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Design and Self-Assembly of Amphiphilic Block Copolymers for Drug Delivery
Yi Yan Yang,Chuan Yang,Jeremy P. K. Tan,Nikken Wiradharma,Shrinivas Venkataraman,Amalina Bte Ebrahim Attia,Zhan Yuin Ong,Wei Cheng,Ashlynn Lee,Lin Kin Yong,Kazuki Fukushima,Sung Ho Kim,Daniel J. Coady 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.1
Chuan-Wei Zhang,Fang-Yi Li,Jianfeng Li,Qi Xie,Jie Xu,An-Fu Guo,Cheng-Zhao Wang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.3
Starch-based biomass composites were prepared with starch and plant fiber. In order to improve the properties of the compos ites, oxidized starches (OS) were prepared using hydroxyl peroxide as oxidizer, then glycerol was added into OS as plasticizer to produce thermoplastic oxidized starches (TPOS). Crystal structure, hydrogen bonds of TPOS were researched to gain comprehensive views on the mechanism of the property differences between the starch-based composites with native starch, OS and TPOS. The changes of crystal structure were analyzed by X-ray diffraction analysis. Starch intermolecular hydroxyl changes were investigated using the method of infrared spectrum analysis. It was found that the new hydrogen bonds were formed between the plasticizer, oxidizer and starch, and the starch intermolecular bonding force was weakened. The structure of starch crystallization was destructed in TPOS. Differential scanning calorimetry showed that cross reaction with oxidization and plasticization changed the crystal structure, glass transition process was not observed in TPOS. The tensile and compressive strengths of composite based on TPOS were improved greatly and mechanical properties were not weakened obviously with water content increased. All the results indicated that TPOS could improve the properties of starch-based composites.
Yi-Chuan Hsieh,Su-Fen Cheng,Pei-Kwei Tsay,Wen-Jen Su,Yen-Hua Cho,Chi-Wen Chen 한국간호과학회 2017 Asian Nursing Research Vol.11 No.4
Purpose: This study aimed to evaluate the effects of cognitive-behavioral program on pain and medical fear in hospitalized school-aged children receiving intravenous (IV) placement. Methods: This study used an quasi-experimental design. Thirty-five participants were assigned to the experimental group and 33 to the control group in the acute internal medicine ward of a children's hospital. The cognitive-behavioral program entailed having the patients read an educational photo book about IV placement before the procedure and having them watch their favorite music video during the procedure. The outcome measures were numeric rating scales for pain intensity and fear during the procedure. Results: After applying the cognitive-behavioral program, the mean scores on pain and fear decreased in the experimental group. However, the difference in pain intensity between these two groups was nonsignificant. The intensity of fear in the experimental group was significantly lower than that in the control group. Conclusion: In this study, the cognitive-behavioral program used with school-aged hospitalized children promoted less fear during IV placement. The results of this study can serve as a reference for empirical nursing care and as care guidance for clinical IV injections involving children.
A Tracking System Using Location Prediction and Dynamic Threshold for Minimizing SMS Delivery
Yuan-Cheng Lai,Jian-Wei Lin,Yi-Hsuan Yeh,Ching-Neng Lai,Hui-Chuan Weng 한국통신학회 2013 Journal of communications and networks Vol.15 No.1
In this paper, a novel method called location-based delivery (LBD), which combines the short message service (SMS) and global position system (GPS), is proposed, and further, a realistic system for tracking a target’s movement is developed. LBD reduces the number of short message transmissions while maintaining the location tracking accuracy within the acceptable range. The proposed approach, LBD, consists of three primary features: Short message format, location prediction, and dynamic threshold. The defined short message format is proprietary. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. The threshold is dynamically adjusted to maintain the location tracking accuracy and the number of shortmessages on the basis of themoving speed of the target. The experimental results show that LBD, indeed, outperforms other methods because it satisfactorily maintains the location tracking accuracy with relatively fewer messages.
Hedging Performance and Stock Market Liquidity: Evidence from the Taiwan Futures Market
Hsiu-Chuan Lee,Cheng-Yi Chien 한국증권학회 2010 Asia-Pacific Journal of Financial Studies Vol.39 No.3
This paper examines the impact of stock market liquidity on the hedging performance of stock index futures, and extends the conditional OLS model described by Miffre [Journal of Futures Markets 24 (2004) 945] by including stock market liquidity in the regression model. The empirical results indicate that information regarding stock market liquidity is useful in predicting the optimal hedge ratio under different market conditions. In a bear market, the conditional OLS model with stock market liquidity provides the best hedging performance for the out-of-sample period. Although the OLS model outperforms the generalized autoregressive conditional heteroskedasticity and conditional OLS models for the out-of-sample period in a bull market, the conditional OLS model with stock market liquidity outperforms the conditional OLS model without stock market liquidity in terms of downside risks (lower partial moment).
