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형건덕 ( Chien Ter Hsing ),김하연 ( Ha Yeon Kim ),이정현 ( Jung Hyun Lee ),한지선 ( Ji Sun Han ),이종훈 ( Jong Hun Lee ),장진석 ( Jin Seok Chang ),최석렬 ( Seok Reyol Choi ),정진숙 ( Jin Sook Jeong ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.5
Symptomatic gastro-intestinal metastasis in lung cancer is extremely rare and only a few case reports have been published. Here, we report a case with lung adenocarcinoma that presented with acute abdominal pain, nausea and vomiting due to duodenum, jejunum, and colon obstruction by the gastro-intestinal metastasis. The patient underwent colonoscopy and the pathologic report was adenocarcinoma. When there are similar histologic findings in both colon and pulmonary lesion, the question is whether both lesions are primary cancer or the colon lesions are metastases from lung cancer. Microscopic examination of a conventional pathologic section was not sufficient to make this determination. Immunohistochemistry was positive for thyroid transcription factor-1 (TTF-1) and cytokeratin 7 (CK7), and negative for cytokeratin 20 (CK20) and caudal-related homeobox transcription factor-2 (CDX-2) on colon mucosa specimen. Accordingly, we used immunohistochemical marker for differential diagnosis of primary adenocarcinoma of the lung with gastro-intestinal metastasis. (Korean J Gastroenterol 2012;59:382-385)
Mitigation the Impact and Survive from Extreme Drought of Climate Change and Global Warming
Chien-Hsing Chu,Ching-yuan Lu,Chung-Yan Li,Fang-Lin Liao,Yu-Chi Lee 한국방재학회 2016 Journal of Disaster Management Vol.1 No.2
Tap Water is the lifeline of human existence. Due to the effect of the Climate Change, the world has experienced an uneven distribution of rainfall in recent years, cause of floods or droughts. A series drought broke out in Taipei city gave chance to protect our county and test our reliabilities to citizen. This developments but has also realize the agricultural water should cooperate effectively shift dial [2], active water conservation ordinance relaxed, provide valuable water resources. Water utilities in response to the challenges of extreme drought, should face the New thinking that the difference between the price of water upon request, considering distinguish the dry season and the rainy season in different water, and the water does not hike the basic livelihood of the people; to consider the idea of building “Our sponge cities sponge Taiwan”; avoid low tariff wasted water, or the use of reasonable price adjustments after yearly, water problems can be solved in Taipei area; contributed to the dry season to strengthen water conservation and carbon reduction to achieve the effect or open consumptive water use of large household[2] and strengthen told: the key to sustainable development of water resources, “NO WATER NO FUTURE”.
Chien Ter Hsing,Sung Yong Oh,Suee Lee,권혁찬,Sung-Hyun Kim,Tae-Ho Park,Jong Soo Woo,Seo Hee Na,김효진 대한암학회 2007 Cancer Research and Treatment Vol.39 No.3
Mesenchymal chondrosarcoma is a rare cartilaginous neoplasm of an extraskeletal origin, and this predominately occurs in the head and neck, and also in the lower extremities. Fewer than twenty cases of cardiac mesenchymal chondrosarcoma have so far been reported on. For the most part, the results of treatment for patients with this condition have been dismal. In this study, we describe a case of cardiac mesenchymal chondrosarcoma that responded to chemotherapy following surgical biopsy. A 46-year-old man was referred for evaluation of his pleural effusions in both lungs. Chest computed tomography revealed an ovoid-shaped mass in the posterior wall of the patient’s left atrium. The echocardiogram revealed a large ovoid-shaped immobile mass (11×6 cm2) in the pericardiac space, which was attached tothe posterior wall of the left atrium. Emergency pericardiostomy with closure thoracostomy was performed. Seven days later, a thoracotomy was performed for reduction and diagnosis of the cardiac mass. The pathological diagnosis was extraskeletal mesenchymal chondrosarcoma of the heart.. Postoperative chemotherapy was performed for the huge remaining mass with a combined regimen of etoposide, ifosfamide and cisplatin. After 6 cycles, the patient showed a partial response without symptoms. Although cardiac mesenchymal chondrosarcoma has been reported to be chemotherapy- resistant with a short survival duration, chemotherapy may prove to be an effective treatment modality. (Cancer Res Treat. 2007;39:131-133)
Application of ANFIS Power Control for Downlink CDMA-Based LMDS Systems
Ze-Shin Lee,Mu-King Tsay,Chien-Hsing Liao 한국전자통신연구원 2009 ETRI Journal Vol.31 No.2
Rain attenuation and intercell interference are two crucial factors in the performance of broadband wireless access networks such as local multipoint distribution systems (LMDS) operating at frequencies above 20 GHz. Power control can enhance the performance of downlink CDMA-based LMDS systems by reducing intercell interference under clear sky conditions; however, it may damage system performance under rainy conditions. To ensure robust operation under both clear sky and rainy conditions, we propose a novel power-control scheme which applies an adaptive neuro-fuzzy inference system (ANFIS) for downlink CDMA-based LMDS systems. In the proposed system, the rain rate and the number of users are two inputs of the fuzzy inference system, and output is defined as channel quality, which is applied in the power control scheme to adjust the power control region. Moreover, ITU-R P.530 is employed to estimate the rain attenuation. The influence of the rain rate and the number of users on the distance-based power control (DBPC) scheme is included in the simulation model as the training database. Simulation results indicate that the proposed scheme improves the throughput of the DBPC scheme.
