Preoperative Evaluation of Living Donor Candidate for Liver Transplantation

( Sanghee Song ),( Ok Kyung Kim ),( Myung Eun Lee ),( Jin Yong Choi ),( Hyeyoung Kim ),( Sung-woo Ahn ),( Hyo-sin Kim ),( Kyung Chul Yoon ),( Suk Kyun Hong ),( Nam-joon Yi ),( Kwang-woong Lee ),( Kyun 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

The downside of living donor liver transplantation, of course, is the risk to the healthy donor. For the donor safety, preoperativeevaluation of donor is important and it should be included psychosocial and ethical issues as well as medical suitability. Here,we introduce a preoperative evaluation of living donor candidate for liver transplantation. Since 2011 our institution`s protocolwas introduced, this three-step evaluation protocol have been used in our center (Fig.1). At Step1, the medical examination ofcandidate for donor by interview includes the medical history, psychosocial circumstance and age; usually 16-60 years. The relationshipbetween the recipient and donor should be within the third degree of consanguinity or an intense emotional relationshipjudged by ethical board of local committee. At Step 2, potential donor undergoes tests two phase medical evaluation, ethicalevaluation and document process. First phase medical evaluation includes basic blood and urine profile, Liver CT scan forgraft/remnant volume of liver, ECG and chest X-ray. Second phase medical evaluation includes viral and neoplastic disease andimaging studies, especially primovist MRI and MRCP, for anatomy and quality of the liver include the degree of fatty change.If necessary, the invasive procedures including liver biopsy and additional consultations required to investigate the potential problemsdiscovered during phases 1 and 2 are done. At Step 3, the multidisciplinary team discuss about donor and decide thedonation. A preoperative liver biopsy was applied to the moderate steatosis from imaging studies. The presence of mild systemicdiseases (e.g., well-controlled hypertension or diabetes) cannot be a contraindication in our protocol. The donors are disciplinedto quit smoking and drinking. The remnant liver volume ≥ 30% of the whole liver is recommended. If macrovesicular steatosisis ≥ 10%, we do liver biopsy and recommend diet control. Donors with a GRWR > 0.8% were generally accepted. Usually minimalanantomical variation of the liver has been accepted. Only candidate who passed these all examination, can be a donor for livertransplantation. This detailed evaluation undoubtedly play a role in our successful living donor liver transplantation program,and there was no donor mortality and the overall donor morbidity was < 6.0%, including 0.9% of major complications (> gradeIII). In conclusion, meticulous donor evaluation is important for the successful LDLT.

Recent advances of aromatic C-F bond borylation and its application to positron emission tomography

Song, Dalnim,Lee, Sanghee,Lee, Byung Chul,Kim, Sang Eun,Lee, Eunsung 대한방사성의약품학회 2015 Journal of radiopharmaceuticals and molecular prob Vol.1 No.2

Carbon-fluorine (C-F) bonds have been found ubiquitously in pharmaceuticals, radiopharmaceuticals, agrochemicals, and material science due to their unique properties such as thermal and oxidative stability and lipophilicity to improve bioavailability. For the past five years, there have been significant advances in F-18 fluorination of aromatic complex molecules combined with the development of late-stage fluorination reactions. More recently, direct incorporation of F-18 to fluorinated aromatic molecules via borylation of C-F bonds has been developed by Niwa and Hosoya. In this minireview, we will discuss the progress of C-F bondborylation of fluorinated arenes utilizing transition metal catalysts and the impact on the development of F-18 radiotracers for positron emission tomography (PET).

Cyber risk measurement via loss distribution approach and GARCH model

Sanghee Kim,Seongjoo Song 한국통계학회 2023 Communications for statistical applications and me Vol.30 No.1

The growing trend of cyber risk has put forward the importance of cyber risk management. Cyber risk is defined as an accidental or intentional risk related to information and technology assets. Although cyber risk is a subset of operational risk, it is reported to be handled differently from operational risk due to its different features of the loss distribution. In this study, we aim to detect the characteristics of cyber loss and find a suitable model by measuring value at risk (VaR). We use the loss distribution approach (LDA) and the time series model to describe cyber losses of financial and non-financial business sectors, provided in SAS® OpRisk Global Data. Peaks over threshold (POT) method is also incorporated to improve the risk measurement. For the financial sector, the LDA and GARCH model with POT perform better than those without POT, respectively. The same result is obtained for the non-financial sector, although the differences are not significant. We also build a two-dimensional model reflecting the dependence structure between financial and non-financial sectors through a bivariate copula and check the model adequacy through VaR.

