변형된 광역학 요법으로 치료한 유방의 침윤성 관상암종의 맥락막 전이 1예

조윤정,박성표,Yoon Jung Cho,MD,Sung Pyo Park,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.3

Purpose: To report a case of choroidal metastasis of breast cancer that was treated with modified photodynamic therapy. Case summary: A 45-year-old woman visited our clinic with blurred vision of the right eye, which began 1 month before. The patient previously suffered from a low back pain for 1 year. The best corrected visual acuity was 20/20 in both eyes. Fundus examination revealed an elevated yellowish mass-like lesion at the superonasal area in the right eye. Ultrasonography of the right eye showed a highly echogenic choroidal mass with moderate to high internal reflectivity. Fluorescein angiography showed hypofluorescence during the prearterial and arteriovenous phase, and well circumscribed hyperfluorescence during the venous phase. Radiologic examination was performed upon suspicion of metastasis. The examination revealed breast cancer with lung, spine and ovary metastasis. Subsequently, biopsy of the breast mass revealed an invasive ductal carcinoma. Based on these results, the patient was diagnosed with choroidal metastasis from breast carcinoma. The patient received systemic chemotherapy, and modified photodynamic therapy (PDT) was performed on the metastatic choroidal mass. Six days after modified PDT, the mass size was unchanged, and serous retinal detachment developed at the macula and inferior retina. However, 22days after treatment, the mass size markedly decreased and the serous retinal detachment was improved. J Korean Ophthalmol Soc 2010;51(3):458-462

식용 버섯의 조리방법에 따른 Jurkat 세포주 DNA 손상 보호 효과

조윤정,김경희,육홍선,Cho, Yun-Jeong,Kim, Kyoung-Hee,Yook, Hong-Sun 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.1

본 연구는 식용 버섯의 조리방법에 따른 항산화 생리활성의 평가를 위해 수행되었으며, 산화적 스트레스에 의한 DNA 손상 감소 효과를 통해 조리방법을 달리한 버섯 추출물의 유전독성학적 방호효과를 살펴보았다. Human lymphocyte에 조리방법을 달리한 3가지 버섯(느타리, 팽이, 표고)의 추출물을 처리하고, hydrogen peroxide($H_2O_2$)로 산화적 손상을 준 후, DNA 감소 효과를 Comet assay로 평가한 결과, 모든 시료군에서 산화적 손상에 의한 DNA 손상 감소 효과를 나타냈다. 3가지 버섯 모두 비조리군이 조리군보다 높은 효과를 나타냈는데, 이는 조리과정에 의한 페놀성 화합물의 감소로 인한 것으로 보이며, 조리군 중에서 볶기와 전이 비교적 낮은 DNA 손상 감소 효과를 나타낸 것은 조리 시 첨가되었던 대두유의 가열 산화에 의한 것으로 사료된다. 결론적으로, 조리된 버섯은 생버섯에 비해 산화적 스트레스에 의한 DNA 손상 감소효과가 낮으나, 양성 대조군과 비교하였을 때 손상을 유의적으로 감소시킨 것으로 나타났다. 또한, 본 연구에서 사용한 네 가지 조리법(굽기, 데치기, 볶기, 전) 중 DNA 손상 감소에 효과적인 조리법은 대두유를 사용하지 않은 굽기와 데치기인 것으로 판단된다. In this study, portective effect on DNA damage several mushrooms (Pleurotus ostreatus, Flammulina velutipes, Lentinula edodes) according to cooking methods was investigated using Comet assay. Three edible mushrooms were cooked by grilling, blanching, pan-frying, or by preparing 'Jeon' (traditional Korean pancake). Cells were incubated in medium with 4 kinds of samples for 48 h ($37^{\circ}C$) were further treated with hydrogen peroxide ($H_2O_2$) for 5 min as an oxidative stimulus. Oxidative damage was evaluated by single-cell gel electrophoresis (Comet assay) and quantified by tail DNA% (TD), tail length (TL), tail moment (TM). Though oxidative DNA damages expressed as TD, TL, TM of 4 cooked samples were higher than raw sample, which means lower protective activities, all samples including raw sample had significantly higher protective effects than the positive control (p<0.05). The protective effect on DNA damage of cooked samples decreased much more when soybean oil added, likely due to the thermal oxidation of oil during cooking. Although heat treatment could degrade protective effect on DNA damage of mushrooms, the cooked mushroom had significant effect on oxidative stress. In conclusion, grilling and blanching were the most advantageous cooking methods to protect oxidative DNA damage induced by $H_2O_2$.

