Thioacetamide에 의한 BALB/c 마우스 간의 시간별 약물대사효소 억제 양상 : A Time-Course Study

이정운,고우석,김갑호,배연경,하현정,한상섭,천영진,정태천 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

Thioacetamide is a potent hepatotoxicant which requires metabolic activation by cytochrome P450s (P450s) for toxicity. In the present study, the elevation kinetic of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities by thioacetamide treatment was investigated in male BALB/c mice. Inaddition, the inhibitory effects of thioacetamide on liver microsomal P450 enzymes were further investigated. Thioacetamide at 100 mg/kg/ was treated intraperitoneally for 6, 12, 24, 36, 48 and 72 hr. The blood was collected at the designated time for assaying the serum enzyme activities. To determine the P450 isozyme-specific activities. ethoxyresorufin O-deethylase (EROD), methoxyresorufin O-demethylase (MROD), and benzyloxyresorufin O-debenzylase (BROD) activities were determined for P450 1A1, 1A2 and 2B1, respectively, in liver microsomal fractions. The activities of ALT and AST were started to be elevated 6 hr after thioacetamide treatment andreached the maximun at 36 hr after the treatment. The elevated activities were dramatically recovered at 72 hr. The microscopic exmination of the liver specimen also showed a similar profile of hepatotoxicity. All P450-associated enzyme activities were time-dependently inhibited by the treatiment with thioacetamide. The maximum inhibition of P450 enzymes was observed 36 hr after the treatment. Because the inhibition of P450 enzymes by thioacetamide was time-dependent, our present results suggest that thioacetamide might inhibit P450 enzymes in mechanism-based inactivation.

근로자 건강증진전략을 위한 행동변화에 대한 요구도 평가

이강숙,임현우,구정완,홍현숙,이정민,이원철,박정일,맹광호,M, O'Donnel 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : In order to evaluate the stage of behavior change for health promotion strategy in workplace Methods : Questionnaire survey was carried out for 309 workers who employed in H Electronics company in Kyong-in area from September to October 1998. Results : According to need assessment of four step such as precontemplation stage, contemplation stage, action stage, maintenance stage which were to change of behavior for health promotion, the percent for quitting smoking were observed 48.8%, 43.1%, 8.1%, 0%, and for the restriction of drinking were 29.8%, 10.6%, 9.3%, 5.3%; for fitness 11.1%, 31.0%, 37.3%, 20.6% in male 26.6%, 27.8%, 26.6%, 19.0% in female, for regular diet 26.1%, 19.8%, 38.7%, 15.3% in male, 27.8%, 22.2%, 40.0%, 10.0% in female and for stress management 5.8%, 10.6%, 8.7%, 75.0% in male, 13.6%, 22.7%, 19.7%, 44.0% in female. In heavy smoker(p=0.017) and heavy drinker,(p=0.021) the percent of precontemplation stage was significantly higher than in lower drinker and light smoker. Conclusions : This study suggested that company support for health promotion in workplace was and workers of high risk group for smoking and drinking were in precontemplation stage. So before conducting the health promotion program, health risk appraisal and need assessment for stage of behavior change should be taken for the efficient health promotion strategy.

농촌 지역 남자 중학생의 라면 섭취실태와 식품가치 인식 및 혈청 지질농도간의 상관관계

이정원,이연호 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

In order to investigate the ramyeon intake patterns, food value recognition, and their effects on blood pressure and blood lipid levels, a total of 385 male students aged 13 - 15 years living in rural area were sampled randomly, and they were surveyed using questionnaire. Blood pressure and fasting serum lipids levels of 123 subjects selected among the total were determined. Of the total subjects 80.3% either liked or liked very much ramyeon and 42.2% of them were eating ramyeon from 1 to 2 times a week, 21.1% 5 - 6 times a week, while 11.7% more than once a day, and 13.1% less than once a month. They took ramyeon from one (56.8%) to two (25.4%) packs each time. Two-third of subjects consumed entire ramyeon soup or more than half of it. Mostly they added egg or onion to ramyeon and took along with kimchi, cooked rice, danmuji, or dried laver. The food value recognition score about ramyeon was 41.33 out of 100 full grade. Comparing to underweight or normal weight subjects, overweight students tended to take ramyeon more frequently when playing with friends and tended to consume less soup of ramyeon. There was a significant negative correlation between ramyeon intake frequencies and HDL-cholesterol levels (r = -.223 p<.05). Moreover, among the normal body weight students (n = 72) adjusted with relative weight, ramyeon intake frequencies showed not only a significant negative correlation with HDL-cholesterol level (r = -.244 p<.05), but also significant positive correlations with atherogenic index (r = .249 p<.05) and systolic blood pressure (r = .259 p<.05). These results suggested that frequent intake of ramyeon with limited sidedishes as a whole meal might have negative influences on blood pressure and serum lipid levels. Nutrition education is needed to have correct food value recognition and proper consumption of ramyeon along with the balanced diet.

