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Enhancement of the Polar Coercive Force for Annealed Co/Ir(111) Ultrathin Films
Wen-Yuan Chan,Du-Cheng Tsai,Wei-Hsiang Chen,Cheng-Hsun-Tony Chang,Jyh-Shen Tsay 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
The alloy formation and the magnetic properties of Co/Ir(111) ultrathin films have been investigated. As the temperature is increased above 400 K, interdiffusion of Co and the Ir substrate occurs. Due to a compositional change in the surface layers, the polar coercive force is greatly enhanced. At temperatures above 600 K, magnetic hysteresis appears only in the polar configuration. Thisshows that the easy axis of the magnetization of Co/Ir(111) may be stabilized in the direction ofthe surface normal by thermal-annealing treatments. From systematic investigations of Co/Ir(111)ultrathin films thinner than 4 monolayers, a magnetic phase diagram has been established. Accordingto the compositional changes and related magnetic properties, the phase diagram can beseparated into three regions. In region I at temperatures below 400 K, Co films are ferromagnetic. In region II where atomic interdiffusion occurs in the surface layers, an enhanced polar coerciveforce is observed. The phase transition from phase I to II is related to the interdiffusion betweenthe Co overlayer and the iridium substrate. In region III for low coverage or at high temperatures,a nonferromagnetic behavior is observed. The phase transition from phase II to III is mainly dueto the reduced atomic percent of cobalt in the Co-Ir alloy and to the lowered Curie temperaturecaused by a reduction in the thickness of the magnetic layers.
Cheng-Chen Chang,Ming-Hong Hsieh,Jong-Yi Wang,Nan-Ying Chiu,Yu-Hsun Wang,Jeng-Yuan Chiou,Hsiang-Hsiung Huang,Po-Chung Ju 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11
Objective Several cell line studies have demonstrated thioridazine’s anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia. Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy. Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer. Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.
Identification, Synthesis, and Evaluation of New Neuraminidase Inhibitors
Kumar, Vathan,Chang, Chih-Kang,Tan, Kian-Pin,Jung, Young-Sik,Chen, Shih-Hsun,Cheng, Yih-Shyun E.,Liang, Po-Huang American Chemical Society 2014 ORGANIC LETTERS Vol.16 No.19
<P>High-throughput screening was performed on ∼6800 compounds to identify <B>KR-72039</B> as an inhibitor of H1N1 and H5N1 neuraminidases (NAs). Structure–activity relationship studies led to <B>3e</B>, which inhibited H5N1 NA with an IC<SUB>50</SUB> of 2.8 μM and blocked viral replication. Docking analysis shows that compounds bind to loop-430 around the NA active site. Compound <B>3l</B> additionally inhibited H7N9 NA, making it a dual inhibitor of N1- and N2-type NAs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2014/orlef7.2014.16.issue-19/ol502410x/production/images/medium/ol-2014-02410x_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol502410x'>ACS Electronic Supporting Info</A></P>
Determining optimal number of cores in a submarine power cable
Hsieh Meng-Chang,Chen Bang-Fuh,Wang Yanyang,Chang Hsun-Cheng,Liu Wen-Hsiu,Hsu Hung-Lin 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
Submarine power cables must be reinforced and must possess suitable mechanical properties to meet operational requirements for complex marine environments. This study numerically investigated the mechanical properties of submarine power cables under tensile, torsional, and compressive loading. The optimal number of cores was determined according to the variation in tensile and torsional stiffness with radial compressive pressure. As the radial compressive pressure increased, the tensile and torsional stiffness of the four- and five-core cable models decreased marginally compared with those of the threecore cable model; thus, the five-core cable model was superior to the two-, three-, and four-core cable models in terms of radial deformation and contact stress. The two-core cable model was superior to the three-, four-, and five-core cable models in terms of tensile and torsional strength. The results of this study can serve as a reference in the design of submarine power cables.
