多環芳香族炭化水素類에 의한 화학발암의 양자생화학적 해석

朴柄珏,都聖鐸,徐萬哲 嶺南大學校附設 基礎科學硏究所 1986 基礎科學硏究 Vol.6 No.-

The interaction of polycyclic aromatic hydrocarbons (PAH) with deoxyrkbonucleic acid(DNA) were studied by means of extended Huckel method. Assuming that the formation of a loose molecular complex between each PAH and DNA is the first step of chemical carcinogenesis, the plausible orientation of the complex formed between the PAH and the the adenine-thymine pair or the guanine-cytosine was figured out. On the basis of the most probable orientation, the charge transfer quantities of the DNA bases (A-T pair and G-C pair) and PAH complexes were calculated and compared with carcinogenicity. It was found that the parallel relationship between charge transfer quantity of the G-C pair and PAH complex and carcinogenicity exists, but not between that of the A-T pair and PAH complex and carcinogenicity. Thus, the interaction of the G-C pair with the carcinogens seems to play an important role in the carcinogenesis.

인체대장암에서의 Cyclin 유전자의 발현

백원기,서민호,서성일,문성희,박종욱,최병길,배옥석 대한대장항문학회 1996 Annals of Coloproctolgy Vol.12 No.2

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

내시경적 점막절제술로 치험한 식도 과립상 세포종 1례

강혁주,김성욱,최석진,이중현,장재식,서영범,윤병구,박건욱,김성자,김용섭,강승완,이구,양창헌,이창우,김욱년,이광헌,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

과립상 세포종은 Schwann 세포 기원으로 생각되며 인체에 비교적 드물게 발생한다. 과립상 세포종은 전신 어느 곳에서나 발견될 수 있으나 주로 혀, 구강, 피부 혹은 유방 등에서 호발하며 드물게 위장관에서 발견된다. 위장관에서는 식도에서 가장 호발하며 다음으로 위, 대장 순이다. 과립상 세포종은 대부분, 특히 위장관에서는 양성이며 소수의 악성 병변이 보고되었다. 이러한 이유와 함께 수술 전의 진단이 어렵기 때문에 과립상 세포종에 대한 근본적인 치료는 현재까지 외과적 절제술이다. 최근에 시도되는 치료방법들로는 내시경적 레이저 치료, 용종절제술, 내시경적 점막 절제술 등이 있다. 저자들은 상부 소화관 내시경검사를 시행하여 식도 과립상 세포종을 진단하고 내시경적 점막 절제술을 시행하여 합병증 없이 퇴원하여 현재 재발없이 경과 관찰중인 1례를 경험하였기에 보고하는 바이다. Granular cell tumors, which occur infrequently, are probably of Schwann cell origin. They can occur almost anywhere in the body but usually affect the tongue, oral cavity, skin, or breasts and are rarely found in the gastrointestinal tracts. The esophagus is the most frequent gastrointestinal site, followed by the stomach and the colon. Granular cell tumors are generally benign, especially in the gastrointestinal tract, some malignant lesions have been reported. For this reason, and also because preoperative diagnosis is difficult, the standard treatment for granular cell tumor has until now been surgical excision. In recent years, other therapeutic methods is endoscopic laser therapy (ELT), polypectiomy, endoscopic mucosal resection (EMR). We report a case of esophageal granular cell tumor which was diagnosed by an endoscopy and managed using an endoscopic mucosal resection without complication.

국내 회전익 조종사 항공 신체 검사 2015년 연간 현황

서병성(Byung-Seong Suh),현우석(WooSeok Hyun),곽인호(Inho Kwak),권영환(Young Hwan Kwon),김규성(Kyu-Sung Kim),안철민(CheolMin Ahn),이진우(Jin-Woo Lee),진희승(Hee Seung Chin),하윤(Yoon Ha),장정순(JoungSoon Jang) 한국항공우주의학협회 2017 항공우주의학회지 Vol.27 No.3

The medical certification for pilots is required by the aviation safety authority in most countries based with the International Civil Aviation Organization (ICAO) recommendation. In this study, medical data of the year of 2015 for the Korean rotary-wing pilot population, including examination findings and reasons of unfitness were reviewed by retrospective analysis. Among the total 591 cases, 64 (10.8%) were determined to be conditioned fit as a consequence of abnormal findings. Three (0.5%) were denied certification as unfit. Hearing loss (32.8%) was the most common cause of disqualification differing from that of fixed-wing pilots. It is not surprising data in that helicopter is notorious for its noise and vibration when flying compared with fixed-wing aircraft. Hypertension (23.9%) and diabetes (9%) were following causes. There was an increasing variation in medical unfitness as pilots" age and total flight time are increased respectively. Rate of the conditioned fit tends to be significantly increasing the age of 55 or more or the flight time of 5,000 hours. These results suggest that aeromedical decision should be made under understanding of the influence of age, total flight time and aircraft type flight environment to ensure flight safety.