Tennis Service動作의 力學的 分析 : 女子大學 優秀選手를 中心으로

李鍾熙,權重鎬 경희대학교 체육과학연구소 1985 體育學論文集 Vol.13 No.-

In order to find the characteristics of service technique and its efficient motion and thus obtain the helpful data for training women players by analyzing dynamically the motional variation of Tennis service, we divide players into the expert group consisted of three women's universities' superior players and the unskilled group consisted of three girls' high school players. And then we shoot their service motions with 8mm highspeed camera. The results of analyzing that film are following: 1.The stance of the expert group (average 47.4 cm) is 6.9 cm more wide than that of the unskilled group. 2.The vertical radius of Racket top's drift locus of the expert group is much the same as that of the unskilled group, but the horizontal radius of Racket top's drift locus of the former is much more circular than that of the latter. 3.There is not much difference of Racket top's drift distance between the former (average 1405 cm) and the latter (average 1410.7 cm). 4.In case of the forward swing, the racket's drift speed of the former (average 20.73 m/sec.) is 2.24 m/sec. faster than that of the latter (average 18.49 m/sec.) 5.The horizontal drift distance of body's center of the former (average 117.3 cm) is 13.3 cm longer than that of the latter (average 104 cm). 6.The vertical drift distance of body's center of the former (average 36.7 cm) is 13.4 cm longer than that of the latter (average 23.3 cm). 7.The left lap's bending angle of the former (average 115.7˚) is 13˚ more than that of the latter (average 128.7˚). 8.At the moment of impact, while the body line of the former becomes vertical and bends forward, the waist and the foot of the latter become vertical. 9.It is impossible to command the flat service because our women players' height is short,

Microprocessor을 이용한 인버터의 비동기-동기방식 PWM변조에 관한 연구

李忠鎬,劉鐘哲 충주대 산업과학기술연구소 1993 産業科學論文集 Vol.1 No.-

As industry grow up, induction motor need to be controlled at wide speed range. Whether carrier signal is synchronized to frequency signal or not, the PWM method is classified into asynchronized and synchronized one. In general, the former is easy to realization but generates sub-harmonics and the latrer is difficult, In order to drive from very low speed to high speed with a power device operating frequency concepts, both must de untilized. Output and reference voltage of inverter must be linear to control induction motor high characteristice. This study is discussed about the pulse width modulation and characteristice.

인버터 TIG용접기의 역률개선에 관한 연구

이정호,김재문,김연충,원충연 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

In this paper, We proposed AC/DC boost converter with high power factor in TIG welder. The proposed power factor correction circuit with UC2854AN acting on constant switching frequency average current control have a three-loop control structure : the inner current loop, the line voltage feedforward loop, and the outer voltage loop. Also, We applied the constant current control strategy to stabilized the output current using the analog PI controller. To demonstrate the practical significance of the proposed methods, some simulation studies and experimental results are presented.

