광대역 고출력 공간 전력 증폭 소자에 관한 연구

이성호,권세웅,이병무,윤영중 연세대학교 산업기술연구소 2002 논문집 Vol.33 No.2

In this paper, spatial amplifier using wideband printed dipole antennas is proposed for spatial power combining. The input and output printed dipole antennas have wide bandwidth of 22 %(5.44 ㎓∼6.75 ㎓) and 26.3 %(5.2 ㎓∼6.78 ㎓), respectively. Gain of the designed amplifier is 9.5 ㏈ at 6 ㎓. As a result, the proposed spatial amplifier using wideband printed dipole antennas and amplifiers shows that the gain is 16.8 ㏈ at 6 ㎓ and 3-㏈ gain bandwidth is 1.04 ㎓.

Molecules of the Tumor Necrosis Factor(TNA) Receptor and Ligand Superfamilies : Endless Stories

Kwon, Byoung Se,Kwon, Byung Suk 생화학분자생물학회 2000 BMB Reports Vol.32 No.5

Tumor necrosis factor (TNF) receptor members have unique structures composed of 2-4 cysteine - rich pseudorepeats in the extracellular domain. On ligation by trimeric ligand molecules, oligomerization of three receptor molecules occurs, which in turn activates the receptor and recruits intracellular signaling molecules to the cytoplasmic tail to initiate biological events. Recently, the numbers of tumor necrosis factor receptor and ligand family members have been rapidly expanding. Functional characterization of the new members has indicated redundant roles with other known members as well as provided insights into novel functions. In particular, identification of soluble decoy receptors which have the ability to bind multiple ligands highlights a complex control mechanism of immune responses by these molecules. Studies of the new members have also revealed that the TNF receptor and ligand family members play an important role in other than the immune system.

Studies on a Method of Rapid Test for Hepatitis Associated Antigen and its Prevalence in Korea

Byoung Se Kwon,Seung Hoon Lee,Ho Wang Lee 대한바이러스학회 1973 Journal of Bacteriology and Virology Vol.3 No.1

인천지역 소아 입원 환자의 엔테로바이러스 역학과 혈청형에 따른 임상양상 비교

조병욱 ( Byoung Wook Cho ),권성은 ( Seong Eun Kwon ),권문주 ( Mun Ju Kwon ),허명제 ( Myong Je Hur ),김경선 ( Kyung Seon Kim ),홍영진 ( Young Jin Hong ),김순기 ( Soon Ki Kim ),권영세 ( Young Se Kwon ),김동현 ( Dong Hyun Kim ) 대한소아감염학회 2016 Pediatric Infection and Vaccine Vol.23 No.1

목적: 소아에서 엔테로바이러스 감염증은 무증상 감염부터 비특이적 발열성 질환, 수족구병, 수막뇌염등 다양한 질환으로 나타날 수 있다. 본 연구는 소아 입원 환자들을 대상으로 엔테로바이러스 감염의 유전자형 별 임상양상에 대하여 알아보고자 하였다. 방법: 2014년 3월부터 2015년 3월까지 인하대병원에 입원한 환자들 중 400명을 대상으로 real-time reverse transcriptase-polymerase chain reaction (RT-PCR)로 엔테로바이러스를 검출하였으며, RT-seminested PCR로 혈청형을 분석하였다. 염기서열의 계통분석을 시행하여 neighbor-joining tree를 작성하였다. 결과: 전체 연구대상 400명 중 112명(28%)에서 엔테로바이러스 양성이 확인되었으며 엔테로바이러스 양성 환자의 평균연령은 2.66세(3일-14세), 남녀 성비는 1.73:1 이었다. 65개의 검체에서 엔테로 바이러스의 혈청형을 확인할 수 있었고, coxsackievirus B5 17례(15.2%), coxsackievirus A16 13례 (11.6%), enterovirus 71 10례(8.9%), coxsackievirus A2 9례(8.0%) 순이었다. 엔테로바이러스 양성 환자들 중 96명(86%)에서 비특이적 발열 증상이 있었으며, 0-11일의 다양한 발열기간을 나타냈고, 평균 발열기간은 3.13일이었다. 발진은 전체 양성환자 중 44명(39%)에서 나타났으며, 수막뇌염은 43명 (38%)에서 나타났다. 염기서열에 따른 계통 분석에서 6개의 유전적 군집이 관찰되었다. 결론: 저자들은 인천지역 단일기관에 입원한 환자에서 분리된 엔테로바이러스의 혈청형과 임상양상을 확인하였다. 본 연구 결과가 앞으로 국내 엔테로바이러스 감염의 역학을 파악하는 데에 도움을 줄 것으로 생각한다. Purpose: Enterovirus (EV) infection in children can manifest various diseases from asymptomatic infection to nonspecific febrile illness, hand-foot-mouth disease, and aseptic meningitis. This study was aimed to investigate epidemiology and clinical significance of various geno types of EV infections in pediatric inpatient. Methods: We collected the stool samples from the admitted pediatric patients in Inha University Hospital from March 2014 to March 2015. EV detection and genotype identification were performed by real-time RT-PCR and semi-nested RT-PCR. Phylogenetic trees were constructed by neighbor joining method. Results: A total of 400 samples were collected during study period and 112 patients (28%) were diagnosed with EV infections. The mean age of EV positive patients was 2.66 years (0.1-14) and sex ratio was 1.73:1. Genetic sequences of EVs were identified; coxsackievirus B5 (17, 15.2%), coxsackievirus A16 (13, 11.6%), enterovirus 71 (10, 8.9%), and coxsackievirus A2 (9, 8.0%). Nonspecific febrile illness (96, 86%) was the most common clinical manifestation and the duration of fever was 0-11 days (mean 3.1 days). Rash (44, 39%) and meningitis (43, 38%) were followed. Patients who were attending daycare center or had siblings accounted for 82.1%. Phylogenetic relationship tree re vealed 6 distinct genogroups among 56 types of EVs. Conclusions: This study is the report of epidemiology, serotype distribution and clinical manifestations of children with EV infection in Incheon. This data will be helpful for further study about the epidemiology of EV infection in Korea.