Tzu-Yi Lin,Eugene Yu-Chuan Kang,Shih-Chieh Shao,Edward Chia-Cheng Lai,Sunir J. Garg,Kuan-Jen Chen,Je-Ho Kang,Wei-Chi Wu,Chi-Chun Lai,Yih-Shiou Hwang 대한당뇨병학회 2023 Diabetes and Metabolism Journal Vol.47 No.3
Background: To compare risk of diabetic retinopathy (DR) between patients taking sodium-glucose cotransporter-2 inhibitors (SGLT2is) and those taking glucagon-like peptide-1 receptor agonists (GLP1-RAs) in routine care.Methods: This retrospective cohort study emulating a target trial included patient data from the multi-institutional Chang Gung Research Database in Taiwan. Totally, 33,021 patients with type 2 diabetes mellitus using SGLT2is and GLP1-RAs between 2016 and 2019 were identified. 3,249 patients were excluded due to missing demographics, age <40 years, prior use of any study drug, a diagnosis of retinal disorders, a history of receiving vitreoretinal procedure, no baseline glycosylated hemoglobin, or no follow-up data. Baseline characteristics were balanced using inverse probability of treatment weighting with propensity scores. DR diagnoses and vitreoretinal interventions served as the primary outcomes. Occurrence of proliferative DR and DR receiving vitreoretinal interventions were regarded as vision-threatening DR.Results: There were 21,491 SGLT2i and 1,887 GLP1-RA users included for the analysis. Patients receiving SGLT2is and GLP-1 RAs exhibited comparable rate of any DR (subdistribution hazard ratio [SHR], 0.90; 95% confidence interval [CI], 0.79 to 1.03), whereas the rate of proliferative DR (SHR, 0.53; 95% CI, 0.42 to 0.68) was significantly lower in the SGLT2i group. Also, SGLT2i users showed significantly reduced risk of composite surgical outcome (SHR, 0.58; 95% CI, 0.48 to 0.70).Conclusion: Compared to those taking GLP1-RAs, patients receiving SGLT2is had a lower risk of proliferative DR and vitreoretinal interventions, although the rate of any DR was comparable between the SGLT2i and GLP1-RA groups. Thus, SGLT2is may be associated with a lower risk of vision-threatening DR but not DR development.
Robin Jung-Cheng Chen,Hsin-Chih Lin,Yi-Lung Hsueh,Chuan-Chung Hsieh 서울대학교 교육연구소 2020 Asia Pacific Education Review Vol.21 No.4
This study aims to explore relationship between teacher self-efficacy and teacher teaching practice in junior high schools at Taiwan. TALIS (2018) survey database is adopted, and 3106 teachers were analyzed in this research. Through literature review and exploratory factor analysis (EFA), the research model is assumed to include two constructs (classroom management efficacy and instruction efficacy) in teacher self-efficacy, and three constructs (clarity of instruction practice, cognitive activation practice, and classroom management practice) in teacher teaching practice. Through the analysis of Structural Equation Modeling (SEM), the main findings are as follows. (1) For clarity of instruction practice, instruction efficacy has more positive influences than classroom management efficacy. (2) For classroom management practice, classroom management efficacy as more positive influences than instruction efficacy. (3) For cognitive activation practice, instruction efficacy has positive influences but classroom management efficacy has negative influences.
Investigation of Visual Perception Under Zen-Meditation Based On Alpha-Dependent F-VEPs
Liao, Hsien-Cheng,Liu, Chuan-Yi,Lo, Pei-Chen The Korean Society of Medical and Biological Engin 2006 의공학회지 Vol.27 No.6
Variation of brain dynamics under Zen meditation has been one of our major research interests for years. One issue encountered is the inaccessibility to the actual meditation level or stage as a reference. In this paper, we propose an alternative strategy for investigating the human brain in response to external flash stimuli during Zen meditation course. To secure a consistent condition of the brain dynamics when applying stimulation, we designed a recording of flash visual evoked potentials (F-VEPs) based on a constant background EEG (electroencephalograph) frontal $\alpha-rhythm$ dominating activities that increase significantly during Zen meditation. Thus the flash-light stimulus was to be applied upon emergence of the frontal $\alpha-rhythm$. The alpha-dependent F-VEPs were then employed to inspect the effect of Zen meditation on brain dynamics. Based on the experimental protocol proposed, considerable differences between experimental and control groups were obtained. Our results showed that amplitudes of P1-N2 and N2-P2 on Cz and Fz increased significantly during meditation, contrary to the F-VEPs of control group at rest. We thus suggest that Zen meditation results in acute response on primary visual cortex and the associated parts.
A Tracking System Using Location Prediction and Dynamic Threshold for Minimizing SMS Delivery
Lai, Yuan-Cheng,Lin, Jian-Wei,Yeh, Yi-Hsuan,Lai, Ching-Neng,Weng, Hui-Chuan The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.1
In this paper, a novel method called location-based delivery (LBD), which combines the short message service (SMS) and global position system (GPS), is proposed, and further, a realistic system for tracking a target's movement is developed. LBD reduces the number of short message transmissions while maintaining the location tracking accuracy within the acceptable range. The proposed approach, LBD, consists of three primary features: Short message format, location prediction, and dynamic threshold. The defined short message format is proprietary. Location prediction is performed by using the current location, moving speed, and bearing of the target to predict its next location. When the distance between the predicted location and the actual location exceeds a certain threshold, the target transmits a short message to the tracker to update its current location. The threshold is dynamically adjusted to maintain the location tracking accuracy and the number of short messages on the basis of the moving speed of the target. The experimental results show that LBD, indeed, outperforms other methods because it satisfactorily maintains the location tracking accuracy with relatively fewer messages.