Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

자동차의 실내공기질에 대한 위해성 평가에 관한 연구

이정주+김병모 용인대학교 자연과학연구소 2006 自然科學硏究所論文誌 Vol.11 No.1

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无涯 梁柱東先生의 國文學

李丙疇 동국대학교 한국문학연구소 1988 한국문학연구 Vol.0 No.11

선생께서 생각하길 멈추시고 릉운의 건필을 놓고 가신지 어언 10년, 그러나 선생께서는 지금 이 자리에도 분명 오셔서 그 회심의 미소로 잇집을 드러내고 계시리라 믿는다. 혜성처럼 나타나 재학으로 닦아 공력으로 쌓아 놓으신 우람스런 금자탑은 길이 국어국문학과 더불어 찬란히 빛날 것을 믿어 의심치 않는다. 일찍이 “독서파만권 하필여유신”의 두보가 『호위육절』에서 “이조신여명구멸 불폐강하만고류”라고 자후한 거오가 바로 선생의 유훈임을 되새기며, 선생이야말로 명수천고의 거장이심을 다시금 받들어 올리며 연화대에 가부앉으신 곳을 우러러 삼가 재배를 올린다.

분화 갑상선암 환자의 수술후 잔여갑상선조직 및 전이병소의 진단 : Tc-99m Pertechnetate 스캔과 고용량 옥소 치료 후 I-131 스캔의 비교 Comparison between Tc-99m Pertechnetate Scan and High Dose I-131 Therapy Scan

