서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

간첩소지 만년필형 독총의 구조 및 성분

홍성욱,이정필,박성우 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

전통 고추장을 이용한 소스의 제조 및 특성

홍상필,김은미,조경현 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.2

To develope a sauce using Gochujang which can give foreigners good overall acceptance such as good flavor, taste, color, viscosity and versatility to many foods, we studied on the rheological properties and color control, recipes with spices, herbs, syrup, salt and flavor ingredients and sensory evaluation by Chinese, American and Japanese including Korean. From the survey, the Americans suggested that the proper fellow food of Gochujang sauce be fried chicken, barbecue, hamburger and pizza, and hoped to reflect red color, low viscosity, hot taste, low sweetness, salty and sourness and diet effect. The Chinese suggested pork and fried food as a fellow food with Gochujang sauce and showed similar opinion in the sensory attributes like the Americans except sweetness. When 5% of starch and xanthan gum was added to sauce, respectively, the yield stress of Gochujang sauce showed 33.21 Pa similar to tomato ketchup. In fluidity measured by voistic flow meter, Gochujang sauce showed 6.2 cm/30sec more or less faster than tomato ketchup which showed 4.7 cm/30sec. Gochujang sauce tended to show strong red color and lightness as pH decreased. The pH adjustant and Paprica oleoresin(2%) improved a value to 12.11 and L value to 24.24 similar to tomato kechup(a:12.42, L:25.48). The 1st gochujang sauce product showed 4.50 to 5.75 points in the overall acceptance in the consumer test including foreigners and koreans. However, the 2nd Gochujang sauce product showed 5.90 points and 6.30 points in the pizza and fried chicken, respectively, in the same consumer test. Therefore, we propose that Gochujang can be used for developing sauce products which is most acceptable for various foreigners.

삼환계 항우울제(Dothiepin)가 우울증 환자의 수면에 미치는 영향 : 수면 다원 검사에 의한 연구 A Polysomnographic Study

홍승철,한진희,이성필,방승규 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

우울증환자군에서 삼환계 항우울제인 dothiepin 투여 후의 수면이 변화양성을 알아보며, 치료 후의 호전정도를 예측할 수 있는 치료 전과 치료 후의 수면변인을 조사하기 위하여 본 연구를 시행하였다. 수면상태는 수면다원검사를 실시하여 평가하였고, 우울증상의 심각도와 임상양상의 정도는 Hamilton 우울척도를 이용하여 평가하였다. 연구대상은 최소 14일 이상 약물을 투여 받지 않은 우울증 환자 16명(남자 7명, 여자 9명, 연령분포 23∼64세)으로 구성되었다. 수면다원검사는 약물을 투여하기 전과 약물투여 후 1주와 3주에 시행하여 다음과 같은 결과를 얻었다. 1) 항우울제 투여 1주와 3주 후 수면 연속성은 기준수면에 비하여 총수면 시간이 유의하게 증가하였고 수면잠재기는 단축되었으며, 수면도중 각성시간은 감소하였고, 수면효율은 증가되었다. 2) 항우울제 투여 1주와 3주 후 수면구조에서는 기준수면에 비하여 2단계 수면이 유의하게 증가하였다. 3) 항우울제 투여 1주와 3주 후 급속안구운동 수면은 기준수면에 비하여 유의하게 감소하였고, 급속안구운동 수면잠재기는 증가하였다. 4) 항우울제 투여 1주 후와 3주 후의 수면을 비교시 수면잠재기가 3주에 유의하게 감소된 외에는 수면 변인의 차이를 보이지 않았다. 5) 우울증상의 평가를 위하여 약물투여 1주 후와 3주 후에 시행한 Hamilton 우울척도 점수는 약물투여 전에 비하여 줄어들어 우울증상이 호전됨을 나타내었다. 6) 항우울제 투여 3주 후 치료반응이 좋았던 군의 수면특징은 기준수면에서 수면도중 각성시간이 증가된 경향을 나타내었고, 약물투여 1주 후의 수면에서는 4단계 수면의 양이 유의하게 감소되었다. 이상의 결과를 볼 때, 우울증환자에서 삼환계 항우울제인 dothiepin 투여 후의 수면변화는 치료초기에 나타났다. 기준수면에서 각성기간의 증가와 1주 후의 수면에서 4단계 수면의 감소는 약물치료에 좋은 반응과 관련된 수면변인으로 생각되었다. Objectives : This study was designed to investigate 1) sleep changes after antidepressant (dothiepin) treatment, and 2) sleep variables which seem to be associated with clinical response in the depressed patients. Methods : The subjects consisted of 16 patients who fullfilled the criteria for major depression by the Diagnostic and statistical Manual, (4th edition). Their sleep was recorded using polysomnography at the baseline and after one week and three weeks of dothiepin treatment. All subjects were further interviewed using Hamilton Rating Scale for Depression (HRSD) to rate the severity of their depression. High response to the drug was defined as a reduction of more than 50% of the HRSD score. Results : The results were as follows : 1) Depressed patients after dothiepin treatment showed more total sleep time(p=0.019), shorter sleep latency(p=0.05), less awake time(p=0.033), more sleep efficiency(p=0.018), more stage 2 sleep(p=0.002), less REM time(p=0.000), and longer REM sleep latency(p=0.004) than before treatment. 2) There were no differences in sleep variables between those who received 1 week and 3 weeks of dothiepin treatment except for the shortening of sleep latency after 3 weeks(p<0.05). 3) Depressive symptom scores on HRSD were reduced after 1 week and 3 weeks of dothiepin treatment as compared with the baseline. 4) High responders showed a tendency of increased wake time(p=0.054), while their stage 4 sleep decreased after 1 week of dothiepin treatment as compared with the low responders(p=0.0136). Conclusion : These results suggest that sleep of the depressed patients after dothiepin treatment tends to be normalized and sleep changes seem to appear early in the treatment phase. In addition, clinical response might be associated with greater wake time at the baseline and lesser stage 4 sleep after 1 week of dothiepin treatment.

