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Niu, Yu-Ming,Shen, Ming,Li, Hui,Ni, Xiao-Bing,Zhou, Juan,Zeng, Xian-Tao,Leng, Wei-Dong,Wu, Ming-Yue Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Objective: Findings for associations between the methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and head and neck cancer risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Methods: Ten published case-control studies were collected and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR A1298C polymorphism and head and neck cancer risk. Sensitivity analysis and publication bias assessment also were performed to guarantee the statistical power. Results: Overall, no significant association between MTHFR A1298C polymorphism and head and neck cancer risk was found in this meta-analysis (C vs. A: OR=1.04, 95%CI=0.87-1.25, P=0.668, Pheterogeneity<0.001; CC vs. AA: OR=1.07, 95%CI=0.70-1.65, P=0.748, $P_{heterogeneity}<0.001$; AC vs. AA: OR=1.06, 95%CI=0.88-1.27, P=0.565, $P_{heterogeneity}<0.001$; CC+AC vs. AA: OR=1.06, 95%CI=0.86-1.30, P=0.571, $P_{heterogeneity}<0.001$; CC vs. AA+AC: OR=1.02, 95%CI=0.69-1.52, P=0.910, $P_{heterogeneity}<0.001$). Similar results were also been found in succeeding analysis of HWE and stratified analysis of ethnicity. Conclusion: In conclusion, our meta-analysis demonstrates that MTHFR A1298C polymorphism may not be a risk factor for developing head and neck cancer.
Comparison of Sulfur Utilization among 10 Different Genotypes of Rape (Brassica napus)
Ming Li(이명),Bok Rye Lee(이복례),Yu Lan Jin(김옥란),Lu Shen Li(이노신),Dae Hyun Kim(김대현),Tae Hwan Kim(김태환) 한국초지조사료학회 2008 한국초지조사료학회지 Vol.28 No.2
유채 품종 간의 황 이용률을 비교하기 위하여 10가지 유채 품종 (Mokpo, Tamra, Youngsan, Naehan, Saturnin, Akela, Mosa, Capitol, Pollen and Colosse)을 정상적인 황 공급 (2.0 mM) 조건하에서 재배하여 품종별로 황 흡수량을 측정하였다. 또한 유채 품종간의 생육 특성을 비교하기 위해 잎의 수, 잎의 길이, 잎의 넓이 및 뿌리의 길이를 조사하였다. 그 결과, 모든 유채품종에서 잎의 수, 잎의 길이와 넓이는 별다른 차이는 나타나지 않았다. 뿌리 길이는 Saturnin에서 36.3 ㎝로 가장 길게 나타났다. Saturnin, Youngsan과 Mokpo에서 SO₄²? 흡수량이 대체적으로 높았고 Mosa와 Pollen에서 SO₄²? 흡수량 상대적으로 낮았다. SO₄²? 흡수량이 높은 Saturnin와 Mokpo에서 NO₃? 흡수량도 높게 나타났다. To investigate the sulfate utilization efficiency in different rape (Brassica napus) cultivars, sulfate uptake are analyzed under complete S-supply level (2.0 mM SO₄²?). This study used ten different genotypes of rape (Mokpo, Tamra, Youngsan, Naehan, Saturnin, Akela, Mosa, Capitol, Pollen and Colosse). For comparison of SO₄²? uptake among 10 cultivars, leaf number, leaf length and width, root length was also observed. Leaf length and width in all cultivars less variable among the cultivars examined. The longest root was shown in Saturnin (36.3 ㎝). SO₄²? uptake in Saturnin, Youngsan and Mokpo was significantly higher whereas that of Mosa and Pollen was relatively lower. Saturnin and Mokpo which have a high SO₄²? uptake exhibited a high NO₃? uptake.
