귀충만감 환자에 대한 임상적 고찰

이상철,정진호,이상목,이재완,엄재욱,박춘근 釜算慶南耳鼻咽喉科學會 1994 임상이비인후과 Vol.5 No.1

옥시토신 증량방법 차이에 따른 유도분만 결과의 비교

목정은,한지수,김암,이인식,이필량,황희복 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.4

1993년 5월부터 1995년 5월가지 유도분만을 위해 입원한 임신부 203명을 대상으로 하염 입원순서대로, 점차적으로 증량하는 protocol A(2,4,6,8 mU/min 등)와 이전용량의 2배씩 증량하는 protocol B (2,4,8,16 mU/min 등)을 사용하여 다음과 같은 결론을 얻었다. 1. 전 대상예 중에서 질식분만을 한 경우는 protocol A(102명)에서 77.5%, protocol B(101명)에서 71.3%였으며, 유도분만을 시작한 2일째까지 대부분이 질식분만을 하였으며(97.5%, 97.2%) 첫째날 질식분만한 경우는 각각 74.7%와 63.9%였다. 또한 질식분만한 경우는 각각 유도분만의 시작으로부터 분만시까지 걸린 평균시간(+-표준편차)은 protocol A의 경우가 11.7(+-11.9)시간, protocol B의 경우에 11.4(+-12.6)시간으로 서로 유의한 차이가 없었다. 2. 분만방법의 빈도와 신생아의 체중 및 아프가점수의 분포는 protocol A와 B사이에 유의한 차이가 없었다. 3. 질식분만의 경우에 사용한 옥시토신의 용량(최대용량 및 적정용량)과 분만까지의 시간은 두 protocol 사이에 유의한 차이가 없었다. 4. 옥시토신 투여 중 자궁의 고장성 수축의 빈도가 B protocol에서 15.8%으로 A protocol의 2.0%에 비해 유의하게 많이 나타났으며(p$lt;0.05), 비정상 태아심음의 빈도 역시 protocol B의 경우 32.7%로 protocol A의 경우 16.7%에 비해 유의하게 높았다(p$lt;0.05). 결론적으로, 유도분만시 옥시토신을 30분간격으로 투여할 경우, 점진적으로 증량하는 방법이 이전 용량의 2배씩 증량하는 방법에 비해 효용성에는 차이가 없으나 더 안전하므로 점진적으로 옥시토신의 용량을 증가시키는 것이 더 좋을 것으로 판단된다. 그러나 유도분만에 사용하는 옥시톡신을 더 안전하며 효과적으로 투여하는 방법을 찾기 위해 앞으로 중량간격과 용량을 달리한 많은 연구가 필요하다. Objective: To compare the efficacy and safety of two oxytocin induction protocols that differ in oxytocin dose increment. Study design: Two hundred and three women admitted for induction of labor were prospectively randomized into one of two oxytocin induction protocols. Starting at 2 mU/min, the amount of oxytocin infused was gradually increased in 102 women(protocol A) and increased by doubling the previous dose in 101 women(protocol B). The efficacy and safety of the two protocols were analyzed with student t test, k^2, and Fisher`s exact test. Results: No differences were observed in confounding clinical and demographic factors between the two groups. There were no statistically significant differences in the maximum and adequate infusion rate of oxytocin, duration of labor, and neonatal outcome. However, the incidence of uterine hyperstimulation and adnormal fetal heart rate patterns was significantly different between two groups(2%, 16.7% in protocol A versus 15.8%, 32.5% in protocol B, respectively, p$lt;0.05). Conclusion : For the oxytocin induction of labor at term, gradual increment method was superior to that by double dose increment in reducing the incidence of uterine hyperstimulation and abnormal fetal heart rate, while showeing same efficacy.

제2형 당뇨비만환자의 수술요법 시 임상영양치료 프로토콜 설정

김혜진 ( Hye Jin Kim ),남궁신아 ( Sin A Namgung ),홍정임 ( Jeong Im Hong ),목희정 ( Hee Jung Mok ) 대한영양사협회 2011 대한영양사협회 학술지 Vol.17 No.2