일반배낭문제의 완전다항시간근사해법군의 존재조건

홍성필,박범환 한국경영과학회 2003 韓國經營科學會誌 Vol.28 No.4

The generalized knapsack problem or gknap is the combinatorial optimization problem of optimizing a nonnegative linear function over the integral hull of the intersection of a polynomially separable 0-1 polytope and a knapsack constraint. The knapsack, the restricted shortest path, and the constrained spanning tree problem are a partial list of gknap. More interestingly, all the problem that are known to have a fully polynomial approximation scheme, or FPTAS are gknap. We establish some necessary and sufficient conditions for a gknap to admit an FPTAS To do so, we recapture the standard scaling and approximate binary search techniques in the framework of gknap. This also enables us to find a weaker sufficient condition than the strong NP-hardness that a gknap does not have an FPTAS. Finally, we apply the conditions to explore the fully polynomial approximability of the constrained spanning problem whose fully polynomial approximability is still open.

정신병적 증상이 동반된 기면병 1예

홍승철,송정민,정종현,권용실,한진희,이성필 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.5

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disrupted nocturnal sleep. We report a patient with a diagnosis of schizophrenia who was subsequently diagnosed as narcolepsy. A case of a 22-year-old woman with concomitant narcolepsy and psychotic symptoms was discussed from a perspective of the diagnosis and therapeutic challenges, particularly on pharmcological treatment dealing with issues raised by their coexistence.

도로교통시설물 관리 하자와 법적 책임에 관한 연구 : 판례를 중심으로 Focus on the Judicial Precedent

홍성필,김만배,장순희 서울대학교 행정대학원 2003 行政論叢 Vol.41 No.2

우리나라의 경우 외국과 달리 도로교통시설물의 설치·관리의 하자에 대한 책임에 대하여 도로이용자는 물론 도로관리자 양측 모두 소극적인 실정이다. 그러나 국민의 권리의식 향상 등으로 이와 관련된 행정책임 관련 소송은 급격히 증가될 것으로 예상된다 이와 같은 배경에서 본 연구는 도로교통시설물의 설치·관리의 하자에 관한 국내·외 판례를 탐색적 방법으로 조사·분석하여 하자(瑕疵)의 판단기준을 제시함으로써 도로이용자나 도로관리청 양측의 예측가능성을 높이고 책임한계를 명확히 하고 도로의 하자로 인한 교통사고를 예방함을 목적으로 한다. 본 연구에서는 여러 가지 한계 때문에 개별적인 도로교통시설물의 하자 유형별 그 판단기준을 도출하는 대신 모든 도로교통시설물의 하자가 가지고 있는 공통적인 하자판단 요소에 대해 판례를 중심으로 분석하였다. 구체적으로는 하자의 유형을 교통안전시설물, 노면관리, 도로의 결손, 공사구간, 갓길의 관리 등으로 나누어 각각의 판례를 조사하고 이를 종합하여 최소한의 하자 판단기준을 제시하였다. In our country, both road user and road manager are passive with respect to a duty for a certain defect in an installation and management of a road traffic facility, differently from other foreign countries. However, it is expected that an administration duty related suit will be sharply increased based on an enhancement of a right awareness of people. Therefore, it is an object of this research to search and analyze a local and foreign judicial precedent concerning any defects in an installation and management of a road traffic facility based on a search method and to increase a prediction possibility for both road user and road managing organ by suggesting a judgment reference with respect to any defects and to clarify a duty limit, for thereby preventing a certain traffic accident due to a defect in road. In this research, a judicial precedent is intensively analyzed with respect to a common defect judgment element of a defect of a road traffic facility, instead of extracting a type based judgment reference of a separate road traffic facility due to various limits. In detail, the judicial precedents are searched in such a manner that the types of the defects are divided into a traffic safety facility, a road surface management, a defect in a road, a construction period, and a management of side road, and a minimum defect judgment reference is suggested by integrating the above matters.