출혈우세병변이 동반된 연령관련 황반변성 환자에서의 유리체강 내 라니비주맙 주입술의 효과

조윤정,박성표,Yoon Jung Cho,Sung Pyo Park 대한안과학회 2011 대한안과학회지 Vol.52 No.7

Purpose: To report the efficacy and safety of intravitreal ranibizumab monotherapy in patients with age-related macular degeneration with a predominantly hemorrhagic lesion. Methods: Nineteen eyes of 19 patients with submacular hemorrhage involving the fovea were treated with intravitreal ranibizumab (0.5 mg/0.05 ml) injections as needed. All patients completed at least 4 months of follow-up. Ophthalmologic examinations, fluorescence angiographic evaluations, optical coherence tomography (OCT) examination, and hemorrhage size were analyzed before the injections, and at 1,2,4,6, and 12 months follow-up. Results: The average VA and mean central retinal thickness (CRT) before ranibizumab treatment were 0.62 ± 0.39 log MAR and 335.76 ± 111.22 μm, respectively. Additionally, the VA and CRT four months after the initial injections were 0.54 ± 0.43 log MAR and 241.42 ± 107.55 μm, respectively. The mean size of the hemorrhage was significantly reduced from 2.87 ± 2.44 DA (disk areas) at baseline to 0.9 ± 1.28 DA at four month follow up. Conclusions: Intravitreal injection of ranibizumab is an effective treatment option for patients with age-related macular degeneration with a predominantly hemorrhagic lesion. J Korean Ophthalmol Soc 2011;52(7):838-845

갑상선 미세 유두암에서 종양 크기의 구분에 따른 임상병리학적 특징의 분석

조윤정,이동호,이상철,김세준,김정구,안창준,이관주,Yun-Jung Cho,M,D,Dong-Ho Lee,M,D,Sang-Chul Lee,M,D,Say-Jun Kim,M,D,Jung-Koo Kim,M,D,Chang-Joon Ahn,M,D,and Kwan-Ju Lee,M,D 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.3

Purpose: Although the detected incidence of papillary thyroid microcarcinoma (PTMC) has increased with development of ultrasonography and fine-needle aspiration biopsy, the best treatment has not yet been established. Treatment decisions require information on many factors including lymph node metastasis, extrathyroidal extension, and bilaterality. With this aim, the present study analyzed clinicopathologic features of PTMC according to cut-off of tumor size. Methods: The clinicopathologic features of patients with PTMC between January 2007 and December 2009 were reviewed retrospectively from medical records. Patients were divided according to tumors lesser than or equal to cut-off (Group I) and tumors exceeding cut-off (Group II). Results: Both capsule invasion and lymphovascular invasion were significantly different at all cut-off diameters (5∼9 mm). Central node metastasis revealed a difference in all cut-off values except 8 mm. Extrathyroidal extension differed at all cut-off values except 5 mm. Bilaterality displayed a statistically significantdifference only at the 8 mm cut-off. Conclusion: A cut-off of 5 mm represents a safe value to discriminate less aggressive from aggressive treatment for PTMC. (Korean J Endocrine Surg 2010;10:152-156)

점막하 침윤 조기위암 환자에서 VEGF-C와 COX-2 발현의 임상적 의의

조윤정,이정의,이관주,박조현,박승만,전해명,안창준,김정구,이동호,이상철,Cho, Yun-Jung,Lee, Jung-Uee,Lee, Kwan-Ju,Park, Cho-Hyun,Park, Seung-Man,Jeon, Hae-Myung,Ahn, Chang-Joon,Kim, Jeong-Goo,Lee, Dong-Ho,Lee, Sang-Chul 대한위암학회 2009 대한위암학회지 Vol.9 No.3