국내 회전익 조종사 항공 신체 검사 2015년 연간 현황

서병성(Byung-Seong Suh),현우석(WooSeok Hyun),곽인호(Inho Kwak),권영환(Young Hwan Kwon),김규성(Kyu-Sung Kim),안철민(CheolMin Ahn),이진우(Jin-Woo Lee),진희승(Hee Seung Chin),하윤(Yoon Ha),장정순(JoungSoon Jang) 한국항공우주의학협회 2017 항공우주의학회지 Vol.27 No.1

임상가검물에서 최근 6년간 분리한 대장균의 항균제내성의 추이

서성일(Seong-Il Suh),백성덕(Sung-Duk Paik),백원기(Won-Ki Beak),박종욱(Jong-Wook Park),최병길(Byung-Kil Choe),서민호(Min-Ho Suh) 大韓微生物學會 1994 大韓微生物學會誌 Vol.29 No.6

Increase of Production Ratio of Pre-selected Superior Dairy Female Offspring by Combination of OPU derived Oocytes and X-bearing Semen

Seong-Su Kim,Byung-Hyun Choi,Kyeong-Lim Lee,Jong-In Jin,Tae-Kwang Suh,Cheol-Ho Son,Chan-Ho Park,Seung-Oh Shin,Kwang-Jin Han,Hyun-Tae Lim,Kyu-Woan Cho,Il-Keun Kong 한국수정란이식학회 2015 한국동물생명공학회지 Vol.30 No.2

This study was designed to evaluate the possibility of increase through dairy female offspring’s ratio by transfer of pre-selected transferrable blastocyst that was produced by pre-selected X-bearing semen with OPU derived oocytes. Elite dairy female cow is demanded strongly compared with male, the so called, farmer wants to produce only an elite female dairy offspring as a candidate female dairy cow for producing milk. In our study, we selected 2 elite dairy bull semen from National Agricultural Cooperative Federation to pre-select X-bearing semen and 5 elite dairy female cows as donor for collecting of OPU derived oocytes. OPU derived embryo production system was carried out an aspiration of immature oocytes from 5 donor cows 2 times per week, total 200 times for 2 to 7 months by an ultrasonographic guided follicular aspiration system and then produced in vitro-produced blastocysts by in vitro maturation, fertilization and culture. Dairy donor semen selected H-319, 320 bull in National Agricultural Cooperative federation was sorted X-bearing semen by flow-cytometer and frozen for using IVF with OPU derived oocytes. Donor cows were selected 5 elite dairy cows from Gyeongju Dairy Cow Community and then disease tests such as 4 kinds of disease before selecting was checked. Oocyte proportion of grade 1 to 3 from total collected oocytes was significantly lower in donor A and B than those in donor C, D and E (82.16 and 70.03% vs. 90.0, 91.78 and 93.57%), respectively (p<0.05). However, number of oocytes per session in donor A, C and E was significantly higher than those in donor B and D (7.77 ± 3.26, 5.85 ± 2.10 and 7.03 ± 2.14 vs. 4.68 ± 2.61 and 5.21 ± 1.97 oocytes), but donor A was significantly higher than donor C (p<0.05). Development to blastocyst in donor B, C and E was significantly higher than those in donor A and D (31.0, 25.0 and 25.0% vs. 14.3 and 4.5%), but donor A was not different in donor C and E (p<0.05). Nine out of 10 blastocysts (90.0%) derived from OPU blastocysts were confirmed male embryos that was induced with Y-bearing semen to confirm sex ratio only. Total 96 blastocysts derived from female bearing semen were transferred into synchronized recipients and then confirmed 42 recipients (43.8%) pregnancy rate, 36 offspring (37.5%) and 91.7% female sex ratio (33 female vs. 3 male offspring). Taken together all data, elite dairy female offspring could be produced effectively by in vitro production system between pre-selected x-bearing semen and OPU derived oocytes that would be influential breeder in the breeding of dairy farm to increase effectively elite dairy offspring ratio as well as net income in the dairy farmer.

