SPH 기법을 이용한 주조공정 용탕 주입 유동 해석

박병래(Byung Lae Park),이상욱(Sang Wook Lee) 한국가시화정보학회 2018 한국가시화정보학회지 Vol.16 No.1

It is important to develop more efficient and productive casting processes for an automated high precision molten-metal casting system. Detailed analysis of molten-metal flow in the casting process by the numerical approach will help to optimize the control of a ladle. In this study, the smoothed particle hydrodynamics method was applied to analyze casting flow characteristics with different tilting angular speed and initial molten-metal level. The smoothed particle hydrodynamics technique has advantages to easily handle non-linear free surface behavior with the absence of a computational mesh. We found that tilting angular speed has relatively greater effect on the casting flowrate and that the effect of the initial molten-metal level is only minor. Further extensive study will be necessary to find an optimal condition for high efficient casting system.

한국인 정신분열병 환자의 안구추적운동 이상과 Dystrobrevin Binding Protein 1(DTNBP1) 유전자의 SNP A와 P1763 다형성의 연합에 대한 연구

이창희,박병래,김령효,김동현,조숙현,박진수,김임렬,이인상,서한길,변기욱,김봉조,한규희,김기훈,신태민,신형두,우성일,Lee, Chang Hee,Park, Byung-Lae,Kim, Lyoung Hyo,Kim, Dong Hyeon,Cho, Sook Hyun,Park, Jin-Soo,Kim, Im-Yel,Lee, In-Sang,Seo, Han-Gil,Byun, 대한생물정신의학회 2006 생물정신의학 Vol.13 No.4

목 적: 정신분열병 환자의 안구추적운동 이상은 유력한 생물학적인 지표이나 유전자적인 원인에 대한 연구가 활발히 진행되지 못하였다. 최근 여러 연구들에서 dystrobrevin binding protein 1(DTNBP1, dysbindin)이 정신분열병의 원인 유전자의 후보 유전자로서 시사되었으나 정신분열병 환자의 안구운동 이상의 원인으로 작용할 것인지에 대한 연구는 거의 없었다. 본 연구의 목적은 DTNBP1 유전자상에 존재한 비교적 인접한 두개의 단염기 다형성들인 SNP A와 P1763이 정신분열병 환자의 안구추적운동 이상의 유전자적인 원인으로 작용할 것인지를 알아보고자 시행되었다. 방 법: 대상군은 217명의 입원한 만성 정신분열병 환자들이며 안구운동(SPEM)을 측정하였고, 신호/잡음의 자연대수 값(Ln S/N ratio)을 구하여 안구운동이 우수한 군과 열등한 군으로 구분하였다. 이후 대상군의 혈액에서 추출한 DNA로부터 DTNBP1 유전자상의 단 염기 다형성들인 SNP A와 P1763를 분석하여 유전자형과 대립인자형을 알아낸 후, 안구운동 이상 유무에 따른 두 군사이의 분포의 차이를 조사하였다. 결 과: 정신분열병 환자들 중 안구운동이 우수한 군의 신호/잡음의 자연대수 값(Ln S/N ratio)의 평균과 표준편차는 $4.39{\pm}0.33$이었고, 안구운동이 열등한 군의 신호/잡음의 자연 대수 값(Ln S/N ratio)의 평균과 표준편차는 $3.17{\pm}0.71$이었다. 두 군 사이에 나이나 성별비율의 차이는 통계적으로 의미가 없었다. SNP A와 P1763의 유전자형과 대립인자형의 분포의 차이는 안구운동 이상 유무에 따라 구분한 두군 사이에 나타나지 않았다. 결 론: DTNBP1 유전자상에 존재한 SNP A와 P1763은 정신분열병 환자의 안구추적운동 이상의 유전자적인 원인으로 작용한다는 증거를 얻지 못하였다. Objectives : We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients. Methods : We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups. Results : The Ln S/N ratio(mean${\pm}$SD) of the good SPEM function group was $4.39{\pm}0.33$ and the ratio of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function. Conclusion : The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

한국인에서 Dystrobrevin Binding Protein 1(DTNBP1) 유전자의 다형성과 정신분열병의 연합에 대한 고찰

문현일,이연정,박병래,신형두,최인근,한선호,우성일,Moon, Hyun-Il,Lee, Yeon Jung,Park, Byung-Lae,Shin, Hyung Doo,Choi, Ihn-Geun,Han, Sun Ho,Woo, Sung-Il 대한생물정신의학회 2009 생물정신의학 Vol.16 No.3

Objectives : This study was designed to investigate the association of schizophrenia and P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene in Korean patients. Methods : We analyzed P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene from their DNAs extracted from their blood in 388 Korean schizophrenic patients (male 198, female 190) and 372 control subjects(male 247, female 125). We compared the differences of genotype and allele distributions of the six polymorphisms on DTNBP1 gene between the Korean schizophrenic patient group and the normal control group. Results : There were no statistically significant differences of genotype and allele distributions of the P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene between the schizophrenic patient group and the normal control group. Conclusion : The results of this study suggest that P1320, P1325, P1635, P1655, P1763 and SNP A polymorphism on DTNBP1 gene do not have influence on the risk of the schizophnenic in the Korean population.

