstrated that the present specimen fabrication method and blister test apparatus have been effective for simultaneous measurement of Young's modulus, residual stress and repture strength of thin solid films. Especially, the electropolishing technique employed here has provided a simple and practical way to fabricate thin membranes in a circular or an arbitrary shape, which could not be obtained by the conventional anisotropic silicon mecromachining technique.

브랜드 개성이 브랜드 애착을 통해 구매의도에 미치는 영향에 관한 연구 : 화장품 브랜드 SK-II, ESTEE LAUDER, LANCOME을 중심으로

조영식;김준석 경희대학교 산업관계연구소 2011 産硏論叢 Vol.36 No.-

본 연구는 수입 화장품 브랜드가 가지는 브랜드 개성이 소비자와의 관계에 있어서 어떻게 그 브랜드 애착을 형성을 하는지와 브랜드 애착을 통해서 구매의도에 미치는 영향에 대해 실증적으로 조사하는데 그 목적이 있다. 연구를 위하여 각 화장품 브랜드 SK-II, ESTEE LAUDER, LANCOME 에 대해 총 270명을 대상으로 설문 조사를 진행하였다. 다중회귀 모형 분석에 의한 실증 분석 결과 첫째, SK-II와 ESTEE LAUDER의 브랜드 개성이 브랜드 애착에 대한 태도는 정(+)의 영향을 미치는 것으로 나타났다. LANCOME 은 유의미한 효과에만 미치는 것으로 나타났다. 둘째, 브랜드 애착이 구매의도에 대한 태도에는 SK-II, ESTEE LAUDER, LANCOME 모두 정(+)의 영향을 미치는 것으로 나타났다. 이러한 연구 결과는 브랜드 개성이 브랜드 애착관계를 통해서 구매의도에 영향을 줄 수 있다는 것에 의의를 찾을 수 있으며 향후 브랜드 개성이 기업 자산 가치의 성장에 중요한 영향을 주는 요소가 된다는 점과 브랜드 애착을 위해 브랜드 커뮤니케이션의 역시 고려되어야 할 중요한 요소임을 시사한다. The purpose of this research is empirically to investigate for How imported cosmetic brand personality establishes brand attachment with consumers and how the brand attachment influences toward purchase intention. In order to accomplish the purpose, the data was collected by total 270 peoples for SK-II, ESTEE LAUDER, LANCOME in cosmetic brand. Firstly, In terms of the attitude of brand personality toward brand attachment, SK-II and ESTEE LAUDER has shown positive result via multiple regression analysis. but LANCOME only determines to meaningful effect, as affect. Secondly, the brand personality toward the purchase intention, SK-II, ESTEE LAUDER and LANCOME all influenced to the effect of positive. Results of this study show that the impact of purchase intention through the strong linkage between brand personality and brand attachment. In addition, brand personality would be the critical factor or growth engine of the value of the company's assets therefore we need to closely monitor brand communication in order to manage brand attachment.

광장공포증 동반유무에 따른 공황장애의 임상적 차이 연구

조주연,이길홍,이영식 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

To investigate certain differences in sociodemographic characteristics and clinical feature between panic disorder with agoraphobic patients and panic disorder without agoraphobic ones, this study was done. The subjects were 46 panic patients(27 were agoraphobic patients and 19 were without agoraphobic ones). Data was processed by computer using SAS program and was statisticaly analysed by Fisher's exact test, t-test Wilcoxon rank sum test. The results were as follows: 1) Agoraphobic group had more family pathology than without agoraphobic group. 2) Agoraphobic group had more frequent panic attack episodes and more severe step of panic disorder than without agoraphobic group. 3) In both group, the most frequent manifestation of panic symptom was palpitation. 4) IN comparison of two groups, the only symptom that were significantly different was dyspnea.