Determination of Medium Components in the Flocculating Activity and Production of Pestan Produced by Pestalotiopsis sp . by Using the Plackett - Burman Design

( Seong Hoon Moon,Soon Duck Hong,Gi Seok Kwon,Hyun Hyo Suh,Hee Sik Kim,Keug Hyun An,Hee Mock Oh,Tae Ick Mheen,Byung Dae Yoon ) 한국미생물생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.4

도시아파트의 실내외 NO₂농도와 관련요인에 관한 연구

서병성,도수영,김인식,김정만,김준연,김성환,허윤영 동아대학교 부설 산업의학연구소 1997 산업의학연구소 논총 Vol.- No.3

부산지역의 한 아파트 단지내 489세대를 대상으로 아파트 실내외의 NO₂농도를 측정하고 동시에 NO₂농도의 관련 변수들을 조사하여 양자간의 관련성을 파악하고자 본 연구를 실시하였다. 아파트 실내외의 NO₂농도는 개인용NO₂포집관(Palmes tube)을 사용하여 1995년 8월 16일 - 8월 25일(하계)과 1996년 1월 15일 - 1월 29일(동계)간에, 그리고 가스렌지 근처, 주방, 거실 및 아파트 옥외에서 측정하였다. 본 연구의 결과를 요약하면 다음과 같다. 1) 각 세대의 가스렌지 근처와 주방, 거실 및 실외의 평균 NO₂농도는 하계는 각각 25.9±10.0ppb, 23.3±8.0ppb, 19.9±6.1ppb 및 19.0±6.0ppb이며, 동계는 34.5±16.8ppb, 28.2±13.4ppb, 25.3±12.5ppb 및 21.8±9.8ppb로서 동하계 공히 부엌의 가스렌지 근처의 NO₂농도가 최고이었고 하계에 비하여 동계의 실내외 NO₂농도가 유의하게 높았다. 2) 아파트 층수별 NO₂농도는 하계에는 층수에 따른 NO₂농도의 유의한 변화가 없었으나, 동계는 16층 이상을 제외하면 층수가 높아짐에 따라 NO₂농도가 감소하였다. 3) 아파트 실내 NO₂농도의 관련변수는 하계의 경우 층수, 가족수, 1회 식사시 평균 가족수, 취사시 가스렌지 1일 평균 사용횟수, 자연 환기이었고, 동계에는 층수, 가족수, 1회 식사시 평균 가족수, 총 식사 인원수, 식사 횟수, 가족의 총 연령, 취사시 가스렌지 1일 평균 사용 횟수, 조리시 가스렌지 1일 평균 사용 횟수, 호흡기 질환자 유무 등이었다. 4) 아파트 실내 NO₂농도의 감소 방안으로는 취사 혹은 조리시 환기를 철저히 하고, 완전연소, 연소의 횟수와 시간 단축 및 연료의 대체가 필요하다고 생각한다. Nitrogen dioxide (NO₂) has been regarded as one of the main elements among air pollutants, and we measured NO₂levels of near gas range, kitchen, living room and outdoor on 489 apartments in Pusan area. NO₂were sampled by using Palmes tubes (diffusion tube sampler) during August 16-25, 1995 (summer) and January 15-29, 1996 (winter), respectively. Authors wanted to know comparison of NO₂levels in summer and winter, NO₂levels categorized by variables, and variables affected to NO₂levels. According to this study, we conducted to establish the degree of indoor-outdoor air pollution of urban apartments in Korea and methods to reduce indoor air pollution. The results of this study were summarized as follows: 1) Mean NO₂levels of near gas range, kitchen, living room, and outdoor were 25.9±10.0 ppb, 23.3±8.0 ppb, 19.9±6.1 ppb, and 19.0±6.0 ppb in summer, and 34.5±16.8 ppb, 28.2±13.4 ppb, 25.3±12.5 ppb, 21.8±9.8 ppb in winter, respectively. 2) Mean NO₂levels according to the floor levels were not significantly different in summer, and in winter, NO₂levels were decreased as the floor levels were increasing, but those were increased above 16th floor. 3) Variables showing significant correlation(p<0.05) with NO₂levels were as follows; Summer: floor level, family size, number of family during a meal, number using gas range during rice cooking per day, and natural ventilation. Winter: floor level, family size, number of person who have been respiratory disease in a house, number of family during a meal, total number of meals, and number using gas range during rice of side-dish cooking per day. 4) We suggest that the methods of reducing indoor NO₂levels are ventilation during cooking, complete combustion, decreasing number and time of cooking, and substitution of fuels.