The complete mitochondrial genome of the mysid shrimp, <i>Neomysis japonica</i> (Crustacea, Malacostraca, Mysida)

Song, Ji-Hun,Kim, Sanghee,Shin, Sook,Min, Gi-Sik Informa UK (Informa Healthcare) 2016 Mitochondrial DNA. Part A Vol.27 No.4

<P>In this study, we determined the mitogenome sequence of Neomysis japonica (Crustacea, Malacostraca, Mysida), which is the first complete mitogenome sequence in the order Mysida. The mitogenome of N. japonica is 17,652 bp in length and contains 13 protein-coding genes (PCGs), 22 transfer RNAs (tRNAs), 2 ribosomal RNAs (rRNAs), and a control region (CR). Mitogenome analysis of N. japonica revealed a novel gene order that included inversions in three PCGs and five tRNAs, compared with H. americanus, the ancestral pancrustacean ground pattern. The results will be useful for the detailed study of mitogenome evolution and the phylogenetic relationships among the orders in the class Malacostraca. As seen from the phylogenetic tree, N. japonica belongs to the order Mysida within Malacostraca.</P>

Architecture Mapping of the Inner Mitochondrial Membrane Proteome by Chemical Tools in Live Cells

Lee, Song-Yi,Kang, Myeong-Gyun,Shin, Sanghee,Kwak, Chulhwan,Kwon, Taejoon,Seo, Jeong Kon,Kim, Jong-Seo,Rhee, Hyun-Woo American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.10

<P>The inner mitochondria membrane (IMM) proteome plays a central role in maintaining mitochondria' physiology and cellular metabolism. Various important biochemical reactions such as oxidative phosphorylation, metabolite production, and mitochondrial biogenesis are conducted by the IMM proteome, and mitochondria-targeted therapeutics have been developed for IMM proteins, which is deeply related for various human metabolic diseases including cancer and neurodegenerative diseases. However, the membrane topology of the IMM proteome remains largely unclear because of the lack of methods to evaluate it in live cells in a high-throughput manner. In this article, we reveal the in vivo topological direction of 135 IMM proteins, using an in situ-generated radical probe with genetically targeted peroxidase (APEX). Owing to the short lifetime of phenoxyl radicals generated in situ by submitochondrial targeted APEX and the impermeability of the IMM to small molecules, the solvent-exposed tyrosine residues of both the matrix and intermembrane space (IMS) sides of IMM proteins were exclusively labeled with the radical probe in live cells by Matrix-APEX and IMS-APEX, respectively and identified by mass spectrometry. From this analysis, we confirmed 58 IMM protein topologies and we could determine the topological direction of 77 IMM proteins whose topology at the IMM has not been fully characterized. We also found several 1MM proteins (e.g., LETM1 and OXA1) whose topological information should be revised on the basis of our results. Overall, our identification of structural information on the mitochondria' inner-membrane proteome can provide valuable insights for the architecture and connectome of the IMM proteome in live cells.</P>

Abdominal wall mass suspected of endometriosis: clinical and pathologic features

( Heekyoung Song ),( Sanghee Lee ),( Min Jeong Kim ),( Jae Eun Shin ),( Dae Woo Lee ),( Hae Nam Lee ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.3

Objective To evaluate the clinical and pathological characteristics of lower anterior abdominal wall masses suspicious for endometriosis. Methods A retrospective review of 38 patients who underwent surgery for a lower anterior abdominal wall mass suspicious for endometriosis was performed. Those with skin and intraperitoneal masses, lipomas, hernias, and metastatic malignant masses were excluded. Patient age, body mass index, delivery history, dysmenorrhea, and mass size and location were analyzed. Results Thirty-seven (97.3%) patients had a relevant surgical history, including 35 (92.1%) with a history of cesarean section (C/S). Among the three patients with no history of C/S, 1 underwent total abdominal and another total laparoscopic hysterectomy, and 1 had no previous surgical history. The mean (±standard deviation) size of the abdominal masses was 3.2±1.2 cm. One patient developed a recurrent mass after excision of abdominal wall endometriosis. Trocar site endometrioma was found in one patient following total laparoscopic hysterectomy. According to the final pathology reports, endometriosis was found in 35 (92.1%) of patients. The remaining 3 patients (7.9%) had malignancy: adenocarcinoma, squamous cell carcinoma, and extra-gastrointestinal stromal tumor. Before surgery, only 3 patients (7.9%) underwent fine-needle aspiration biopsy of the masses, which were all postoperatively confirmed to be pathologically benign. Conclusion Although most abdominal wall masses in the present sample were endometriosis occurring at the scar site from a previous operation, 7.9% of patients ultimately exhibited malignancy. Therefore, all patients with suspected anterior wall endometriosis should undergo preoperative biopsy to identify the few that will have an alternative diagnosis.