[PF-0048] Broad bean wilt virus 2 Resistance Source Screening and Gene Mapping in Hot Pepper

Jung-Min Kim(Jung-Min Kim ),Joung-Ho Lee(Joung-Ho Lee ),Se-Ran Park(Se-Ran Park ),Jin-Kyoung Kwon(Jin-Kyoung Kwon ),Byoung-Cheorl Kang(Byoung-Cheorl Kang ) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Enhanced Charge Transfer of QDs/Polymer Hybrid LED by Interface Controlling

Byoung-Ho Kang,Sang-Won Lee,Sung-Woo Lim,Tae-Yang You,Se-Hyuk Yeom,Kyu-Jin Kim,Dae-Hyuk Kwon,Shin-Won Kang IEEE 2013 IEEE electron device letters Vol.34 No.5

<P>We propose a quantum dots (QDs)/poly(N-vinylcarbazole) (PVK) hybrid light-emitting diode (LED) to improve the electron and hole confinement in the QDs layer. QDs used as monochromatic emitters are dispersed in a PVK matrix with a wide bandgap for quantum wells. The HOMO and LUMO level of the PVK can act as a hole transport buffer and an electron-blocking buffer in the hybridized layer. We fabricate an LED using a simplified QDs/PVK hybrid emissive layer (EML) and compare its performance with that of the hybrid LED with controlled QDs concentration. From the result, it is found that the 1.0 wt% QDs within the PVK hybrid LED show the best performance among the compared LEDs, with a luminance of 5989 cd/m<SUP>2</SUP> and an efficiency of 4.2 cd/A. The efficient energy transfer and performance of the QDs/PVK hybrid EML are highly depended on the doping concentration of the QDs.</P>

CRISPR/Cas9-mediated knockout of neuraminidase genes in CHO cells for production of glycoproteins with increased content of sialic acids.

Se-Jong Lim,Keun Koo Shin,Ohsuk Kwon,Doo-Byoung Oh 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07

Sialic acids present on non-reducing terminal of glycan is important for prolonged in vivo half-life of glycoproteins. Many efforts have been made to increase the sialic acid content in the manufacturing of therapeutic glycoproteins because glycoproteins containing non-sialylated glycans do not show effective in vivo efficacies owing to a short half-life. It was reported that knock down of neuraminidase expression using the RNA interference (RNAi) technology enhanced protein sialylation in CHO cells which are the most widely used for therapeutic glycoprotein production [1]. However, knock down strategy did not completely shut down the neuraminidase expression. In this study, we performed knockout of neuraminidase genes in CHO cells by using the CRISPR/Cas9 genome editing technology. Only three neuraminidase (Neu1, Neu2, and Neu3) were actively expressed in CHO cells when analyzing their expressions using real-time polymerase chain reaction (PCR). Neu3 is located in the plasma membrane while Neu1 and Neu2 exist in lysosome and cytosol, respectively. After the transfection of vectors expressing Cas9 and sgRNAs, Neu-disrupted clones were selected by using the T7 endonucleases 1 (T7E1) assay and further confirmed by the sequencing analysis of the corresponding editing sites. All of single mutants (Neu1-, Neu2-, and Neu3-disrupted clones) displayed similar proliferation ability compared to wild-type CHO cells. Two of double Neu-disrupted mutants (Neu1Neu3- and Neu2Neu3-dirupted mutants) were currently constructed. Our goal is to construct the triple knockout CHO cell mutant (Neu1Neu2Neu3-disrupted clone) and investigate its phenotypes and features.

