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정의권,임석원 중앙대학교 스포츠과학연구소 2003 體育硏究 Vol.- No.19
The essence of sportsmanship as applied to athletics can be determined by the application of the same principle. Honorable victory is the goal of the athlete and, as a reretended to a certain moral relevancy, although its precise place among the moral virtues has been uncertain. In spite of this confusion, distinguished advsult, the code of the athlete demands that nothing be done before, during, or after the contest to cheapen or otherwise detract from such a victory. Fairness or fair play, the pivotal virtue in athletics, emphasizes the need for an impartial and equal application of the rules if the victory is to signify, as it should, athletic excellence. Modesty victory and a quiet composure in defeat testify to an admirable and extraordinary self-control and, in general, dignify and enhance the goal of the athlete.
BRAFV600E 형질전환 마우스를 이용한 갑상선유두암 모델의 확립
이정의,정경혜,조영석,송민호 대한갑상선학회 2011 International Journal of Thyroidology Vol.4 No.1
Background and Objectives: The BRAF^(V600E) mutation has been regarded as the leading cause of papillary thyroid cancer (PTC). However, the multi-step carcinogenic process induced by BRAF^(V600E) has been remained to be elucidated in thyroid gland. In this study, to investigate staged development of papillary thyroid carcinoma, we observed the histo-pathological findings of thyroid gland from BRAF^(V600E) transgenic mice with a period of 60 weeks. Materials and Methods: We histologically inspected 3, 9, 20, 27, 39, 44, 48 and 60 week old BRAF^(V600E) transgenic mice derived from FVB/N background mice with a bovine thyroglobulin promoter which are providing thyroid specific BRAF^(V600E) expression. Results: Thyroid glands from 3 and 9 week old BRAF^(V600E)transgenic mice were enlarged and showed abnormal histologic feature such as distorted follicular architectures. The 20 and 27 week old BRAF^(V600E) transgenic mice showed irregularly enlarged thyroid gland sprouting out above the carotid arteries. Thyroid gland derived from 39 week old mice showed reduced formation of intact follicular structure and increased solid area. Thyroid glands were entirely replaced by firm tumor mass composed of poorly differentiated cell at 44 weeks. Interestingly, we could observe tracheal invasion, surrounding muscle invasion in thyroid gland from 48 week old mice and detect lung metastasis in 60 week old mice. Conclusion: Thyroid specific expression of BRAF^(V600E) induced staged development of thyroid cancer. This finding may support that BRAF^(V600E)have a role in entire carcinogenic process such as tumor initiation, development and progression.
Solitary Schwannoma of the Breast- A Case Report -
이정의,설혜정,박병전 대한병리학회 2005 Journal of Pathology and Translational Medicine Vol.39 No.1
Schwannomas arise from the neural crest-derived Schwann cells. Their most common locations are the extremities, neck, mediastinum, retroperitoneum, and cerebellopontine angle. They have rarely been reported to occur in the breast. We herein report on a case of schwannoma of the breast in a 30-year-old woman. The ultrasonographic examination showed a well defined ovoid hypoechoic mass in the upper outer quadrant of her left breast. A presumptive diagnosis of fibroadenoma was made, and the mass was then removed. The histopathologic and immunohistochemical features confirmed the diagnosis of schwannoma of the breast.
이정의,김군순,이민호,김연수,이민희,이승은,김용경,유민정,김성정,최민정,조영석 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.5
Purpose: NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic factors for cancer development and progression. The purpose of this study is to investigate the relationship between NQO1/NQO2 genotype and clinico-pathological features of papillary thyroid microcarcinoma (PTMC). Materials and Methods: Genomic DNA was isolated from 243 patients;and clinical data were retrospectively analyzed. NQO1*2 and tri-allelic polymorphism of NQO2 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: PTMC with NQO1*2 frequently exhibited extra-thyroidal extension as compared to PTMC with wild-type NQO1 (p=0.039). There was a significant relationship between I29/I29 homozygosity of NQO2 and lymph node metastasis (p=0.042). Multivariate analysis showed that the I29/I29 genotype was associated with an increased risk of lymph node metastasis (OR, 2.24; 95% CI, 1.10-4.56; p=0.026). Conclusion: NQO1*2 and I29 allele of the NQO2 are associated with aggressive clinical phenotypes of PTMC, and the I29 allele represents a putative prognostic marker for PTMC.