급성 출혈성 대장염으로 오인된 궤양성 대장염 1예

문희정,장병익,김승범,이호찬,박재현,은종렬,김태년 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract that affects the large bowel, Its etiology remains controversial. However, an infectious or immunologic origin is considered the primary cause. The onset of UC is typically slow and insidious, but some patients may present acutely with symptoms mimicking infectious colitis. We report a case of ulcerative colitis mimicking acute hemorrhagic colitis at initial presentation. A 60-year-old man was referred to Yeungnam University Hospital for bloody diarrhea and abdominal pain. Sigmoidoscopy revealed mildly edematous mucosa in the rectum and hyperemic mucosa with petechiae in the sigmoid colon. The patient was treated with antibiotics for several days, and his symptoms improved. However, after one month, his bloody diarrhea relapsed. Follow-up sigmoidoscopy revealed mucosal friability in the rectum and sigmoid colon. He was diagnosed with ulcerative colitis, and his symptoms were improved with mesalazine and a steroid enema.

DTBP 분해를 이용한 난류연소 모델링 가능성 연구

문희장,조성찬 한국항공대학교 항공우주산업기술연구소 2003 航空宇宙産業技術硏究所 硏究誌 Vol.13 No.-

Flame propagation is analysed with the use of simple statistical model in a one dimensional spherical coordinate. The objective of this study is the use of novel fuel which is decomposed in an inert gas atmosphere making the reaction with a single step chemical kinetics. DTBP(Di-Tert-Butyl-Peroxide) chemical kinetics is a potential candidate for the study of turbulent combustion since this fuel may be used in conjunction with the development of turbulent combustion models. It was found that the proposed model results approach that of experimental results of DTBP decomposition. The fact that its heat release is at a low level compared to other substances as hydrocarbon fuel, makes the modeling study with DTBP promising. Results of turbulent flame propagation speed by the numerical study under work show that the general trend of the flame propagation is achieved, however numerical results could not simulate the time increase rate of the turbulent flame speed found by experiments.

돼지설사 원인균 E. coli의 생육저해에 대한 유산균의 효과

姜國熙,成文喜,方泰瑛,龍球淵,林讚洙 成均館大學校 科學技術硏究所 1985 論文集 Vol.36 No.1

E. coli A_2 diarrhea causing bacteria of pigs was anaerobically inoculated with 10^5/ml into prereduced YS medium (10% reconstituted skim milk+0.1% yeast extract), and then lactic acid bacteria were inoculated with 10^5/ml and 10^7ml into previous inoculated samples of E. coli A_2. Inoculated samples cultured at 37℃, were tested to determine changes in viable numbers of organisms and pH. The experimental results are summerized as follows: 1. In the mixed culture medium of 10^5/ml E. coli A_2 and L. casei YIT9018, E. coli A_2 decreased after 36 hours from incubation. 2. In the mixed culture medium of 10^5/ml E. coli A_2 and L. acidophilus, E. coli A_2 drastically decreased after 24 hours from incubation and was almost disappeared after 72 hours from incubation. 3. In the mixed culture medium of 10^5/ml E. coli A_2 and L. bulgaricus, E. coif A_2 drastically decreased after 24 hours from incubation and was almost disappeared after 72 hours from incubation. 4. In the mixed culture medium of 10^5/ml E. coli A_2 and Str. thermophilus, E. coli A_2 decreased after 12 hours from incubation. 5. When the pH value of the mixed culture, was, 4. 5 below, E. coli A_2 decreased.

성인원외폐렴의 원인미생물에대한 전향적 다기관 연구 : 성인원외폐렴의 원인으로 세균의 역할을 중심으로

우준희,강재명,김양수,신완식,류진홍,최정현,김양리,정희진,어수택,박춘식,정문현,정기석,이찬주,류지소 대한감염학회 2001 감염 Vol.33 No.1

Background : Communite-acquired peumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49% of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. Methods : A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. Results : Five hundred eighty eight cases of community-acquired peumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streprococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%), The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. Conclusion : In Korea, S.pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases. (Korean J Infect Dis 33:1∼7, 2001)

예혼합 난류유동장내 점화핵의 난류화염두께 및 난류화염속도의 예측

조성찬,문희장 한국항공대학교 항공우주산업기술연구소 2003 航空宇宙産業技術硏究所 硏究誌 Vol.13 No.-

The propagation of a flame front subjected in a given intensity of turbulent flow is numerically investigated using the presumed PDF methods. The main characteristics of a turbulent flame thickness is also calculated in order to capture the basic behavior of a turbulent flame. It was found that the proposed models can achieve the prediction of these fundamental properties of turbulent flame, and demonstrate the capacity of probability density function based statistical model. A spherical coordinate is used to simulate the on growing kernel characteristics at the early stage of spark event. The result shown for the turbulent flame thickness allowed us that this method have the potential and can be extended to low Damko¨hler number regime. A more concrete analysis is expected in the future with a more elaborated chemical reaction model.