미역 폐기물의 중금속 흡탈착 특성

조주식,박일남,허종수,이영석 한국환경농학회 2004 한국환경농학회지 Vol.23 No.2

본 연구에서는 생물흡착제인 미역을 사용하여 인공폐액 내의 중금속의 흡착 특성을 조사하였으며, 다음과 같은 결론을 얻었다. 미역 폐기물을 이용하여 제조된 생물흡착제의 단일 중금속 흡착효율은 각 중금속 100 mg/L인 용액에 biosorbent 3 g을 처리했을 때 Pb는 거의 100%였고 Cu와 Cd가 약 85~86% Zn과 Cr은 약 60~64%, Co와 Ni은 약 57%, Mn은 약 48%였다. 복합중금속 흡착효율은 단일중금속 흡착효율에 비하여 Pb를 제외한 다른 중금속들은 크게 감소되었으나 biosorbent g당 전체 중금속 흡착량은 더 증가되었다. 온도, pH에 따른 중금속 흡착효율은 별 차이가 없었으며 전반적으로 pH는 pH 5~6 범위, 온도는 20~30℃ 범위의 실온이 적당한 것으로 나타났다. 생물흡착제의 흡착평형은 모든 중금속이 1시간 이내에 이루어졌다. Freundlich와 Langmuir 등온흡착식을 구하여 실제 폐수처리에 적용여부를 검토한 결과 Pb, Cu, Cr, Cd, Co 순으로 비교적 친화도가 큰 것으로 나타났다. Freundlich 등온흡착식에 가장 잘 일치하였다. 모든 중금속의 Freondlich 지수 1/n값이 0.1~0.5 범위에 포함되어 흡착이 용이하고, Pb, Cr, Cu, Cd 순으로 비교적 평형 흡착량이 큰 것으로 나타났으며, 이 결과는 Langmuir 흡착등온식의 결과와 거의 유사하였다. 따라서, 중금속 농도범위에 따른 한계범위를 설정하여 등온흡착식을 적용시키면 매우 높은 중금속 처리효율을 나타낼 것으로 판단된다. 생물흡착제가 중금속 흡착 후의 구조적인 특성을 조사하기 위하여 FT-IR 분석 결과, 중금속 이온과 치환될 것으로 생각되는 functional group을 확인할 수 있었으며, 3,400/cm에서의 -OH group, 1,648/cm에서의 C=O bond, 1,426/cm에서의 C-O bond 그리고 850/cm에서의 S=O등이 전반적으로 중금속 흡착 후에 peak가 커지는 것이 관찰되었다. 생물흡착제의 재사용 가능성을 검토하기 위하여 최적의 중금속 탈착조건 검토하였는데, 탈착제 종류에 따른 중금속 탈착효율은 탈착제 종류와 중금속 종류에 따라 차이가 있었고, 전반적으로 NTA>H₂SO₄>HCl>EDTA 순으로 우수하였으며, 전체적으로 특정 중금속의 탈착효율이 떨어지지 않는 NTA가 탈착제로 가장 적합하였다. NTA농도에 따른 중금속 탈착효율은 NTA 0.1~0.3% 농도범위에서는 농도 증가에 따라 탈착효율도 약간 증가되었으나 그 이상의 농도에서는 별 차이 없었다. 온도와 pH 변화에 따른 중금속 탈착효율은 Cr을 제외한 다른 중금속들은 크게 영향을 받지 않는 것으로 나타났으며 전반적으로 온도는 30℃, pH는 2에서 높았다. 탈착제 접촉 반응시간에 따른 탈착효율은 10분 이내에 전체 탈착량의 80%이상이 탈착 되었으며 1시간 이후에는 거의 변화가 없었다. The adsorption and desorption of Pb, Cd, Co, Zn, Cr, Co, Ni, and Mo on the waste Undaria sp. were studied. Except for Pb, the mono adsorption rate for all heavy metals were lower than that of the heavy metals mixed. However, the adsorption capacity of the heavy metals by 1 g of biosorbent in mixed heavy metals increased. According to FT-IR analysis of the biosorbent after heavy metal biosorption, the replacement of the functional group by the heavy metals ions could be confirmed and the inverted peaks became larger after heavy metals adsorption. The adsorption equilibrium of heavy metals was reached in about 1 hour. The equilibrium parameters were determined based on Langmuir and Freundlich isotherms. The affinity of metals on the biosorbent decreased in the following order: Pb>Cu>Cr>Cd>Co. The desorption rate decreased in the following sequence: NTA>H₂SO₄>HCl>EDTA. The desorption rate of heavy metals by NTA increased with increase in the concentration from 0.1 to 0.3% but the desorption rate became constant beyond 0.3%. Therefore, it represented that desorption rate of heavy metals was suitable under optimized condition (30℃, pH 2 and 0.3% NTA solution) and was fast with 80% or more the uptake occurring within 10 min of contact time.

MSGC형 센서를 위한 제어시스템 및 영상 획득 S/W 개발

조진호,진경찬,채승표,박영식,김명남 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-