이주령,안병철,정신영,이재태,이규보 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.2

목적 : 갑상선 절제술을 받은 분화 갑상선암 환자의 경우 잔여 갑상선 조직이나 전이 병소를 찾기 위해서는 진단적 I-131 스캔이 주로 사용되고 있으나, I-131 스캔은 갑상선 호르몬 중지가 필요하고, 방사성 옥소 투여후 2~3일에 영상을 얻어야 하며, 기절 현상이 발생할 수 있다는 점 등의 단점이 있다. 이에 비하여 Tc-99m 스캔은 검사가 용이하고 영상의 질이 좋아 진단적 I-131 스캔을 대체할 수 있을 지에 대한 논란이 있다. 이에 저자들은 고용량 방사성옥소 치료 후 시행한 I-131 스캔을 기준으로 하여 치료전 시행한 Tc-99m 스캔의 진단성능을 알아보고자 하였다. 대상 및 방법 : 갑상선 절제술을 받은 분화 갑상선암 환자 135명을 대상 (여: 114, 연령: 45±15.3세)으로 하였고, 방사성옥소 치료 병력이 있는 환자는 23명 (1회 16명, 2회 4명, 3회 3명)이었다. 갑상선 호르몬 복용을 4주간 중단한 후 370 MBq의 Tc-99m pertechnetate를 정맥주사 한 20분 후에 전경부의 평면 및 바늘구멍 Tc-99m 스캔 영상을 얻었고, 3.7~7.4 GBq의 I-131 옥소를 경구 복용한 3일 후 전경부 평면 및 바늘구멍 I-131 스캔 영상을 얻었다. Tc-99m 스캔과 I-131 스캔은 최대 7일 간격이내에 시행되었다. 영상의 판독은 두명의 핵의학 전문의가 함께 합의에 의하여 시간적으로 섭취여부 및 섭취부위의 개수를 구하였다. 결과 : 대상 환자 모두는 혈청 TSH는 30㎖U/L 이상으로, 갑상선 기능저하증 상태에 있었다. 전체 환자 135명 가운데 65명 (48.1%)에서 Tc-99m 스캔과 I-131 스캔이 불일치 소견을 보였다. 두 스캔사이에 불일치를 보인 환자 가운데 23명 (35.4%)은 Tc-99m 스캔에서는 전경부 방사능 섭취부위가 발견되지 않았으나 I-131 스캔에서 옥소 섭취부위가 발견된 경우이며, 42명 (64.6%)은 Tc-99m 스캔보다 I-131 스캔에서 전경부옥소 섭취부위가 더 많이 발견되었다. 방사성 옥소치료병력이 없는 환자 112명 가운데 51명 (45.5%)은 Tc-99m 스캔과 I-131 스캔이 불일치 소견을 보였다. 이들 가운데 Tc-99m 스캔에서 전경부 방사능 섭취부위가 발견되지 않았던 11명 가운데 9명 (81.8%)은 I-131 스캔에서 옥소 섭취부위가 발견되었다. 수술후 방사성옥소 치료를 받은 병력이 있는 전체 23명은 Tc-99m 스캔상 전경부 섭취부위가 발견되지 않았으나, 이들 중 14명 (60.9%)은 I-131 스캔에서 전경부의 옥소 섭취부위가 나타났었다. 결론 : 이상의 결과로 보아 분화 갑상선암 환자의 수술후 잔여 갑상선조직이나 전이병소를 평가시 Tc-99m 스캔은 고용량의 방사성 옥소 치료후 얻은 I-131 스캔을 기준으로 볼때 진단적 예민도가 낮았으며, 특히, 방사성 옥소 치료병력을 가진 환자의 경우, 진단적 유용성이 없는 것으로 생각된다. Purpose : To evaluate diagnostic sensitivity of nuclear imaging in the detection of residual thyroid tissue and metastatic lesion, we have compared neck scintigrams with Tc-99m pertechnetate (Tc-99m scan) and high dose I-131 iodide (I-131 scan) in patients with differentiated thyroid cancer. Subjects and Methods : One hundred thirty-five thyroidectomized patients for differentiated thyroid cancer were enrolled in this study. Twenty-three had a previous history of radioiodine Therapy. Planar and pin-hole images of anterior neck with Tc-99m were acquired at 20 minutes after injection, followed by I-131 scan three days after high-dose radioiodine therapy within 7 days interval. Patients were asked to discontinue thyroid hormone replacement more than 4 weeks. Results : All subjects were in hypothyroid state. Seventy out of 135 patients (51.9%) showed concordant findings between Tc-99m and I-131 scans. I-131 scan showed higher number of uptake foci in all of 65 patients showing discordant finding. Tc-99m scan showed no thyroid bed uptake in 34 patients, whereas 23 of them (67.6%) showed bed uptake in I-131 scan. Tc-99m scan did not show any uptake in thyroid bed in 11 or 112 patients without previous history of radioiodine therapy, but 9 of them showed bed uptake in I-131 scan. Tc-99m scan showed no bed uptake in all of the 23 patients with previous history of radioiodine therapy, in contrast 14 of them (60.9%) showed bed uptake in I-131 scan. Conclusion : These results suggest that Tc-99m scan has poor detectability for residual thyroid tissue or metastatic lesion in thyroidectomized differentiated thyroid cancer patients, compared to high dose I-131 therapy scan. Tc-99m scan could not detect any remnant tissue or metastatic lesion in patients with previous history of radioiodine treatment, especially.

고주파수 PWM제어를 이용한 ABS의 맥동 저감에 관한 연구

이용주,김병우,박호 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.3

The solenoid valve in ABS hydraulic modulator is a two directional on-off valve and is controlled by around 100㎐ high speed pulse width modulation. When the valve is switched from open state to closed state, noise and vibration due to pressure surge phenomena in the hydraulic line and wheel cylinder are made. In this study, we identify pressure surge phenomenon in the braking process of a ABS, and investigate the way to reduce the phenomenon. For the purpose of theoretical analysis on the pressure surge in the closed state hydraulic line, characteristic curve method based on wave equation was utilized. To reduce the surge, high frequency control of 20KHz was attempted. The result showed that the surge pressure of 50% was reduced compared to one observed in the low frequency control. Duty variation of high frequency can control current of solenoid valve and prevent sudden changed of displacement.

專門大學海洋土木科模型敎育課程 修正開發硏究

李東周,林秉龍,張仁奎,申文燮,金榮燮,朴昌圭,金康洙 군산대학교 1988 群山水産專門大學 硏究報告 Vol.22 No.1

This is a study to modify the curriculum of the ocean civil engineering department in junior college. We collected and analyzed data which are concerned on the curriculum development or improvement, the marine techniques and the ocean policy. And then we also gathered the opinions of the professors serving at the ocean civil engineering department by holding several conferences and investigated the opinions of the ocean civil engineers serving at the industrial organization by way of the inquring papers. In addition we collected the advices of educational specialists and ocean civil specialists by visiting personally. On the basis of above opinions we developed the jobs of graduates and made a model curriculum shown in Table 6. We tried to intensify the subjects of special basic field related to the ocean & civil engineering and the subjects of basic experiment & practise. The ocean observation practise was newly formed and the E. D. P.S was reinforced.