균류 분화과정의 유전적 조절기작

박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

골격성 고정원을 이용한 상악 6전치 후방 견인시 힘의 적용점 변화에 따른 치아 이동 양상에 관한 유한 요소법적 분석

김찬년,성재현,경희문 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.5

본 연구에서는 활주법을 이용한 전치부 후방 견인시 micro-implant의 다양한 수직적 위치와 전치부에서 힘의 적용점에 따른 치아 이동 양상을 관찰하여 공간 폐쇄시 전치부의 설측 경사와 정출력을 방지할 수 있는 micro-implant의 위치와 전치부 힘의 적용점의 위치를 알아보고자 하였다. 유한 요소 모델을 이용하여 제1소구치가 발거된 상악 치열궁형태를 제작하고 .022" × .028" 슬롯 브라켓을 모형 화하여 치아에 부착시켰다. .019" × .025" stainless steel 선재를 3차원 beam모형으로 제작하고 상악 측절치와 견치 브라켓 사이의 선재 상에 .032" × .032"크기의 stainless steel hook을 수직으로 8mm의 높이로 형성하였으며, 선재로부터 2mm높이에서 1mm간격으로 8mm까지 힘 적용점을 설정하였다. 지름 1.2mm, 길이 6mm의 micro-implant를 제2소구치와 제1대구치 사이의 치조골에 선재로부터 4mm에서 10mm까지 2mm간격으로 4개를 위치시켰다. 각각의 micro-implant와 전치부 hook에 150gm의 힘을 적용시켜 다양한 힘 적용점에 따른 치아의 초기 변위를 분석하여 다음의 결과를 얻을 수 있었다. 1. Micro-implant 높이가 4mm일 경우 5mm이하의 전치부 hook 높이에서는 전치부 설측 경사 이동이 일어났으며 전치부 hook 높이가 6mm이상 되었을 때 전치부 순측 경사 이동이 일어났다. 2. Micro-implant 높이가 6mm일 경우 5mm 이하의 전치부 hook높이에서 전치부 설측 경사 이동이 일어났으며 전치부 hook높이가 6mm이상 되었을 때 전치부 순측 경사 이동이 일어났다. 이것은 4mm micro-implant에서의 실험결과와 유사한 이동 양상을 나타내었지만, micro-implant 높이가 6mm일 때 전치부 설측 경사 이동이 좀더 감소하였다. 3. Micro-implant 높이가 8mm일 경우 전치부 hook 높이가 2mm일 때 전치의 설측 경사 이동이 일어났으며 3mm 이상의 전치부 hook 높이에서 순측 경사 이동이 비례적으로 증가하였다. 4. Micro-implant 높이가 10mm일 경우 전치부 hook높이가 2mm이상에서 전치의 순측 경사 이동이 비례적으로 증가하였다. 5. 전치부 hook 높이가 증가할수록 전치의 순측 경사 이동이 증가되지만 선재의 뒤틀림에 의한 변형이 증가되므로 견치와 소구치 부위에서 정출력이 발생하는 바람직하지 못한 치아 이동 양상이 일어났다. 6. Micro-implant를 이용한 상악 6전치 후방 견인시 구치부의 이동은 선재와 브라켓 사이의 마찰력에 의해서 원심경사 이동이 발생하였다. The purpose of this study was to investigate the micro-implant height and anterior hook height to prevent maxillary six anterior teeth from lingual tipping and extruding during space closure. We manufactured maxillary dental arch form, bracket and wire, using the computer aided three-dimensional finite element method. Bracket was .022" × .028" slot size and attached to tooth surface. Wire was .019" × .025" stainless steel and .032" × .032" stainless steel hook was attached to wire between lateral incisor and canine. Length of hook was 8mm and force application points were marked at intervals of 1mm. Four micro-implants were implanted on alveolar bone between second premolar and first molar. The heights of them were 4, 6, 8, 10mm starting from wire. We analyzed initial displacement of teeth by various force application point applying force of 150gm to each micro-implant and anterior hook. The conclusions of this study are as the following : 1. When the micro-implant height was 4mm and the anterior hook height was 5mm and below, anterior teeth were tipped lingually. When the anterior hook height was 6mm and above, anterior teeth were tipped labially. 2. When the micro-implant height was 6mm and the anterior hook height was 5mm and below, the anterior teeth were tipped lingually. When the anterior hook height was 6mm and above, the anterior teeth were tipped labially. But lingual tipping of anterior teeth decreased and labial tipping increased when the micro-implant height was 6mm, compared with 4mm micro-implant height. 3. When the micro-implant height was 8mm and the anterior hook height was 2mm, the anterior teeth were tipped lingually. When the anterior hook height was 3mm and above, labial tipping movement of the anterior teeth increased proportionally. 4. When the micro-implant height was 10mm and the anterior hook height was 2mm and above, labial tipping of the anterior teeth increased proportionally. 5. As the anterior hook height increased, anterior teeth were tipped more labially. But extrusion occurred on canine and premolar area because of the increase of wire distortion. 6. Movement of the posterior teeth was tipped distally during maxillary six anterior teeth retraction using micro-implant because of the friction between bracket and wire. Based on the results of this study, we could predict the pattern of the tooth movement according to position of micro-implant and height of anterior hook. It seems that we can find the force application point for proper tooth movement in consideration of inclination of maxillary anterior teeth, periodontal condition, overjet and overbite.