목적: Vascular endothelial growth factor (VEGF)-C와 -D 및 Cyclooxygenase (COX)-2는 위암에서 림프절 전이와 연관이 있다고 알려져 있다. 이에 저자들은 점막하 침윤 조기위암에서 VEGF-C와 -D 및 COX-2의 발현과 림프절 전이 등을 포함하는 다양한 임상병리학적 인자와의 관련성을 알아 보고자 하였다. 대상 및 방법: 1991년 1월부터 2007년 10월까지 본원에서 점막하 침윤 조기위암으로 수술을 시행 받은 85명의 환자를 대상으로 VEGF-C, -D 및 COX-2와 VEGF-C에 대한 면역 조직화학 염색을 시행하였다. 염색의 결과에 따라 환자군을 나누어 다양한 임상병리학적 인자와의 연관성을 조사하였고, 또 이 세 가지 인자들 상호 간의 연관 관계를 분석하였다. 결과: 전체 85명의 환자 중 16명이 림프절 전이가 있었다(18.8%). VEGF-C는 34.1% VEGF-D는 22.3% 그리고 COX-2는 37.6%가 양성으로 판정되었다. 이 중 VEGF-C와 COX-2 모두 림프절 전이와 유의한 상관관계를 보였고(P<0.001, P=0.023). VEGF-D와 연관성을 보이는 인자는 확인하지 못하였다. 또 VEGF-C와 COX-2의 발현은 밀접한 상관관계를 보였다(P=0.001). 결론: 점막하 침윤 조기위암에서 VEGF-C와 COX-2는 림프절 전이와 연관이 있고, 따라서 이 두 인자가 점막하 침윤 조기위암의 림프절 전이를 예측하는 인자로서의 가능성이 있다고 할 수 있겠다. Purpose: Lymph node metastasis is an important factor in determining prognosis and therapeutic options for early gastric cancer (EGC) patients. Vascular endothelial growth factor (VEGF)-C and D are known as lymphangiogenic factors, and cyclooxygenase (COX)-2 is thought to play a role in lymph node metastasis in gastric carcinoma. This study was designed to determine whether the expression of VEGF-C, VEGF-D, and COX-2 is associated with clinicopathologic factors, especially lymph node metastasis in EGCs invading the submucosa. Materials and Methods: Tissue samples were obtained from 85 Patients undergoing standard gastrectomy with lymph node dissection between 1991 and 2007 in the Department of Surgery of Daejeon St. Mary's Hospital in Daejeon, Korea. All patients were diagnosed with gastric cancers and submucosal invasion. We examined the expression of VEGF-C, VEGF-D, and COX-2 using immunohistochemical methods. Results: Of the 85 patients, 16 (18.8%) had lymph node metastasis. VEGF-C, VEGF-D, and COX-2 were positively expressed in 34.1% (29/85), 22.3% (19/85), and 37.6% (32/85) of the patients. VEGF-C and COX-2 expression was significantly correlated with lymph node metastasis (P<0.05). A positive correlation existed between VEGF-C and COX-2 expression (P< 0.001). Conclusion: VEGF-C and COX-2 expression is associated with lymph node metastasis in gastric cancer with submucosal invasion. VEGF-C and COX-2 may thus be predictive markers for lymph node metastasis in EGC patients with submucosal invasion.

Depressive Mood and the Risk of Future Functional Decline in an Elderly Population

조윤정,홍영호,박형준,이지은,윤재문,신동욱,손기영,Be-Long Cho,김상혁 대한노인병학회 2017 Annals of geriatric medicine and research Vol.21 No.3