SO₄²? Uptake and Assimilation in Forage Rape(Brassica napus)
Ming Li(이명),Yu Lan Jin(김옥란),Bok Rye Lee(이복례),Lu Shen Li(이노신),Dae Hyun Kim(김대현),Tae Hwan Kim(김태환) 한국초지조사료학회 2008 한국초지조사료학회지 Vol.28 No.2
유채의 황 이용성에 대한 영향을 조사하기 위하여 유채 2 품종 (cv. Akela, Colosse)을 2.0 mM SO₄²?와 0.2 mM SO₄²?에서 SO₄²? 흡수, ATP sulfurylase의 활성과 엽조직내의 glutathione (GSH) 함량을 측정하였다. 0.2 mM SO₄²?에서 두 품종 모두 2.0 mM SO₄²?에 비해 현저하게 낮은 SO₄²? 흡수율을 나타냈다. 0.2 mM SO₄²?에서 APT sulfurylase의 활성은 어린잎에서 두 품종 모두 증가하였으나 성숙된 잎에서의 활성은 큰 변화가 없었다. 0.2 mM SO₄²?에서 glutathione의 함량은 어린잎에서 두 품종 모두 증가하였으나 성숙된 잎에서는 Akela에서만 현저하게 감소하였다. 이러한 결과들은 유채품종간의 SO₄²? 흡수와 ATP sulfurylase의 특이성 뿐만 아니라, SO₄²? 흡수가 glutathione과 같은 황을 포함하고 있는 화합물로의 동화와 밀접한 관련이 있음을 나타낸다. To investigate the sulfate utilization efficiency that has been examined in rape (Brassica napus L.) cultivars (cv. Akela and Colosse). During 72 h of treatment, in two cultivars, SO₄²? uptake was significantly higher in complete S condition (2.0 mM SO₄²?) than that of the S-deficient condition (0.2 mM SO₄²?). In young leaves, ATPsulfurylase activity increased after S-deficient treatment. However, in old leaves, ATP sulfurylase activity was not significantly changed in Akela. Glutathione concentration in young leaves significantly increased in all cultivars examined under S-deficient condition. The rate of increase in glutathione concentration caused by S-deficiency treatment was higher in Akela. However, in old leaves, the glutathione concentration in Akela significantly decreased. The results suggest that SO₄²? uptake and ATP sulfurylase in rape plants were species specific, and that SO₄²? uptake was highly related to its assimilation into S containing compound such as glutathione.
A Study on Improve Share Image of Visual Cryptography
Chao-Ming Wu,Wen-Jan Chen,Yu-Yen Shen 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
The visual cryptography is a method of encrypt secret image in to two or several share images and use the mankind's visual scheme to decipher. The sizes of the two share images produced by our method will be different. So, the transmission bandwidth and storage space needed are less than the traditional visual cryptography system. In addition the security of the data is increased.
Zhen-Yu Shen,Xiao-Ming Xu 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.5
We study the unpolarized cross sections for the endothermic nonresonant reactions, ππ → ρρ forI = 2, KK → K∗K∗for I = 1, KK∗ → K∗K∗for I = 1, πK → ρK∗for I = 3/2, πK∗ → ρK∗for I = 3/2, ρK → ρK∗for I = 3/2, and πK∗ → ρK for I = 3/2, which take place in hadronicmatter. We obtain the temperature-dependent meson masses from the Schr¨odinger equation withthe potential that is given by perturbative quantum chromodynamics (QCD) with loop correctionsat short distances, that becomes a distance-independent and temperature-dependent potential atlong distances, and that has a spin-spin interaction with relativistic modifications. In the first Bornapproximation with the quark-interchange mechanism, the temperature dependences of the potential,the meson masses, and the mesonic quark-antiquark wave functions bring about a temperaturedependence of the unpolarized cross sections for the seven nonresonant reactions. Noticeably, rapidchanges in the π and K radii cause a rapid increase in peak cross sections, except for the πK∗ → ρKcross section, as the temperature approaches a critical temperature. Compared to in-vacuum crosssections, the medium modifications of the cross sections are remarkable.