서울시 일부 대학생들의 건강습관과 건강상태의 관련성 연구

옥찬명,문인옥,김연희 대한보건협회 2001 대한보건연구 Vol.27 No.3

The purpose of this study was to find the association with the health practices and health status for university students. The subjects were taken 804 university students in seoul. The data were collected by self-administered questionnaire during 2 weeks from October 15, 2000. The findings were as follows: 1. Only 33.3% of the subjects had taken a health education-related class. 2. The male students showed better health practices than females on no snacks (p<0.001), going to bathroom regularly(p<0.001), taking a walk(p<0.01), and doing exercise(p<0.001). On the other hands the female students showed better practices such as no smoking and no drinking. 3. Religious showed higher health practice scores than non-religious ones(p<0.001). 4. Seventy five point nine percent of the respondents were in healthy group showing significant difference by sex (p<0.001) with 2.79 odds ratio. 5. The healthy group showed better health practices than non-healthy group such as on going to bathroom regularly(p<0.01), taking a walk (p<0.01), and having low stress(p<0.001). And the healthy group got more stress than the unhealthy group showing significant difference statistically (p<0.001). 6. To designate the factors influencing students' health status, logistic regression analysis has been done. According to the results of this analysis, health practices, and sex were selected as significant factors associated with the health status. The students who got higher health practices perceived their health better than lower health practices with odds ratio [OR] = 3.73 (p<0.001). And health practices had the most significant effect on health status. And the odds ratio of good health status was 2.61 for male students(p<0.001).

퍼지 신경망을 이용한 압전구동기 변위의 비선형성제어

채재희,문찬영,김인수 金烏工科大學校 2000 論文集 Vol.21 No.-

Piezoelectric actuator is a promising actuator to be expected to play a key role in the mechatronics. However it has a nonlinear characteristics due to hysteresis between input voltage and displacement. This paper proposes a method to model and linearize the nonlinear characteristics of piezoelectric actuator using fuzzy-neural network and feedforward control. Experimental result describes that nonlinearity may be reduced 70 percentage by the proposed method.

만성 화농성 중이염의 세균학적 고찰

윤신의,문문만,김승찬,박희완,나한조,최봉남 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The chronic suppurative otitis media is one of the most common disease in the otologic field. And the works on bacterial distribution of chronic suppurative otitis media were studied by many otologist, but there is some difference. The bacteriologic study was done on 126 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Chosun University Hospital between January 1989 and December 1989 and the following conclusions were obtained. 1) In sex distribution, the male had higher incidence rate than female (M: 56.3%, F:43.7%). 2) In age distribution, 3rd decade (34.1%), 2nd decade (34.1%), were most prevalent. 3) In duration of the disease, the hightest frequence was below 5 years duration 4) Among 126 cases, 98 cases(77.8%) were unilateral (right ear was 47 cases(37.3%) and left ear was 51 cases(40.5%))and 28 cases(22.2%) were bilateral. 5) The 136 cases(88.3%) showed the positive results under culture, but 18 cases(11.7%) didn't growthed. Among 136 cases 95 cases(61.7%) had single infection and the 41 cases(26.6%) had mixed infection. 6) The most frequently isolated bacteria was staphylococcus(38 strains, 27.9%) and next were proteus(27 strains, 19.9%) and pseudomonas (22 strains, 16.2%). 7) The Staphylococcus was sensitive to cephalothin(94.7%), amikacin(78.9%) and resistant to penicaIin(63.2%). 8) The Proteus was sensitive to amikacin(92.6%), cephalothin(88.9%) and resistant to minocycline(81.5%) and gentamicin(70.4%). 9) The Pseudomonas was sensitive to amikadn(86.4%), gemtamicin(59.1%) and resistant to minocycline(90.9%), ampicillin(86.4%) and cephalothin(86.4%).