Currently, metabolic surgery (Laparoscopic Roux-en-Y gastric bypass, LRYGB) has an important role and should be recommended as an intervention in the management of obese patients with type 2 diabetes mellitus (T2DM). A successful outcome of surgery requires medical nutrition therapy. Therefore, we performed a retrospective study on 25 patients with T2DM who underwent LRYGB at Yeouido St. Mary`s Hospital from October 2008 to May 2010. The patients were followed up for an average of 6 months after surgery (range: 2∼19 months). Diabetes was resolved in 80% of the patients. Percentage of excess weight loss was (%EWL) was 56.2%. After surgery, fasting blood sugar (FBS) and HbA1c were significantly reduced (123 mg/dl, A1c 6.7%, P<0.001) and triglyceride was also significantly reduced to 107.6 mg/dl (P<0.05). As diets of the patients progressed from liquid to soft to regular diet, energy, carbohydrates, and fat intakes increased significantly (P<0.001). But protein intake did not change significantly. Nutrient intake of the patients after the surgery was significantly lower than the recommended diet for the non-surgery group. Patients experienced side-effects related to the diets after surgery, including hair-loss (76%), smelly gas (52%), vomiting (48%), etc. A significantly positive correlation was observed between vomiting and FBS (P<0.001). There was a significant relationship between side effects and the amount of nutrient intakes. Therefore, guide patients to a diet progression with treatment to minimize side effects, especially vomiting. And monitor their dietary life to be healthy and not to regain weight until remission of T2DM.

삼채의 조추출물과 유기용매 분획물에 대한 항산화 및 항염증 효과

이용범(Yong-Bum Lee),함영민(Young-Min Ham),윤선아(Seon-A Yoon),오대주(Dae-Ju Oh),송상목(Sang-Mok Song),홍인철(In-Choel Hong),이시택(Si Taek Lee),현호봉(Ho Bong Hyun),김창숙(Chang-Suk Kim),윤원종(Weon-Jong Yoon) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.1

본 연구는 삼채의 조추출물과 유기용매 분획물들을 가지고 DPPH 라디칼 소거 활성에 의한 항산화 활성 검색 결과 디클로로메탄(CH2Cl2) 분획물과 에틸아세테이트(EtOAc) 분획물에서 라디칼 소거 활성을 나타냈으며, xanthine oxidase 억제 효과는 DPPH 활성 라디칼 소거 활성에서 제일 뛰어났던 에틸아세테이트 분획물에서, superoxide 소거 활성은 헥산(n-hexane) 분획물에서 활성이 나타났다. RAW 264.7 세포에 lipopolysaccharide로 자극을 주고 삼채 주정 추출물 및 유기용매 분획물들을 처리하여 확인해본 결과, 조추출물과 물 분획물을 제외한 나머지 유기용매 분획물에서 염증 유발 인자(NO, PGE2, iNOS, COX-2, IL-6 및 IL-1β) 생성억제 효과가 나타났으며, 그중 디클로로메탄 분획물과 에틸아세테이트 분획물에서 억제 효과를 확인할 수 있었다. 본 실험 결과 삼채 조추출물과 유기용매 분획물에서 항산화 효과 및 염증 유발 인자의 생성 억제 효과가 나타났으며, 이러한 결과 삼채에서 유효성분 추출을 통한 항산화, 항염증 물질의 연구 또는 예방하거나 치료할 수 있는 염증 억제 성분의 분리 및 그 작용기전 연구에 중요한 기초 자료가 될 것이라 생각한다. This study describes the preliminary evaluation of antioxidant and anti-inflammatory activities of Allium hookeri. A. hookeri was extracted using crude extract and then fractionated sequentially with n-hexane, CH2Cl2, EtOAc, and n-BuOH. To screen for antioxidant and anti-inflammatory agents effectively, we first examined the inhibitory effect of A. hookeri extracts on production of oxidant stresses (2,2-diphenyl-1-picrylhydrazyl, xanthine oxidase, and superoxide). In addition, we examined the inhibitory effects of A. hookeri on production of pro-inflammatory factors (nitric oxide, prostaglandin E2, inducible nitric oxide synthase, and cyclooxygenase-2) in murine macrophage RAW 264.7 cells stimulated with lipopolysaccharide. Of the sequential solvent fractions of A. hookeri, EtOAc fractions showed decreased production of oxidant stresses, and CH2Cl2 and EtOAc fractions of A. hookeri inhibited production of pro-inflammatory factors. EtOAc fraction inhibited production of pro-inflammatory cytokines (interleukin-6 and -1β). These results suggest that A. hookeri has significant effects on oxidant stresses and pro-inflammatory factors and is a possible antioxidant and anti-inflammatory therapeutic and preventive material.

