용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

혈관 생성 억제 제를 투여한 신생마우스 폐 조직에서 Retinoic acid의 세포자멸사의 억제

주선영 ( Sun Young Ju ),조경아 ( Kyoung Ah Cho ),유경하 ( Kyung Ha Ryu ),우소연 ( So Youn Woo ),박은애 ( Eun Ae Park ),조수진 ( Su Jin Cho ) 대한주산의학회 2008 Perinatology Vol.19 No.1

목적: Retinoic acid는 폐포 재생에 중요한 역할을 하는 것으로 알려져 있어서 미숙아의 기관지폐이형성중의 예방에 사용되고 있다. 기관지폐이형성중의 병태생리는 미숙한 폐의 내피세포와 외피세포의 세포자멸사를 일으킴과 관련이 있다. 이에 본 연구에서 VEGFR2 억제가 신생 폐에서 세포자멸사를 증가시키는지, 또 retinoic acid의 투여가 본 폐 발달 억제 동물모형에서 세포자멸사를 억제하는지 알아보고자 하였다. 방법: VEGFR2 억제제인 SU1498을 생후3일된 마우스에 주사하고, 폐포발달이 이루어지는 그 후 10일간 retinoic acid나 위약을 주사하였다. 형태학적인 분석을 하였고, 세표자멸사를 비교분석하기 위해서 TUNEL 염색과 Annexin V을 표지자로 FACS출 시행하였다. 자멸사한 세포를 확인하기 위해서 동일초점 현미경으로 분석하였다. 결과: SU1498를 주사한 마우스에서 폐포면적과 평균폐포용적이 의미 있게 감소하였다. 세포자멸사도 약 3배 의미 있게 증가하였다. 자멸사한 세포는 내피세포와 상피세포에 분포하였다. Retinoic acid를 주사한 약 50%의 세포자멸사가 감소하였고, 형태학적으로 정상에 가까운 폐포 발달이 유지되었다. 결론: VEGFR2 억제를 하면 내피세포와 상피세포의 세포자멸사가 증가되면서 폐 발달이 저해되었다. 이어서 retinoic acid를 주사하면 세포자멸사가 억제되어 폐 발달유지에 도움이 되었다. 이러한 retinoic acid에 의한 세포자멸사의 억제가 기관지폐이형성증 예방에 기여할 것으로 추정된다. Background: Retinoic acid is known to play a role in alveolar regeneration and is used in the prevention of bronchopulmonary dysplasia (BPD) in premature infants. Many factors involved in the pathogenesis of BPD induce apoptosis of the endothelium and epithelium of the premature lung. We hypothesized that VEGFR2 inhibition would increase apoptosis in the newborn lung and retinoic acid would decrease apoptosis in our model of inhibited lung growth. Material and Methods: SU1498, a VEGFR2 inhibitor or vehicle was given to three-day-old mice. Subsequent retinoic acid or vehicle injection was given for ten days for the duration of alveolarization. Morphometric analyses were performed. Apoptosis was assessed with TUNEL staining and Annexin V staining. Co-localization of apoptotic cells with endothelial and epithelial cells was performed. Results: SUI498 injection reduced alveolar surface area and mean alveolar volume in newborn mice. Apoptosis was increased by three-fold in SU1498 injected mice. Apoptotic cells co-localized to endothelial and epithelial cells. Retinoic acid significantly reduced the degree of apoptosis by 50% in SU1498 injected mice and maintained lung development. Conclusion: VEGFR2 inhibition caused an arrest in lung development accompanied by an increase in apoptosis of endothelial and epithelial cells of the neonatal lung in mice. Subsequent retinoic acid treatment reduced apoptosis and we speculate that retinoic acid may preserve lung growth in bronchopulmonary dysplasia by inhibiting apoptosis in the neonatal lung.

Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

노년기 주관적 연령과 건강노화와의 관계: 연령집단별 분석

최은영 ( Choi Eun Young ),조성은 ( Cho Sung Eun ),오영삼 ( Oh Young Sam ),장희수 ( Chang Hee Su ),김영선 ( Kim Young Sun ) 한국보건사회연구원 2017 保健社會硏究 Vol.37 No.1

본 연구의 목적은 노년기 주관적 연령(스스로를 노인 혹은 비(非)노인으로 인지하는지 여부)과 건강노화와의 관계를 연령집단에 따라 검증하는 것이다. 이를 위해 2014년 노인실태조사 대상자 중 연소노인(65~74세)과 고령노인(75~84세)을 연구대상으로 선정하였다. 연구의 주목적인 주관적 연령과 건강노화 간의 관련성을 검증하기 위해 연소노인 및 고령노인 집단별로 다중회귀분석(multiple regression analysis)을 실시하였다. 연구결과, 주관적 연령과 건강노화의 관계는 연령집단별로 다른 양상을 보이는 것으로 나타났다. 연소노인에서 주관적 연령이 비(非)노인인 경우, 높은 수준의 인지기능과 적은 만성질환 수, 낮은 수준의 우울, 그리고 높은 수준의 사회활동 참여를 보이는 것으로 밝혀졌다. 반면, 고령노인인 경우 주관적 연령은 인지기능을 제외하고 건강노화의 다른 세 요소와 유의미한 관련이 없었다. 본 연구는 주관적 연령을 건강노화의 새로운 고려요소로 제시하여, 두 요소의 관련성을 통합적인 차원에서 살펴보았다는 의의가 있다. 또한 노인을 연령대에 따라 구별된 집단으로 살펴봄으로써, 주관적 연령과 건강노화의 연관성이 연령집단마다 상이한 양상을 보임을 밝혔다는 의의를 가진다. The purpose of this study is to examine the relationship between subjective age (whether one subjectively perceives himself as `the elderly` or `not the elderly`) and healthy aging. Using data from the 2014 National Elderly Survey (KIHASA), this study selected a total of 9,653 participants consisting of young-olds (aged 65-74) and old-olds (aged 75-84) For both the young-old and the old-old, multiple regression analyses were conducted to examine the research model. In the young-old population, one`s considering oneself as “non-elderly” was significantly associated with higher cognitive functioning, fewer chronic diseases, lower depressive symptoms, and higher level of social engagement. On the other hand, in the old-old population, one`s considering oneself as “non-elderly” was associated only with higher cognitive functioning, and not with the other domains of healthy aging. The findings suggest that subjective age can be considered as an important predictors of older adults` healthy aging. These findings indicate that the association between subjective age and healthy aging has a different pattern depending on the age group.

중금속 제거 및 pH 상승을 위한 폐달걀껍질의 재활용

조영수,최영락,손희정,김은호 東亞大學校生命資源科學大學附設 農業資源硏究所 1997 農業生命資援硏究 Vol.6 No.1

In the present, batch test was conducted to evaluate the neutralization and adsorption of heavy metals from wastewater using waste egg shells. Neutralization and removal rate of heavy metals were excellent in the increase of waste concrete amounts and a small size. It seemed that adsorption efficiencies of heavy metals were influenced by solubility. As a result on the experiments of Freundlich isotherm, the adsorption capacities(k) were Cr 3.11, Cu 2.61, Mn 3.02 and Pb 0.95, respectively and the adsorption intensities(1/n) were Cr 0.35, Cu 0.44, Mn 0.4 and Pb 0.41, respectively. In view of these results, it showed that wastes containing the similar compositions as waste egg shells could utilize the neutralization and adsorption of heavy metals in wastewater.

지식 베이스의 에이젠트화에 의한 지식 미디어 시스템에 관한 연구

조정래,손영수,배상현 조선대학교 기초과학연구소 1996 自然科學硏究 Vol.19 No.1

The knowledge of the specialized fields has been changed rapidly in the both side of quantity and quality. A hyper media as a knowledge based system is so fixed in the linked media in mutual that we couldn't tell it information provision with the view of user. In this paper, we propose the way of offering intellectual and flexible information which is same with demand in the side of user, selecting, searching and composing the hypertext at the point of user's view through the design of knowledge media system. three concepts is used in order to challenge the knowledge media system : special document, agent system and ontology. The special document is a knowledge using special fields. The agent system is a homogeneous controller that operates on and application to ensure that its activities are coordinated with those of the others within the community, providing a uniform control mechanism. The last 3th concept, ontology is a language for knowledgement, which is a message exchanged among agents to ensure the proper interaction among them. The combination of these three concepts is used designed the prototype of knowledge media system.