Wu Yu,Li Bing,Yu Dandan,Zhou Zhixuan,Shen Ming,Jiang Fei 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.3
BACKGROUND: Ever-growing tissue regeneration causes pressing need for large population of stem cells. However, extensive cell expansion eventually leads to impaired regenerative potentials. In this study, chromobox protein homolog 7 (CBX7) was overexpressed to rejuvenate late passage dental pulp stem cells (DPSCs-P9). METHODS: The recruitment of copper ions (Cu2?)-activated hypoxia-inducible factor-1a (HIF-1a) to the CBX7 gene promoter was confirmed by chromatin immunoprecipitation assay. Functions subsequent to Cu2?-induced or recombinant overexpression of CBX7 on proliferation, multipotency, odontoblastic differentiation and angiogenesis were investigated in vitro, while murine subcutaneous transplantation model was used to further detect the effects of Cu2?-induced CBX7 overexpression in vivo. RESULTS: Our data displayed that CBX7 overexpression maintain proliferation and multipotency of DPSCs-P9 almost as strong as those of DPSCs-P3. Both gene level of odontoblast-lineage markers and calcium precipitation were nearly the same between CBX7 overexpressed DPSCs-P9 and normal DPSCs-P3. Moreover, we also found upregulated expression of vascular endothelial growth factor in DPSCs-P9 with CBX7 overexpression, which increased the number of capillary-like structures and migrating co-cultured human umbilical vein endothelial cells as well. These findings indicate CBX7 as an effective factor to rejuvenate late passage stem cells insusceptible to cell expansion. Cu2? has been proved to achieve CBX7 overexpression in DPSCs through the initiation of HIF-1a-CBX7 cascade. Under Cu2? stimulation since P3, DPSCs-P9 exhibited ameliorated regenerative potential both in vitro and in vivo. CONCLUSION: Long-term stimulation of Cu2? to overexpress CBX7 could be a new strategy to manufacture large population of self-renewing stem cells.
Hou Ming-Feng,Ou-Yang Fu,Li Chung-Liang,Chen Fang-Ming,Chuang Chieh-Han,Kan Jung-Yu,Wu Cheng-Che,Shih Shen-Liang,Shiau Jun-Ping,Kao Li-Chun,Kao Chieh-Ni,Lee Yi-Chen,Moi Sin-Hua,Yeh Yao-Tsung,Cheng Chi 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In Western countries, breast cancer tends to occur in older postmenopausal women. However, in Asian countries, the proportion of younger premenopausal breast cancer patients is increasing. Increasing evidence suggests that the gut microbiota plays a critical role in breast cancer. However, studies on the gut microbiota in the context of breast cancer have mainly focused on postmenopausal breast cancer. Little is known about the gut microbiota in the context of premenopausal breast cancer. This study aimed to comprehensively explore the gut microbial profiles, diagnostic value, and functional pathways in premenopausal breast cancer patients. Here, we analyzed 267 breast cancer patients with different menopausal statuses and age-matched female controls. The α-diversity was significantly reduced in premenopausal breast cancer patients, and the β-diversity differed significantly between breast cancer patients and controls. By performing multiple analyses and classification, 14 microbial markers were identified in the different menopausal statuses of breast cancer. Bacteroides fragilis was specifically found in young women of premenopausal statuses and Klebsiella pneumoniae in older women of postmenopausal statuses. In addition, menopausal-specific microbial markers could exhibit excellent discriminatory ability in distinguishing breast cancer patients from controls. Finally, the functional pathways differed between breast cancer patients and controls. Our findings provide the first evidence that the gut microbiota in premenopausal breast cancer patients differs from that in postmenopausal breast cancer patients and shed light on menopausal-specific microbial markers for diagnosis and investigation, ultimately providing a noninvasive approach for breast cancer detection and a novel strategy for preventing premenopausal breast cancer.
R. Karthik,Yu-Shen Hou,Shen-Ming Chen,A. Elangovan,M. Ganesan,P. Muthukrishnan 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-
In the present investigation, we report a facile, reproducible and effortless biological synthesis of silvernanoparticles (Ag-NPs) utilizing Cerasus serrulata (C. serrulata) leaves extract as reducing as well asstabilizing agent. The size of synthesized Ag-NPs was in the range of 15–24 nm when examined withtransmission electron microscopy (TEM) and X-ray diffraction studies. The Ag-NPs obtained using C. serrulata exhibited excellent catalytic activity towards reduction of 4-nitrophenol (4-NPh) to 4-aminophenol in the presence of NaBH4 and demonstrate noteworthy electrochemical performance for 4-NPh reduction. The linear range, detection limit and sensitivity are estimated as 0.09–82.5 mM(r = 0.991), 0.06 mM and 3.0 mA mM 1 cm2 respectively. The Ag-NPs were found to show higherantimicrobial efficiency against Streptococcus mutans and Staphylococcus aureus.