Litsenolide A2: The major anti-inflammatory activity compound in <i>Litsea japonica</i> fruit

Ham, Young-Min,Cho, Su-Hyeon,Song, Sang-Mok,Yoon, Seon-A,Lee, Yong-Bum,Kim, Chang-Sook,Kwon, Seung-Hae,Jeong, Myeong Seon,Yoon, Weon-Jong,Kim, Kil-Nam Elsevier 2017 Journal of Functional Foods Vol.39 No.-

<P><B>Abstract</B></P> <P>In this study, we investigated the anti-inflammatory effect of litsenolide A2 (LNA2) isolated from <I>L. japonica</I> fruit and its mechanism of action in LPS-induced RAW 264.7 cells. LPS-induced production of anti-inflammatory mediators and cytokines such as NO, PGE<SUB>2</SUB>, iNOS, COX-2, TNF-α, and IL-6 was significantly inhibited by LNA2. Next, western blot experiments were performed to investigate the mechanism of action of the anti-inflammatory effect of LNA2. The results indicated that LNA2 markedly reduced the LPS-induced activation of NF-κB and the nuclear translocation of NF-κB p65. Furthermore, LNA2 also inhibited the phosphorylation of MAPK by LPS. LNA2 was the major component in the ethanol extract of <I>L. japonica</I> at 59 mg/g according to high performance liquid chromatography (HPLC). These results indicate that LNA2 can be used as a functional and marker compound for standardization of the manufacturing process when <I>L. japonica</I> fruit is used as a functional food.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We study the anti-inflammatory effect of LNA2 in LPS-activated RAW 264.7 cells. </LI> <LI> LNA2 inhibited production of pro-inflammatory mediator and cytokines. </LI> <LI> LNA2 exhibited anti-inflammatory properties by suppression of NF-κB and MPAKs. </LI> <LI> LNA2 was the major component in the ethanol extract of <I>L. japonica</I> at 59 mg/g. </LI> </UL> </P>

코로나방전플라즈마제트를 이용한 생식용 곡류의 미생물 저감

윤금아(Geum-A Youn),목철균(Chulkyoon Mok) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.1

생식제조에 사용되는 곡류의 미생물 오염을 저감하기 위하여 코로나방전플라즈마제트(CDPJ)를 사용하여 곡류 표면의 미생물을 살균을 시도하고, CDPJ 처리에 따른 곡류 품질변화 여부를 조사하였다. 곡류의 초기 오염도는 1.7×10<SUP>3</SUP>-9.9×10<SUP>5</SUP> CFU/g 정도를 보였다. 곡류에 대한 CDPJ의 살균력은 1-1.5 A 범위에서 전류세기에 따라 증가하였으며, 토출거리 25 mm에서 가장 양호한 살균효과를 나타냈다. 곡류 미생물의 CDPJ 살균패턴은 의사 1차반응 모델인 Singh-Heldman 모델에 부합하였고, 세균이 진균에 비해 더 민감한 살균효과를 보였다. 곡류별로는 백미가 가장 잘 살균 되었고, 압맥, 현미 순으로 살균효과가 낮아졌다. 처리시간 10분 이하의 처리는 곡류의 TBA가에 영향을 주지 않아 CDPJ 처리는 생식제조용 곡류의 지방특성을 변화시키지 않고 미생물을 저감함으로써 생식의 위생 향상에 활용될 수 있을 것으로 기대된다. Inactivation of microorganisms in grains used for saengshik, a formulated health food, was attempted by corona discharge plasma jet (CDPJ). The initial microbial counts of the grains were in the range of 1.7×10<SUP>3</SUP>-9.9×10<SUP>5</SUP> CFU/g. The CDPJ-inactivation effect was increased with electric current in the range of 1-1.5 A. Regarding span length between the tips of the electrodes and the treatment surface, the highest inactivation effect was observed at 25 mm. The inactivation pattern fitted well to the Singh-Heldman model. Bacteria were more labile to the CDPJ inactivation than yeasts and molds. Among tested grains, white rice showed the highest sterility followed by pressed barley and brown rice. Despite the inactivation by plasma, the thiobarbituric acid content of the grains remained unchanged over 10 min of treatment. Our results indicated the potential of the CDPJ treatment to improve the hygiene of saengshik products with no remarkable changes in lipid quality.

Clinical Characteristics and Metabolic Features of Patients with Adrenal Incidentalomas with or without Subclinical Cushing’s Syndrome

Bo-Yeon Kim,A-Reum Chun,Kyu-Jin Kim,Chan-Hee Jung,Sung Koo Kang,Ji-Oh Mok,Chul-Hee Kim 대한내분비학회 2014 Endocrinology and metabolism Vol.29 No.4

