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Kim, Y.H.,Chang, K.I.,Park, J.J.,Park, S.K.,Lee, S.H.,Kim, Y.G.,Jung, K.T.,Kim, K. Elsevier 2009 Journal of marine systems Vol.78 No.2
Reanalyzed products from a MOM3-based East Sea Regional Ocean Model with a 3-dimentional variational data assimilation module (DA-ESROM), have been compared with the observed hydrographic and current datasets in the Ulleung Basin (UB) of the East/Japan Sea (EJS). Satellite-borne sea surface temperature and sea surface height data, and in-situ temperature profiles have been assimilated into the DA-ESROM. The performance of the DA-ESROM appears to be efficient enough to be used in an operational ocean forecast system. Comparing with the results from Mitchell et al. [Mitchell, D. A., Watts, D. R., Wimbush, M., Teague, W.J., Tracey, K. L., Book, J. W., Chang, K.-I., Suk, M.-S., Yoon, J.-H., 2005a. Upper circulation patterns in the Ulleung Basin. Deep-Sea Res. II, 52, 1617-1638.], the DA-ESROM fairly well simulates the high variability of the Ulleung Warm Eddy and Dok Cold Eddy as well as the branching of the Tsushima Warm Current in the UB. The overall root-mean-square error between 100 m temperature field reproduced by the DA-ESROM and the observed 100-dbar temperature field is 2.1 <SUP>o</SUP>C, and the spatially averaged grid-to-grid correlation between the two temperature fields is high with a mean value of 0.79 for the inter-comparison period. The DA-ESROM reproduces the development of strong southward North Korean Cold Current (NKCC) in summer consistent with the observational results, which is thought to be an improvement of the previous numerical models in the EJS. The reanalyzed products show that the NKCC is about 35 km wide, and flows southward along the Korean coast from spring to summer with maximum monthly mean volume transport of about 0.8 Sv in August-September.
Kim, Han-Seop,Lee, Chang-Ho,Min, Churl K. The Korean Society for Integrative Biology 1998 Korean journal of biological sciences Vol.2 No.4
The G protein-activated inwardly rectifying $K^+$ channel (GIRK1) was coex-pressed in Xenopus oocytes along with the $5-HT_{1A}$ receptor, a 7-helix receptor known to be coupled to $K^+$ channels in many neural tissues. Thus, the activation of the $5-HT_{1A}$ receptor by its agonist leads to the opening of GIRK1. The GIRK1 current was measured using the two electrode voltage clamp technique with bath application of 5-HT in the presence of various external potassium concentrations $[K^+]_0$. GIRK1 showed a strong inward rectification since only hyperpolarizing voltages evoked inward currents. $K^{+}$ was the major ion carrier as evidenced by about 44㎷ voltage shift corresponding to a 10-fold external 〔$K^+$〕 change. 5-HT induced a concentration-dependent inward $K^+$ current ($EC_{50}{\equation omitted}10.7nM$) which was blocked by $Ba^{2+}$. Pertussis toxin (PTX) pre-treatment reduced the $K^+$ current by as much as about 70%, suggesting that PTX-sensitive G protein ($G_i or G_o$ type) are involved in the $5-HT_{1A}$ receptor-GIRK1 coupling in Xenopus oocytes.
Chang, S-H,Kim, J-E,Lee, J-H,Minai-Tehrani, A,Han, K,Chae, C,Cho, Y-H,Yun, J-H,Park, K,Kim, Y-S,Cho, M-H Nature America, Inc. 2013 Cancer gene therapy Vol.20 No.6
Conventional radiotherapy or chemotherapy for the long-term survival of patients with lung cancer is still difficult for treatment in metastatic and advanced tumors. Therefore, the safe and effective approaches to the treatment of lung cancer are needed. In this study, the effect of delivered eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) on lung cancer progression was evaluated. Recombinant adeno-associated virus (rAAV)-M3/4E-BP1 was delivered into 6-week-old K-ras<SUP>LA1</SUP> lung cancer model mice through a nose-only inhalation system twice a week for 4 weeks. Long-term repeated delivery of 4E-BP1 effectively reduced tumor progression in the lungs of K-ras<SUP>LA1</SUP> mice. Reduction of eIF4E by overexpression of 4E-BP1 resulted in suppression of cap-dependent protein expression of basic fibroblast growth factor (bFGF or FGF-2) and vascular endothelial growth factor (VEGF). In addition, delivered 4E-BP1 inhibited the proliferation of lung cancer cells in K-ras<SUP>LA1</SUP> mice model. Our results suggest that long-term repeated viral delivery of 4E-BP1 may provide a useful tool for designing lung cancer treatment.