우안의 시력 저하를 주소로 내원한 10세 여자에서 진단된 Clinically isolated 증후군 1례

권세호,이병국,이흔지,문지영,민성주,박철용,박수연 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1

Clinically isolated 증후군은 염증성 탈수초가 원인으로 추정되는 중추신경계 증상이 급성으로 처음 발현하는 경우를 일컫는다. 이 때 뇌 또는 전척수 자기 공명 영상에서 무증상적 다발성 병변이 있을 경우 추후 다발성 경화증으로 진행될 가능성이 높아진다. 다발성 경화증은 시신경을 포함한 중추신경계의 여러 부위에 발생하는 탈수초성 질환으로 시간 간격을 두고 다양한 형태의 임상 양상을 보이며 호전과 재발을 반복하는 질환이다. 이 질환은 성인기에 주로 발병한다고 알려져 있으나 소아에서도 드물게 발생하며 발병 후 다양한 정도의 합병증 및 후유증을 남길 수 있다. 저자들은 우안의 시력 저하를 주소로 내원하여 시행한 자기 공명 영상 검사에서 중추신경계의 다발성 병변을 보여 clinically isolated syndrome (CIS)으로 진단된 1례를 경험하였고 이 경우 다발성 경화증으로 이행할 가능성이 있기에 문헌 고찰과 함께 보고하는 바이다. A clinically isolated syndrome is a first acute clinical episode of CNS symptoms with a presumed inflammatory demyelinating cause for which there is no prior history of a demyelinating event. MRI evidence of multiple clinically silent lesions may be associated with an increased risk of multiple sclerosis. Multiple sclerosis is a demyelinating disorders that affects discrete areas of the CNS, including the optic nerve, in a quite variable relapsing-remitting fashion over a prolonged period of time. Although usually considered to be a disease that affects people in early to middle adulthood, children develop multiple sclerosis and may account for up to 4% to 5% of all reported cases. We present a case of clinically isolated syndrome in 10 year-old girl with decreased right visual acuity. She was admitted due to decreased unilateral visual acuity that known incidentally. We founded abnormal finding on brain and whole spine magnetic resonance imaging and treated her with steroid.

Identification and Characterization of a Novel Chemokine , Leukotactin -1 , in Atherosclerosis

N/A,N/A,이원하,N/A,N/A,N/A 한국지질학회 2000 韓國脂質學會誌 Vol.10 No.1

Hematological manifestations of human immunodeficiency virus infection and the effect of highly active anti-retroviral therapy on cytopenia

Se Youn Choi,Inho Kim,김남중,Seung-Ah Lee,Youn-Ak Choi,Ji-Yeon Bae,Ji Hyun Kwon,Pyoeng Gyun Choe,박완범,Sung-Soo Yoon,Seonyang Park,Byoung Kook Kim,Myoung-Don Oh 대한혈액학회 2011 Blood Research Vol.46 No.4

Background :The aim of this study is to investigate the hematological manifestations of human immunodeficiency virus (HIV) infection, the risk factors for cytopenia, and the effect of highly active anti-retroviral therapy (HAART) on cytopenia. Methods :Medical records of patients treated for HIV at the Seoul National University Hospital from January 2005 to March 2010 were retrospectively reviewed. To determine the impact of HIV itself, we excluded HIV patients who had other conditions that could have resulted in hematological manifestations. Multiple logistic regression analyses were performed to identify risk factors for cytopenia. Results :A total of 621 cases were investigated, and after exclusion, data of 472 patients were analyzed. The frequency of cytopenia was anemia, 3.0% (14/472); neutropenia, 10.0% (47/472); thrombocytopenia, 2.4% (12/472); lymphopenia, 25.7% (121/470); isolated cytopenia, 11.2% (53/472); and bicytopenia, 2.1% (10/472). The leading risk factor for cytopenia identified by multivariate logistic regression methods was AIDS status at initial presentation. After HAART, cytopenia was reversed in the majority of patients (thrombocytopenia, 100%; neutropenia, 91.1%; and anemia, 84.6%). Conclusion :This study isolated the impact of HIV infection alone on hematologic manifestations and confirmed that these changes were reversible by HAART. Control of the HIV infection will have the main role in the management of hematological manifestations of the virus.