Background: As the elderly population increases in number, prediction and prevention of functional decline in this population are of great importance. This study evaluated whether depression in an elderly population could predict functional decline in activities of daily living and the components of instrumental activities of daily living 2 years after baseline. Methods: Data from the Korean Longitudinal Study of Aging panel, a national, representative sample of aging Koreans, were used. The subjects were the elderly aged 65 years or older who had no disabilities that hindered them from performing activities of daily living at baseline. Depression was measured using the Short-form (10-item) Center for Epidemiological Studies Depression Scale. Multivariable logistic regression analysis was performed to evaluate the effect of functional impairment according to baseline depression. Results: Of the 3,477 participants, 166 (4.8%) showed at least 1 impairment in the 7 activities of daily living (ADL) categories after 2 years. The participants with depression (scored 15 or higher on the depression scale) were more likely to have functional decline 2 years later (odds ratio, 1.82; 95% confidence interval, 1.23-2.71). All the components of the ADL had an increased tendency to develop functional decline (all odds ratios>1.00). Furthermore, negative items were significantly associated with functional decline (all p-values adjusted for trend<0.05). Conclusion: The participants with depression were more likely to have functional decline 2 years later. Such decline was observed in all types of ADL. Therefore, depression should be monitored and used as a predictor of functional decline in elderly adults.

폐경기 한국 여성에서 운동 빈도와 스트레스와의 상관관계

조윤정(Yoon Jeong Cho),이건호(Geon Ho Lee) 대한스트레스학회 2016 스트레스硏究 Vol.24 No.3

본 연구는 폐경기 여성에서의 일상생활의 스트레스와 운동 횟수와의 연관성 여부에 알아보기 위해 시행하였다. 2005년 1월에서 2009년 12월 사이 대구의 한 대학병원에서 건강검진을 위해 내원한 수검자중 폐경 여성 1,883명을 대상으로 분석하였다. 스트레스의 척도는 심리사회적 웰빙지표 단축형(Pshchosocial well being index short form, PWI-SF)을 사용하였으며 연령, 교육수준, 사회경제적 상태 및 음주, 흡연, 신체적 활동을 포함하여 조사하였다. 운동횟수는 일주일에 0회, 1∼2회, 3∼4회, 5회 이상으로 나누었다. PWI-SF 총 점수를 구하여 8점 이상을 건강군, 9∼26점을 잠재적 스트레스군 그리고 27점 이상을 고위험군으로 나누어 분석하였다. 통계 분석은 카이제곱 검정, 일원배치분산분석, 공분산분석을 이용하였다. 본 연구 결과 PWI-SF 점수와 운동 빈도는 유의한 음의 상관관계를 보였다. 연령, 흡연, 음주, 교육수준, 소득수준, 결혼여부, 약물치료 여부를 보정한 결과에서도 주당 운동빈도가 높을수록 스트레스 점수가 낮은 결과를 보였다. 폐경기 여성에서 주당 운동 횟수가 많을수록 PWI-SF 점수가 낮아, 유의한 음의 상관관계를 보여주었다. This study was conducted to understand the relationship between stress and exercise frequency in postmenopausal women of Korea. The participants were 1,883 postmenopausal women who had visited a single medical center in Daegu, between 2005 January to 2009 December. We excluded women who had been previously diagnosed depressive disorders or had been treating in hormonal replacement therapy. We used PWI-SF (psychosocial well being index short form) for measuring stress. The sum of PWI-SF score was classified into healthy (less than 8), latently stressed (9∼26) and high risk stressed (more than 27) groups. The frequency of exercise was divided into none, mild (1∼2 times a week), moderate (3∼4 times a week) and intense (more than 5 times a week) groups. We analyzed the data by utilizing chi-square test, ANOVA and ANCOVA. Our study showed a significant negative correlation between PWI-SF and frequency of exercise. Furthermore our result showed a statistically significant correlation between level of education, income and stress, while alcohol and smoking were not significantly associated with PWI-SF. Our result demonstrated that higher frequency of exercise was associated with low PWI-SF score in postmenopausal women of Korea.

