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      • SCOPUSKCI등재
      • KCI등재

        Clinical Features of Polyarteritis Nodosa in Korea

        Bae, Young Deok,Choi, Hyo Jin,Lee, Jung Chan,Park, Jeong Jin,Lee, Yun Jong,Lee, Eun Bong,Song, Yeong Wook The Korean Academy of Medical Sciences 2006 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.21 No.4

        <P>Polyarteritis nodosa (PAN) is a systemic vasculitis characterized by multi-organ involvement with protean manifestations. We evaluated the clinical features of PAN in Korea. Twenty-seven patients were diagnosed as PAN at Seoul National University Hospital between January 1990 and July 2003. The male-to-female ratio was 1.7:1 and mean age at onset (±SD) was 47.4±20 yr. Their presenting features at diagnosis were similar to those reported previously, i.e., myalgia, muscle weakness or leg tenderness (70%), fever (52%), weight loss >4 kg (44%), skin rash (44%), peripheral edema (33%), abdominal pain (33%), and arthralgia/arthritis (30%). However, the prevalence of testicular pain or tenderness was higher (24%) than reported previously and only three (11.5%) had HBsAg positivity without liver enzyme elevation. Nine patients (33%) had a five-factor score (FFS) of 2. Fourteen patients (52%) responded to treatment, 2 patients relapsed and 4 died within 1 yr of diagnosis. During a median follow-up of 55.5 months, three of the four PAN-related deaths had an initial FFS of 2. The clinical features of PAN were not significantly different from those reported previously. However, testicular pain or tenderness was more frequent and patients with a high FFS tended to have a poorer prognosis.</P>

      • Improvement of efficiency in graphene/gallium nitride nanowire on Silicon photoelectrode for overall water splitting

        Bae, Hyojung,Rho, Hokyun,Min, Jung-Wook,Lee, Yong-Tak,Lee, Sang Hyun,Fujii, Katsushi,Lee, Hyo-Jong,Ha, Jun-Seok Elsevier 2017 APPLIED SURFACE SCIENCE - Vol.422 No.-

        <P><B>Abstract</B></P> <P>Gallium nitride (GaN) nanowires are one of the most promising photoelectrode materials due to their high stability in acidic and basic electrolytes, and tunable band edge potentials. In this study, GaN nanowire arrays (GaN NWs) were prepared by molecular beam epitaxy (MBE); their large surface area enhanced the solar to hydrogen conversion efficiency. More significantly, graphene was grown by chemical vapor deposition (CVD), which enhanced the electron transfer between NWs for water splitting and protected the GaN NW surface. Structural characterizations of the prepared composite were performed using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The photocurrent density of Gr/GaN NWs exhibited a two-fold increase over pristine GaN NWs and sustained water splitting up to 70min. These improvements may accelerate possible applications for hydrogen generation with high solar to hydrogen conversion efficiency.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pristine GaN NWs were grown on n-type Si (111) substrates using radio-frequency plasma-assisted MBE. </LI> <LI> The graphene grown by CVD was coated on surface of GaN nanowires (Gr/GaN NWs). </LI> <LI> The photoelectrochemical properties of these structures were investigated. </LI> <LI> The saturated photocurrent density increased in Gr/GaN NWs than ref GaN NWs. </LI> <LI> We reported the reason for this difference. </LI> </UL> </P>

      • 고분자 전해질의 기계적 물성 및 이온전도 특성 향상을 위한 가교제 구조 제어

        배효원(Hyo Won Bae),박호석(Ho Seok Park),김동욱(Dong Wook Kim) 한국전지학회 2021 한국전지학회지 Vol.1 No.2