고주파수 PWM 제어를 이용한 ABS의 특성 평가에 관한 연구

김병우,이용주,박호 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.2

In general the surge pressure generated in hydraulic systems causes noise, vibration and odd effect to the system. To reduce the surge pressure, high frequency PWM control of 20KHz was attempted. To estimate the braking noise caused by surge, a vehicle equipped with on-board ABS hydraulic modulator has been experimented with respect to the various breaking condition. Though this experiments, it was found that breaking noise has been reduced using high frequency PWM control method compare with low frequency method. To evaluate high frequency control in practice, including verification of general functionality, EM tests was experimented. Its was found that it is necessary to have the solution to electromagnetic interference(EMI) generated by switching elements.

Schiff Base에 의한 구리 부식 억제

정병구,이현석,장영학,문채주 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

The inhibiting action of copper in 5% hydrochloric acid(HCI) solutions with or without Schiff base, 1,2-bis(naphthylideneimine)ethane(NET), 1,3-bis(naphthylideneimine) propane(NPR), 1,4-bis(naphthylideneimine)butane(NBU), and 1,5-bis(naphthylideneimine) pentane(NPE), has been studied by the Tafel method and AC impedance technique. The corrosion parameters were obtained at different inhibitor concentrations and the temperature effect was also investigated. The inhibiting efficiency increases with a decrease in temperature or increase in concentration of the Schiff base. NPE is the best inhibitor in this series and the maximum inhibition efficiency at a concentration of 5×10^-4 M at 298 K approached 90.07%. Schiff base with longer-chain are superior to shorter-chained analogues in inhibition efficiency.

다양한 입력을 가진 컨버터 출력 특성에 관한 연구

정병열,이종찬,송재주 順天靑巖大學 1998 論文集-順天靑巖大學 Vol.22 No.2

Converter would be destroyed by the many variable input voltage between the drain and source in switching or the reverse voltage of diode because the voltage exceed the rated value in according to increasing of input voltage. In this work, we developed the converter circuit with variable input which stabilize a system by means of preventing the reverse boltage of the switching and diode from increasing of imput voltage highly. Also the steady state characteristic is show by applying the slope method, these simulation results are verified though experiment, and therefore it is shown that this converter circuit proper to application for the variable imput.

傳門大學 海洋土木科 敎育課情 開發硏究

林秉龍,鄭營采,申文燮,李東周,張仁奎,金榮燮 군산대학교 1982 群山水産專門大學 硏究報告 Vol.16 No.1

To carry out the study on the curriculum development for the ocean civil department in junior college, we collected and analyzed data which are on the curriculum development or improvement of the inside and outside of the country. We also gathered the opinion through the inquiring paper investigation and the consultation to the industrial organization, concerned school and authorities during 6 months from May, 1981. In addition, we analyzed and compared the present curriculum of special civil and ocean civil department in junior college. On the basis of above methods, a result we made a model curriculum shown in Table 10. Under current trend and circumstances of the industrial society, the best way for the curriculum development is to make like the course curriculum. But, it is is difficult to make the course curriculums of the ocean cavil department at present. Because the ocean civil is a branch of general civil engineering, furthermore the oceanic industry of our country is not developed well. So, dividing the major subjects in four fields for operating the model curriculum flexibly with the characteristics of the community and college, we developed the suitable curriculum in junior college course, such as general basic field, special basic field related to the ocean, special basic field related to the general civil and application field. We also tried to entensify the subjects of general basic field, special basic field related to the ocean, and to simplify the number of subjects in the model curriculum. Of course we can't say this model curriculum is perfect. But we believe firmly that the results of this paper will be a help to another curriculum development or improvement study for the ocean civil department in junior college.