雷雲內의 電荷分離 Mechanism에 關한 硏究

趙英男,柳承蘭,柳贊洙 조선대학교 사범대학 부설 교과교육연구소 1999 敎科敎育硏究 Vol.2 No.1

It is known that frictional rubbing between different ice surfaces causes electric charge separation, and Yoshida(1944) reported the colder ice was positively electrified. The mechanism of charge electric separation in thunderclouds is considered to be related to the friction or impact between ice crystal particles. In order to explain the mechanism for the electric charge separation in thunderclouds, the experiment was conducted. The results from that experiment through rubbing asymmetrically the artifially provided ice rods are as follows: Asymmetric rubbing was charged with effect of the temperature difference by a theory of thermoelectricity, when the colder ice was positively charged and the warmer ice negatively charged. The average difference of charge between them was 0.35volt. Opaque ice rod with air bubbles was chagred regardless of the effect of a theory of thermoelectricity. As the result of it, the cold ice rod was negatively charged and the effect of the friction was maximized by air bubbles. under a polarizing microscope, contact surface ice crystal cell was melted and frozen by the friction heat, and then was decreased in size. the charged volume was greatly increased at the colder range of -21℃∼-16℃ and was irregularly developed at warmer temperature region. the cooling apparatus made for experiment can be used in measuring the frictional charge generation.

그란닥신 정(토피소팜 50mg)에 대한 토핌 정의 생물학적 동등성

조혜영,정현철,허수희,임동구,문재동,이용복 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2

Tofisopam is a new type of tranquilizer valuable for the relief of anxiety and tension in a wide range of emotional disorders. Tofisopam has the therapeutic characteristics of a minor tranquilzer and a mild stimulatory effect. The purpose of the present study was to evaluate the bioequivalence of two tofisopam tablets, Grandaxin^TM (Hwan In Pharmaceutical Co., Ltd.) and Tofim^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 23.11±2.83 years in age and 65.43±7.64 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 50 mg of tofisopam was orally administered, blood was taken at predetermined time intervals and the concentrations of tofisopam in serum were determined using HPLC method with UV detector. The pharmacokinetic parameters such as AUC_t C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t C_max and T_max between two tablets based on the Grandaxin^TM were -5.59%, 2.22% and -13.18%, respectively. Minimum detectable differences (Δ) at α=0.10 and 1-β=0.8 were less than 20% (e.g., 14.95% and 19.34% for AUC_t and C_max respectively). The powers (1-β) at α=0.10, Δ=0.2 for AUC_t and C_max were 95.21% and 81.93%, respectively. The 90% confidence intervals were within ±20% (e.g., -15.64∼4.45 and -10.77∼15.21 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Tofim^TM tablet is bioequivalent to Grandaxin^TM tablet.

당귀의 품질평가법에 관한 연구

조창희,김수정,이남윤,우영아,김효진 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-

Angelicae gigantis radix is the root of the perennial plant, which belongs to family Umbelliferae. However, this herbal drug has quite different chemical components according to its different geographical origin though other herbal drugs (i.e. Leonuri Herba, Xanthii Fructus and so on) show similar major constituents. In other word, the root of Angelica gigas containing the coumarin compounds is commonly used in Korea as Angelicae gigantis radix, while Angelica sinensis and Angelica acutiloba including phthalide compounds are used in China and Japan, respectively. In this paper, Near-Infrared spectroscopy was developed to determine Genus name of Angelica spp., especially Angelica gigas and Angelica sinensis which are generally misused in the herbal market. Also X-ray fluorescence spectrometry was evaluated to analyze the differences between Angelica gigas and Angelica sinensis with their specific properties.

증발농축을 이용한 방사선 필름의 폐액처리 특성

조영미,정원문,임봉수,박영성 대전대학교 환경문제연구소 2001 환경문제연구소 논문집 Vol.5 No.-

A concetrated evaporation experimnt was carried out in this study, to find out the removal and concoentration efficiency of havy metals from concentration process as well as analysis and investigation for the characteristics of the condensed water. In the experiment of wastewater treatment from X-ray film by using concentrated evaporation, the results show that COD removal efficency rate was more than about 99%, the major toxic metals, including Pb, CN, F, Zn was almost removed. It could be seen that the early boiling point of each wastewater was 108.5℃ for the wastewater of the fixing solution, 106.7℃ for the wastewater of developing solution and 107℃ for the mixture(1:1) of both wastewater. The increasing rate of boiling point was the greatest in the wastewater of the developing solution and the mixture and the wastewater of fixing solution in descending order. The boiling point under latm in a vacuum was 30℃ for the wastewater of the developing solution, 37℃ for the wastewater of fixing solutions, and 35℃ for the mixture.