        고분자 전해질의 낮은 기계적 물성 및 이온전도도는 리튬 고분자 전지의 상업화에 걸림돌로 작용하고 있다. 본 논문에서는 가교제 구조 제어를 통하여 고분자 전해질의 기계적 물성 및 이온전도 특성 향상 연구를 진행하였다. 가교제의 가교 기능기의 수가 많아질수록, 에틸렌옥사이드(EO) 반복단위의 수가 적을수록 기계적 물성이 향상됨을 확인하였다. 이온전도도는 가교 기능기가 3인 가교제에서 가장 높은 수치를 나타낸 반면 EO 반복단위의 수가 미치는 영향은 미미하였다. 결국 기계적 물성 및 이온전도도 면에서 3개의 가교 기능기를 지니면서 EO 반복단위가 1개인 CL3-1이 가장 적합함을 확인하였다. 리튬 음극, NCM 양극에 적용하여 리튬금속 고분자 전지를 제조하고, 45℃에서 진행된 여러 율속에서의 충방전 특성 평가 결과, 0.1 C 대비 1.0 C에서 89%의 용량 유지율을 나타내었다. 또한 50회 충방전 사이클 동안 94%의 용량유지율을 나타내는 우수한 사이클 안정성을 나타냄을 확인하였다. The poor mechanical properties and low ionic conductivity of polymer electrolyte (PE) are main hurdle for commercialization. In this work, we report on enhancement of the mechanical properties and ionic conductivity of PE by controlling the molecular structure of the cross-linkers. Mechanical property of PE was enhanced with the number of cross-linking groups (acrylate) increased and with the number of ethylene oxide (EO) repeating units decreased. Ionic conductivity of PE was maximized at the cross-linker with three acrylates, but it was not affected by the number of EO units. As a result, CL3-1 with three acrylates and one EO unit was found the most suitable cross-linker for the mechanical property and ionic conductivity of SPE. We prepared lithium polymer battery by using lithium metal anode, NCM cathode, and SPE with CL3-1 crosslinker. The discharge-charge cycle test at a different C-rate at 45℃ showed that the battery exhibited capacity retention as high as 89% at 1.0 C when compared with one at 0.1 C. In addition, the battery showed 94% capacity retention during 50 cycles.

      • SCOPUSKCI등재
      • KCI등재
      • 제대혈의 적혈구 제거 방법에 관한 연구 : 제대혈 은행 설립을 위한 기초 연구 Basic Study for the Establishment of Cord Blood Bank

        김효정,서철원,김상희,김상위,김성배,김강욱,조화정,민영주,박진희,김암,이인식,이필량,지현숙,서종진,강위창,이정신,김우건 대한조혈모세포이식학회 2000 대한조혈모세포이식학회지 Vol.5 No.1

        배경:제대혈에서 적혈구를 제거하는 것은 제대혈 은행의 효율적인 운영 및 제대혈이식시 ABO 부적합 수혈, DMSO 독성 등의 부작용을 해결하기 위한 이상적인 방법이다. 저자들은 동일한 제대혈로 여러가지 적혈구 제거법을 동시에 시행하여, 이들에서 CD34양성 세포의 수득률 및 조혈세포 집락형성능을 비교하여 제대혈 은행 설립의 기반 기술을 확립하고자 하였다. 방법:제왕절개 직후 헤파린 처리된 용기에 제대혈을 채취하였다. 제대혈은 5개의 용기에 분산하여 실온에서 보관하였고 12시간 이내에 적혈구를 분리하였다. 적혈구 제거 방법으로 Ficoll 비중 분리법, gelatin 침전법, 적혈구 용혈법, starch 침전법을 각각의 제대혈에서 시행하였다. 전혈과 적혈구가 제거된 제대혈에서의 세포 생존율, 적혈구 제거율과 단핵구 및 CD34양성 세포의 수득률, 조혈세포 집락형성능을 비교 분석하였다. 결과:18례에서의 평균 제대혈 채취양은 81.3 mL(범위 42~128 mL)이었다. 서로 다른 적혈구 제거법들간에 세포 생존률과 적혈구 제거율은 차이가 없었다. 단핵구 수득률은 3% gelatin침전법(47.7±14.5%)이 다른 적혈구 제거법보다 유의하게 높았다. 3% gelatin침전법은 Ficoll비중 분리법과 Starch침전법에 비해 CD34 양성 세포수가 통계적으로 유의하게 높았다(36.1±5.4×10³/mL, 15.0±3.5×10³/mL, 20.7±4.2×10³/mL). 또한 CFC의 집락수도 3% gelatin침전법에서 Ficoll 비중 분리법과 적혈구 용혈법에 비해 우수한 결과를 보였다(52.0±7.1×10²/mL, 32.8±4.7×10²/mL, 36.8±5.7×10²/mL). 그러나 제대혈 전혈의 CD34 양성 세포수(65.7±11.2×10³/mL) 및 CFC의 집락수(117.8±15.8×10²/mL)를 적혈구 제거법을 이용한 실험군과 비교하였을 때 전혈군에서 높은 것을 알 수 있었다. 결론:3% gelatin 침전법은 다른 적혈구 제거법과 비교해 볼 때 더 우수한 단핵구, CD34 양성 세포 수득률 및 조혈세포 집락형성능을 보였다. 그러나 다른 보고들과는 달리 3% gelatin 침전법은 CD34양성 세포 및 CFC 집락수의 절대값이 제대혈 전혈과 비교하여 의미있게 낮았다. 이러한 결과는 시약의 종류와 실험방법의 차이에 기인하는 것으로 사료되며, 최상의 세포 수득률을 얻기 위하여 적혈구 분리 방법의 표준화를 위한 연구가 진행되어야 할 것으로 생각된다. Background:Efficient volume reduction is important to make a cost-effective umbilical cord blood (UCB) banking system. The aim of this study was to find a method of red cell depletion of UCB without major losses of the hematopoietic progenitor-CD34+ cells. Methods:Eighteen cord blood samples were collected in heparinized bottle immediately after Cesarean section. Five aliquots of each cord blood were stored at room temperature and processed within 12 hours. We used 4 different RBC depletion methods (Ficoll density gradient separation, gelatin sedimentation, red cell lysis, starch sedimentation) and compared the results of viability, RBC reduction rate, mononuclear cell (MNC) recovery rate, CD34+ cells and colony forming unit (CFC).Results: The mean collected cord blood volume was 81.3 mL (range 42~128 mL). There were no differences of viability and RBC reduction rate among groups. MNC recovery rate were significantly higher in gelatin group (47.7±14.5%) than other RBC depletion methods. Gelatin group had significantly higher CD34+ cell count than Ficoll and starch group (36.1±5.4×10³/mL, 15.0±3.5×10³/mL, 20.7±4.2×10³/mL) and higher CFC count than Ficoll and RBC lysis group (52.0±7.1×10²/mL, 32.8±4.7×10²/mL, 36.8±5.7×10²/mL). But the results of CD34+ cell count (65.7±11.2×10³/mL) and CFC count (117.8±15.8×10²/mL) of untreated control group are significantly higher than those of all other treated groups. Conclusion:Umbilical cord blood processed with 3% gelatin sedimentation has higher recovery rate of MNC, CD34+, cell and CFC than other groups. Unlike other reports, the absolute numbers of CD34+ cell and CFC count of 3% gelatin sedimentation method are significantly lower than those of untreated control group. Different laboratory processes with gelatin could be one cause of these differences, a study for standardized laboratory methods should be established to obtain higher recovery rate of hematopoietic cells after RBC depletion.