시각장애학교 음악특기적성교육 참여에 따른 음악수업 인식

조윤정 ( Yun Jeong Cho ),이해균 ( Hae Gyun Lee ) 한국특수교육문제연구소 2014 특수교육저널 : 이론과 실천 Vol.15 No.2

본 연구는 시각장애학교 학생의 음악특기적성교육 참여에 따른 음악수업에 대한 인식과 음악특기적성교육에 대한 인식을 알아보고자 전국시각장애학교 초ㆍ중학생을 대상으로 설문조사를 실시하였다. 그 연구 결과를 요약하면 다음과 같다. 첫째, 학생의 배경변인에 따른 음악수업에 대한 인식은 보통수준 이상이었다. 그리고 음악수업에 대한 관심은 초등학생이 중학생보다 높았고 맹학생이 저시력학생보다 높았다. 둘째, 학생들의 음악특기적성교육 참여에 따른 음악수업에 대한 인식은 음악특기적성교육에 참여하는학생 집단이 더 높았다. 셋째, 학생들의 음악특기적성교육 참여에 따른 인식은 참여집단은 ‘참여자의 흥미 및 적극적인 태도’가 높았고, 비참여집단은 ‘다양하고 흥미 있는 프로그램’이 높았다. 음악특기적성교육 활성화를 위한 필요사항에 대해 참여집단은 ‘장애특성을 고려한 지도교사의 체계적인 수업’이 높았고, 비참여집단은 ‘학생들의 관심 및 적극적인 태도’가 높았다. 그리고 이러한 연구 결과를 바탕으로 향후 후속 연구에 대한 제언을 제시하였다. The purpose of this study is to raise efficiency of music class in the schools for the visually impaired by attracting students to extra music programs and searching for methods to introduce wider varieties and vitalities to the programs. Findings from the study are as follows. First, visually impaired students’ perception about regular music class was higher than ordinary level by the study’s background variables. Moreover, secondary students were more interested in music class than elementary level children, and also blind students showed higher interest in music class than those with low vision. Second, as for the effect of extra music lessons on regular music classes at school, when compared with the others, students who have attended the additional music programs are shown to have higher level of perception in each variable such as students’ interest, acquisitions from music class, instructor’s teaching style, curriculum and evaluation, and learning environments. Third, as for the awareness of students with visual impairments on extra music lessons, when they were asked about the motivation to take part in the lessons, students who have participated in the extra programs mostly chose the item of ‘Interest and participants’ attitude’, while those who have not attended the programs largely chose ‘Variety of attractive programs’.

교사동기 연구의 동향과 과제

조윤정(Cho, YoonJung) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.5

교사동기는 교사의 교직업무 뿐만 아니라 학생의 학습에 광범위하게 영향을 미친다는 점에서 매우 중요한 연구주제임에도 불구하고, 학업동기에 비해 연구자들의 관심을 받은 지 얼마 되지 않았다. 본 연구의 목적은 교사동기를 살펴본 선행연구들의 연구동향을 고찰함으로써 교사동기 연구의 현주소를 이해하고 향후 연구의 방향을 제시하는 데 있다. 그동안 수행된 교사동기 연구들은 교직의 특수성을 반영한 동기이론을 개발하여 적용하기 보다는, 학생을 대상으로 한 기존 연구에 사용되었던 동기이론을 교사동기에 단순히 적용한 경우가 대부분이었다. 본 연구에서는 교사동기 연구에 적용된 주요 동기이론들(자기효능감, 성취목표이론, 자기결정성이론, 기대-가치이론, 성취정서이론)을 검토하고, 이러한 이론에 근거하여 도출된 주요 교사동기 구인들(교사효능감, 성취목표, 자율성동기, 교직선택동기, 성취정서)을 중심으로 연구동향의 주요 특징과 패턴을 분석하였다. 향후 교사동기 연구에서 주목해야할 과제로 교사동기 특수성에 부합하는 동기이론 개발 및 적용, 교사동기의 종단적 변화와 안정성, 교사가 ‘지각한’ 동기의 특성과 선행요인, 교사동기와 관련 변인들 간의 인과적 관계, 교사동기 측정방식의 다각화를 제안하였다. 본 연구는 교사동기에 대한 학문적 관심이 급격히 증가하는 시점에서 교사동기 연구자들이 주목해온 주제들과 연구결과들을 살펴보고, 중요성에 비해 소홀히 다루어진 연구주제들을 발굴하여 향후 과제로 제안했다는 점에서 학문적 의의를 찾을 수 있다. Despite the significant influence of teacher motivation on student learning and instructional practices, teacher motivational research is still in its infancy. It is critical to understand teacher motivation in terms of its unique characteristics, antecedents and consequences to effectively promote adaptive teacher motivation. Early research on teacher motivation focused on examining whether the motivational theories utilized in student motivational research are applicable to explain teacher motivation. The purpose of this study is to understand the current status of teacher motivation research and to suggest directions for future research. This study focused on reviewing teacher motivation studies that applied the main theories of motivation (self-efficacy, achievement goal, self-determination, expectancy-value, achievement emotion theories) as theoretical framework and examined the main characteristics and patterns of research trend in the field of teacher motivation. In addition, this study suggested the direction and prospect of future research on teacher motivation. It was discussed that researchers need to pay attention to revising and expanding the motivation theories suitable for the research on teacher motivation in order to reflect unique and distinctive aspects of teacher motivation. This study also suggested that domain-specific and situation-specific nature of teacher motivation need to be captured and that causal relationships between teacher motivation and related variables need to be investigated. As research interest in teacher motivation is rapidly increasing, it is meaningful to identify the important research topics of teacher motivation that have been relatively neglected.