IN VIVO에서 고양이 상아세관을 통한 상아세관액이 흐름

박수정,손호현,이광원 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1

성인 양극성장애와 정신분열병 환자의 아동기 주의력결핍 : 과다활동 증상

신정호,안정숙,이계성 대한소아ㆍ청소년정신의학회 1998 소아청소년정신의학 Vol.9 No.1

E-초등학교 어린이의 영구치 맹출시기 및 순서

권정현,최병재,이제호,김성오,손흥규,최형준 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

치아 맹출은 나이, 성별, 인종, 시대에 따라 시기 및 순서의 차이가 있으나, 교과서에 인용되어 임상에서 사용되는 영구치 맹출 및 치근 형성에 대한 자료는 1933년 Logan과 Kronfeld가 발표한 것이므로 현재 한국 어린이의 영구치 맹출 경향과 차이가 있을 수 있다. 따라서 이번 연구의 목적은 한국 어린이의 영구치 맹출연령을 구하고, 이를 근거로 맹출순서를 알아보며, 이전 국내외 연구자료와 비교하여 차이를 알아보는 것이다. 이에 1998년부터 2005년까지 연세대학교 치과대학병원 소아치과에 내원하여 구강검진을 시행한 E-초등학교의 어린이 중 만 6세에서 만 12세의 2,619명 (남자 1,307명, 여자 1,312명)의 자료를 수집하여 영구치의 맹출시기 및 순서에 대해 연구 한 바 다음과 같은 결론을 얻었다. 1. 상악의 영구치 맹출시기는 중절치는 남자 만 6.81세, 여자 만 6.73세, 측절치는 남자 만7.78세, 여자 만7.65세, 견치는 남자 만10.48세, 여자 만9.92세, 제1소구치는 남자 만9.76세, 여자 만9.63세, 제2소구치는 남자 만10.66세, 여자 만10.49세, 제1대구치는 남자 만6.39세, 여자 만6.26세, 제2대구치는 남자 만12.13세, 여자 만 12.03세로 나타났다. 2. 하악의 영구치 맹출시기는 중절치는 남녀 모두 정확한 시기의 측정은 불가능하였지만, 만 6.08세 이전에 맹출한다는 것을 추정 할 수 있었고, 측절치는 남자 만6.78세, 여자 만6.65세, 견치는 남자 만9.76세, 여자 만9.05세, 제1소구치는 남자 만9.82세, 여자 만9.59세, 제2소구치는 남자 만10.67세, 여자 만10.52세, 제1대구치는 남자 만6.22세, 여자 만6.12세, 제2대구치는 남자 만11.58세, 여자 만 11.14세로 나타났다. 3. 맹출순서는 상악은 제1대구치, 중절치, 측절치, 제1소구치, 견치, 제2소구치, 제2대구치 순이었고, 하악은 중절치, 제1대구치, 측절치, 견치, 제1소구치, 제2소구치, 제2대구치 순이었다. 4. 모든 영구치에서 남자보다 여자가 빨리 맹출하였으며, 상악은 약 0.19세, 하악은 약 0.29세 먼저 맹출하였다. 5. 남녀 모두 상악은 측절치와 제1소구치 사이, 하악은 측절치와 견치 사이에 휴지기가 있었고, 남자의 휴지기는 상악 1.98년, 하악 2.98년, 여자는 상악 1.98년, 하악 2.40년이었다. The purpose of this study was to present new data on the timing and sequence of permanent teeth emergence and to compare these findings with the results of earlier studies. The dental examinations had been performed to E-elementary school students, who visited the Yonsei University Dental Hospital between 1998 and 2005; 1,307 boys and 1,312 girls with the age ranging from 6 to 12 years old. The followings were concluded. 1. Eruption time of the maxillary permanent teeth is as follows, It was 6.81 years in male and 6.73 years in female for the central incisor, 7.78 years in male and 7.65 years in female for the lateral incisor, 10.48 years in male and 9.92 years in female for the canine, 9.76 years in male and 9.63 years in female for the first premolar, 10.66 years in male and 10.49 years in female for the second premolar, 6.39 years in male and 6.26 years in female for the first permanent molar, and 12.13 years in male and 12.03 years in female for the second permanent molar. 2. Eruption time of the mandibular permanent teeth is as follows. The central incisor could not be determined in this study, but it is assumed to erupt before the age of 6.08. In the mandible, eruption time was 6.78 years in male and 6.65 years in female for the lateral incisor, 9.76 years in male and 9.05 years in female for the canine, 9.82 years in male and 9.59 years in female for the first premolar, 10.67 years in male and 10.52 years in female for the second premolar, 6.22 years in male and 6.12 years in female for the first permanent molar, and 11.58 years in male and 11.14 years in female for the second permanent molar. 3. The eruption sequence is as follows. In the maxilla, the first permanent molar erupted first, followed by the central incisor, the lateral incisor, the first premolar, the canine, the second premolar, and the second permanent molar. In the mandible, the central incisor erupted first, followed by the first permanent molar, the lateral incisor, the canine, the first premolar, the second premolar, and the second permanent molar. 4. Tooth eruption occurred earlier in female compared to male by average of 0.19 year in the maxilla and 0.29 year in the mandible. 5. In both male and female, the hiatus (interval of rest) occurred between the emergence of lateral incisor and first premolar in the maxilla while it was observed between the lateral incisor and canine in the mandible. Male had a hiatus of 1.98 years in the maxilla and 2.90 years in the mandible, while the female's were 1.98 years and 2.40 years, respectively.

산 표면처리후 상아질과 법랑질 표면의 습윤이 결합강도에 미치는 영향

박수정,이광원,손호현 大韓齒科保存學會 1995 Restorative Dentistry & Endodontics Vol.20 No.1