      • KCI등재

        한국인의 치과의원 내원요인 조사 연구

        류영욱,배현숙,성진효,김동기 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1

        According to the increase of the number of dental clinics and the level of the patient's recognition about oral health care, the need for effective clinical management to provide proper oral health care service to the patients has arisen. Many patients has selected the dental clinics based on self estimation or other recommendation. Therefore the main reasons for selecting the dental clinic by the patients needed to analyze, So we conducted the survey which prepared questionnaire were provided to 700 subjects and collected data related to the factors for patients to select the dental clinics. The results were as follows : 1. In the view of access, the place easy of access and parking capacity was important to the degree of 43.0% and 30.8%, respectively. 2. In relation to the dentist, the quality of treatment and the trust was important to the degree of 80.7% and 71.3%, respectively. 3. Modern clinical facility was occupied 65.5% in the basic environment factors. 4. In the basic factors, kindness and cleanliness was 76.6% and 76.7%, respectively, and it showed that these factors were more important than the number of the clinicians and comfort of the waiting room. 5. In relation to the satisfaction of treatment, cheaper treatment cost, decreased waiting tine, the variety of treatment tine and various payment method were important to the degree of 51.8%, 48.4%, 42.8% and 39% in order.

      • KCI등재후보

        골 건강을 위한 우유 및 콜라겐 펩타이드

        배효주 ( Hyo Ju Bae ),장진희 ( Jin Hee Chang ),김형민 ( Hyoung Min Kim ),홍성욱 ( Sung Wook Hong ),설국환 ( Kuk Hwan Seol ),박범영 ( Beom Young Park ),오미화 ( Mi Hwa Oh ) 한국유가공기술과학회 2013 Journal of Dairy Science and Biotechnology (JMSB) Vol.31 No.2

        The prevalence rate of osteoporosis in older men and women has recently increased, and thus bone health is a major concern in Korea. This concern, along with increasing concern regarding youth height, has led to growth of the functional food industry for children, reaching approximately 200 billion won. It is necessary to develop safe and effective functional materials for bone growth and health. Foods are excellent sources of functional material as they are safe to use. It is well known that the phosphopeptide casein, which is derived from milk, is effective against osteoporosis by aiding in the absorption of calcium. In our study, collagen peptides derived from porcine skin were evaluated as a functional material for bone growth, as several peptides have been shown to aid in osteoblast formation.

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