Wu Carol P.,Chang Chia‐Jung,Li Cheng‐Hsun,Wu Yueh‐Lung 한국곤충학회 2021 Entomological Research Vol.51 No.4
The baculovirus expression system has been widely used for industrial-scale production of recombinant proteins. These recombinant proteins are expressed from recombinant baculoviruses carrying an expression cassette for a particular protein. Even though the baculovirus genome can accommodate large fragments of foreign genetic material, it has been shown that defective interfering particles (DIs) are generated over many passages of the recombinant virus. Defective interfering particles can affect the stability of the inserted gene, which can result in sub-optimal expression of the recombinant protein; this can, therefore, have a significant impact on production. The stability of exogenous genes in recombinant viruses over serial passage has not yet been investigated. As such, the present study set out to assess the effect of serial passage on the stability of the expression of an exogenous gene inserted into a recombinant baculovirus and its subsequent recombinant protein yield. To achieve this, a recombinant baculovirus carrying the classical swine fever virus E2 gene was serially passaged up to 20 times. The results showed that the E2 gene expression by the recombinant baculovirus was stable for up to 10 passages without any effect on recombinant E2 production in insect cells.
A value-added analysis of trade in Taiwan and Korea’s ICT industries
Hsing-Chun Lin,Shih-Hsun Hsu,Ruey-Wan Liou,Ching-Cheng Chang 한국무역학회 2016 Journal of Korea trade Vol.20 No.1
Purpose – The purpose of this paper is to extricate value-added exports in information and communications technology (ICT) industry earned by Taiwan and Korea. Additionally, the authors decompose Taiwan and Korea’s gross exports into various meaningful components. Design/methodology/approach – The authors use the inter-country input-output (ICIO) table which endows with cost structures of industries as well as trade information, facilitating in keeping track of the flow of products and value-added. The ICIO table used in this paper comes from the World Input-Output Database. The authors also use the way Wang et al. (2013) decomposed the intermediate goods exports into various components to provide further insights. Findings – The empirical results indicate that Taiwan and Korea’s ICT export to the world shrink by 47.8 and 40.9 percent when the trades are measured in value-added terms. Taiwan and Korea’s ICT export will also decrease by 75.1 and 57.8 percent. From the viewpoint of value added in trade, the share of value added embodied in Taiwan and Korea’s gross ICT exports continued to decrease and reached 24.9 and 42.2 percent in 2011, while the components of pure double counted terms kept growing in recent years. Originality/value – With global value chains flourishing in recent years, conventional trade statistics not only fails to highlight the vertical specialization among different countries, but also distorts the measurement of a country’s competitiveness. This paper extricates value-added exports in ICT industry earned by Taiwan and Korea and bring into focus the importance of trade in value added.
Impact Assessments of High Oil Prices on the Agro-Food System and the Role of Bioenergy Crops
Lee, Duu-Hwa,Lin, Hsin-Chun,Chang, Ching-Cheng,Hsu, Shih-Hsun,Chen, Chi-Chun,Sun, Jenny Chin-Hwa Korean Resource Economics Association 2007 자원·환경경제연구 Vol.16 No.3
In this study, multi-sectoral partial equilibrium and computable general equilibrium models of Taiwan are used to investigate the direct and indirect effects of energy price increases on overall economies and agro-food sector in Taiwan. The results suggest that agricultural prices, production cost would increase between 0.27% to 1.88%, and a reduction in GDP around 0.39% to 0.54 %. The negative impact on livestock sector is slightly higher than that on the crop sector. Negative impacts are also observed in the employment and wages. The rising oil price has the potential to discourage production of energy-intensive activity because of the possibility of substitution and adaptations. The growth rate of real GDP will shrink by 0.64% to 1.06% and CPI will increase by 1.17% to 1,95%. Both the agriculture and non-agricultural sector also respond by raising output prices by 0.80% to 1.33%. The rising international oil price has urged the government to take policy actions like using alternative fuels such as biodiesel, bioethanol, and adopting measures to cut down on energy consumptions mainly in transportation sectors in response to public concern over economic shocks.