저선량 전자선 조사 수입 오렌지의 상온저장 중 품질 특성

조윤정(Yun-Jeong Cho),김경희(Kyung-Hee Kim),육홍선(Hong-Sun Yook) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.3

저선량 전자선 조사에 의한 수입 오렌지의 품질 특성을 조사하여 방사선 식품 검역 관리의 기초자료로 삼고자 미국산 수입 navel orange에 선량 0.2, 0.4, 0.6, 0.8, 1.0 kGy의 전자선을 조사하여 상온(20±0.1°C)에서 12일간 저장하면서 이화학적 품질 특성 및 관능적 특성을 조사하였다. 전자선을 조사한 오렌지의 색도, 당산비, 총당 및 환원당 함량, 비타민C 함량은 조사선량에 의한 영향을 받지 않았으며, 저장기간이 경과함에 따라 비조사구와 유사한 경향을 나타냈다. 경도는 저장 초기 모든 조사구에서 유의적으로 감소하였으나 저장 후기에는 그 차이가 감소하여 비조사구와 유사한 수준을 나타냈으며, 조사선량에 따른 일률적 감소의 경향은 없었다. 관능평가 결과 0.6 kGy 이하의 조사구에서는 단맛과 신맛을 제외한 모든 항목에서 비조사구와 유의적인 차이를 나타내지 않았고, 저장일 전반에 걸쳐 조사선량과는 무관하게 비조사구와 조사구 모두 선호도가 감소하였다. 결론적으로 0.6 kGy 이하의 전자선 조사는 상온저장 중 오렌지의 이화학적 품질 특성과 관능적 품질 특성에 영향을 미치지 않았으며, 전자선 조사를 통한 병해충 방제 효과를 얻기 위한 최적 선량은 0.6 kGy 이하인 것으로 판단된다. This study investigated the effects of low-dose electron beam irradiation treatment on the physicochemical and sensorial properties of imported navel oranges during storage at 20°C for 12 days. The samples were irradiated at doses of 0.2, 0.4, 0.6, 0.8, and 1.0 kGy, after which changes in color value, hardness, Brix/acid ratio, total sugar contents, reducing sugar contents, vitamin C contents, and sensory evaluation were investigated. There were no significant differences between non-irradiated and irradiated samples in terms of color value, Brix/acid ratio, total sugar contents, total reducing sugar contents, and vitamin C contents. Hardness of irradiated samples significantly decreased in the early storage period in an irradiation dose-independent manner, and the difference between non-irradiated and irradiated samples decreased again at the end of storage. For the sensory evaluation, there was no significant difference between non-irradiated and irradiated samples up to 0.6 kGy, and all sensory item scores decreased at the end of the storage period regardless of irradiation. These results suggest that electron beam irradiation below 0.6 kGy does not affect physicochemical and sensory properties during storage at 20°C. Thus, electron beam irradiation up to 0.6 kGy applied to imported navel oranges is the optimum dose for minimizing quality changes and disinfestation treatment.