이수이,오성용,권혁찬,김성현,Kyung A Kwon,Chien Ter Hsing,김대철,이진화,이형식,Mi Ri Lee,조세헌,김효진 한국유방암학회 2009 Journal of breast cancer Vol.12 No.4
Purpose: The patients with metastatic breast cancer are routinely exposed to taxane and anthracycline as neoadjuvant, adjuvant, and palliative chemotherapeutic agents. This study was designed to evaluate the efficacy and safety of using a vinorelbine and ifosfamide (Ⅵ) combination treatment in patients with taxane-resistant metastatic breast cancer. Methods: We evaluated the use of a VI regimen (25 mg/㎡ vinorelbine administered on days 1 and 8 plus 2,000 mg/㎡ ifosfamide administered on day 1-3 every 3 weeks) for breast cancer patients who evidenced tumor progression after palliative taxane treatment. Results: Overall, 35 patients were enrolled in this study: Their median age was 50 years (range, 38-72 years). The overall response rate was 40.0% (14 patients; 95% confidence interval [CI], 23-57%). The median time to progression was 4.5 months (95% CI, 3.5-5.4 months). The median overall survival was 18.3 months (95% CI, 12.9-23.6 months). In the 190 cycle of treatment, the incidence of grade ≥3 neutropenia, anemia, and thrombocytopenia was 29.3%, 4.2%, and 2.0%, respectively. Neutropenic fever was noted in 6 cycles (3.1%). The non-hematological toxicities were not severe: grade 1 or 2 vomiting was observed in 22.8% of the patients. Conclusion: Our results suggest that the use of vinorelbine and ifosfamide (Ⅵ) combination chemotherapy appears to be effective and it showed an acceptable toxicity profile in the patients with taxane-resistant metastatic breast cancer.
Tsai Li-Jen,Chung Chi-Hsiang,Lin Chien-Jung,Su Sheng-Chiang,Kuo Feng-Chih,Liu Jhih-Syuan,Chen Kuan-Chan,Ho Li-Ju,Kuo Chih-Chun,Chang Chun-Yung,Lin Ming-Hsun,Chu Nain-Feng,Lee Chien-Hsing,Hsieh Chang-H 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2
Background: Diabetic patients are at high risk of developing cancer. Traditional Chinese medicine (TCM) has become increasingly popular as an adjuvant treatment for patients with chronic diseases, and some studies have identified its beneficial effect in diabetic patients with cancer. The purpoes of this study was to outline the potential of TCM to attenuate hospitalization and mortality rates in diabetic patients with carcinoma in situ (CIS). Methods: A total of 6,987 diabetic subjects with CIS under TCM therapy were selected from the National Health Insurance Research Database of Taiwan, along with 38,800 of 1:1 sex-, age-, and index year-matched controls without TCM therapy. Cox proportional hazard analysis was conducted to compare hospitalization and mortality rates during an average of 15 years of follow-up. Results: A total of 3,999/1,393 enrolled-subjects (28.62%/9.97%) had hospitalization/mortality, including 1,777/661 in the TCM group (25.43%/9.46%) and 2,222/732 in the control group (31.80%/10.48%). Cox proportional hazard regression analysis showed a lower rate of hospitalization and mortality for subjects in the TCM group (adjusted HR=0.536; 95% CI=0.367–0.780, P<0.001; adjusted HR=0.783; 95% CI=0.574– 0.974, P = 0.022). Kaplan-Meier analysis showed that the cumulative risk of hospitalization and mortality in the case and control groups was significantly different (log rank, P<0.001 and P = 0.011, respectively). Conclusions: Diabetic patients with CIS under TCM therapy were associated with lower hospitalization and mortality rates compared to those without TCM therapy. Thus, TCM application may reduce the burden of national medical resources.