Background: The aim of this study was to examine the clinical characteristics of adrenal incidentalomas discovered by computed tomography (CT) and to investigate metabolic features of subclinical Cushing’s syndrome (SCS) in patients with adrenal incidentalomas in a tertiary hospital in Korea. Methods: This retrospective study examined the clinical aspects of 268 patients with adrenal incidentalomas discovered by CT at Soonchunhyang University Bucheon Hospital. Clinical data and endocrine function of the patients as well as histological findings were obtained from medical records, while anatomic characteristics were analyzed by reviewing imaging studies. Hormonal tests for pheochromocytoma, Cushing’s syndrome, and aldosterone-secreting adenoma were performed. Results: Most (n=218, 81.3%) cases were nonfunctioning tumors. Of the 50 patients with functioning tumors (18.7%), 19 (7.1%) were diagnosed with SCS, nine (3.4%) with overt Cushing’s syndrome, 12 (4.5%) with primary aldosteronism, and 10 (3.7%) with pheochromocytoma. Malignant tumors (both primary and metastatic) were rare (n=2, 0.7%). Body mass index, fasting glucose, hemoglobin A1c, and total cholesterol were significantly higher in patients with SCS in comparison with those with nonfunctioning tumors. The prevalence of type 2 diabetes mellitus and hypertension were significantly higher in patients with SCS compared with those with nonfunctioning tumors. Conclusion: Functioning tumors, especially those with subclinical cortisol excess, are commonly found in patients with adrenal incidentalomas, although malignancy is rare. In addition, patients with SCS in adrenal incidentalomas have adverse metabolic and cardiovascular profiles.

임신 중 발생한 객혈로 인한 전폐허탈

조정제 ( Jung Je Cho ),나승원 ( Seung Won Ra ),이광하 ( Kwang Ha Lee ),이정아 ( Jung A Lee ),강채훈 ( Chae Hoon Kang ),권동일 ( Dong Il Gwon ),오연목 ( Yeon Mok Oh ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.1

Pregnancy induces many physiologic changes, and it can cause hemoptysis in relation to the underlying or potential pulmonary diseases. Although hemoptysis is not a frequent event during pregnancy, a thorough search for its etiology and then immediate management should be initiated for a case of massive hemoptysis to avoid serious adverse effects on both the fetus and the mother. Most hemoptysis events during pregnancy are related to well known etiologies, but there are a few reported cases of hemoptysis in pregnant women who are without any underlying lung lesion. We report here on a case of a pregnant woman with total lung collapse due to hemoptysis, and a thorough search for the etiology after delivery could not reveal any etiology.

Wetting and Interfacial Reaction Characteristics of Sn-1.2Ag-0.5Cu-xIn Quaternary Solder Alloys

A-Mi Yu,Mok-Soon Kim,Chang-Woo Lee,이종현 대한금속·재료학회 2011 METALS AND MATERIALS International Vol.17 No.3

Through the use of a wetting balance technique, the wetting characteristics of Sn-1.2Ag-0.5Cu-xIn quaternary solder alloys with respect to the In content and soldering temperature were investigated to validate the applicability of compositions with a low Ag content as solder material. It was found that a small addition (0.4-0.6 wt.%) of In significantly improved the wetting properties of the Sn-1.2Ag-0.5Cu-xIn composition at soldering temperatures ranging from 230 °C to 240 °C due to the excellent wetting property of In. In an observation of the interfacial reaction, it was found that the added In element did not participate in the interfacial reaction with a Cu or Ni pad, unlike in the Sn-Ag-Cu-In case, which has a high In content. The package or boardside IMC layers in Sn-1.2Ag-0.5Cu-0.4In joints were thinner than those of Sn-3.0Ag-0.5Cu, especially after aging.

Effect of bio-mediated route synthesized silver nanoparticles for modification of polyethersulfone membranes

Ananth, A.,Arthanareeswaran, G.,Ismail, A.,Mok, Y.S.,Matsuura, T. Elsevier 2014 Colloids and surfaces. A, Physicochemical and engi Vol.451 No.-

This article reports the modification of polyethersulfone (PES) membrane using silver nanoparticles (n-Ag), their characterizations and protein separation performances. As a bio-mediated synthesis route, gram-positive Bacillus subtilis bacterial supernatants were employed for preparing n-Ag. The resulting n-Ag exhibited uniform and well defined spherical morphology with size less than 50nm. The effect of the incorporation of n-Ag on PES membrane in terms of cross sectional morphology, surface roughness, crystallinity and hydrophilicity were investigated systematically. XPS analysis showed that a significant portion of silver was in silver oxide form. Depth profiling by argon plasma etching and XPS showed the partition of Ag<SUB>2</SUB>O and Ag between the membrane surface and the bulk. A minor oxidation on the surface of the silver was observed whereas the internal structure of the membrane retained Ag in its metallic state. The potential of the nano composite membrane for the separation of BSA with varying feed concentration and transmembrane pressure were performed. At 1.5wt% loading of n-Ag in neat PES, enhancement in bovine serum albumin (BSA) flux and decrease in the rejection were observed. The results and performance of the PES/n-Ag nanocomposite membranes indicate that it would be a deserving candidate for future industrial separations. The experimental results confirm that the incorporation of Ag nanoparticles in PES UF membrane can increase hydrophilicity and reduce the fouling.