Porphyromonas gingivalis에 대한 Polyphosphate의 항균효과

최인식(In-Shik Choi),박병래(Byung-Lae Park),김홍렬(Hong-Yeoul Kim),신제원(Je-Won Shin),최유진(Eu-Gene Choi),최영철(Yeong Chul Choi),이진용(Jin-Yong Lee) 大韓微生物學會 1999 大韓微生物學會誌 Vol.34 No.3

B형 간염의 만성화 및 간세포암종 발생과 Interleukin-12 유전자 다형성

박진선 ( Jin Sun Park ),정재연 ( Jae Youn Cheong ),강준구 ( Joon Koo Kang ),조진희 ( Jin Hee Cho ),유수경 ( Su Kyong Yu ),신형두 ( Hyoung Doo Shin ),박병래 ( Byung Lae Park ),조성원 ( Sung Won Cho ) 대한소화기학회 2007 대한소화기학회지 Vol.50 No.5

목적: B형 간염바이러스(hepatitis B virus, HBV) 감염은 다양한 임상 경과를 갖는다. HBV 감염의 자연경과의 다양성의 원인으로 유전자 다형성을 포함한 숙주 요인을 들 수 있으며, 사이토카인은 숙주 면역능에 중요한 역할을 한다. 이번 연구는 HBV 감염 후의 자연 경과와 간세포암종 발생에서 interleukin (IL)-12A 유전자 다형성(single neucleotide polymorphisms, SNP)과의 상관성을 알아보고자 하였다. 대상 및 방법: 2002년 3월부터 2004년 12월까지 외래를 내원한 HBV 만성화군 730명과 HBV 감염 후 자연 회복된 HBV 제거군 320명을 포함하여 총 1,050명을 대상으로 하였다. B형 간염의 만성화와 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군과 HBV 제거군의 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였고, 간세포암종 발생과 IL-12A의 유전자 다형성과의 관련성을 조사하기 위하여, HBV 만성화군을 간세포암종군과 비간세포암종군으로 나누어 IL-12A SNP 및 haplotype에 따른 차이를 비교 분석하였다. 결과: IL-12A의 SNP는 IL-12A 유전자 번역 시작 부위로부터 +6400, +6624, +7003 부위에서 조사하였다. 대상 환자를 HBV 만성화군과 HBV 제거군으로 분류하고, IL-12A SNP와 HBV 만성화와의 관련성을 조사한 결과 IL-12A exon 7 +6400 및 +6624 두 부위 및 3` UTR +7003 한 부위의 SNP는 HBV 만성화군과 HBV 제거군 간에 유의한 차이를 보이지 않았다. 또한 +6400/+6624/+7003 haplotype에 따른 HBV 만성화 관련성 조사에서도 양 군 간에 유의한 차이점은 관찰되지 않았다. IL-12A SNP와 간세포암종과의 관련성을 조사한 결과 각각의 SNP 및 +6400/ +6624/+7003 haplotype에 따른 HBV 감염 후 간세포암종 발생과의 연관성도 관찰되지 않았다. 결론: IL-12A SNP 및 haplotype은 HBV 간염 진행 및 간세포암종 진행과는 무관함을 알 수 있었다. HBV 감염의 자연 경과에서 숙주의 유전적인 인자의 중요성을 인지하고, 향후 환자의 유전 소인에 대한 연구가 더 진행되어야 할 것으로 판단한다. Background/Aims: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection is influenced by various host immune factors and cytokines play a crucial role in host immune defense. This study was undertaken to investigate the association between HBV persistence and development of hepatocelluar carcinoma (HCC) and single nucleotide polymorphisms (SNPs) of interleukin (IL)-12A. Methods: Between March 2002 and December 2004, seven hundred thirty Korean patients with HBV infection and 320 healthy individuals who recovered from HBV infection were enrolled. We assessed polymorphisms and haplotype in IL-12A, and the genotype distributions of the HBV clearance and persistence groups were compared in order to investigate the association between HBV persistence and SNPs of IL-12A. Moreover, the genotypic distributions between patients with HCC and without HCC were compared to investigate the association between the development of HCC and SNPs of IL-12A. Results: We asssesed the SNPs of IL-12A at position +6400, +6624 and +7003. On the basis of logistic regression analysis, no statistically significant association with HBV persistence was observed with IL-12A exon 7 +6400, +6624, 3` UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003. Furthermore, no statistically significant association of HCC development with IL-12A exon 7 +6400, +6624, 3` UTR +7003 SNP and haplotype of IL-12A +6400/+6624/+7003 was observed. Conclusions: These results suggest that SNPs and haplotype of IL-12A are not associated with HBV persistence and development of HCC. Further studies are needed to identify the host genetic factors in immune defense including cytokine gene polymorphisms of both IL-12A and IL-12B. (Korean J Gastroenterol 2007;50:313-318)

