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      • KCI등재

        Dislocation Density-Based Constitutive Model and Processing Map for T2 Copper During Isothermal and Time-Variant Deformation

        Gang Chen,Yu Jin,Jing Wang,Cheng Zhang,Qiang Chen,Hongming Zhang,Xingjian Zhao,Zhiyong Li,Changhai Xie,Zhiming Du 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.9

        Isothermal compression tests were carried out to study the hot deformation behavior of T2 copper under various conditions. The deformation parameters, such as temperature and strain rate, have strong influence on flow stress and microstructureevolution of the alloy. A unified dislocation density-based model considering dynamic recovery and recrystallization wasestablished. And material parameters of the developed model were optimized by genetic algorithm. Comparisons betweenthe experimental and model data demonstrates that the developed model can precisely describe the flow behavior at quitewide range of deformation conditions. Meanwhile, the designed iterative procedure allows the model to be applied in timevariantdeformation conditions. Processing map and microstructure examination were constructed to optimize the processingwindow of the studied alloy. According to the processing maps, flow instability mainly appeared at low temperatures of500–650 °C and strain rates higher than 0.1 s−1. The optimum deformation parameters of T2 copper was concluded as thetemperature range of 700–800 °C and the strain rate of 0.1–1 s−1.

      • KCI등재

        The feasibility of detecting endometrial and ovarian cancer using DNA methylation biomarkers in cervical scrapings

        Cheng-Chang Chang,Hui-Chen Wang,Yu-Ping Liao,Yu-Chih Chen,Yu-Chun Weng,Mu-Hsien Yu,Hung-Cheng Lai 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1

        Objective: We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. Methods: We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verified in training set using cervical scrapings of 10 EC/10 OC patients and 10 controls, and further validated in the testing set using independent cervical scrapings in 30 EC/30 OC patients and 30 controls. We generated cutoff values of methylation index (M-index) from cervical scrapings to distinguish between cancer patients and control. Sensitivity/specificity of DNA methylation biomarkers in detecting EC and OC was calculated. Results: Of 14 genes, 4 (PTGDR, HS3ST2, POU4F3, MAGI2) showed hypermethylation in EC and OC tissues, and were verified in training set. POU4F3 and MAGI2 exhibited hypermethylation in training set were validated in independent cases. The mean M-index of POU4F3 is 78.28 in EC and 20.36 in OC, which are higher than that in controls (6.59; p<0.001 and p=0.100, respectively), and that of MAGI2 is 246.0 in EC and 12.2 in OC, which is significantly higher that than in controls (2.85; p<0.001 and p=0.480, respectively). Sensitivity and specificity of POU4F3/MAGI2 were 83%–90% and 69%–75% for detection of EC, and 61% and 62%–69% for the detection of OC. Conclusion: The findings demonstrate the potential of EC/OC detection through testing for DNA methylation in cervical scrapings.

      • KCI등재

        Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson’s Disease

        Hung-Li Wang,Chin-Song Lu,Tu-Hsueh Yeh,Yu-Ming Shen,Yi-Hsin Weng,Ying-Zu Huang,Rou-Shayn Chen,Yu-Chuan Liu,Yi-Chuan Cheng,Hsiu-Chen Chang,Ying-Ling Chen,Yu-Jie Chen,Yan-Wei Lin,Chia Chen Hsu,Huang-Li 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.4