Leiomyoma of the nipple : case report

JungHyun SONG,Dongsuk LEE,Sanghee SEOK,Dongsuk KIM 대한외과학회 2019 대한외과학회 학술대회 초록집 Vol.2019 No.10

비재무적 요인과 기업의 재무적 특성 간의 관계 : 국민연금 국내주식 보유 기업을 중심으로

원상희(Sanghee Won),송헌재(Heonjae Song) 한국자료분석학회 2020 Journal of the Korean Data Analysis Society Vol.22 No.2

최근 기업의 사회적 책임 등과 같은 이슈와 함께, 기업의 장기 지속 가능성에 영향을 미치는 요인으로 ESG 요인을 고려해야 한다는 목소리가 높아지고 있다. 이러한 배경 하에 본 연구는 ESG와 재무적 특성 사이 연결성을 확인하기 위해, 국민연금 보유 주식의 기업단위 패널 데이터를 활용하여, fixed effect 모형, 2SLS 모형을 통해, ESG 요인이 기업의 재무적 특성에 미치는 영향을 분석하였다. fixed effect 연구결과 S 요인이 우수할수록 기업의 수익성이 개선되는 것을 확인하였으며, E 요인이 우수할수록 부채비율이 증가하는 것을 확인하였다. 그러나 역의 인과성을 고려한 2SLS 분석에서 S가 수익성(ROE)에 미치는 영향은 유효하였지만, 그 부호는 반대로 나타났으며, E와 부채비율 간에는 유의미한 결과가 확인되지 않아, E 요인과 부채비율의 경우 역의 인과성이 존재할 가능성이 있음을 확인하였다. 연구결과, 비재무적 요인과 재무적 특성을 연결하기에 아직은 불안정한 상황이라 사료되나, 그럼에도 ESG 요인을 투자 전략으로 활용한다면, 재무적 특성에 따라 이에 연결되는 ESG 요인이 다르다는 점을 참고하여, 투자 목적에 맞는 ESG 요인에 조금 더 집중하는 방안을 제안한다. Recently, The demand for corporate social responsibility is increasing, and accordingly, there is a growing interest in ESG factor. In this background, this study analyzed the relationship between ESG factors and financial characteristics of NPS investment companies. Regression analysis was performed using panel data from companies, and this paper employed the fixed effect model to investigate the effects of ESG factors. We also reviewed the reverse causality issue through the 2SLS model. Estimation results showed that the higher the S factor, the higher the ROE. Also, Estimate showed that the higher the E factor, the higher the debt ratio. However, 2SLS Estimation results showed that the effect of S on ROE was reversed. And there is the possibility of a reverse causal relationship between E and the debt ratio. This finding means that it is still unstable to link non-financial factors to financial characteristics. Nevertheless, when ESG factors are used as an investment strategy, it should be taken into account that there are differences in ESG factors associated with each financial characteristic.

Protective effects of compound B1 on liver injury in alcohol-fed rats

Shin, Sanghee,Yang, Keum-Jin,Piao, Longzhen,Shin, Eulsoon,Li, Yuwen,Park, Kyeong Ah,Byun, Hee Sun,Won, Minho,Kim, Young-Rae,Lee, Hyunji,Hur, Gang Min,Seok, Jeong Ho,Kim, Jin Man,Song Minho,Park, Jongs 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

한국관광공사 API를 활용한 무장애 여행 일정 시스템

신상희(Sanghee Shin),조우성(Wooseong Jo),박소현(Sohyeon Park),송주혜(Juhye Song),오병우(Byoungwoo Oh) 한국정보기술학회 2023 Proceedings of KIIT Conference Vol.2023 No.6