14.6 A GeV ^28Si 중이온이 원자핵건판내에서 발생시킨 핵반응에서 생성된 2차입자의 발생각 분포
김종오,김태연,남신우,신택수,우종관,이세병,임계엽,장세덕,조재희,천병구,임인택,김기영 慶尙大學校 기초과학연구소 1990 基礎科學硏究所報 Vol.6 No.-
14.6A GeV^28Si 중이온이 원자핵 건판내에서 발생시킨 N_h=1인 핵반응에서 생성된 47개의 파쇄 α 입자와 537개의 단일하전 2차입자의 발생각들을 측정하여 변수 exp(γ-η_b)의 포괄적 분포를 회귀함수 dN=exp[a+χ{exp(γ-η_b)d{exp(γ-η_b)}로 적합시켰다. 여기서 의사신속도 γ=arctanh(cosθ)=-ln tan(θ/2)이고, 입사 중이온의 신속도 η_b=3.445이다. 그 적합결과 파쇄 α입자의 경우 χ=-0.052±0.011이고, 파쇄 p입자의 경우 χ=-0.141±0.015이었다. For LS emission angles of 47 α fragments and 537 single-charged shower particles, produced by the N_h (the number of heavyprongs)=1 interactions of 14.6 A GeV^28Si nuclei in the nuclear emulsion, the distribution of the parameter exp(γ-η_b) is well expressed by dN=exp[a+χ{exp(γ-η_b)d{exp(γ-η_b)}with χ=-0.052±0.011 for αfragments and χ=-0.141±0.015 for p 'fragments', where the pseudorapidity of secondaries γ=arctanh(cosθ)=-ln tan(θ/2) and the rapidity of incident heavy ions, η_b=3.445.
K-SADS-PL을 사용하여 평가한 주의력결핍과잉행동장애 외래 환자의 공존질환에 대한 연구
김진용 ( Jin Yong Kim ),유한익 ( Han Ik K. Yoo ),고진경 ( Jin Kyung Goh ),전정원 ( Jeong Won Jeon ),홍진표 ( Jin Pyo Hong ),김성윤 ( Seong Yoon Kim ),김창윤 ( Chang Yoon Kim ) 한국정신병리진단분류학회 2005 精神病理學 Vol.14 No.1
Objectives: This study was performed to assess the comorbidity and associated emotional and behavioral manifestations in attention deficit hyperactivity disorder(ADHD) subjects, and the parenting stress and sense of competence in their mothers. Method: To investigate the comorbid conditions of ADHD, 102 ADHD patients(82 males, 9.58±2.65) and their caregivers visiting outpatient clinic were interviewed using the Korean version of Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime. The Korean-Child Behavior Checklist, Children`s Depression Inventory, and Revised Children`s Manifest Anxiety Scale(RCMAS) were used to measure the psychopathologies in the subjects. The Parenting Stress Index/Short form and Parenting Sense of Competence Scale were also applied to the caregivers of ADHD patients. Results: Eighty-four(82.4%) of ADHD subjects had comordid psychiatric disorders. Comorbid oppositional defiant disorder, anxiety disorders, tic disorders, and elimination disorders were accompanied with ADHD in 54.9%, 24.9%, 19.6%, and 12.7%, respectively. Mean scores of Social Problems, Total Behavior Problems, and RCMAS were significantly higher in comorbid ADHD group than pure ADHD group. Parents of ADHD patients with comorbidity reported higher parenting stress and lower parenting sense of competence. Conclusion: Majority of ADHD patients had comorbid psychiatric conditions, and more psychopathologies and related parenting complications were associated with comorbidity.
김태남,오길호,신윤식,임은기,장춘서,오득환,김병만,이기수 金烏工科大學校 1996 論文集 Vol.17 No.-
Interactive multimedia application(IMA) has been emerged as a hot-spot trend with the advance of technology to handle sound and motion video. But, it is still difficult to build IMA since it gets more complex to specify the temporal and spatial synchronizations and interactions with users inherent in IMA as the complexity of IMA grows. In this paper, we propose a formal specification and verification mechanism to detect specification errors of complex IMAs. In our system, the specification is carried out via top-down approach, which means a high-level specification of an IMA is completed and each component of high-level specification is specified in more detail. The detailed description are verified to be equivalent to its high-level specification. We show the usefulness of the specification and verification mechanism by illustrating an example.