한국인에서 Neuregulin 3(NRG3) 유전자와 조현병의 연합 연구

신수진,최종택,김지원,노양호,박병래,배준설,신형두,최인근,한상우,황재욱,우성일,Shin, Su-Jin,Choi, Jong-Taek,Kim, Ji-Won,Roh, Yang-Ho,Park, Byung-Lae,Bae, Joon-Seol,Shin, Hyoung-Doo,Choi, Ihn-Geun,Han, Sang-Woo,Hwang, Jae-Uk,Woo, Sung-I 대한생물정신의학회 2012 생물정신의학 Vol.19 No.3

Objectives : Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population. Methods : Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates. Results : Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity. Conclusions : This study does not support the role of NRG3 in schizophrenia in a Korean population.

한국인에서 조현병과 Cannabinoid Receptor 1 유전자의 삼핵산 반복서열의 연합에 대한 연구

김지원,노양호,김민재,김채리,박병래,배준설,신형두,최인근,한상우,황재욱,우성일,Kim, Ji-Won,Roh, Yang-Ho,Kim, Min-Jea,Kim, Chea-Ri,Park, Byung-Lae,Bae, Joon Seol,Shin, Hyoung Doo,Choi, Ihn-Geun,Han, Sang-Woo,Hwang, Jaeuk,Woo, Sung-Il 대한생물정신의학회 2014 생물정신의학 Vol.21 No.3

Objectives Previous studies suggest that the cannabinoid receptor 1 (CNR1) gene could be an important candidate gene for schizophrenia. According to linkage studies, this gene is located on chromosome 6q14-q15, which is known to harbor the schizophrenia susceptibility locus (locus 5, SCZ5, OMIM 803175). The pharmacological agent delta-9-tetrahydrocannabinol (${\Delta}$-9-THC) seems to elicit the symptoms of schizophrenia. The association between CNR1 polymorphisms and schizophrenia is actively being investigated, and some studies have linked the AAT-trinucleotide repeats in CNR1 to the onset of schizophrenia. In this study, we have investigated the association between the AAT-trinucleotide repeats in CNR1 and schizophrenia by studying schizophrenia patients and healthy individuals from Korea. Methods DNA was extracted from the blood samples of 394 control subjects and 337 patients diagnosed with schizophrenia (as per the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria). After polymerase chain reaction amplification, a logistic regression analysis, with age and gender as the covariates, was performed to study the variations in the AAT-repeat polymorphisms between the two groups. Results In total, 8 types of trinucleotide repeats were identified, each containing 7, 8, 10, 11, 12, 13, 14, and 15 repeats, respectively. $(AAT)_{13}$ allele was most frequently observed, with a frequency of 33.6% and 31.6% in the patient and control groups, respectively. The frequency of the other repeat alleles in the patient group (in the decreasing order) was as follows : $(AAT)_{13}$ 33.6%, $(AAT)_{14}$ 21.6%, $(AAT)_{12}$ 18.5%, and $(AAT)_{7}$ 11.1%. The frequency of the repeat alleles in the control group (in the decreasing order) was as follows : $(AAT)_{13}$ 31.6%, $(AAT)_{14}$ 24.5%, $(AAT)_{12}$ 17.2%, and $(AAT)_{7}$ 11.6%. However, there were no significant differences in the AAT-repeat polymorphisms of the CNR1 gene between the patient group and the control group. Conclusions Although our study revealed no significant association of the AAT-repeat polymorphism of the CNR1 gene with schizophrenia, it will serve as a good reference for future studies designed to examine the cannabinoid hypothesis of schizophrenia.

한국인 정신분열병 환자의 안구추적운동 이상과 COMT 유전자의 Val108/158Met 다형성의 연합 연구

장호준,문현일,이연정,김임렬,이인상,서한길,김기훈,신태민,박병래,신형두,한선호,한상우,우성일,Jang, Ho Joon,Moon, Hyun-Il,Lee, Yeon Jung,Kim, Im-Yel,Lee, In-Sang,Seo, Han-Gil,Kim, Ki-Hoon,Shin, Tae-Min,Park, Byung-Lae,Shin, Hyung Doo,Han, Sun 대한생물정신의학회 2008 생물정신의학 Vol.15 No.4

Objectives : We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. Methods : We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. Results : The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was $4.39{\pm}0.33$(mean${\pm}$s.d.) and that of poor SPEM function group was $3.17{\pm}0.71$. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. Conclusions : The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.