白鼠 肝障碍에 對한 補肝湯 瀉肝湯의 效果에 關한 實驗的 硏究

洪茂昌,李學仁,金完熙 慶熙大學校韓醫科大學韓醫學硏究所 1983 慶熙韓醫大論文集 Vol.6 No.-

북한의 급변사태 및 대량탈북에 따른 경찰 대응방안 연구

남재성(Nam Jae Sung),이창무(Lee Chang Moo) 한국공안행정학회 2013 한국공안행정학회보 Vol.22 No.1

국내외를 불문하고 김정은 체제에 대한 심각한 우려가 제기되고 있는 현실에 비추어 볼 때 가까운 장래에 북한의 급격한 정세변화와 대한민국에 대한 잠재적 위해요소의 등장은 우리가 반드시 겪게 될 현실이고 반드시 막아야할 문제라는 점에서 개방된 사고로 모든 가능성을 염두하고 대책을 수립해야 한다. 따라서 이 연구에서는 국가 차원뿐만 아니라 세부적으로 경찰 차원에서, 김정은 체제 이후 예상되는 북한 내부의 권력투쟁과 그에 따른 사회적 혼란 및 잠재적 위해요소, 그리고 그로 인한 북한 주민의 대량 탈북사태와 국내 유입 등 치안과 안보위해 상황을 다각도로 검토해보고 무엇보다도 경찰의 대응방안을 중심으로 대책을 마련하고자 하였다. 연구결과 여러 위협 변수들에도 불구하고 현 상태에서 당장 급격한 변화와 북한 정권의 붕괴 가능성은 높지 않다고 보인다. 하지만 북한체제의 특성상, 북한의 급변사태가 언제든 발생할 수 있다는 측면에서 항상 예의주시해야 할 것이며, 경찰은 북한의 급변사태에 따라 대량 탈북사태가 발생했을 경우 신속히 대응할 수 있는 즉응적 대비태세를 갖추어야 할 것이다. 특히, 이에 대한 대비태세는 대량 탈북 등 급변사태 발생이전의 사전적 역량강화 방안, 평시상황이지만 준 급변사태 발생단계에서 나타날 수 있는 대량 탈북사태 대응 방안, 급변사태 발생시의 대량 탈북사태 대응 방안 등으로 구분하여 수립하는 것이 타당할 것이다. 따라서 향후 보안경찰은 이 세 가지의 대응방안을 중심으로 조직적, 인력적 역량을 강화하고 대응을 위한 세부 시나리오를 마련하는 등 대량탈북 사태와 같은 북한의 급변사태에 신속히 대응할 수 있는 철저한 준비태세를 확립해야 할 것이다. In the midst of present situation where a serious concern is being raised at the national and international level on Kim Jong-un regime, it is inevitable that we will certainly experience North Korea's sudden changes in the state of affairs and the appearance of potentially dangerous elements towards South Korea against which we must defend. Accordingly, we must develop measures of responses for every possibility with open mind. The purpose of this study, accordingly, was to extensively examine not only at the national level but also at the specific level of the police the North Korean power struggle and according social disorder, potentially dangerous elements, massive defections of North Koreans and their inflow to South Korea and situations that present risk to public order and national security in order to develop various measures of responses centering on the response of the police. The study result shows that in spite of numerous variables of threat, the possibility of immediate and sudden changes in North Korea and the collapse of its regime does not appear to be high. According to the characteristics of the North Korea regime, however, there is a need for constant and close watch in the sense that sudden changes could occur at anytime in North Korea. Additionally, it was found that it would be necessary for the police to be equipped with instant readiness for swiftly responding to any massive defections of North Koreans according to sudden changes in North Korea. It was revealed that it would be appropriate to develop measures of responses by dividing them into a preemptive measure of reinforcing capabilities prior to the occurrence of sudden changes such as massive defections, a response measure against massive defections that could occur at the stage of semi-sudden changes during peacetime situation and a response measure against massive defections that occurs at the occurrence of sudden changes. Accordingly, it would be necessary for the security police to establish through readiness for swiftly responding to sudden changes in North Korea such as massive defections such as reinforcing organizational and personnel capabilities and develop specific scenarios of response centering on the three types of measures of responses mentioned above.

Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1

<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>

반복매매모형을 활용한 아파트 매매가격지수

이창무,김병욱,이현 한국부동산분석학회 2002 不動産學硏究 Vol.8 No.2

Stock price index type of housing price indices were commonly used in Korea. However, this type of indices are not suitable for Korean housing market experiencing rapid changes in stock including both new constructions and demolitions. Especially, the recent Korean housing market has experienced substantial changes in housing characteristics. Basically, the stock price index type of housing price index requires a constant survey stock over time in order to maintain the comparability in total housing values. However, the constant stock concept is hard to accept in the Korean housing market accompanying with rapid increase and qualitative changes in housing stock. An alternative is a hedonic price index. However, the basic data requirements for the application of the hedonic model cannot be fulfilled in the Korean housing market where actual sale information is mostly unknown. In order to overcome this structural deficiency, the price indices in Korea are based o periodical price survey with the help of real estate brokers. If we accept the assumption that the whole condominium units belonging to a basic survey unit (an area type in an condominium complex) share the same housing characteristics and the surveyed price, we can use the repeat sale index concept with some modifications. The persistent price survey generates a perfect form of repeat sales data. This paper proposes a practical method for the application of repeat sale index to condominium sales price indexing.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

문재인 정부 부동산정책의 비판적 평가

이창무 ( Lee Chang-moo ) 한국행정연구원 2020 韓國行政硏究 Vol.29 No.4

문재인 정부에서 주택시장 안정을 목표로 수 십 차례 대책을 발표했음에도 수도권 아파트 매매시장은 급등추세를 피하지 못하고 있다. 정책의 주요 타깃은 서울, 특히 강남권의 재건축이라는 면에서 노무현 정부의 정책을 답습하고 있다. 주택시장 또한 노무현 정부 시기 반응했던 방식을 반복하고 있다. 한 가지 차이점은 참여정부 시기에는 서울의 가격 급등세가 수도권 전역으로 파급되는 동조화 현상이 강했지만 문재인 정부에서는 상당한 기간 동안 경기도 아파트 시장과 서울 아파트 시장이 탈동조화 현상을 보였다는 점이다. 많은 비판을 받는 문재인 정부의 주택정책에는 그 기본적인 시각에 적지 않은 문제점이 있다. 국내 주택시장의 독특한 기제인 유기적인 매매시장과 전월세시장의 관계에 대한 이해 부족, 본질적으로 모호할 수밖에 없고 원인이라기보다는 시장상황에 대한 반응으로 발생하는 투기적인 행태에 매몰된 과도한 규제, 1가구 1주택 소유주의란 구호성 목표와 다주택자의 긍정적 측면을 무시한 징벌적인 조세정책 등 여러 가지 문제점을 안고 있다. 이렇게 반복된 규제정책의 발표와 적절한 공급 확대를 만들어내는 데 실패한 결과는 대부분의 국민들이 체감하고 있다. 본 논문에서는 과거 노무현 정부 시기부터 현 문재인 정부까지의 정책 추이를 분석하는 것으로 시작하여 문재인 정부의 주택시장 상황을 종합적으로 진단하고자 한다. 이어서 1가구 1주택 소유주의에 기반한 다주택자 정책, 도심에 주택공급 위축을 초래한 정비사업 정책, 그리고 최근 논란이 되고 있는 임대차3법 정책의 실효성을 분석 및 평가함으로써 정부정책의 바람직한 방향성을 제시하고자 한다. Even though Moon Jae-in govenrment introduced dozens of policies to control the housing market, housing price in the Seoul Metropolitan Area has kept increasing rapidly. The housing policy framework of the Moon's government resembles that of Roh Moo-Hyun govenrment, which was focused on the strong regulations to restrict redevelopments in the Gangnam area and multi-house ownership. The Moon's government has shared the failures with the Roh's governemnt, too. One noticeable difference between two governments is that during the Roh’s administration period, the price surge in Seoul was spread into wider Gyunggi province promptly. while it was retained in Seoul during the first half of the Moon's. For now, Gyeonggi province is however suffering from soaring housing price following Seoul. This difference in trends provides important clues to understand the housing market conditions during the Moon's government. This study attempts to assess the housing policies of Moon Jae-In govenrment in the comparative framework with those of other governments, espeically focused on Roh Moo- hyun government. The final results indicate that unitended side effects have been stronger than the designated effects.

TRANSIENT ISCHEMIA-INDUCED EXPRESSION AND CHANGES OF TYROSINE KINASE A IN THE HIPPOCAMPAL DENTATE GYRUS OF THE GERBIL

HWANG, IN,LEE, HYEON,YOO, KI-YEON,KIM, DAE,KIM, JUNG,KIM, CHANG,LIM, BEONG,KANG, TAE-CHEON,BANG, KYUNG,SEONG, NAK,LEE, HAK,KIM, JONG,WON, MOO Taylor Francis 2006 International journal of neuroscience Vol.116 No.8