        Background and Purpose It is essential to develop a reliable predictive serum biomarker for Parkinson’s disease (PD). Te accumulation of alpha-synuclein (αSyn) and up-regulated expression of Rab35 participate in the etiology of PD. Te purpose of this investigation was to determine whether the combined assessment of serum αSyn and Rab35 is a useful predictive biomarker for PD. Methods Serum levels of αSyn or Rab35 were determined in serum samples from 59 sporadic PD patients, 19 progressive supranuclear palsy (PSP) patients, 20 multiple system atrophy (MSA) patients, and 60 normal controls (NC). Receiver operating characteristics (ROC) curves were calculated to determine the diagnostic accuracy of αSyn or/and Rab35 in discriminating PD patients from NC or atypical parkinsonian patients. Results The levels of αSyn and Rab35 were increased in PD patients. The serum level of Rab35 was positively correlated with that of αSyn in PD patients. Compared to analyzing αSyn or Rab35 alone, the combined analysis of αSyn and Rab35 produced a larger area under the ROC curve and performed better in discriminating PD patients from NC, MSA patients, or PSP patients. When age was dichotomized at 55, 60, 65, or 70 years, the combined assessment of αSyn and Rab35 for classifying PD was better in the group below the cutof age than in the group above the cutof age. Conclusions Combined assessment of serum αSyn and Rab35 is a better biomarker for discriminating PD patients from NC or atypical parkinsonian patients, and is a useful predictive biomarker for younger sporadic PD patients.

      • The association of ambient air pollution with airway inflammation in schoolchildren.

        Chen, Bing-Yu,Chan, Chang-Chuan,Lee, Chung-Te,Cheng, Tsun-Jen,Huang, Wen-Chuan,Jhou, Ji-Ci,Han, Yueh-Ying,Chen, Chu-Chih,Guo, Yue Leon School of Hygiene and Public Health of the Johns H 2012 American Journal of Epidemiology Vol.175 No.8

        <P>The biologic mechanisms involved in airway inflammatory response to air pollution are not clearly understood. The authors conducted a longitudinal study to investigate whether exposure to ambient air pollutants affected inflammatory cells and mediators from nasal lavage in schoolchildren. Study participants were 100 elementary and middle-school students in New Taipei City, Taiwan. A structured respiratory health questionnaire was administered in September 2007, followed by monthly measurement of nasal inflammation from October 2007 to November 2009. During the study period, daily concentrations of air pollutants were obtained from the Environmental Protection Administration monitoring station and the Aerosol Supersite. Mixed-effects models were applied to examine the association between air pollution and nasal inflammatory cells and mediators, including percentages of neutrophils, eosinophils, and monocytes in lavaged cells and interleukin-8. A total of 824 measurements were obtained from 100 participants over a period of 10 months. The level of particulate matter with an aerodynamic diameter of 2.5 μm or less (PM(2.5)) was found to be associated with percentage of neutrophils (β = 3.45%, 95% confidence interval: 0.89, 6.01) and interleukin-8 level (β = 29.98 pg/mL, 95% confidence interval: 3.26, 56.69) in the nasal lavage on the day of exposure. In this longitudinal cohort study of schoolchildren, results indicated that exposure to PM(2.5) might induce nasal inflammation.</P>

      • KCI등재

        Construction of Z-scheme W18O49/NiAl-LDH heterojunction with photothermal effect for photocatalytic reduction of CO2

        Cheng Xia,Rui-Tang Guo,Zhen-rui Zhang,Chen-yuan Fan,Yu-zhe Liu,Yu-cheng Lin,Chu-fan Li,Wei-Guo Pan 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

        Recently, the photocatalytic CO2 reduction technology is an effective solution to remit the energy crisis. Inorder to improve the photocatalytic performance, Z-scheme W18O49/NiAl-LDH composite catalysts wereprepared by hydrothermal method. Fortunately, the prepared catalysts revealed excellent photocatalyticperformance under the simulated sunlight, and CO and CH4 could be detected in the reduction products. WO/LDH-0.5 catalyst possessed the optimal activity, with CO and CH4 yield of 37.09 and 8.01 lmol g-1h1separately, which were 7.9 and 3.6 times that of NiAl-LDH monomer. In addition, W18O49 endowedW18O49/NiAl-LDH catalysts with photothermal effect, which raised the surface temperature andfacilitated the catalytic reaction. Meanwhile, the Z-scheme heterojunction composed of flower-likeNiAl-LDH and urchin-like W18O49 accelerated the separation of photoexcited carriers and enhanced theredox ability. Through a series of characterizations and investigations, this work is promising to breaknew ground for the design of photocatalysts with photothermal effect.