Creutzfeldt-Jacob병 1례

홍승철,한진희,정종현,김소양,허균,이성필 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

저자들은 Creutzfeldt-Jacob병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 약 4개월에 걸친 비교적 짧은 기간 동안 중증의 인지 기능 장애와 시각 장애, 보행장애와 하지의 약화, 불수의적 운동 등과 함께 섬망상태에까지 이르게 되어 본원 정신과에 입원하게 되었다. 정신상태 검사상, 반응시간의 지체, 언어장애와 보속증, 시간에 대한 지남력 장애, 주의 집중력 장애, 단기 및 장기 기억 장애, 추상적 사고능력 장애 등의 소견을 보였고, 이러한 증상들은 입원후 치료에도 불구하고 빠르게 악화되었다. 뇌파검사상 지속적인 다발초점성 서파가 모든 전극에서, 특히 우측 전두부에서 현저하게 나타나는 소견을 보였고, 병리조직학적 검사상 대뇌 피질에 신경손실을 동반한 해면화와 신경교 증식증을 나타냈다. 이상의 소견들은 모두 CJD의 진단에 합당하였다. We report a case of Creutzfeldt-Jacob disease and review the relevant literatures. This 56-year-old male patient was admitted to our hospital with a history of rapidly progressing cognitive dysfunction, visual disturbance, gait disturbance, weakness, involuntary movement of lower extremities, and the symptoms of delirium. On mental status examination, he showed psychomotor retardation, speech disturbance, perseveration, disorientation, impairment of short-term and long-term memory, and inability of abstract thinking. He had a rapid downhill course, along with shakiness of trunk, rigidity of the limbs, myoclonus, confusion, and finally, inability to speak or move on the bedside. On electroencephalogram(EEG), continuous multifocal show delta activities were found in all leads, especially in the right frontal areas. Brain biopsy showed, spongiosis with neuronal loss and gliosis noted at the cerebral cortex. These findings were compatible with Creutzfeldt-Jacob disease.

農家副業으로서의 畜産現況과 그 改善方案에 關한 硏究

洪鐘旭,李熙碩,朴恒均,崔源弼,李鉉凡,金祥基 慶北大學校 1978 論文集 Vol.25-26 No.-

Recently, there have been much corncerns about the strategies which can reasonably increase farm income at the average farm level. In other words, as a result of third-term Five Year Economic Development Plan there was a remarkable gap between farm household and non-farm household incomes. Therefore, various policy tasks to eliminate this unbalanced income growth are currently being implemented. This study was carried out to identify the situation of livestock farming at general farm level, regarded as one of income generation strategies for the farm sector. Some results of the study can be summarized as follows: First of all, it was found that a group of farms which raise a small size of animals like Korean cattle, hog, and various poultry gave higher resource bases as compared with that of non-livestock farms. Secondly, it was also recognized that both farm and farm household income levels of small-scale livestock farms were higher than those of non-livestock farm group within the same region, specifically as much as approximately ￦200,000. Thirdly, it was known that the average size of animal raising per household in 0.9 head of cattle, 0.8 head of hog, and 34 lyers of poultry, respectively. To the end, according to the farm disposal practices of major by-products, only about 18 percent of total rice straws produced at individual farms was utilized for the animal raising, and about 45 percent of all the brans available at farms for the livestock enterprise. The rest of straw and brans in regarded as selling at farm level. In this respect, it may be recommended either to increase current size of animals or to expand number of livestock farms.

철결핍성 빈혈과 동반된 심부뇌정맥 혈전증

정필욱,홍석찬,이광호,정진상 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5