<P>The present study examined ischemia-related changes in tyrosine kinase A (trkA) immunoreactivity and its protein content in the dentate gyrus after 5 min of transient forebrain ischemia in gerbils. One day after ischemic insult, cresyl violet-positive polymorphic cells showed ischemic degeneration. The ischemia-induced changes in trkA immunoreactivity were found in the polymorphic layer (PL) and granule cell layer (GCL) of the dentate gyrus. In the sham-operated group, trkA immunoreactivity in the dentate gyrus was very weak. From 30 min after ischemia, trkA immunoreactivity was increased in the dentate gyrus and peaked in the dentate gyrus at 12 h after ischemia-reperfusion. Thereafter, trkA immunoreactivity was decreased time-dependently after ischemia-reperfusion. Four days after ischemic insult, trkA immunoreactivity was similar to that of the sham-operated group. In addition, it was found that ischemia-related changes in trkA protein content were similar to the immunohistochemical changes. These results suggest that the chronological changes of trkA in the dentate gyrus after transient forebrain ischemia may be associated with ischemic damage in polymorphic cells of the dentate gyrus.</P>

대장암종에서 암관련 유전자들의 Promoter Methylation과 암종 발생 및 진행과의 관게에 대한 연구

정동준,이정은,민영기,조성우,백무준,양승하,김의한,김창진 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

The colorectal corcinoma is one of the most common malignant tumor in Korea and its carcinogenic mechanism has not been elucidated exactly yet. So far, the most common carcinogenic mechanism has been known to be multiple genetic changes. But, the CpG island hypermethylation has been revealed to be one of the most important carcinogenic mechanism second to the genetic changes. The epigenetic changes characteristically imprint and transfer to the next generation without changes of nucleotide sequences. When the CpG island of promoter or 5'- exon 1 of a specific gene is methylated by DNA methyltrasferases (DNMTs), the gene expression is inhibited. Carcinogenic mechansisms by promoter methylation has been well known, but the progression of the cancer has not been elucidated yet. The molecular researches on the carcinogenic mechanisms largely depended on the tumor tissue containing various components of cell, due to difficulties in harvesting pure homogeneous tumor cells. Promoter methylatonof the cancer related genes as APc, hMLH2, p16, DAP-K and MGMT in 50 cases of sporadic colorectal carcinoma was studied. The pure normal colorectal epithelial cells, and cancer cells from superficial and deep invasive portion were harvested respectively by laser captured microdissection(LCM), and DNA was extracted from them. The promoter methylation was studied by methylation specific poymerase reaction (MSP) after bisulfite modification of the DNA and the expression of the genes by immunohistochemistry. The results suggests that promoter methylation of the cancer related genes are closely related with the colorectal carcinogenesis and it occurrs from early phase of carcinogenesis, progressing constantly to the late stage. And the promoter methylation of normal epithelial cells increased by age. The p15, known to be the genes related to hematologic malignancy, was closely related to the colorectal carcinoma as well.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

맥파전달속도(PWV)와 말초체열분포(DITI)와의 관계 연구

이윤재,조정훈,이창훈,이진무,장준복,이경섭,Lee, Yoon-Jae,Cho, Jung-Hoon,Lee, Chang-Hoon,Lee, Jin-Moo,Jang, Jun-Bock,Lee, Kyung-Sub 대한한방체열의학회 2008 대한한방체열의학회지 Vol.6 No.1

Objective: The purpose of this study is to identify relationship between the PWV and the temperature difference. Methods: When it comes to senile patients who suffer from cold limbs, there is need to see whether or not the patient's low temperature of the limbs is do to arteriosclerosis. The Pulse Wave Velocity(PWV) is a non-invasive method measuring the artery's rigidness. And the Digital Infrared Thermal Imaging(D.I.T.I) is a non-invasive method to see the body's thermal change. Research on the interrelationship of the artery's rigidness and body's thermal distribution was done by using these two tests. The subjects of this research were patients between the age 40~65 who have done both the D.I.T.I and PWV in March 2005~ September 2005. They had to have no history of diabetes, coronary illnesses or cerebrovascular diseases which are diseases that can effect the outcome of the PVW, nor history of spondylopathy or dermatosis which can effect the outcome of the D.I.T.I. Results: The results were as follows. 1. There was a significant interrelationship between the right wrist-ankle PWV and the temperature difference of the right wrist-palm. 2. There was a significant interrelationship between the left wrist-ankle PWV and the temperature difference of the left wrist-palm. 3. There was no significant interrelationship between the right wrist-ankle PWV and the temperature difference of the right thigh-dorsum of foot. 4. There was no significant interrelationship between the left wrist-ankle PWV and the temperature difference of the left thigh-dorsum of foot. 5. The right ABI showed no significant interrelationship between the temperature difference of the right wrist-palm and the right thigh-dorsum of foot. 6. The left ABI showed no significant interrelationship between the temperature difference of the left wrist-palm and the left thigh-dorsum of foot. Conclusion: The study shows that there was a significant interrelationship between wrist-ankle PWV and the temperature difference of wrist-palm.