      • A study on Safe Pork Consumption Behavior in Taiwan

        ( Cheng-wei Chen ),( Yu-ping Fan ),( Cheng-hsing Yeh ) 한국농업경제학회 2009 KOREAN JOURNAL OF AGRICULTURAL ECONOMICS(KJAT) Vol.50 No.3

        Pork is the most popular meat in Taiwan, that makes hog industry an important agriculture industry. The government had lauched the traceability system of agricultural products from 2004. It is needed to appreciate the policy affecting consumers’ willingness to buy safe pork for hog industry to separate market. This research use consumer decision process model and market segmentation to separate four respective factors as age group, educational background, family income, and the population element as family structure to find out the habit of safe pork consumption. This study was based on household as its unit, and had conducted questionnaire survey upon the primary purchasers of pork, which were then analyzed with descriptive statistics, Chi-square test, and the logit model so as to differentiate the preference of demographic characteristics among consumers with various features. This research indicated consumers with more members of household, older, less educated,less income, less cognitive about pork risk would have higher possibility to buy warm pork. Consumers with female, more educated, more income, more cognitive about pork risk would have higher willingness to pork with traceability system.However consumers in Taiwan still prefer buy warm body pork, little perception about pork marketing risk. The government should improve pork safety by more inspecting hog farms, processing factories and markets and educating consumers the knowledge of safe pork by television broadcasting and other mass media.

      • KCI등재

        The Effects of Electro Slag Welding on Material Properties of Box Column Plates

        Cheng-Cheng Chen,Yu-Chen Liang2 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.2

        The effects of electro slag welding (ESW) on the material properties of box column plates, which is ASTM A572 Gr. 50steel, were investigated experimentally and numerically. The material properties of the column plates before and after ESW were evaluated by macro-etching observation, micro-structural observation, and CVN impact tests. The temperature distribution of the column plates, with the ESW heat cycle as the heat input, was simulated by using the ANSYS FEM software. It was found that: (1) The CVN values in the through thickness direction of the base metal can be as low as 14J, 8.1J, and 8.1J at 0oC for plate thicknesses of 32, 40, and 50 mm respectively; (2) During the ESW process, the measured peak temperature for a 25×50 mm column plate surface was as high as 1033, 880 and 744oC for plate thicknesses of 32, 40 and, 50 mm respectively;(3) After the ESW heat cycle, the through thickness CVN value decreased by 68% for the coarse grain heat affected zone (HAZ) of the column pate; (4) The FEM thermal conduction model developed was able to simulate the temperature distribution of the steel plate during the ESW process with reasonable accuracy; (5) To avoid welding penetration due to ESW, a minimum plate thickness is suggested; (6) The impact of ESW heat cycle is more significant for thin column plates compared to thick ones.

      • SCIESCOPUSKCI등재
      • KCI등재

        A Study on Safe Pork Consumption Behavior in Taiwan

        Cheng-Wei Chen,Yu-Ping Fan,Cheng-Hsing Yeh 한국농업경제학회 2009 農業經濟硏究 Vol.50 No.4

        Pork is the most popular meat in Taiwan, that makes hog industry an important agriculture industry. The government had lauched the traceability system of agricultural products from 2004. It is needed to appreciate the policy affecting consumers’ willingness to buy safe pork for hog industry to separate market. This research use consumer decision process model and market segmentation to separate four respective factors as age group, educational background, family income, and the population element as family structure to find out the habit of safe pork consumption. This study was based on household as its unit, and had conducted questionnaire survey upon the primary purchasers of pork, which were then analyzed with descriptive statistics, Chi-square test, and the logit model so as to differentiate the preference of demographic characteristics among consumers with various features. This research indicated consumers with more members of household, older, less educated, less income, less cognitive about pork risk would have higher possibility to buy warm pork. Consumers with female, more educated, more income, more cognitive about pork risk would have higher willingness to pork with traceability system.However consumers in Taiwan still prefer buy warm body pork, little perception about pork marketing risk. The government should improve pork safety by more inspecting hog farms, processing factories and markets and educating consumers the knowledge of safe pork by television broadcasting and other mass media.

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